WO2005120246A1 - Guanidinoessigsäure als futtermittelzusatz - Google Patents

Guanidinoessigsäure als futtermittelzusatz Download PDF

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Publication number
WO2005120246A1
WO2005120246A1 PCT/EP2005/006110 EP2005006110W WO2005120246A1 WO 2005120246 A1 WO2005120246 A1 WO 2005120246A1 EP 2005006110 W EP2005006110 W EP 2005006110W WO 2005120246 A1 WO2005120246 A1 WO 2005120246A1
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WO
WIPO (PCT)
Prior art keywords
salts
creatine
acid
guanidinoacetic acid
use according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2005/006110
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German (de)
English (en)
French (fr)
Inventor
Thomas Gastner
Hans-Peter Krimmer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Evonik Operations GmbH
Original Assignee
Degussa GmbH
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Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34969080&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO2005120246(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority to RSP-2008/0122A priority Critical patent/RS50556B/sr
Priority to CA2569269A priority patent/CA2569269C/en
Priority to EP05747802A priority patent/EP1758463B1/de
Priority to BRPI0511842-5A priority patent/BRPI0511842B1/pt
Priority to HK07104006.7A priority patent/HK1096263B/xx
Priority to US11/596,771 priority patent/US20070231370A1/en
Priority to AU2005251451A priority patent/AU2005251451B2/en
Priority to DE502005002355T priority patent/DE502005002355D1/de
Application filed by Degussa GmbH filed Critical Degussa GmbH
Priority to DK05747802T priority patent/DK1758463T3/da
Priority to JP2007526278A priority patent/JP5227021B2/ja
Priority to NZ551661A priority patent/NZ551661A/xx
Priority to HR20080035T priority patent/HRP20080035T3/xx
Priority to CN2005800181881A priority patent/CN1964633B/zh
Priority to PL05747802T priority patent/PL1758463T3/pl
Priority to MXPA06014279A priority patent/MXPA06014279A/es
Priority to KR1020077000485A priority patent/KR101230977B1/ko
Publication of WO2005120246A1 publication Critical patent/WO2005120246A1/de
Anticipated expiration legal-status Critical
Priority to NO20066085A priority patent/NO335082B1/no
Priority to US13/164,973 priority patent/US8501810B2/en
Priority to US13/738,452 priority patent/US20130296431A1/en
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/105—Aliphatic or alicyclic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K61/00—Culture of aquatic animals
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/142—Amino acids; Derivatives thereof
    • A23K20/147—Polymeric derivatives, e.g. peptides or proteins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/153—Nucleic acids; Hydrolysis products or derivatives thereof
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/158—Fatty acids; Fats; Products containing oils or fats
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/174—Vitamins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/20—Inorganic substances, e.g. oligoelements
    • A23K20/30—Oligoelements
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K50/00—Feeding-stuffs specially adapted for particular animals
    • A23K50/30—Feeding-stuffs specially adapted for particular animals for swines
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K50/00—Feeding-stuffs specially adapted for particular animals
    • A23K50/70—Feeding-stuffs specially adapted for particular animals for birds
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K50/00—Feeding-stuffs specially adapted for particular animals
    • A23K50/80—Feeding-stuffs specially adapted for particular animals for aquatic animals, e.g. fish, crustaceans or molluscs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K61/00—Culture of aquatic animals
    • A01K61/10—Culture of aquatic animals of fish
    • A01K61/13—Prevention or treatment of fish diseases
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A40/00—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production
    • Y02A40/80—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production in fisheries management
    • Y02A40/81—Aquaculture, e.g. of fish
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A40/00—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production
    • Y02A40/80—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production in fisheries management
    • Y02A40/81—Aquaculture, e.g. of fish
    • Y02A40/818—Alternative feeds for fish, e.g. in aquacultures

