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Definitions

• the present invention relates to a pharmaceutical composition for preventing, treating or alleviating allergic diseases, pain, infection, cold, thrombosis or coagulation, inflammation, cancer, viral infection, poisoning, memory loss, caffeine addiction by lowering the pH of body fluids And its healthy food.
• the invention also relates to a non-toxic addictive coffee, its use and a method of preparation.
• the invention also relates to feeds that can be used in animals.
• Type I is a real-time allergic reaction, an allergic reaction using IgE antibodies as a medium.
• the allergic diseases include allergic rhinitis, anaphylactic shock, atopic dermatitis, asthma, Parkinson's disease, hay fever, food allergies and the like.
• Type I I is a cytotoxic type and is an allergic reaction using IgM and IgG antibodies as a medium.
• the diseases caused by this allergic disease include hemolytic disease in children, autoimmune hemolytic anemia, acute rheumatic fever, nephritis, drug allergy, and hepatitis.
• the first ⁇ type is an allergic immune response to an immune complex type.
• the diseases caused by such allergies include lupus nephritis, Ar such reaction, rheumatoid arthritis, vasculitis, and serum diseases.
• Type IV is a delayed allergic reaction and is an allergic reaction using T cells as a medium.
• the allergies cause local allergies, tissue allergies such as the first type of disease, erythema, and multiple scleroderma.
• Immunodeficiency diseases can be divided into congenital immunodeficiency diseases and acquired immunodeficiency syndromes.
• the latter is a disease caused by human immunodeficiency virus, and the former involves diseases such as respiratory infection, herpes virus, chronic pneumonia, influenza and skin inflammation.
• diseases such as respiratory infection, herpes virus, chronic pneumonia, influenza and skin inflammation.
• the therapeutic agents for immune disorders can be divided into three groups: the first group is a corticosteroid anti-inflammatory agent such as adrenal corticosterone and an antihistamine; the second group is a cytotoxic agent such as azathioprine and a ring. Phosphoramide; the third group is a mold or bacterial derivative that inhibits signal transduction in T cells, such as cyclosporin A and rapamycin.
• corticosteroids Although anti-inflammatory agents can widely suppress the immune system, they also cause damage. Corticosteroids have anti-inflammatory activity, but there are also many unfavorable serious side effects, such as retention of water in the body, weight gain, diabetes, bone loss and thinning of the skin, because the use of corticosteroids leads to a decline in autologous hormone function. At the same time, it also reduces autoimmune function.
• Cytotoxic agents can inhibit allergies by killing cells. They can also cause serious side effects, including reduced immune function, anemia, damage to intestinal epithelial cells, hair loss and fetal damage or death.
• Mold and bacterial derivative agents not only poison the kidneys and other organs, but are also expensive to treat because they are complex natural substances that are not easy to prepare and must be taken for a long time.
• histamine a powerful medium that causes many physiological reactions. Mast cells and basophils will explode a large amount of histamine and other substances after being stimulated by antigen, and enter the surrounding tissues and body fluids. The result of this reaction is usually to exhaust the blood vessels of the blood vessels, thereby causing Histamine poisoning or histamine shock, which is commonly known.
• antihistamines It is common to use antihistamines to control allergic symptoms like hay fever. From a chemical point of view, antihistamines contain many kinds of drugs, and it is not possible to treat all the diseases by only one drug, and the drugs that are effective for one person are not necessarily effective for others. Traditional antihistamines have major side effects such as dizziness, lethargy, and inability to concentrate.
• amines are highly alkaline, toxic to humans, and can cause severe physical damage to the stomach, and amines. Most of the compounds are substances that are poorly soluble in water.
• an acid including a mineral acid and an organic acid, is often used to neutralize the amine compound to become an amine salt compound, thereby reducing the toxicity of the amine compound and improving its solubility.
• Commonly used inorganic acids are hydrochloric acid; commonly used organic acids are maleic acid, fumaric acid, tartaric acid, citric acid, malic acid, tannic acid and succinic acid, and the like.
• a conventional antihistamine agent for example, a diphenhydramine system, and a chlorpheniramine system are exemplified. These preparations are prepared by reacting diphenhydramine with hydrochloric acid to form a compound of diphenhydramine hydrochloride; or a compound which reacts with chlorpheniramine and hydrochloric acid to form chlorpheniramine hydrochloride.
• other acids such as maleic acid, citric acid, tannic acid, salicylic acid, malic acid, and the like, may be used to form, for example, the following compounds: chlorpheniramine maleate, diphenella Ming tannic acid salt, diphenhydramine salicylate, chlorpheniramine malate, and the like.
