WO2005063859A1 - ポリブタジエン成形品の接着方法、これより得られるポリブタジエン複合成形品、医療用部材、および輸液セット - Google Patents
ポリブタジエン成形品の接着方法、これより得られるポリブタジエン複合成形品、医療用部材、および輸液セット Download PDFInfo
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- WO2005063859A1 WO2005063859A1 PCT/JP2004/019296 JP2004019296W WO2005063859A1 WO 2005063859 A1 WO2005063859 A1 WO 2005063859A1 JP 2004019296 W JP2004019296 W JP 2004019296W WO 2005063859 A1 WO2005063859 A1 WO 2005063859A1
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- WIPO (PCT)
- Prior art keywords
- polybutadiene
- molded product
- resin
- bonding
- treatment
- Prior art date
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- 229920002857 polybutadiene Polymers 0.000 title claims abstract description 104
- 238000000034 method Methods 0.000 title claims abstract description 30
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- 229910001868 water Inorganic materials 0.000 claims abstract description 35
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- ZWEHNKRNPOVVGH-UHFFFAOYSA-N 2-Butanone Chemical compound CCC(C)=O ZWEHNKRNPOVVGH-UHFFFAOYSA-N 0.000 claims description 12
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- 229920000122 acrylonitrile butadiene styrene Polymers 0.000 claims description 9
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 claims description 8
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- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 3
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Classifications
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- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09J—ADHESIVES; NON-MECHANICAL ASPECTS OF ADHESIVE PROCESSES IN GENERAL; ADHESIVE PROCESSES NOT PROVIDED FOR ELSEWHERE; USE OF MATERIALS AS ADHESIVES
- C09J5/00—Adhesive processes in general; Adhesive processes not provided for elsewhere, e.g. relating to primers
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- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09J—ADHESIVES; NON-MECHANICAL ASPECTS OF ADHESIVE PROCESSES IN GENERAL; ADHESIVE PROCESSES NOT PROVIDED FOR ELSEWHERE; USE OF MATERIALS AS ADHESIVES
- C09J2409/00—Presence of diene rubber
- C09J2409/008—Presence of diene rubber in the pretreated surface to be joined
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/31504—Composite [nonstructural laminate]
- Y10T428/31855—Of addition polymer from unsaturated monomers
- Y10T428/31931—Polyene monomer-containing
Definitions
- the present invention relates to a method for bonding a polybutadiene molded product, a polybutadiene composite molded product obtained therefrom, a medical member, and an infusion set.
- infusion sets are commercialized by solvent bonding (adhesion) of tubes and connectors.
- the above-mentioned infusion set has been commercialized as PVC tube Z solvent (polar solvent) Z polar resin connector.
- PVC tube Z solvent polar solvent
- RB studies are increasing in place of PVC tubes.
- bonding with polar solvent Z-polar resin may be insufficient.
- a pump may be used to infuse a patient using an infusion set.
- the infusion set is under pressure, for example, the connection between a tube and a connector is used. There is a possibility that the liquid leaks more.
- Patent Document 1 Japanese Patent Application Laid-Open No. 2004-321788
- the present invention improves the bonding (adhesion) force between a polybutadiene molded product and a polar resin molded product, and further improves the bonding force by selecting (combining) solvents for these molded products. It is aimed at.
- the present invention provides (1) a step of reducing the water contact angle on the surface of the polybutadiene molded article (hereinafter also referred to as “(1) step”);
- the polybutadiene is preferably syndiotactic 1,2 polybutadiene having a crystallinity of 5% or more!
- the above-mentioned step (1) includes ozone treatment, electron beam treatment, corona discharge treatment, plasma discharge treatment, radiation (X-ray, ⁇ -ray, j8-ray) treatment, ultraviolet treatment, ultraviolet laser treatment, and Processing strength At least one selected species is included.
- the water contact angle (CA) of the polybutadiene molded product having a reduced water contact angle obtained by the above step (1) is 80 degrees or less.