Definitions

  • the present invention is the use of guanidinoacetic acid or Guanidi ⁇ oessigklare salts as feed additive.
  • Guanidinoacetic acid is a naturally occurring substance in animals and also in humans, which plays a central role in the biosynthesis of creatine. Creatine can be absorbed by food as well as endogenously produced. The biosynthesis starts from glycine and L-arginine. In mammals, especially in the kidneys, but also in the liver and the pancreas, the enzyme aminotransferase cleaves the guanidino group of L-arginine and transferred an N-C-N group to the glycine. The L-arginine is converted into L-ornithine. The guanidinoacetic acid thus formed is converted in the next step, in vertebrates this happens exclusively in the liver, with the help of the enzyme transmethylase in creatine.
  • the S-adenosyl methionine serves as a methyl group donor.
  • the creatine then diffuses into the bloodstream and is thus transported to the target organs.
  • the transport through the cell membrane into the cells happens here through a specific creatine transporter.
  • Guanidinoacetic acid is also known to have antibacterial activity and has been successfully used in animal studies against bacterial infections (Staphyllococcus aureus) (Preparation for protecting mammals against infection) (Stanley Drug Products Inc., USA) .Neth. Appl. , 7 pp. NL 7411216).
  • creatine plays an important role in the energy metabolism of the cell, being a high-energy phosphocreatine in addition to the adenosine triphosphate (ATP) represents an essential energy reserve of the muscle.
  • ATP adenosine triphosphate
  • the enzyme creatine kinase can transfer a phosphate group to adenosine diphosphate and thus rebuild ATP. This is also called Lohmann reaction.
  • Creatine has long been known as a suitable food supplement and feed. In strong and prolonged muscle work, the naturally present in the body creatine reserves are quickly exhausted. For this reason, targeted creatine additions have had a positive effect on endurance and performance, especially in competitive athletes, whereby undesired enrichment processes in the body or adverse degradation products are unknown. The reason for this is that creatine is excreted from the body as creatinine if it is ingested excessively.
  • creatine supplementation leads to an increase in body mass. This is initially due to an increased intake of water in the muscle. In the long run, the creatine leads but indirectly by increased protein synthesis or decreased protein catabolism in the myofibrils to an increase in muscle mass (Int J Sports Med 21 (2000), 139-145). The result is thus an increased fat-free body mass.
  • creatine monohydrate numerous creatine salts, such as creatine ascorbate, citrate, pyruvate and others, have also proved to be suitable dietary supplements. Representative may be mentioned at this point the European patent EP 894 083 and the German patent application DE 197 07 694 A1 as prior art.
  • Creatine is also found to have positive effects on humans in animals, which is why its use in various feedstuffs is well documented.
  • international patent application WO 00/67 590 describes the use of creatine or creatine salts as feed additive for breeding and fattening animals, as a substitute for meat-and-bone meal, fish meal and / or antimicrobial performance enhancers, growth hormones and anabolic steroids.
  • GB 2 300 103 teaches the use of creatine in the form of a dog biscuit, for which the creatine monohydrate is offered together with meat in an extruded mass.
  • creatine monohydrate is only insufficiently bioavailable due to its poor solubility, its joint use with other physiologically active compounds, preferably in salt form, is recommended.
  • German Offenlegungsschrift DE 198 36450 A1 relates to the use of stable pyruvic acid salts and in particular of creatine pyruvate in formulations which are suitable for animal nutrition.
  • DE 100 03 835 A1 relates to formulations in dehydration states, as they generally occur in the elderly and in particular those with limited mobility.
  • creatine acts as a transport medium for water, so as to add moisture to the tissues most affected by dehydration.
  • creatine also has the disadvantage that it has no pronounced stability as creatine monohydrate in the corresponding aqueous solutions, whereby it converts over a longer period of time into creatinine. This is a problem, especially in acidic solutions, and is therefore also important for the oral uptake and bioavailability of creatine.
  • the pH of the stomach from 1 to 2, depending on the residence time to a significant degradation of creatine lead to creatinine.
  • the claimed compounds actually have the desired properties according to the object, since they can be prepared in a simple and economical manner, for example by processes such as the reaction of glycine and cyanamide in aqueous solutions (Production of guanidino fatty acids (US Pat. Vassel, Bruno, Janssens, Walter D.) (1952), US 2,620,354; Method of preparation of guanidino fatty acids (Vassel, Bruno; Garst, Roger) (1953), 5 pp. US 2,654,779).
  • guanidinoacetic acid and its salts In contrast to creatine or creatine monohydrate, guanidinoacetic acid and its salts also have a significantly higher stability in acidic aqueous solution and they are only converted into creatine under physiological conditions. Surprisingly, it has turned out to be particularly advantageous that the guanidino In contrast to creatine, acetic acid and its salts are actually converted into creatine only after absorption, especially in the liver. Thus, in contrast to creatine, the majority of the administered or fed compounds, guanidinoacetic acid and / or salts of guanidinoacetic acid, not by instability reactions, eg in the stomach, degraded and excreted before absorption, but is actually available in the corresponding physiological metabolic reactions available.