• the acid components contained in these traditional antihistamines are simple in antihistamines.
• As a modifier of amine it is used to reduce the harm of amine to human body and improve water solubility. This is the origin of traditional antihistamines widely used in the treatment of allergic diseases.
• the former is, for example, caused by pathogenic toxin poisoning caused by eating bacteria or spoilage foods, and the latter is poisoning caused by toxins injected by animals such as insects (such as bees) or snakes. These poisonings also cause severe allergic reactions, and most of them are treated with anti-allergic drugs or anti-toxins and anti-toxic serum.
• anti-toxins and anti-toxoids such as diphtheria, tetanus
• serum such as snakes, black widows
• no special allergies can be used. This is a disadvantage of this treatment.
• Allergic reactions are natural phenomena of human immunity. The reason is that foreign proteins (including toxins, etc.) contain active protein residues, that is, hydrophobic nucleophiles, such as nitrogen, which mostly contain histamine receptors. Amine residue. Many pharmaceuticals also contain such nitrogen-containing amine residues. These nitrogen-containing amine residues act on the histamine receptors on the cells, causing a reaction.
• the agent of the present invention neutralizes the nucleophilicity of a foreign substance or isolates a histamine receptor, thereby suppressing an allergic reaction. Use this feature to prevent and eliminate side effects of the drug. For example, pac li taxel has recently been found to treat a variety of cancers, but it has many side effects.
• the action of protons and their anions dissociated by carboxylic acids can be combined with viruses and cell receptors to form an isolation function, thereby preventing the virus from approaching the cells and avoiding the action of the cell membrane.
• the virus is close to the cell.”
• HIV human immunodeficiency virus
• it must be maintained in a neutral condition. If not in a neutral condition, the receptor of the virus cannot target the target cel l receptor, and this does not invade the cell and cause infection.
• the reduction of the pH value of the body fluid of the present invention is suitable for this function, because as long as the pH value of the body fluid is lowered, the hydrogen proton can bind to the nitrogen-containing residue of the nucleophilic group, thereby stopping the contact between the virus receptor and the cell receptor, that is, Will not make it further and The cell membrane fuses and enters the intracellular replication infection.
• acetylcholine ( Acethylchol ine) is responsible for the transmission of information at the synapse of the neuron. If the amount of acetylcholine is insufficient, the information transmission function cannot be fully utilized. The only way to increase acetylcholine is to inhibit the activity of acetylcholine (A c hE).
• acetylcholine enzyme can hydrolyze 10,000 acetylcholine per second, eliminating the hydrolysis ability of acetylcholine enzyme is very important for maintaining the level of acetylcholine.
• the agents studied in this area have not been successful due to the relationship between toxicity and side effects. The Applicant has found that such an effect can be attained by the present invention, and that there is no side effect at all.
• the bait speculates that the mechanism is such that glutamic acid (g lutamate) and tryptophan (tryptophan) have a negative charge, which is one of the active sites of acetylcholine enzyme, and this negative charge is responsible for the band.
• the positively charged acetylcholine amine group is pulled in order to carry out the hydrolysis of the acetylcholine ester end. If the negatively charged active site is neutralized by a positively charged hydrogen proton, the acetylcholine enzyme loses its ability to hydrolyze acetylcholine.
• a positively charged hydrogen proton can be provided to achieve the purpose of neutralizing the negative charge on the acetylcholine enzyme.
• acetylcholine a large number of neurotransmitters, acetylcholine, are available for use.
• the learning efficiency and memory ability of the brain is to make people smarter. This function is also suitable for improving Alzheimer's disease, etc. (KP Minneman et si, Bordy's Human Pharmacology 4th, Elesv ier Mosby, 2005, China.).
• the use of a carboxylic acid to lower the pH of a body fluid can suppress allergy and greatly improve learning, memory and work efficiency.
• Caffeine is a central nervous system stimulant. Its high dose or high frequency of use can be addictive, leading to allergic reactions to caffeine. The reason is long-term coffee addiction. Caffeine occupies adenosine receptors and dopamine receptors. There is pleasure, waking and not sleepy, but there will be powerlessness and loss after the medicinal failure, and it is necessary to strengthen the taking of more to restore the spirit. This addiction can destroy your health, which is a big problem with coffee addiction. The current treatment for this addiction is treatment with antihistamine or aspirin, but with undesirable side effects. It has been found in the present invention that the coffee alkaloid addiction can be withdrawn by the present invention without side effects.