- polar resin examples include polycarbonate resin, polyester resin, ABS resin, polystyrene resin, polyurethane resin, polyamide resin, polyalkyl acrylate resin, polyalkyl methacrylate resin, and polyvinyl acetate. At least one selected from the group consisting of resin, polychloride resin, and polychloride resin.
- the difference (A CA) between the water contact angle (CA) of the polybutadiene molded product having a reduced water contact angle obtained in the above step (1) and the water contact angle (CA) of the polar resin molded product is +60.
- the bonding in the step (2) is preferably bonding with an organic solvent.
- Preferred examples of the organic solvent include at least one selected from the group consisting of cyclohexanone, tetrahydrofuran, cyclohexane, methylethyl ketone, acetone, and ethyl acetate.
- the polybutadiene molded article and the polar resin molded article each having a reduced water contact angle obtained in the step (1) are previously treated with the above-mentioned organic solvent.
- the present invention relates to a polybutadiene composite molded product obtained by the above method for bonding a polybutadiene molded product. Further, the present invention relates to a medical member including at least the polybutadiene composite molded article.
- the present invention relates to an infusion set including the medical member as a component.
- a polar group is planted on the surface of the polybutadiene molded article.
- the bonding (adhesion) force with the polar resin molded product is improved, and the solvent of these molded products is improved.
- the bonding strength can be further improved.
- FIG. 1 is a plan view of an infusion set including a polybutadiene composite molded article (medical member) of the present invention as a component.
- FIG. 2 (a) is a schematic diagram of a connector, and (b) is a schematic diagram of a tube.
- a composition comprising (A) syndiotactic 1,2-polybutadiene alone or (A) syndiotactic 1,2-polybutadiene and (B) another thermoplastic polymer is preferably used.
- This (A) syndiotactic 1,2 polybutadiene is a syndiotactic 1,2 polybutadiene having a crystallinity of 5% or more, preferably 10 to 40%, and a melting point of preferably 50 to 50%. It is in the range of 150 ° C, more preferably 60-140 ° C. When the crystallinity and the melting point are in these ranges, the result is an excellent balance between mechanical strength such as tensile strength and tear strength and flexibility.
- a syndiotactic 1,2 polybutadiene having a crystallinity of about 5 to 25% by mass is used.
- low crystal RB (Hereinafter, also referred to as “low crystal RB”) is used as a tube body because of its excellent flexibility.
- the (A) syndiotactic 1,2-polybutadiene used in the present invention has, for example, a 1,2-bond content of 70% or more, and includes, for example, a catalyst containing a cobalt compound and an aluminoxane.
- the force obtained by polymerizing butadiene in the presence of is not limited to this production method.
- the 1,2 bond content in the butadiene bond unit of the (A) syndiotactic 1,2-polybutadiene used in the present invention is usually 70% or more, preferably 80% or more, and more preferably 90% or more. It is. When the content of the 1,2 bond is 70% or more, the 1,2-polybutadiene exhibits excellent properties as a thermoplastic elastomer.
- the (A) syndiotactic 1,2-polybutadiene used in the present invention may be obtained by copolymerizing a small amount of a conjugated diene other than butadiene.
- the conjugated diene other than butadiene include 1,3-pentadiene, 1,3-butadiene derivatives substituted with a higher alkyl group, and 2-alkyl-substituted 1,3-butadiene.
- 1,3-butadiene derivatives substituted with higher alkyl groups include 1 pen Chinole 1,3 butadiene, 1-hexyl-1,3-butadiene, 11-heptyl-1,3-butadiene, 1-year-old octyl 1,3-butadiene, and the like.
- 2-alkyl-substituted 1,3-butadiene examples include 2-methyl-1,3-butadiene (isoprene), 2-ethyl-1,3-butadiene, 2-propyl-1,3 butadiene 2 Isopropyl 1,3 butadiene, 2-butyl-1,3 butadiene, 2 isobutyl-1,3 butadiene, 2 amylane 1,3 butadiene, 2 isoamylene 1,3 butadiene, 2-hexyl-1,3 butadiene, 2-cyclohexyl 1 2,3-butadiene, 2-isohexyl-1,3-butadiene, 2-butyl-1,3-butadiene, 2-isoheptyl-1,3-butadiene, 2-butyl-1,3-butadiene, 2-isooctyl-1,3-butadiene, etc.