  • guanidinoacetic acid and its salts can be used according to the invention, thus in turn, in contrast to creatine and its derivatives, with identical effect with significantly lower dosage.
  • guanidinoacetic acid and its salts as a feed additive has proved to be very effective for example for poultry, such as chickens, turkeys, ducks and geese, but also for pigs.
  • the present invention additionally provides guanidinoacetic acid and / or its suitable salts as feed additive in aquaculture, preferably as partial or total replacement for fishmeal and / or antimicrobial performance enhancers, the proposed use for salmonid (salmonids) and prawn-like (Natania) is preferred.
  • Antimicrobial performance enhancers are substances such as Carbadox, Olaquindox, salinomycin, monensin, avilamycin or flavomycin. These are used in particular to prevent the spread of diseases in animals. Furthermore, a higher efficiency in animal production is to be achieved. Antimicrobial performance enhancers are also used to prevent the transmission of zoonoses to humans, thus enabling the production of high quality and safe animal food.
  • the present invention also relates to the use of guanidinoacetic acid and / or its salts for the preparation of a therapeutic agent for breeding and fattening animals, which can be used to strengthen the immune system and to improve the reproductive performance.
  • the described therapeutic agent is preferably used in poultry and / or pigs in a preferred embodiment.
  • guanidinoacetic acid salt are suitable, which are nutritionally acceptable.
  • guanidinoacetic acid salts which have been obtained with hydrochloric acid, hydrobromic acid and phosphoric acid have proved favorable. It is also possible to use mixtures of guanidinoacetic acid with one or more of these salts or else mixtures of the salts with one another.
  • guanidinoacetic acid and its salts can be used in a wide dosing range.
  • daily doses for chickens per kilogram of live weight range between about 10 mg and about 1200 mg, more particularly in the range of about 50 mg to about 250 mg.
  • Single doses are generally in the range of about 10 mg and about 600 mg, preferably in the range of about 25 to about 125 mg.
  • daily doses per kilogram of live weight are in the range of about 10 mg and about 1000 mg, especially in the range of about 25 mg to about 150 mg.
  • Single doses are generally in the range of about 10 mg and about 500 mg, preferably in the range of about 10 mg to about 500 mg, preferably in the range of about 10 to 100 mg.
  • feed additive depending on the animal species, preferably doses of from about 0.01 to about 100 g / kg of feed or therapeutic agent are possible, with amounts of from about 1.0 to about 5.0 g being considered particularly preferred . Since the claimed use is preferred in the non-veterinary field of application, application forms of feed additives which are powders, granules, lozenges, capsules, pellets or jelly (hydrocolloid) products have proven particularly suitable.
  • guanidinoacetic acid and its salts as a feed additive in combination with other physiologically active ingredients, in particular carbohydrates, fats, amino acids (eg creatine), proteins, vitamins, minerals, trace elements and derivatives thereof and any mixtures thereof are particularly suitable.
  • Preferred are methionine, betaine and choline as well as other physiologically active methyl donors.
  • Betaine and choline can be converted to methionine in the body in the presence of homocysteine, which plays a major role in the synthesis of creatine from guanidinoacetic acid.
  • methyl groups are required, which are transferred to form homocysteine from S-adenosylmethionine. If betaine or choline are not sufficiently available, methionine is consumed and methionine deficiency can occur in the metabolism.
  • Another aspect of the present invention is thus the use of guanidinoacetic acid and / or salts thereof for the preparation of a composition for breeding and fattening animals for the prevention and mitigation of the consequences of heat stress, in particular for the reduction of mortality due to increased ambient temperatures.
  • the invention provides in particular that the therapeutic agent in predominantly vegetarian diets as partial and / or total replacement for fish meal, meat meal, anabolic steroids (eg, stilbenes, steroids, antithyroid drugs and ß-agonists), antimicrobial performance enhancer and / or growth hormones ,
  • guanidinoacetic acid and its salts can be used as a feed additive for wet and dry food for dogs and cats, with positive effects on the immune system and the general condition of the animals.
  • guanidinoacetic acid and its salts uses as feed or feed additive in the diet of breeding and fattening animals or as a therapeutic agent for breeding and fattening animals fed, which in contrast to the creatine compounds previously used significant and surprising benefits exhibit.
  • the following examples further illustrate the present invention.
  • Fodder for chickens for fattening It was found that the addition of 0,092% guanidinoacetic acid (0,92 g / kg) to the dried feed at 42 days fattening increased the final weight by 7% compared to previous feeding methods without guanidinoacetic acid. This increase in weight was achieved only by meat gain, but not by fat gain or water retention (improvement in Lean Body Mass Index), with the meat also having improved quality. In addition, this feed additive reduced feed consumption by about 6% compared to previous feeding methods.