• Another important shortcoming of coffee is that people who drink coffee can't get calcium, iron, magnesium and other ingredients from food. Therefore, the body will lack calcium, iron, magnesium and other ingredients, which will make the body unhealthy and easy to get sick. This is also an issue that cannot be solved at present.
• Another important shortcoming of coffee is that coffee has no nutritional value other than refreshing.
• Cafci t caffe ine c i t rate
• the ratio of caffeine to citric acid in the drug is 1:1.
• This drug has toxic problems such as nucleoli activity allergy, muscle tremor, anxiety, tachycardia, etc., and still has the toxicity of caffeine.
• the citric acid in the caffeine citrate as in the case of the conventional antihistaminic compound described above, neutralizes the plant base with an organic acid to obtain a salt compound.
• the amount of the organic acid in the agent of the present invention is more than twice as large (usually several times larger) than that of the caffeine, so that the agent of the present invention and the commercially available caffeine citrate agent are completely different in composition, function and purpose.
• Anti-inflammatory agents and analgesics can be divided into steroids and non-steroids.
• Non-steroids can be divided into narcotic analgesics and non-narcotic analgesics.
• Narcotic analgesics such as morphine, cocaine, etc., have disadvantages such as dependence, surface infection, habituation, hypotension, oliguria, hypothermia, constipation, inhibition of breathing, itching, and the like.
• Non-steroidal anti-inflammatory, analgesic agents such as aspirin and acetaminophen also have disadvantages of adverse side effects. The various treatments of inflammation, pain, and shortcomings of the above-mentioned drugs have also prompted the applicant to work on research and improvement to develop anti-inflammatory agents and analgesics without side effects.
• the medicament of the invention also has a good effect on colds.
• Sodium citrate can act as an anticoagulant during blood transfusions with calcium in plasma.
• the occurrence of cardiovascular disease is mainly the occurrence of blood clots.
• the present invention inhibits the activity of free radicals, phospholipases, and cyclooxygenases, thereby inhibiting the entire prostaglandin production process, such as prostaglandin A 2 (TxA 2 ). Release is restricted, thereby eliminating the formation of embo lus and thrombus, while inhibiting the residual cholesterol, triglycerides, etc. in the cardiovascular, and finally eliminating the chance of thrombosis.
• the agent of the present invention can be used as an anticoagulant in blood transfusion and dialysis instead of injection of an anticoagulant.
• tartaric acid anion can bind to prostatic acid phosphatase (phospha tase) to prevent prostatic acid phosphatase activity, thereby achieving prostate cancer.
• used in this patent is tartaric acid
• the anion is completely different from the basic principle of the invention in which the cation of tartaric acid is used to lower the pH of the body fluid, because the combination of the tartaric acid anion causes the acid phosphatase to decrease and the pH to rise without decreasing.
• the polyphenol substance is extracted from the immature fruit as an antiviral, allergy, antioxidant, and anti-mutagenic effect.
• the medicament has other disadvantages: first, the medicament contains pyrrolidone carboxylic acid, which is a strong active ingredient; secondly, the medicament cannot be orally administered because of its toxicity; third, the active ingredient of the medicament is added after the acid is added. Neutralization with a strong alkaline sodium hydroxide to pH 3. 5-5. 5 is not treated by lowering the pH of the body fluid, see Examples I to V. Xie Yi et al. showed in CN 1565435 that 0.1 to 2% (V/V) acetic acid was used as a nasal care solution for the treatment of respiratory diseases, and no oral use was mentioned.
• CN1112956 (Chen Gang) Displaying beer companion organisms and additives to make beer soak for a long time, although it contains caffeine and citric acid, but only to improve the flavor and improve the taste, so to add alkaline sodium bicarbonate to reduce the sour taste (each group B) Ingredients), this and The present invention differs in the purpose and method of preventing or treating diseases by lowering the pH of body fluids.
• CN1080S 6 4 (Chen Yingjie, etc.) shows that sea buckthorn fruit, fresh orange fruit, licorice, ginseng and the like are the main components as a sobering and hangover agent, and the purpose of preventing or treating diseases and caffeine addiction treatment by reducing the pH value of body fluid of the present invention is different.
• the present invention can be used in combination with garlic and caffeine, and has a high function.
• the inventors have found that the use of natural edibles
• the carboxylic acid and/or its acid salt lowers the pH of the body fluid, which can improve the production of complement, enhance the phagocytic cells, CD4 T cells and B cells, and other physiological and therapeutic effects, and prevent or treat or alleviate allergies.
• the present invention provides a pharmaceutical composition for preventing, treating or ameliorating an allergic reaction disease or the like.
• the invention also provides a medicine for preventing, treating or relieving allergic diseases Use of the composition.
