WO2005094681A1 - Vorrichtung zur entnahme von kapillarblut - Google Patents
Vorrichtung zur entnahme von kapillarblut Download PDFInfo
- Publication number
- WO2005094681A1 WO2005094681A1 PCT/DE2005/000221 DE2005000221W WO2005094681A1 WO 2005094681 A1 WO2005094681 A1 WO 2005094681A1 DE 2005000221 W DE2005000221 W DE 2005000221W WO 2005094681 A1 WO2005094681 A1 WO 2005094681A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- capillary
- blood
- blood collection
- vessel
- collection vessel
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150007—Details
- A61B5/150015—Source of blood
- A61B5/150022—Source of blood for capillary blood or interstitial fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150007—Details
- A61B5/150206—Construction or design features not otherwise provided for; manufacturing or production; packages; sterilisation of piercing element, piercing device or sampling device
- A61B5/150213—Venting means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150007—Details
- A61B5/150343—Collection vessels for collecting blood samples from the skin surface, e.g. test tubes, cuvettes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150007—Details
- A61B5/150755—Blood sample preparation for further analysis, e.g. by separating blood components or by mixing
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/02—Burettes; Pipettes
- B01L3/0289—Apparatus for withdrawing or distributing predetermined quantities of fluid
- B01L3/0293—Apparatus for withdrawing or distributing predetermined quantities of fluid for liquids
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/06—Fluid handling related problems
- B01L2200/0684—Venting, avoiding backpressure, avoid gas bubbles
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/06—Auxiliary integrated devices, integrated components
- B01L2300/0681—Filter
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
- B01L2400/0406—Moving fluids with specific forces or mechanical means specific forces capillary forces
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
- B01L2400/0478—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure pistons
Definitions
- the invention relates to a device for withdrawing capillary blood, comprising a blood collection vessel which is formed at its front end with a capillary which automatically draws in blood and is permeable to air at the rear.
- such a blood collection device which consists of a volume which is open on both sides and has a conically enlarged vessel.
- the front end of the vessel is tapered in such a way that, as a capillary, it automatically draws the blood to be drawn into its interior by capillary action as soon as the front end or the tip is brought into contact with the blood collection point, usually on the fingertip of a patient.
- the vessel merges in one piece into a holder provided with a flushing window.
- An actuating rod serving as an extended handle and having a closure piece at the front is arranged in the holder, the closure piece being seated on the end of the capillary when the blood is drawn. Air outlet openings remaining on the closure piece allow the air displaced when the vessel or the capillary is filled to escape.
- this blood collection device requires that, in order to empty the capillary, the vessel held indirectly by an operator via the actuating rod is first opened by lifting the closure piece from the capillary end and then immersed in a sample tube filled with a dilution liquid (reagent). By moving the device opened in this way, the small amount of blood withdrawn can then be rinsed out in the sample tube filled with reagent.
- liquid domes are formed at the air outlet openings of the closure piece when capillary blood is drawn, the volume of which, although only small, nevertheless does not allow a very exact dosage when emptying the blood.
- the invention is therefore based on the object of providing a generic blood sampling device which, with simple handling, enables exact dosing of even the smallest amounts of blood.
- the rear end of the capillary is provided with an air-permeable, porous limiting element that is pressed in in a defined position and that automatically stops the blood flow and is pressed in for a precise determination of a sample volume, and the end of the blood collection vessel that is removed from the capillary is temporarily removed from one for blood collection ventable plunger is closed, which empties the capillary by excess pressure to deliver blood with a sealed seal in the blood collection vessel.
- the air-permeable limiting element stops further blood absorption at the first blood contact, i.e. as soon as the capillary is filled up to the limiting element.
- the limiting element enables an exact volume determination of the blood sample to be taken, since it experiences a defined and unchanged positioning, preferably through an internal stop against which the limiting element is pressed, in the capillary, up to which it is inserted in a defined manner during manufacture.
- the filter element is there to contaminate the pipette, e.g. Prevent aerosols, whereby contact with the absorbed liquid is not desired. Exact adherence to a defined filter position is also essential to ensure the functionality of such a pipette tip.
- the invention makes it possible in a simple manner to squeeze out the amount of blood determinedly taken up in the capillary for analysis in the desired dosage, ie the capillary can be emptied completely, alternatively but also in stages, by a tappet stroke.
- the ventability of the plunger for example via a plunger holder leaking from the delivery state of the blood collection device and thus in the blood collection or blood collection position, or through a vent hole in the plunger, preferably at its upper end, creates the ventilation necessary for the capillary blood collection.
- Figure 1 is an overall view in longitudinal section of a capillary blood withdrawal device
- Figure 2 is an overall view in a longitudinal section of another embodiment of a capillary blood withdrawal device.
- a capillary blood withdrawal device 1 shown in FIGS. 1 and 2 has a blood withdrawal vessel 2, which has a capillary 3 at its front end in a trumpet-like shape and, integrally formed therewith, has a cylinder section 4 which adjoins to the rear and is much larger in diameter.
- the capillary 3 is separated from the chamber volume 5 of the cylinder section 4 by a porous limiting element 6, which is pressed against a stop 7 of the blood collection vessel 2 in a defined manner and precisely determines the receiving volume of the capillary 3 on the basis of this precise positioning.
- the aspiration of the capillary 3 is stopped, i.e. completed.
- a sample volume 13 can thus be determined or determined very precisely.
- a plunger 8 is arranged, which is shown in FIGS. 1 and 2 in its starting position for blood collection or withdrawal.