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Polymers & Plastics (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Animal Husbandry (AREA)
  • Food Science & Technology (AREA)
  • Birds (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Marine Sciences & Fisheries (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
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  • Insects & Arthropods (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Diabetes (AREA)
  • Reproductive Health (AREA)
  • Communicable Diseases (AREA)
  • Inorganic Chemistry (AREA)
  • Nutrition Science (AREA)
  • Oncology (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Fodder In General (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
PCT/EP2005/006110 2004-06-09 2005-06-07 Guanidinoessigsäure als futtermittelzusatz Ceased WO2005120246A1 (de)

Priority Applications (19)

Application Number Priority Date Filing Date Title
KR1020077000485A KR101230977B1 (ko) 2004-06-09 2005-06-07 동물 식품 첨가제로서 이용되는 구아니디노 아세트산
JP2007526278A JP5227021B2 (ja) 2004-06-09 2005-06-07 飼料添加剤としてのグアニジノ酢酸
EP05747802A EP1758463B1 (de) 2004-06-09 2005-06-07 Guanidinoessigsäure als futtermittelzusatz
BRPI0511842-5A BRPI0511842B1 (pt) 2004-06-09 2005-06-07 Uso de ácido guanidino acético como aditivo para ração animal
HK07104006.7A HK1096263B (en) 2004-06-09 2005-06-07 Guanidino acetic acid used as an animal food additive
US11/596,771 US20070231370A1 (en) 2004-06-09 2005-06-07 Guanidino Acetic Acid Used as an Animal Food Additive
AU2005251451A AU2005251451B2 (en) 2004-06-09 2005-06-07 Guanidino acetic acid used as an animal food additive
HR20080035T HRP20080035T3 (hr) 2004-06-09 2005-06-07 Guanidino octena kiselina kao dodatak hrani za životinje
CA2569269A CA2569269C (en) 2004-06-09 2005-06-07 Guanidino acetic acid used as an animal food additive
DK05747802T DK1758463T3 (da) 2004-06-09 2005-06-07 Guanidinoeddikesyre som fodermiddeltilsætning
NZ551661A NZ551661A (en) 2004-06-09 2005-06-07 Guanidino acetic acid used as an animal food additive
RSP-2008/0122A RS50556B (sr) 2004-06-09 2005-06-07 Guanidino sirćetna kiselina kao dodatak hrani za životinje
DE502005002355T DE502005002355D1 (de) 2004-06-09 2005-06-07 Guanidinoessigsäure als futtermittelzusatz
CN2005800181881A CN1964633B (zh) 2004-06-09 2005-06-07 作为饲料添加剂的胍基乙酸
PL05747802T PL1758463T3 (pl) 2004-06-09 2005-06-07 Kwas guanidynooctowy jako dodatek do pasz
MXPA06014279A MXPA06014279A (es) 2004-06-09 2005-06-07 Acido guanidinoacetico como aditivo para piensos.
NO20066085A NO335082B1 (no) 2004-06-09 2006-12-29 Anvendelse av guanidinoeddiksyre og/eller salter derav for fremstilling av dyrefôr og terapeutisk sammensetning
US13/164,973 US8501810B2 (en) 2004-06-09 2011-06-21 Guanidino acetic acid used as an animal food additive
US13/738,452 US20130296431A1 (en) 2004-06-09 2013-01-10 Guanidino acetic acid used as an animal food additive

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE102004028193.9 2004-06-09
DE102004028193 2004-06-09
DE102004059761 2004-12-11
DE102004059761.8 2004-12-11

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US11/596,771 A-371-Of-International US20070231370A1 (en) 2004-06-09 2005-06-07 Guanidino Acetic Acid Used as an Animal Food Additive
US13/164,973 Continuation US8501810B2 (en) 2004-06-09 2011-06-21 Guanidino acetic acid used as an animal food additive

Publications (1)

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WO2005120246A1 true WO2005120246A1 (de) 2005-12-22

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PCT/EP2005/006110 Ceased WO2005120246A1 (de) 2004-06-09 2005-06-07 Guanidinoessigsäure als futtermittelzusatz

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US (3) US20070231370A1 (https=)
EP (1) EP1758463B1 (https=)
JP (1) JP5227021B2 (https=)
KR (1) KR101230977B1 (https=)
CN (1) CN1964633B (https=)
AT (1) ATE381892T1 (https=)
AU (1) AU2005251451B2 (https=)
BR (1) BRPI0511842B1 (https=)
CA (1) CA2569269C (https=)
CY (1) CY1107249T1 (https=)
DE (1) DE502005002355D1 (https=)
DK (1) DK1758463T3 (https=)
ES (1) ES2296186T3 (https=)
HR (1) HRP20080035T3 (https=)
MX (1) MXPA06014279A (https=)
NO (1) NO335082B1 (https=)
NZ (1) NZ551661A (https=)
PL (1) PL1758463T3 (https=)
PT (1) PT1758463E (https=)
RS (1) RS50556B (https=)
RU (1) RU2341972C2 (https=)
SI (1) SI1758463T1 (https=)
WO (1) WO2005120246A1 (https=)
ZA (1) ZA200609861B (https=)