• the present invention also provides a pharmaceutical composition for preventing, treating or ameliorating caffeine addiction.
• the invention provides a non-toxic addictive coffee beverage and a method of making the same.
• the present invention also provides a pharmaceutical composition for preventing, treating or relieving pain.
• the present invention also provides a pharmaceutical composition for preventing, treating or ameliorating a cold or an antiviral.
• the invention also provides an anti-inflammatory pharmaceutical composition.
• the present invention further provides an anticoagulant pharmaceutical composition for anticoagulation or coagulation problems during blood transfusion or dialysis.
• the invention further provides a pharmaceutical composition for preventing, treating or ameliorating cancer.
• the present invention also provides a pharmaceutical composition for improving learning memory or preventing, treating or alleviating Alzheimer's disease.
• the present invention provides, in another aspect, the use of a naturally edible carboxylic acid and/or an acid salt thereof to lower the pH of a body fluid, thereby preventing, treating or ameliorating allergic diseases, pain, colds, viral infections, thrombosis or blood transfusion or washing Use of blood clotting, inflammation, cancer, poisoning, memory loss, and caffeine addiction in the kidney process.
• the present invention also provides a health food comprising a naturally edible carboxylic acid and/or an acid salt thereof, which can reduce the pH of a body fluid for preventing, treating or alleviating food allergies, allergic diseases, pain, colds, viruses Coagulation, inflammation, cancer, poisoning, memory loss, or caffeine addiction during infection, thrombosis, or blood transfusion or dialysis.
• the present invention also provides a feed for preventing, treating or alleviating allergic diseases and viral infections in animals.
• edible organic acids especially carboxylic acids and their acidic salts, such as succinic acid, fumaric acid, maleic acid, hydrazine hydroxy acid, malic acid, tartaric acid, citric acid, lactic acid, hydrazine Hydroxyoctanoic acid, gluconolactone, oxoglutaric acid, aconitic acid, oxaloacetate; acidic salts of sodium or potassium; acetic acid, propionic acid, etc.; and mixtures thereof, for lowering the pH of body fluids .
• carboxylic acids and their acidic salts such as succinic acid, fumaric acid, maleic acid, hydrazine hydroxy acid, malic acid, tartaric acid, citric acid, lactic acid, hydrazine Hydroxyoctanoic acid, gluconolactone, oxoglutaric acid, aconitic acid, oxaloacetate
• acidic salts of sodium or potassium acetic acid
• One of the acidic group salts can be obtained by mixing a salt thereof and a diacid salt, and forms an acid salt in a solution or after entering the human body, so that a combination of a salt and a diacid salt is also within the present invention.
• caffeine, coffee powder, coffee extract or caffeine-containing plant extracts can also be used.
• the medicament of the present invention When the medicament of the present invention is used for preventing, treating or alleviating allergy, it can be divided into oral and non-oral.
• the general dose is 0.1-300 mg/kg/day, and the dosage can be increased under special circumstances, wherein the amount of caffeine is low.
• the total amount per dose is 200 mg or less, preferably 50 mg or less.
• various preparations can be prepared, and even formulated together with other medicines.
• the raw medicine ingredients must be extracted with the active ingredient when the injection preparation is made, which is the basic common sense of the pharmaceutical.
• the content of the caffeine should be gradually reduced until it is substantially absent.
• a non-toxic addictive coffee beverage When used in a non-toxic addictive coffee beverage, it can be made into a dry powder with other ingredients, or added to a liquid, or even packaged with organic acids and/or other nutrients, added after the coffee is cooked, or before drinking coffee separately. Or take it later.
• the agents of the invention may also be administered parenterally, including subcutaneously, intramuscularly, intravenously, intradermally, intra-articularly, enterally, etc., or may be administered by in vitro routes.
• Non-oral in vitro preparations can be prepared according to conventional pharmaceutical methods, including liquids, bones, sputum, and skin.
• Liquid patches, etc., liquid solvents include water, alcohol, and other alcohols.
• Other compatible active substances may be included in the pharmaceutical compositions of the present invention.
• Oral agents can be made into capsules, tablets, tablets, granules, granules, pills, mouth, syrup, liquid, suspension, and the like.
• the edible organic carboxylic acid and/or its acidic salt and caffeine can also be used to prepare an addictive coffee beverage.
• the edible carboxylic acid and/or its acidic salt and caffeine which lower the pH of the body fluid can also be used as an analgesic agent due to its anti-pain effect.