- conjugated genes to be copolymerized with butadiene include isoprene and 1,3 pentadiene.
- the content of butadiene in the monomer component used for the polymerization is preferably at least 50 mol%, particularly preferably at least 70 mol%.
- the above-mentioned conoreto compound an organic acid salt of cobalt having preferably 4 or more carbon atoms can be mentioned.
- the organic acid salts of cobalt include butyrate, hexanoate, heptylate, octylate such as 2-ethylhexylate, decanoate, stearic acid, oleic acid, and erlic acid.
- the so-called octylates of 2-ethylhexyl acid, stearates and benzoates are preferred for their excellent solubility in hydrocarbon solvents.
- Examples of the aluminoxane include those represented by the following general formula (I) or general formula ( ⁇ ). [0016] [Formula 1]
- R is a hydrocarbon group such as a methyl group, an ethyl group, a propyl group, and a butyl group. Preferred are a methyl group and an ethyl group, and particularly preferred is a methyl group.
- M is an integer of 2 or more, preferably 5 or more, and more preferably 10-100.
- Specific examples of aluminoxane include methyl aluminoxane, ethyl aluminoxane, propyl aluminoxane, butyl aluminoxane, and the like, and methyl aluminoxane is particularly preferred! /.
- the polymerization catalyst contains a phosphine compound in addition to the above-mentioned cobalt compound and aluminoxane.
- the phosphine conjugate is a component effective for activating the polymerization catalyst, controlling the vinyl bond structure and the crystallinity, and preferably includes an organic phosphorus conjugate represented by the following general formula ( ⁇ ).
- Ar represents a group shown below.
- R 1 , R 2 , and R 3 are the same or different and are each a hydrogen atom, preferably an alkyl group having 16 carbon atoms, a halogen atom, and preferably 1 to 11 carbon atoms. And represents an alkoxy group having 6 or an aryl group having preferably 6 to 12 carbon atoms.
- R ′ represents a cycloalkyl group or an alkyl-substituted cycloalkyl group, and n is an integer of 0-3.
- phosphine conjugate represented by the general formula (III) include tri (3-methylphenyl) phosphine, tri- (3-ethylphenyl) phosphine, and tri (3,5-dimethylphenyl) phosphine.
- the compound represented by the above general formula (IV) is a complex having a phosphine compound in which n is 3 in the above general formula ( ⁇ ) as a ligand with respect to cobalt chloride.
- this cobalt conjugate it may be used as synthesized in a rough manner, or may be used in such a manner that the cobalt chloride and the phosphine conjugate are brought into contact in the polymerization system.
- various phosphine compounds in the complex it is possible to control the amount of 1,2-bonds and the crystallinity of the resulting syndiotactic 1,2-polybutadiene.
- cobalt compound represented by the above general formula (IV) include cobalt bis (triphenylphosphine) dichloride, cobalt bis [tris (3-methylphenylphosphine)] dichloride, cobalt bis [ Tris (3-ethylphenylphosphine)] dichloride, cobalt bis [tris (4-methylphenylphosphine)] dichloride, cobalt bis [tris (3,5-dimethylphenylphosphine)] dichloride, cobalt bis [tris (3,4- Dimethylphenylphosphine)] dichloride, cobalt bis [tris (3-isopropylphenylphosphine)] dichloride, cobalt bis [tris (3-tbutylphenylphosphine)] dichloride, cobalt bis [tris (3,5-jetylphenyl) -Luphosphine)] dichloride, cobalt bi [Tris (3-methylphenyl
- cobalt bis (triphenylphosphine) dichloride cobalt bis [tris (3-methylphenylphosphine)] dichloride, and cobalt bis [tris (3,5-dimethylphenyl) dichloride.
- the amount of the phosphine compound used is usually 0.1 to 50, preferably 0.5 to 20, and more preferably 112, as a ratio of phosphorus atom to cobalt atom (PZCo).