Cited By (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006092298A1 (de) * 2005-03-04 2006-09-08 Alzchem Trostberg Gmbh Salze, anlagerungs- und komplexverbindungen der guanidinoessigsäure
WO2007014756A1 (de) * 2005-08-02 2007-02-08 Alzchem Trostberg Gmbh Flüssig-formulierung auf basis einer guanidinoessigsäure- komponente
WO2007098952A1 (de) * 2006-03-01 2007-09-07 Alzchem Trostberg Gmbh Fertigfutter für haustiere
WO2008052712A1 (de) * 2006-10-28 2008-05-08 Alzchem Trostberg Gmbh Feste oder wässrige alkalische zubereitung umfassend eine kreatin-komponente, verfahren zu deren herstellung und ihre verwendung
DE102007004781A1 (de) * 2007-01-31 2008-08-07 Alzchem Trostberg Gmbh Verwendung von Guanidinoessigsäure(-Salzen) zur Herstellung eines gesundheitsfördernden Mittels
WO2009012960A3 (de) * 2007-07-21 2009-04-02 Alzchem Trostberg Gmbh Abriebfeste und rieselfähige glycocyamin-haltige formlinge und verfahren zu deren herstellung
DE102007053369A1 (de) * 2007-11-09 2009-07-02 Alzchem Trostberg Gmbh Verwendung einer eine Kreatin-Komponente enthaltende Zusammensetzung zur Verbesserung der männlichen Fruchtbarkeit
US8536222B2 (en) 2005-03-04 2013-09-17 Alzchem Ag Addition compounds of guanidinoacetic acid
CN103549198A (zh) * 2013-11-05 2014-02-05 安徽科技学院 一种无抗生素肉鸡复合饲料添加剂
CN103549134A (zh) * 2013-11-05 2014-02-05 安徽科技学院 一种不含抗生素的肉鸡复合饲料添加剂
CN104082205A (zh) * 2014-06-17 2014-10-08 怀远县孔津湖农业开发有限公司 一种泥鳅人工养殖池塘的防逃、防敌害设施
CN104082202A (zh) * 2014-06-17 2014-10-08 怀远县孔津湖农业开发有限公司 一种泥鳅产卵孵化用环道
EP2904911A1 (de) * 2014-02-11 2015-08-12 Evonik Degussa GmbH Verwendung von Guanidinoessigsäure und/oder Kreatin zur Erhöhung der Schlupfrate
CN105076769A (zh) * 2015-08-04 2015-11-25 固安君德同创生物工程有限公司 一种猪饲料添加剂及其制备和使用方法
CN105076719A (zh) * 2015-08-04 2015-11-25 北京君德同创农牧科技股份有限公司 一种肉鸡用预混料及其制备和使用方法
WO2019185408A1 (en) 2018-03-27 2019-10-03 Evonik Degussa Gmbh Use of guanidinoacetic acid and/or creatine in aquaculture
WO2020151829A1 (en) 2019-01-24 2020-07-30 Sil'innov Srcl Poultry feed and drinking water composition comprising a stable, bioavailable silicon complex
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EP3839051A1 (en) 2019-12-19 2021-06-23 Evonik Operations GmbH Method for the fermentative production of guanidinoacetic acid
WO2021175677A1 (de) * 2020-03-04 2021-09-10 Alzchem Trostberg Gmbh Verfahren zur verminderung von verhaltensstörungen bei schweinen
WO2022048913A1 (en) 2020-09-01 2022-03-10 Evonik Operations Gmbh Method for preparing guanidino acetic acid
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WO2022243116A1 (en) 2021-05-21 2022-11-24 Evonik Operations Gmbh Improved biotechnological method for producing guanidino acetic acid (gaa) by inactivation of an amino acid exporter
DE102021126581A1 (de) 2021-10-13 2023-04-13 Alzchem Trostberg Gmbh Verwendung eines Futtermitteladditives in energiearmen Futter für Schweine
WO2023232584A1 (en) 2022-06-03 2023-12-07 Evonik Operations Gmbh Method for producing guanidino acetic acid (gaa)
WO2023232583A1 (en) 2022-06-03 2023-12-07 Evonik Operations Gmbh Improved biotechnological method for producing guanidino acetic acid (gaa) by using nadh-dependent dehydrogenases
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WO2024160790A1 (en) 2023-02-01 2024-08-08 Evonik Operations Gmbh Method for the fermentative production of guanidinoacetic acid using a microorganism comprising a heterologous l-threonine aldolase gene
WO2024160791A1 (en) 2023-02-01 2024-08-08 Evonik Operations Gmbh Method for the fermentative production of guanidinoacetic acid using a microorganism comprising a heterologous l-threonine 3-dehydrogenase gene (tdh) and a glycine c-acetyltransferase gene (kbl)
RU2826581C1 (ru) * 2020-03-04 2024-09-12 Альцхем Тростберг Гмбх Способ снижения нарушений поведения свиней
WO2024261127A1 (en) 2023-06-20 2024-12-26 Apr Pharma Srl Bioavailable silicon dispersion for poultry
DE102023123941A1 (de) * 2023-09-06 2025-03-06 Alzchem Trostberg Gmbh Verwendung eines Futtermitteladditivs zur Fütterung trächtiger Sauen
EP4578446A1 (en) * 2023-12-15 2025-07-02 Curafyt BV Composition for use in the treatment of ovulatory sub- or infertility in equidae