• a binding agent such as a binding agent; a tackifier; a softening agent; a dispersing agent; an emulsifier; Preservatives; lubricants; enzymes; sweeteners; spices; colorants; crude drugs, such as brown tea, betel nut and its products, garlic, onion, white codonopsis, polygonatum, cinnamon, Sichuan cattle paint, Chuanxiong, wolfberry, ginger , winter return, licorice, scutellaria, almond, ginseng, rehmannia, Hewushou, mother, Atractylodes, French Pinellia, Chenpi, Asparagus, Suzi, Rehmannia, Perilla, Zhimu, White mustard, Mulberry Powders of skin, hawthorn, carotene, lily, flax, or extracts thereof; processed fruits; other nutrients such as mineral shields
• the present invention prevents, treats or alleviates allergic diseases, pain, colds, viral infections, thrombosis or blood coagulation, inflammation, cancer, poisoning, memory during the process of blood transfusion or dialysis by lowering the pH of the body fluid.
• the pharmaceutical composition of the reduced, caffeine addiction contains 4 - 100 ° /. , preferably 4 - 94wt ° /. 5%, more preferably 0. 5%, more preferably 5% to 5%, more preferably 0. 5% to 5%, more preferably 0. Particularly preferred is 1-3% caffeine as the active ingredient, 0-80% crude drug, and optionally 0-96% pharmaceutically acceptable carrier.
• the content of the edible organic carboxylic acid and/or its acid salt in the medicament is absolutely greater than the content of the caffeine, preferably more than three times, and the total amount of the caffeine in each dose of the drug is below 200 mg, preferably below 50 mg.
• the invention is pre-reduced by lowering the pH of the body fluid 4 - 100% in a pharmaceutical composition that prevents, treats, or alleviates allergic diseases, pain, colds, viral infections, blood clots, or blood clotting, inflammation, cancer, poisoning, memory loss, and caffeine addiction during blood transfusion or dialysis , 5%, more preferably 10 - 90%, particularly preferably 15 - 85 %, of an edible organic carboxylic acid and/or an acidic salt thereof, as an active ingredient, 0 - 6%, preferably 0.1-5%, more Preferably, from 0.5 to 4%, particularly preferably from 1 to 3%, of caffeine, from 1 to 80% or 0% of the crude drug, and optionally from 0 to 80% or from 0 to 96% of the pharmaceutically acceptable carrier.
• the content of the edible organic carboxylic acid and/or its acidic salt in the medicament is absolutely greater than the content of the caffeine, preferably more than three times, and the total amount of the caffeine in each dose of the drug
• the pharmaceutical composition comprises edible carboxylic acid 14% - 89.9%, garlic 10 ° /. - 80%, caffeine 0. 1 - 6°/. , and 0 - 80% pharmaceutically acceptable ingredients.
• the composition since the amount and frequency of ingestion depend on the speed and condition of the treatment, and the ingredients are foods, so they are non-toxic and need not be particularly limited.
• the use of edible organic carboxylic acids and/or their acidic salts can alleviate or eliminate the side effects associated with paclitaxel drugs. It may be treated with an edible organic carboxylic acid and/or an acid salt thereof during the preparation of the paclitaxel injection, or both may be injected simultaneously, or treated with an edible organic carboxylic acid and/or an acid salt thereof after injection of the paclitaxel injection. Or, instead of other agents such as steroids and antihistamines, it is required that the edible organic carboxylic acid and/or its acidic salt be used in an amount greater than paclitaxel.
• the present invention provides a pharmaceutical combination for preventing, treating or ameliorating the side effects of paclitaxel drugs, including a combination of paclitaxel and an edible organic carboxylic acid and/or its acid salt, and optionally other Active ingredient.
• the finely pulverized edible organic carboxylic acid and/or its acid salt may be mixed.
• the content is preferably between more than one to five times that of paclitaxel.
• the present invention is also applicable to the prevention, treatment and/or mitigation of related diseases in spinal pushes, as in the human body.
• an oral preparation it is preferred to coat the active ingredient microparticles or disperse them in a powder form with a limestone powder carrier, and then blend them into a feed.
• the present invention provides an animal feed additive comprising 4-94%, preferably 5 - 90%, more preferably 10 - 90 °/.
• Particularly preferred is from 15 to 85% of the edible organic carboxylic acid and/or its acid salt, from 0.1 to 6%, preferably from 0.1 to 5%, more preferably from 0.5 to 4%, particularly preferably from 1 to 3%, of the caffeine as the active ingredient, 0-80% crude drug, and optionally 0-96% pharmaceutically acceptable carrier.
• the present invention also provides an animal feed comprising the above feed additive and conventional animal feed.
