WO2005087912A3 - Erfindung betreffend bioreaktoren und bioreaktorsysteme - Google Patents

Erfindung betreffend bioreaktoren und bioreaktorsysteme Download PDF

Info

Publication number
WO2005087912A3
WO2005087912A3 PCT/DE2005/000199 DE2005000199W WO2005087912A3 WO 2005087912 A3 WO2005087912 A3 WO 2005087912A3 DE 2005000199 W DE2005000199 W DE 2005000199W WO 2005087912 A3 WO2005087912 A3 WO 2005087912A3
Authority
WO
WIPO (PCT)
Prior art keywords
pressure
cells
bioreactor
inventive
cell
Prior art date
Application number
PCT/DE2005/000199
Other languages
English (en)
French (fr)
Other versions
WO2005087912A2 (de
Inventor
Peter Czermak
Dirk Nehring
Christian Weber
Stephanie Gokorsch
Original Assignee
Fachhochschule Giessen Friedbe
Peter Czermak
Dirk Nehring
Christian Weber
Stephanie Gokorsch
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fachhochschule Giessen Friedbe, Peter Czermak, Dirk Nehring, Christian Weber, Stephanie Gokorsch filed Critical Fachhochschule Giessen Friedbe
Publication of WO2005087912A2 publication Critical patent/WO2005087912A2/de
Publication of WO2005087912A3 publication Critical patent/WO2005087912A3/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M35/00—Means for application of stress for stimulating the growth of microorganisms or the generation of fermentation or metabolic products; Means for electroporation or cell fusion
    • C12M35/04—Mechanical means, e.g. sonic waves, stretching forces, pressure or shear stimuli
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/02—Form or structure of the vessel
    • C12M23/12—Well or multiwell plates

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Sustainable Development (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Mechanical Engineering (AREA)
  • Clinical Laboratory Science (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Es wird ein Bioreaktorsystem zur Druckstimulation von Zellen, Zell-Matrix­Kompositen oder anderen biologischen Proben bereitgestellt, bestehend aus einem Bioreaktor und einer Vorrichtung zur Druckstimulation, das vielseitige Anwendungsmöglichkeiten bezüglich der optimalen Versuchsparameter zur Kultivierung bzw. Züchtung von Zellen oder Zell-Matrix-Kompositen aufweist. Es zeichnet sich dadurch aus, dass die Stimulation der Zellen oder Komposite mit definiertem oder undefiniertem Druck erfolgen kann und Dauer und Fre­quenz der Druckstimulation frei programmierbar sind. Der Mediumwechsel und Probennahme erfolgen bei geschlossenem System und eine einfache Reini­gung ist möglich. Das erfindungsgemäße Bioreaktorsystem weist zu dem Heiz­- oder/und Kühlelemente und Pumpmittel, sowie Sensoren und Regeleinheiten für pH-Wert, Temperatur und Druck auf und läuft wahlweise im Perfusions­- (kontinuierlichen) oder batch-Betrieb.
PCT/DE2005/000199 2004-03-10 2005-02-05 Erfindung betreffend bioreaktoren und bioreaktorsysteme WO2005087912A2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE200410012010 DE102004012010A1 (de) 2004-03-10 2004-03-10 Erfindung betreffend Bioreaktoren und Bioreaktorsysteme
DE102004012010.2 2004-03-10

Publications (2)

Publication Number Publication Date
WO2005087912A2 WO2005087912A2 (de) 2005-09-22
WO2005087912A3 true WO2005087912A3 (de) 2006-03-16

Family

ID=34895251

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DE2005/000199 WO2005087912A2 (de) 2004-03-10 2005-02-05 Erfindung betreffend bioreaktoren und bioreaktorsysteme

Country Status (2)

Country Link
DE (1) DE102004012010A1 (de)
WO (1) WO2005087912A2 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102008015633B4 (de) * 2008-03-25 2010-07-01 Nova Tissue Gmbh Perfundierbarer Bioreaktor zur Herstellung und/oder Kultivierung eines menschlichen oder tierischen Blutgefäßes und/oder eines menschlichen oder tierischen Gewebes
EP2288688A2 (de) * 2008-03-25 2011-03-02 Novatissue Gmbh Perfundierbarer bioreaktor zur herstellung von menschlichen oder tierischen geweben
AT506826B1 (de) * 2008-05-23 2010-03-15 Greiner Bio One Gmbh Bioreaktor und verfahren zum kultivieren von zellen und geweben
DE102008058782A1 (de) * 2008-11-24 2010-05-27 Rheinische Friedrich-Wilhelms-Universität Bonn Vorrichtung zur physiologischen, dynamischen in-vitro Zelldehnung
DE102008059731A1 (de) * 2008-12-01 2010-06-02 Gottfried Wilhelm Leibniz Universität Hannover Verfahren und Vorrichtung zum Stimulieren von Zellen
DE102018221415B3 (de) * 2018-09-19 2020-03-05 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Anordnung zur Durchführung von in-vitro Biokompatibilitätstests
CN111518694A (zh) * 2020-05-07 2020-08-11 吉林大学 一种多项调节式细胞移动培养装置