- a plunger head 9 which is immersed in the cylinder section 4 is designed according to FIG. 1 with an air gap 10 to the inner wall of the cylinder.
- air gap 10 closes by, for example, complementary constructive design of the mutually facing walls of plunger head 9 and inner wall of cylinder section 4 with the occurrence of Ram head 9 in the discharge path 11.
- FIG. 2 An alternative embodiment for venting when taking capillary blood and for forcibly emptying the capillary by excess pressure can be seen in FIG. 2.
- the plunger head 9 is arranged from the outset and is immersed in the cylinder chamber of the cylinder section 4. He then maintains this sealed engagement during the stroke via the discharge path 11, for which purpose a vent hole 12 provided at the upper end of the plunger 8 in the shown initial state for the blood plunger is closed by an operator during the displacement by placing a finger on it.
- the very specific amount of blood sucked into the capillary 3 can be pressed out as a preferably metered total amount, but also as a metered partial amount, by the tappet 8, which is sealed in the cylinder section 4 with its tappet head 9 and sealed at least over the stroke of the delivery path 11.
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
- Pathology (AREA)
- Physics & Mathematics (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Medical Informatics (AREA)
- Hematology (AREA)
- Surgery (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Clinical Laboratory Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dermatology (AREA)
- Manufacturing & Machinery (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
Abstract
Description
Claims
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE202004004951U DE202004004951U1 (de) | 2004-03-26 | 2004-03-26 | Vorrichtung zur Entnahme von Kapillarblut |
DE202004004951.1 | 2004-03-26 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2005094681A1 true WO2005094681A1 (de) | 2005-10-13 |
Family
ID=32892582
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/DE2005/000221 WO2005094681A1 (de) | 2004-03-26 | 2005-02-10 | Vorrichtung zur entnahme von kapillarblut |
Country Status (2)
Country | Link |
---|---|
DE (1) | DE202004004951U1 (de) |
WO (1) | WO2005094681A1 (de) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3108962A1 (de) | 2015-06-22 | 2016-12-28 | Thinxxs Microtechnology Ag | Probenträger |
EP3248683A1 (de) | 2016-05-24 | 2017-11-29 | KABE-Labortechnik GmbH | Kapillarentleerungshilfe |
US10126211B2 (en) | 2013-09-05 | 2018-11-13 | Miyuki Yamakawa | Bodily fluid sampler |
CN110201548A (zh) * | 2019-04-23 | 2019-09-06 | 江苏科华医疗器械科技有限公司 | 一种快速末梢血浆采集器及其使用方法 |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4589421A (en) * | 1984-03-14 | 1986-05-20 | Syntex (U.S.A.) Inc. | Sampling device |
US5059398A (en) * | 1985-07-22 | 1991-10-22 | Drummond Scientific Company | Disposable preselected-volume capillary pipet device |
US5851491A (en) * | 1997-06-13 | 1998-12-22 | Labcon, North America | Pipette tip and filter for accurate sampling and prevention of contamination |
EP1287784A1 (de) * | 2001-08-30 | 2003-03-05 | Becton, Dickinson and Company | Spritze zur Gewinnung von Gasen im Blut, mit verbesserter Blutsperre |
US20040052689A1 (en) * | 1999-08-17 | 2004-03-18 | Porex Technologies Corporation | Self-sealing materials and devices comprising same |
-
2004
- 2004-03-26 DE DE202004004951U patent/DE202004004951U1/de not_active Expired - Lifetime
-
2005
- 2005-02-10 WO PCT/DE2005/000221 patent/WO2005094681A1/de active Application Filing
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4589421A (en) * | 1984-03-14 | 1986-05-20 | Syntex (U.S.A.) Inc. | Sampling device |
US5059398A (en) * | 1985-07-22 | 1991-10-22 | Drummond Scientific Company | Disposable preselected-volume capillary pipet device |
US5851491A (en) * | 1997-06-13 | 1998-12-22 | Labcon, North America | Pipette tip and filter for accurate sampling and prevention of contamination |
US20040052689A1 (en) * | 1999-08-17 | 2004-03-18 | Porex Technologies Corporation | Self-sealing materials and devices comprising same |
EP1287784A1 (de) * | 2001-08-30 | 2003-03-05 | Becton, Dickinson and Company | Spritze zur Gewinnung von Gasen im Blut, mit verbesserter Blutsperre |
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10126211B2 (en) | 2013-09-05 | 2018-11-13 | Miyuki Yamakawa | Bodily fluid sampler |
EP3108962A1 (de) | 2015-06-22 | 2016-12-28 | Thinxxs Microtechnology Ag | Probenträger |
WO2016206854A1 (de) | 2015-06-22 | 2016-12-29 | Thinxxs Microtechnology Ag | Probenträger |
US11045802B2 (en) | 2015-06-22 | 2021-06-29 | Thinxxs Microtechnology Ag | Sample carrier |
EP3248683A1 (de) | 2016-05-24 | 2017-11-29 | KABE-Labortechnik GmbH | Kapillarentleerungshilfe |
DE102016109536A1 (de) | 2016-05-24 | 2017-11-30 | Kabe-Labortechnik Gmbh | Kapillarentleerungshilfe |
CN110201548A (zh) * | 2019-04-23 | 2019-09-06 | 江苏科华医疗器械科技有限公司 | 一种快速末梢血浆采集器及其使用方法 |
Also Published As
Publication number | Publication date |
---|---|
DE202004004951U1 (de) | 2004-08-19 |
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