• animal feed additives and animal feeds can also be prepared by conventional methods including, for example, mixing, blending, coating, and the like.
• the edible organic carboxylic acid and/or its acidic salt can also be used as a food additive in a health food, the carrier of which is a food acceptable substance, and the acid-containing fruit processed product can be directly used as a raw material, for example. Tangerine, umbilical orange, lemon, plum, grapefruit, sour carambola, mulberry, strawberry, pineapple, etc.
• the form of the healthy food is a general oral food such as a beverage, a candy, a biscuit, a capsule, an ingot, a tablet, a granule, a powder, a pill, a syrup, a liquid, a suspension, etc.; wherein the dry matter weight comprises 0.1 - 10 % of edible carboxylic acid and/or sodium or potassium acid salt, 0-6%, preferably 0.1-5%, more preferably 0.5-4%, especially preferably 1-3% caffeine, and optionally 0-80 % of the crude drug as the active ingredient and 0-90% of the food-acceptable carrier, the content of the edible acid and / or its acid salt is greater than the content of caffeine, and the total amount of the caffeine in each dose is below 200 mg, preferably at 50 mg. the following.
• Edible organic carboxylic acids and/or their acid salts can also be used to reduce the allergic risk of food by treating the food with an edible organic carboxylic acid and/or its acid salt or adding it in an amount of from 0.1 to 10%. Edible carboxylic acid and / or sodium or potassium acid salt. This hair It also relates to the health food thus obtained.
• the content of each of the ingredients mentioned in the present invention is based on the weight of the dry state.
• the agents of the present invention can be prepared according to conventional methods well known in the art, and many references in this regard are available in the art, including, for example.
• the drug effect test actually employs a mouse or a human body.
• "individual” means any ridge pusher, including poultry and mammals, such as pigs, dogs, cats, horses, cows, monkeys, sheep, goats, rabbits, chimpanzees, humans, chickens, ducks, geese , birds, etc., preferably human.
• the supernatant is partially added with water 0. lml and 100% trichloroacetic acid 0. 2 ml.
• the precipitate was partially added to the Loose solution 1. 5 ml and 100% trichloroacetic acid 0.2 ml, and allowed to stand at room temperature for 30 minutes and then separated at 3,000 rpm for 15 minutes.
• the 5% o-phthalaldehyde (OPT) was added to the supernatant portion of the supernatant and the supernatant.
• OPT o-phthalaldehyde
• 2 M citric acid was added in 0.2 ml to terminate the reaction, and finally the fluorescence of each sample was measured by a fluorometer. The thus measured values can be used to calculate the histamine inhibition rate of each agent.
• the Lok solution was used instead of the drug, and the blank group (b lank group) was replaced with the Lok solution and the 48/80 compound.
• the other operations were the same as in the test group.
• the experimental dose is 100mg/ml, the purpose is to compare with the efficacy of traditional medicaments. Further efficacy can be achieved by selecting two reagents, succinic acid and sodium glycyrrhizinate, to change the amount of the test agent, and to test the concentration required to achieve 50% inhibition ( Known by the IC50 value).
• the histamine free rate (%) is represented by (A), and its value is equal to: the amount of histamine (Hs) contained in the supernatant fraction, and the amount of histamine (Hr) contained in the precipitate portion of the washing liquid, both The total amount is used as the denominator, and the amount of histamine (Hs) in the supernatant fraction is taken as a molecule, multiplied by 100%. Namely: histamine free rate (A) % - (Hs) X 100 % / (Hs + Hr)
• Inhibition rate (%) 100% - ⁇ (A value of the drug - A value of the blank group) I (A value of the control group - A value of the blank group) ⁇ X 100%.
• the calculation results are shown in Table 1 below:
• the succinic acid plus coffee extract has an IC50 value of 5.8 mg, and the succinic acid plus coffee extract has an IC value of 5.8 mg, while succinic acid does not contain coffee.
• the IC50 value of the extract was 7 mg, from which the significant inhibitory effect of succinic acid and the lifting function of caffeine were observed.
• histamine and the like are the main substances that cause swelling, heat, redness, pain and blood clotting, it can inhibit histamine, which can resist itching, anti-tumor, analgesia and anti-thrombosis.