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4839280A (en) * 1987-05-04 1989-06-13 Banes Albert J Apparatus for applying stress to cell cultures
US4940853A (en) * 1988-07-22 1990-07-10 Vandenburgh Herman H Method for growing tissue specimens in vitro
US5348879A (en) * 1990-08-24 1994-09-20 The General Hospital Corporation Cell stretching method
EP1380640A1 (de) * 2001-04-17 2004-01-14 TAKAGI INDUSTRIES CO., Ltd. Zell- und strukturinkubator

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6048723A (en) * 1997-12-02 2000-04-11 Flexcell International Corporation Flexible bottom culture plate for applying mechanical load to cell cultures
DE19962456A1 (de) * 1999-12-22 2001-07-12 Biotechnologie Ges Mittelhesse Verfahren und Apparatur zur Herstellung, Untersuchung und mechanischen Stimulation dreidimensionaler Gewebezellkulturen
DE10041988B4 (de) * 2000-08-26 2006-02-09 Artmann, Gerhard, Prof. Dr. Vorrichtung und Verfahren zur Messung von Kräften von belebtem Material
FR2821853B1 (fr) * 2001-03-09 2003-05-16 Natural Implant Sa Bioreacteur pour tissu cultive en couche mince et utilisations
DE10130512B4 (de) * 2001-06-25 2007-08-16 Bionethos Holding Gmbh Vorrichtung zur Druckperfusion für das Züchten und/oder für das Behandeln von Zellen
JP2003061642A (ja) * 2001-08-30 2003-03-04 Takagi Ind Co Ltd 細胞・組織培養装置
JP4451582B2 (ja) * 2001-12-21 2010-04-14 高木産業株式会社 細胞・組織培養装置
KR100452403B1 (ko) * 2002-11-19 2004-10-12 한국과학기술연구원 세포배양용 복합 생물반응기

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4839280A (en) * 1987-05-04 1989-06-13 Banes Albert J Apparatus for applying stress to cell cultures
US4940853A (en) * 1988-07-22 1990-07-10 Vandenburgh Herman H Method for growing tissue specimens in vitro
US5348879A (en) * 1990-08-24 1994-09-20 The General Hospital Corporation Cell stretching method
EP1380640A1 (de) * 2001-04-17 2004-01-14 TAKAGI INDUSTRIES CO., Ltd. Zell- und strukturinkubator

Also Published As

Publication number Publication date
DE102004012010A1 (de) 2005-09-29
WO2005087912A2 (de) 2005-09-22

Similar Documents

Publication Publication Date Title
WO2005087912A3 (de) Erfindung betreffend bioreaktoren und bioreaktorsysteme
WO2011005236A3 (en) Climate simulation system with cold accumulation technique
WO2004008100A3 (en) Methods and media for controlling sialylation of proteins produced by mammalian cells
WO2006128641A3 (en) Fermenter system for biotechnical processes
DK2029722T3 (da) Fremgangsmåde og system til celleproduktion
WO2010069319A3 (en) Method and device for industrial biolayer cultivation
EP4220168A3 (de) Identifizierung von pathogenen in körperflüssigkeiten
IL177110A0 (en) Biochip electroporator and its use in multi-site, single-cell electroporation
Rajan et al. Monitoring pH, temperature and humidity in long-term stem cell culture in CO 2 incubator
Konstantinov et al. Control of long‐term perfusion Chinese hamster ovary cell culture by glucose auxostat
CY1110267T1 (el) Μεθοδος για την καλλιεργεια κυτταρων για την παραγωγη ουσιων
WO2009016078A3 (en) Method for culturing mammalian stem cells
WO2008073348A3 (en) Microgravity bioreactor systems for production of bioactive compounds and biological macromolecules
WO2004033615A8 (de) Verfahren zur kultivierung von zellen, insbesondere menschlicher oder tierischer zellen
ATE552331T1 (de) Fermentationsverfahren und anordnung zu dessen durchführung
MD3625G2 (ro) Heptaazotat de hexa-(m-b-alanin-(O,O'))-m3-oxo-tri(aqua)trifier(III) 3,5-hidrat şi procedeu de obţinere a biomasei de Spirulina platensis
Kwak et al. A microscale approach for simple and rapid monitoring of cell growth and lipid accumulation in Neochloris oleoabundans
Spagni et al. Modelling wastewater treatment in a submerged anaerobic membrane bioreactor
DK1794280T3 (da) Reaktor og fremgangsmåde til fastfasefermentering
CN203159625U (zh) 高压细胞培养箱
Takahashi et al. Development of a feed-forward control system for medium in shake-flask culture
CN108148749A (zh) 保持培养液溶解氧浓度和酸碱度的微流控芯片培养系统
CN205188300U (zh) 一种摇床
CN202297600U (zh) 一种水质生物毒性连续培养及连续运行装置
Vostiar et al. Intracellular monitoring of superoxide dismutase expression in an Escherichia coli fed-batch cultivation using on-line disruption with at-line surface plasmon resonance detection

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BW BY BZ CA CH CN CO CR CU CZ DK DM DZ EC EE EG ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NA NI NO NZ OM PG PH PL PT RO RU SC SD SE SG SK SL SM SY TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): BW GH GM KE LS MW MZ NA SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LT LU MC NL PL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
122 Ep: pct application non-entry in european phase