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101423801B1 (ko) 2006-11-28 2014-07-25 도쿄 오카 고교 가부시키가이샤 후막용 화학증폭형 포지티브형 포토레지스트 조성물, 후막용 화학증폭형 드라이 필름 및 후막 레지스트 패턴의 제조 방법
CN101912044A (zh) * 2010-08-13 2010-12-15 青岛天通生物科技有限公司 促肌肉生成的组合物及其制备方法
CN104605161B (zh) * 2015-01-23 2018-02-27 长沙兴嘉生物工程股份有限公司 胍基乙酸配合物的制备方法及其应用
CN106036197A (zh) * 2016-05-25 2016-10-26 中国水产科学研究院黑龙江水产研究所 一种无鱼粉鲟鱼饲料的添加剂及其制备方法和使用方法
CN107183341A (zh) * 2017-06-13 2017-09-22 肖鹏宏 无草育肥驴饲料及其制备方法
CN108308402A (zh) * 2018-04-02 2018-07-24 四川铁骑力士实业有限公司 一种用于60kg以上乌金猪的配合饲料
CN109258935A (zh) * 2018-10-10 2019-01-25 江苏奥迈生物科技有限公司 饲料用促生长抗氧化复合添加剂及其制备方法和应用
EP3677329B1 (en) 2019-01-02 2021-07-21 Evonik Operations GmbH Process for preparing guanidino acetic acid
DE102019120246A1 (de) 2019-07-26 2021-01-28 Alzchem Trostberg Gmbh Verfahren zur Fütterung von Geflügel
CN116133528A (zh) * 2020-06-15 2023-05-16 澳泽化学特罗斯特贝格有限公司 增加动物饲料中的代谢能
CN115803442A (zh) 2020-07-09 2023-03-14 赢创运营有限公司 发酵制备胍基乙酸的方法
IL299713A (en) 2020-07-09 2023-03-01 Evonik Operations Gmbh A method for the fermentation production of guanidinoacetic acid
WO2023196159A1 (en) * 2022-04-08 2023-10-12 Can Technologies, Inc. Fish feed or fish feed additive
CN114938830A (zh) * 2022-05-05 2022-08-26 北京中科万联科技有限公司 一种基于氨基酸提升畜禽瘦肉率的饲料添加剂及其制备方法和应用
CN114751845B (zh) * 2022-06-13 2022-09-20 北京君德同创生物技术股份有限公司 一种易溶的胍基乙酸络合物的合成方法
CN115553403A (zh) * 2022-11-03 2023-01-03 上海海洋大学 凡纳滨对虾肉质改善剂及其制备方法和应用
WO2024165348A1 (en) 2023-02-06 2024-08-15 Evonik Operations Gmbh Process for preparing an n-guanylamino acid
CN116268200B (zh) * 2023-03-15 2026-02-06 广东瑞科营养科技有限公司 提高动物肌细胞atp利用率的饲料添加剂、制法及应用
CN121358347A (zh) 2023-07-03 2026-01-16 住友化学株式会社 饲料添加物及家畜用饲料
CN117044840A (zh) * 2023-08-15 2023-11-14 青岛诺安百特生物技术有限公司 一种增强猫肠道功能的宠物食品制备方法
DE102023135640A1 (de) * 2023-12-18 2025-06-18 Alzchem Trostberg Gmbh Verwendung eines Futtermitteladditivs zur Verkürzung der Abferkeldauer
US20250221430A1 (en) * 2024-01-05 2025-07-10 Numega Nutrition Pte. Ltd A newest preparation method (NT-PB) and applications for improving ATP utilization in animal muscle cells

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3089771A (en) * 1960-02-16 1963-05-14 Armoar And Company Method of feeding chicks
DD206735A1 (de) * 1981-07-15 1984-02-08 Helmut Just Verfahren zur anwendung ergotroper wirkstoff-kombinationen in der gefluegelmast

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE738131C (de) 1936-07-26 1943-08-04 Ig Farbenindustrie Ag Eiweissersetzendes Futtermittel
US2654779A (en) 1950-12-23 1953-10-06 Int Minerals & Chem Corp Method of preparation of guanidino fatty acids
US2620354A (en) 1951-01-12 1952-12-02 Int Minerals & Chem Corp Production of guanidino fatty acids
US3843798A (en) * 1973-03-12 1974-10-22 Stanley Drug Products Inc Methods and compositions for inducing resistance to bacterial infections
DE2441777A1 (de) 1974-08-31 1976-03-11 Stanley Drug Products Inc Antibakterielles mittel
DE2937358A1 (de) 1979-09-13 1981-04-02 Erhard Heisler Praeparat aus pflanzlichen und/oder tierischen extrakten zur enteralen und parenteralen ernaehrung
US6413962B1 (en) * 1988-05-02 2002-07-02 N. Eric Naftchi Guanidino compounds effective as anesthetics
JP2749871B2 (ja) * 1989-05-26 1998-05-13 協和醗酵工業株式会社 魚類の養殖法および養魚用飼料
IT1237519B (it) 1989-11-27 1993-06-08 Impiego dell'acido guanidinacetico per indurre un incremento del contenuto muscolare di creatina
GB9508443D0 (en) 1995-04-26 1995-06-14 Gilbertson & Page Biscuit for working racing or sporting dogs
US5962043A (en) * 1996-02-29 1999-10-05 Seal Rock Technologies Incorporated Weight reduction method for dogs and other pets
WO1998028263A1 (de) 1996-12-20 1998-07-02 Skw Trostberg Aktiengesellschaft Kreatin-pyruvate und verfahren zu deren herstellung
DE19707694A1 (de) 1997-02-26 1998-08-27 Sueddeutsche Kalkstickstoff Kreatin-ascorbate und Verfahren zu deren Herstellung
DE19836450A1 (de) 1998-08-12 2000-02-17 Sueddeutsche Kalkstickstoff Stabile, Brenztraubensäure (Salze) enthaltende Formulierung für die Tierernährung
EP1051914A1 (de) * 1999-05-08 2000-11-15 DSM Fine Chemicals Austria GmbH Verwendung von Kreatin als Futterzusatz
WO2001000212A1 (en) * 1999-06-25 2001-01-04 Avicena Group, Inc. Use of creatine or creatine analogs for the prevention and treatment of transmissible spongiform encephalopathies
GB2358135A (en) * 1999-12-09 2001-07-18 Finnfeeds Int Ltd Animal feed additives comprising betaine and a protease
DE10003835A1 (de) 2000-01-28 2001-08-16 Sueddeutsche Kalkstickstoff Formulierungen bei Dehydratationszuständen
JP3827139B2 (ja) 2000-07-17 2006-09-27 伊藤忠飼料株式会社 グリシンによって強化された採卵鶏用植物性飼料組成物及び採卵鶏の飼育方法
AU2003247224A1 (en) 2002-06-19 2004-01-06 N.V. Nutricia Nutritional or pharmaceutical compositions for increasing the creatine response of organisms