- the amount of aluminum Noo hexane as the ratio of aluminum atoms (Al / Co) to pair the cobalt atom of Kobaruti ⁇ was typically 4 one 10 7, Ru preferably 10-10 6 Der.
- the amount of the phosphine compound used is such that the ratio of the phosphorus atom to the cobalt atom (PZCo) is 2, and the amount of the aluminoxane is as described above. Obey.
- Examples of the inert organic solvent used as the polymerization solvent include aromatic hydrocarbon solvents such as benzene, toluene, xylene, and cumene; aliphatic hydrocarbon solvents such as n-pentane, n-hexane, and n-butane; Examples include alicyclic hydrocarbon solvents such as cyclopentane, methylcyclopentane, and cyclohexane, and mixtures thereof.
- the polymerization temperature is usually 50-120 ° C, preferably -20-100 ° C.
- the polymerization reaction may be a batch type or a continuous type.
- the concentration of the monomer in the solvent is usually 5 to 50% by mass, preferably 10 to 35% by mass.
- the weight average molecular weight of the (A) syndiotactic 1,2 polybutadiene used in the present invention is preferably 11 to 5,000,000, more preferably 11 to 1.5 million, and particularly preferably 50 to 1,000,000. It is. If the weight-average molecular weight is less than 10,000, the flowability is extremely high, making it extremely difficult to process. Also, the molded product (medical member) becomes sticky, which is not preferable, while if it exceeds 5,000,000, the flowability is extremely low. Processing becomes very difficult, which is not preferable.
- thermoplastic polymer includes thermoplastic resins other than the above-mentioned component (A) and
- thermoplastic elastomer specifically, polyethylene, polypropylene, styrene butadiene styrene block copolymer (SBS), styrene isoprene styrene block copolymer (SIS), and hydrides thereof (SEBS, SEPS), polybutadiene (BR) other than the above-mentioned syndiotactic 1,2-polybutadiene, ABS resin, polyisoprene, various polyethylenes (LLDPE, ULDPE, LDPE), ethylene butyl acetate copolymer, ethylene acrylate copolymer, and Group of ethylene-methacrylic acid copolymers At least one selected.
- SBS styrene butadiene styrene block copolymer
- SIS styrene isoprene styrene block copolymer
- SEBS polybutadiene
- BR polybutadiene
- the amount of the component (B) is 40 parts by mass or less, preferably 0 to 35 parts by mass, per 100 parts by mass of the total amount of the components (A) and (B).
- the amount exceeds 40 parts by mass the proportion of the component (A) used is reduced, and the inherent flexibility of the component (A) is lost.
- the composition used in the present invention may contain additives such as a lubricant, a filler or a foaming agent, if necessary, in addition to the components (A) and (B).
- additives such as paraffin oil, silicone oil, liquid polyisoprene, liquid polybutadiene, L-acid amide, stearic acid amide and other lubricants, talc, silica, magnesium hydroxide, calcium carbonate, glass , Carbon fiber, glass balloons, and other foaming agents; and microspheres, ADCA, OBSH, baking soda, AIBN, etc., manufactured by Matsumoto Yushi Co., Ltd.
- the amount of lubricant used is 100 parts by mass of the total amount of the resin component, that is, the components (A) and (B).
- the amount is 10 parts by mass or less, preferably 0.01 to 8 parts by mass. If the amount exceeds 10 parts by mass, the lubricant bleeds out of the product and elutes in the used drug, which is not preferable.
- additives for example, a polyfunctional monomer such as trimethylpropanetrimetha- talate, a light-sensitive material such as hydroxycyclohexylphenol-ketone or the like.
- a polymerization initiator, a photosensitizer such as benzophenone, or the like may be contained in an amount of 5 parts by mass or less based on 100 parts by mass of the syndiotactic 1,2-polybutadiene.
- the composition used for the polybutadiene molded article in the present invention comprises the above-mentioned component (A) alone, or the components (A)-(B), and if necessary, the above-mentioned additives and the like are added thereto.