• mice weighing 20-30 g were applied to the abdomen of the hair removal with an oxazo lone alcohol solution (0.5 w/v %) 0.1 ml. After 5 days, the medicament was dissolved in an acetone solution of oxazolone (0.5 w/v%), wherein the medicament of the present invention (2.0 w/v%) contained caffeine (0.1 w/v%), using micro Pipette each 10 ⁇ l of the solution and apply it to both sides of the mouse's right ear. Twenty-four hours later, the rats were sacrificed, and the corresponding positions of the left and right ears were taken, and the circular area of the 5. 5 legs (the part of the right ear coated with the drug and the part of the left ear not coated with the drug) was cut out. The weight is calculated based on the weight of the left ear. The calculation is as follows:
• Inhibition rate of swelling [(weight of the right ear coated with the drug part) - (unapplied weight of the left ear part)] X 100% / (weight of the left ear is not applied)
• Example 39 Experiment with seafood The five testers who were very sensitive to shrimp were taking two capsules of the present invention (500 mg each; containing 125 mg of garlic powder, caffeine 5 mg and 370 mg of citric acid) twenty minutes before eating the shrimp. After the shrimp, everything is safe and there are no symptoms of any immune disease.
• Example 40-45 Test for the lower concentration of the drug content
• the oral administration agent of the present invention such as a tablet or a capsule, can be increased in an oral dose according to the usual dosage, but if the medicament is doped with other foods, the primary intake is the total amount of food.
• the restriction therefore, has a certain requirement on the content of effective pharmaceutical ingredients in food, and the oral food is 100ml once.
• test solution There are six different doses of test solution, each of which is made up of 10 Oml of water, which contains propylene glycol sodium alginate 0. lg, fructose 10 g, garlic powder 300 mg, ginger powder 100 mg > angelica powder 10 mg, Honey 3g, almond powder 10mg.
• each dose is divided into 10 mg, 60 mg, 100 mg, 200 mg, 300 rag, 600 mg of malic acid, respectively, with or without 5% of the edible acid/acid salt content of the agent of the present invention.
• Caffeine The six groups of medicinal agents were given to six groups of first-time flu patients for one dose every two hours, five for each group. Observe the cure of the cold over time and calculate the approximate time of termination of the symptoms. The results are shown in Table 4.
• a total amount of 1000 g of citric acid 36 g, potassium dihydrogen citrate 34 g, caffeine lg, and sterilized pure water was used as a raw material.
• citric acid, caffeine and lemon Potassium dihydrogen hydride is dissolved in purified pure water to become 1000ml.
• the solution is filtered through a porphyrin, dispensed in a 10ml ampule, sealed under a nitrogen atmosphere, and then sterilized by ordinary high pressure steam. The procedure becomes a finished product.
• citric acid 350 g of citric acid, 200 g of garlic powder, 50 g of ginger powder, 10 g of angelica powder, 10 g of almond powder, 30 g of caffeine, and 300 g of fructose were used as ingredients.
• the ingredients were ground and mixed, and then filled in a hard plastic capsule to obtain a total of 1,000 capsules.
• Example 48 Granules and Lozenges
• Fumaric acid 50 g, microcrystalline cellulose 400 g, corn starch 550 g, caffeine 3 g, and a total amount of 1000 g were used as ingredients.
• the fumaric acid is first dissolved in water, then absorbed in microcrystalline cellulose, dried and mixed with corn starch, and made into a powder according to a usual method. Or the four components are ground and mixed to form a powder.
• Example 50 Coffee (Instant Coffee and Tetra Pak Coffee)
• Coffee beans 10kg (including caffeine 2%), malic acid 1. 5kg, sugar 9. 6kg, creamer 7. 2kg, water is the ingredients.
• Example 51 - 55 Analgesic, anti-itch, anti-inflammatory test of tincture (alcohol solution)
• the agent of the present invention has a good function and has no color and does not contaminate clothes. There will be irritation when the broken skin is applied, but then it will not hurt. It is apparent that the anti-inflammatory, analgesic and anti-itch functions of the agent of the present invention are very good and can be used as an anti-inflammatory agent, an analgesic agent and an anti-itch agent.
• Example 56 Glucose Injection (with other active ingredients)
• a pharmaceutical composition of the present invention contains 300 mg of malic acid, 300 mg of tartaric acid, 300 mg of citric acid, 50 mg of caffeine, 10 mg of catechin, and is administered to five people suffering from physical pain and headache, and the pain is after 10-30 minutes. Start mitigation, as shown in Table 6. Table 6 Time of pain relief
• the caffeine component was removed from the agent used in the above Examples 57-61, and the other components were unchanged, and an anti-pain test was also carried out. The results are shown in Table 7. Because of the absence of caffeine, the time to start pain relief is clearly much slower than that of caffeine-containing.