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3089771A (en) * 1960-02-16 1963-05-14 Armoar And Company Method of feeding chicks
DD206735A1 (de) * 1981-07-15 1984-02-08 Helmut Just Verfahren zur anwendung ergotroper wirkstoff-kombinationen in der gefluegelmast

Cited By (71)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006092298A1 (de) * 2005-03-04 2006-09-08 Alzchem Trostberg Gmbh Salze, anlagerungs- und komplexverbindungen der guanidinoessigsäure
US8536222B2 (en) 2005-03-04 2013-09-17 Alzchem Ag Addition compounds of guanidinoacetic acid
JP4928473B2 (ja) * 2005-03-04 2012-05-09 アルツケム トロストベルク ゲゼルシャフト ミット ベシュレンクテル ハフツング グアニジノ酢酸の塩、付加化合物及び錯化合物
US8153685B2 (en) 2005-03-04 2012-04-10 Alzchem Trostberg Gmbh Salts, addition compounds and complex compounds of guinadinoacetic acid
JP2008531029A (ja) * 2005-03-04 2008-08-14 アルツケム トロストベルク ゲゼルシャフト ミット ベシュレンクテル ハフツング グアニジノ酢酸の塩、付加化合物及び錯化合物
WO2007014756A1 (de) * 2005-08-02 2007-02-08 Alzchem Trostberg Gmbh Flüssig-formulierung auf basis einer guanidinoessigsäure- komponente
AU2006275051B2 (en) * 2005-08-02 2012-03-29 Alzchem Trostberg Gmbh Liquid formulation based on a guanidinoacetic acid component
JP2009528038A (ja) * 2006-03-01 2009-08-06 アルツケム トロストベルク ゲゼルシャフト ミット ベシュレンクテル ハフツング ペット用完成飼料
RU2443121C2 (ru) * 2006-03-01 2012-02-27 Альцхем Тростберг Гмбх Промышленно изготовленный стабильный при хранении готовый корм для домашних животных (варианты)
KR101443226B1 (ko) * 2006-03-01 2014-09-22 알즈켐 아게 애완동물용 즉석 사료
WO2007098952A1 (de) * 2006-03-01 2007-09-07 Alzchem Trostberg Gmbh Fertigfutter für haustiere
WO2008052712A1 (de) * 2006-10-28 2008-05-08 Alzchem Trostberg Gmbh Feste oder wässrige alkalische zubereitung umfassend eine kreatin-komponente, verfahren zu deren herstellung und ihre verwendung
DE102007004781A1 (de) * 2007-01-31 2008-08-07 Alzchem Trostberg Gmbh Verwendung von Guanidinoessigsäure(-Salzen) zur Herstellung eines gesundheitsfördernden Mittels
US8703819B2 (en) 2007-01-31 2014-04-22 Alzchem Trostberg Gmbh Use of guanidinoacetic acid (salts) combination with betaine and/or choline to produced an agent that is beneficial to health
US20100055182A1 (en) * 2007-01-31 2010-03-04 Thomas Gastner Use of guanidinoacetic acid (salts) combination with betaine and/or choline to produced an agent that is beneficial to health
WO2009012960A3 (de) * 2007-07-21 2009-04-02 Alzchem Trostberg Gmbh Abriebfeste und rieselfähige glycocyamin-haltige formlinge und verfahren zu deren herstellung
RU2469550C2 (ru) * 2007-07-21 2012-12-20 Альцхем Тростберг Гмбх Абразивоустойчивые и свободносыпучие, содержащие гликоциамин формованные изделия и способы их получения
JP2010534064A (ja) * 2007-07-21 2010-11-04 アルツケム トロストベルク ゲゼルシャフト ミット ベシュレンクテル ハフツング 耐摩耗性でかつ流動性のグリコシアミンを含有する成形体及びその製造法
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CN105076769A (zh) * 2015-08-04 2015-11-25 固安君德同创生物工程有限公司 一种猪饲料添加剂及其制备和使用方法
WO2019185408A1 (en) 2018-03-27 2019-10-03 Evonik Degussa Gmbh Use of guanidinoacetic acid and/or creatine in aquaculture
WO2020151829A1 (en) 2019-01-24 2020-07-30 Sil'innov Srcl Poultry feed and drinking water composition comprising a stable, bioavailable silicon complex
BE1027018A1 (fr) 2019-01-24 2020-08-26 Silinnov Scrl Composition d’aliment et d’eau de boisson pour volailles comprenant un complexe de silicium biodisponible stable
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WO2021008846A1 (de) 2019-07-12 2021-01-21 Alzchem Trostberg Gmbh Verfahren zur herstellung einer metastabilen kristallmodifikation von n-(aminoiminomethyl)-2-aminoethansäure (iv)
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US11512047B2 (en) 2019-07-12 2022-11-29 Alzchem Trostberg Gmbh Metastable crystal modification and method for producing the same (I)
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WO2021122400A1 (en) 2019-12-19 2021-06-24 Evonik Operations Gmbh Method for the fermentative production of guanidinoacetic acid
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WO2021175677A1 (de) * 2020-03-04 2021-09-10 Alzchem Trostberg Gmbh Verfahren zur verminderung von verhaltensstörungen bei schweinen
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US11633373B2 (en) 2020-03-04 2023-04-25 Alzchem Trostberg Gmbh Method for reduction of behavioral disorders in pigs
WO2022048913A1 (en) 2020-09-01 2022-03-10 Evonik Operations Gmbh Method for preparing guanidino acetic acid
US11795142B2 (en) 2020-09-01 2023-10-24 Evonik Operations Gmbh Method for preparing guanidino acetic acid
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WO2023061916A1 (de) 2021-10-13 2023-04-20 Alzchem Trostberg Gmbh Verwendung von guanidinoessigsäure in energiearmem futter für schweine während der mastphase
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WO2023232584A1 (en) 2022-06-03 2023-12-07 Evonik Operations Gmbh Method for producing guanidino acetic acid (gaa)
US12312622B2 (en) 2022-06-03 2025-05-27 Evonik Operations Gmbh Method for producing guanidino acetic acid (GAA)
WO2023232583A1 (en) 2022-06-03 2023-12-07 Evonik Operations Gmbh Improved biotechnological method for producing guanidino acetic acid (gaa) by using nadh-dependent dehydrogenases
WO2024094483A1 (en) 2022-11-03 2024-05-10 Evonik Operations Gmbh Improved biotechnological process to produce guanidinoacetic acid (gaa) by targeted introduction or by increasing the activity of a transmembrane transport protein belonging to the amino acid-polyamine-organocation superfamily
WO2024094481A1 (en) 2022-11-03 2024-05-10 Evonik Operations Gmbh Improved biotechnological process to produce guanidinoacetic acid (gaa) by targeted introduction or by increasing the activity of a transmembrane exporter protein
WO2024160790A1 (en) 2023-02-01 2024-08-08 Evonik Operations Gmbh Method for the fermentative production of guanidinoacetic acid using a microorganism comprising a heterologous l-threonine aldolase gene
WO2024160791A1 (en) 2023-02-01 2024-08-08 Evonik Operations Gmbh Method for the fermentative production of guanidinoacetic acid using a microorganism comprising a heterologous l-threonine 3-dehydrogenase gene (tdh) and a glycine c-acetyltransferase gene (kbl)
WO2024261127A1 (en) 2023-06-20 2024-12-26 Apr Pharma Srl Bioavailable silicon dispersion for poultry
BE1031726A1 (fr) 2023-06-20 2025-01-27 Apr Pharma Srl Dispersion de silicium biodisponible pour volaille
DE102023123941A1 (de) * 2023-09-06 2025-03-06 Alzchem Trostberg Gmbh Verwendung eines Futtermitteladditivs zur Fütterung trächtiger Sauen
WO2025051667A1 (de) 2023-09-06 2025-03-13 Alzchem Trostberg Gmbh Verwendung eines futtermitteladditivs zur fütterung trächtiger sauen
EP4578446A1 (en) * 2023-12-15 2025-07-02 Curafyt BV Composition for use in the treatment of ovulatory sub- or infertility in equidae
BE1032231B1 (nl) * 2023-12-15 2025-07-14 Curafyt Bv Samenstelling voor gebruik ter behandeling van ovulatoire sub- of infertiliteit bij paardachtigen