- molded products such as tubes and connectors
- press molding, extrusion molding, injection molding, blow molding, profile extrusion molding, T-die film molding, inflation molding, nodder slush molding, rotational molding, etc. are used. It is molded into a tube or other connector with a tube connection.
- a low-crystal RB is used because the tube requires flexibility, but since the melting point is low, in order to develop steam sterilization resistance, it is then irradiated with an electron beam. Can be crosslinked.
- the vinyl group of the syndiotactic 1,2-polybutadiene undergoes a radical polymerization to form a three-dimensional crosslinked structure, thereby imparting heat resistance to the molded article (tube).
- the electron beam is permeable to the synthetic resin, and the degree of transmission depends on the thickness of the molded product and the kinetic energy of the electron beam.
- a molded article (tube) having a uniform degree of crosslinking in the thickness direction can be obtained.
- the connector may be irradiated with an electron beam.
- the electron beam irradiation may be performed before or after bonding the tube and the connector.
- the electron beam accelerating voltage is preferably 50-3, OOOkV, more preferably 300-2, OOOkV with respect to the polybutadiene molded article (medical member) such as the above tube. If it is less than 50 kV, the proportion of electrons captured and absorbed in the surface layer becomes relatively large, so that the number of electron beams transmitted through the molded article decreases, and the internal crosslinking is delayed compared to the surface layer, and the degree of crosslinking increases. Is not preferred because of the difference in On the other hand, if it is larger than 3, OOOkV, the degree of cross-linking becomes too large, and it becomes hard and elasticity and elongation become small, which is not preferable.
- the irradiation amount of the electron beam is preferably in the range of 100 Mrad (corresponding to 10-1 or OOOkGy in SI unit system), and more preferably in the range of 50 Mrad. Let me do it. If it is less than lMrad, the degree of cross-linking of 1,2-polybutadiene is small, while if it exceeds lOOMrad, the degree of cross-linking becomes too large and becomes hard, which is not preferable because elasticity and elongation are small.
- Crosslinking by electron beam irradiation can be represented by the product of the electron beam acceleration voltage and the irradiation dose.
- the product of the electron beam acceleration voltage (kV) and the irradiation dose (Mrad) is preferably used. 2,000 to 20, 20, OOO (kV'Mrad), and more preferably, 5,000 to 16,000 (kV-Mrad).
- the elastic modulus (M2) at 50% elongation of the medical member after electron beam irradiation is increased.
- M2 / Ml is the above electron beam acceleration voltage (kV) and irradiation dose (Mrad)
- the polybutadiene molded article such as a cross-linked tube obtained after electron beam irradiation obtained in this way has steam sterilization resistance, and is, for example, a cross-linked product of the present invention. It does not deform when steam sterilized using an infusion tube at 100-121 ° C for about 10-20 minutes.
- the steam sterilization resistance refers specifically to a resin molded product such as an infusion tube (for example, an inner diameter of 3 ⁇ , an outer diameter of 4.4mm ⁇ , a wall thickness of 0.7mm, and a tube length of 20cm).
- an infusion tube for example, an inner diameter of 3 ⁇ , an outer diameter of 4.4mm ⁇ , a wall thickness of 0.7mm, and a tube length of 20cm.
- the haze value of the polybutadiene molded article (medical member such as a tube) irradiated with the electron beam of the present invention is preferably 30 or less, more preferably 25 or less.
- the haze value is a measure of transparency, the smaller the value, the better the transparency. This haze value was measured according to ASTM D-1003.
- the polybutadiene formed article of the present invention after electron beam irradiation is toluene insoluble component force typically 50- 99 mass 0/0, preferably from 80- 95 wt%.
- the toluene insoluble content is a barometer that indicates to what extent the double bond in (A) syndiotactic 1,2-polybutadiene is crosslinked by irradiating the polybutadiene molded article with an electron beam.