• Example 69 Experiment for lowering cholesterol and the like
• the gelatizer of the present invention 150 mg of gluconolactone, 150 mg of succinic acid, 200 mg of citric acid, 150 mg of garlic, 1 mg of caffeine is administered before and after each meal. Take 3 capsules. After continuing to take for four weeks, blood was taken for 12 hours and blood was tested for levels of cholesterol, triglyceride, low-density cholesterol, high-density cholesterol, etc., and the results are shown in Table 8.
• the results of the blood test total cholesterol by 12.0%, triglyceride 23.9% decrease, the body beneficial HDL-C increased by 5.3% and decrease LDL-C reduction 15.0% o LDL-C of Reduces plasma total cholesterol and significantly reduces the subject's LDL-C/HDL-C cardiovascular risk ratio by 18.1%.
• the reduction in total cholesterol also causes other cardiovascular risk ratios, ie total cholesterol/ The ratio of HDL-C was significantly reduced by 16.7%.
• the agent of the invention can reduce total cholesterol, triglyceride, LDL-C and cardiovascular risk value (LDL-C/HDL-C) in blood, indicating that the product of the invention can prevent atherosclerosis from forming thrombus. And can reduce the occurrence of cardiovascular disease.
• the results in Table 8 also show the number of platelets before and after the test, and the number of platelets in the blood has reached a very low level.
• the average number of blood plates in healthy people is 130 - 400 (103/uL). Therefore, the present invention can reduce the number of platelets, thereby greatly reducing the chance of thrombosis and preventing the occurrence of stroke diseases.
• Example 72 Bee Venom Treatment
• Example 73 Dental pain and pus
• the experience of blood in HIV patients showed that the concentration of CD4+ T cells was 129/ul and the virus concentration was 70,000/cc.
• the patient is administered the capsules of the present invention (each containing 500 mg of malic acid, 200 mg of garlic, and 5 mg of caffeine), 3 capsules per three hours. After taking the blood for four weeks, the blood concentration was zero, and the concentration of CD4+ T ce l l was 700/u l. It was apparent that the antiviral effect of the drug was quite good.
• a 69-year-old man has symptoms of a cold, dry cough, chills, fever, loss of appetite, headache, etc., showing obvious flu characteristics.
• each tablet contains 200 mg of malic acid, 100 mg of succinic acid, 100 mg of citric acid, 100 mg of tartaric acid, garlic 170 mg, ginger 30 mg, caffeine l Offlg), 3 capsules per two hours.
• the symptoms on the first day improved and most of the symptoms recovered the next day.
• Example 76 Canned health fish for prevention of allergies
• Example 77 Health-care cake for allergy prevention
• the flour, sugar, salt and glycolic acid are respectively pulverized and ground, and the solid components are finely mixed and mixed, and the baking powder and a part of the starch are also sieved and mixed, and then maltose, caffeine and ghee are added.
• the temperature in the C range is baked.
• Example 78 Health cake for preventing allergy Flour lkg, granulated sugar lkg, egg lkg, gluconolactone 150g, caffeine 2g, water 300g, etc. are used as raw materials. First, the protein is bubbled with a foaming machine, and then other raw materials such as egg yolk, sugar, gluconolactone, caffeine and water are added and stirred evenly, and then the flour is sieved, added, gently hooked, and injected into the model. Baking is ready.
• Example 79 Health-care candy for preventing allergies
• White sugar 430g, starch syrup 350g, invert syrup 170g, dry gelatin 50g, potassium dihydrogen citrate 20g, sodium dihydrogen citrate 20g, caffeine l g, vanillin 2ml, etc. are used as raw materials.
• Example 80 Health-care mineral-containing lactic acid beverage for preventing allergy
• the skim milk was heated to about 50, and after adding sugar to dissolve the sugar, propylene glycol alginate, caffeine and calcium lactate were added, and the mixture was kept at 80 ° C for 20 minutes, sterilized, filtered, and cooled to 15. C. After the lactic acid was first added with water to 75 ml, the above filtrate was added under continuous stirring, and then placed in a bottle to form a finished product.
• Example 81 Health-care peanut products for preventing allergy
• Example 83 Health-care orange juice drink for preventing allergy
• the total amount is 10 liters of orange juice beverage after adding pure water, and the product is divided into finished products.
• Example 84 Health food for preventing allergy
• 100 g of malic acid, 100 g of tartaric acid, 100 g of hydroxyoctanoic acid, 200 g of yam, 100 g of garlic, 10 g of caffeine, and 6 g of carotene are used as raw materials.
• the raw materials were mixed and filled in 1000 capsules. If you eat shrimp, you will be allergic. If you take this product and eat 2 shrimps, you will be safe.
• the resulting data clearly has the ability to increase memory capacity.

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