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ES2296186T3 (es) 2008-04-16
NO20066085L (no) 2006-12-29
HK1096263A1 (zh) 2007-06-01
CY1107249T1 (el) 2012-11-21
US20070231370A1 (en) 2007-10-04
DE502005002355D1 (de) 2008-02-07
CN1964633B (zh) 2011-04-27
PT1758463E (pt) 2008-04-03
US20130296431A1 (en) 2013-11-07
BRPI0511842A (pt) 2008-01-15
US8501810B2 (en) 2013-08-06
CN1964633A (zh) 2007-05-16
HRP20080035T3 (hr) 2008-07-31
AU2005251451B2 (en) 2010-12-02
EP1758463B1 (de) 2007-12-26
MXPA06014279A (es) 2007-07-25
PL1758463T3 (pl) 2008-04-30
SI1758463T1 (sl) 2008-08-31
KR20070034052A (ko) 2007-03-27
CA2569269A1 (en) 2005-12-22
RU2341972C2 (ru) 2008-12-27
AU2005251451A1 (en) 2005-12-22
NZ551661A (en) 2009-10-30
CA2569269C (en) 2011-12-20
ZA200609861B (en) 2007-12-27
NO335082B1 (no) 2014-09-08
ATE381892T1 (de) 2008-01-15
JP5227021B2 (ja) 2013-07-03
EP1758463A1 (de) 2007-03-07
RU2006146983A (ru) 2008-07-20
US20110257075A1 (en) 2011-10-20
BRPI0511842B1 (pt) 2014-08-12
DK1758463T3 (da) 2008-05-05
RS50556B (sr) 2010-05-07
KR101230977B1 (ko) 2013-02-07

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