- the toluene-insoluble matter is determined by immersing the polybutadiene molded article (medical member) [(a) g] of the present invention in 100 ml of toluene, leaving it at 30 ° C. for 48 hours, and then filtering it using a 100 mesh wire mesh. After collecting a part of the filtrate ((c) ml), evaporating it to dryness and solidifying it, weighing the remaining solid matter [soluble matter in toluene: (b) g], the gel content is calculated by the following formula. Was calculated.
- toluene insoluble content is less than 50% by mass, crosslinking by electron beam irradiation is insufficient, heat resistance is poor, and steam sterilization resistance is poor. On the other hand, if the content exceeds 99% by mass, the crosslinking by electron beam irradiation proceeds excessively, and the medical member becomes too hard and loses flexibility, which is not preferable.
- the toluene insoluble content can be easily adjusted by setting the product of the electron beam acceleration voltage (kV) and the irradiation dose (Mrad) to 2,000 to 20,000 (kV. Mrad).
- the polybutadiene molded article (medical member such as a tube) of the present invention preferably has a halogen atom content of 200 ppm or less, more preferably 100 ppm or less.
- the content of the halogen atom can be adjusted, for example, by using a non-halogen inert organic solvent as the polymerization solvent, as described above, so that the content of the halogen atom in the obtained 1,2-polybutadiene is preferably 200 ppm. Or less, more preferably 100 ppm or less. It is preferable to use only a non-halogen compound in the catalyst system because the halogen atom content in the polybutadiene molded article (medical member) can be further reduced.
- the polybutadiene molded product irradiated with the electron beam in this way is excellent in flexibility and hardness, and has steam sterilization resistance, so that it is useful not only for tubes but also for connectors.
- the polybutadiene molded article used in the present invention includes a tube made of 1,2 polybutadiene as described above, a tube made of a blend of 1,2-polybutadiene and a styrene isoprene block copolymer (SIS), 2—Tube made of a blend of polybutadiene and rubber; 1, 2-tube made of a blend of polybutadiene and an olefin resin.
- the combination with the styrene isoprene block copolymer may be hydrogenated styrene, ethylene propylene styrene, or a partially hydrogenated potato product.
- a force that can use various rubbers isoprene rubber and natural rubber are preferred.
- the combination with the olefin resin LDPE, L LDPE and EVA are mentioned as preferred resins.
- thermoplastic resins such as ABS resin, polystyrene resin, acrylic resin, polyacrylamide, polyacrylic acid, polymethyl acrylate, Polyalkyl acrylates such as polyethyl acrylate, polyacrylonitrile, acrylonitrile styrene copolymer, polymethacrylamide, polymethacrylic acid, polyalkyl methacrylate such as polymethyl methacrylate and polyethyl methacrylate Ester, polyurethane resin, polymethary resin-tolyl, acetal resin, polyoxymethylene, ionomer, chlorinated polyethylene, coumarone's indene resin, regenerated cellulose, petroleum resin, cellulose derivative, alkali cellulose, cellulose ester , Senorelose acetate, senorelose acetate butyrate, senorelose xanthate, senorelose citrate,
- Aromatic polyamides such as polyphenylene isophthalamide, polyphenylene terephthalamide, metaxylylene diamine, polyimide, polyphenylene sulfide, polyether ether ketone, polyamide imide, polyarylate, polyethylene terephthalate, etc.
- Polyester resin polyvinyl chloride, polyvinyl chloride, polyvinyl chloride, chlorinated polyethylene, chlorosulfonated polyethylene, polycarbonate, CR-39, polysulfone, polyethersulfone, polysulfonamide, polybutyl alcohol, polybutyl ester, polycarbonate Cinnamate, polyacetate, polybutyl ether, polyisobutyl vinyl ether, polymethylbutyl ether, polyphenylene oxide, polybutylene terephthalate, etc., and thermosetting plastics such as amino resin and a phosphorus resin , Urea resin, polysulfonamide, melamine resin, aryl resin, diaryl phthalate resin, alkyd resin, epoxy resin, silicone resin, vinyl ester resin, phenol resin, novolac resin, resorcinol resin , Unsaturated poly Ester ⁇ , low shrinkage unsaturated polyester, such as furan ⁇ is like et be.
- preferred polar resins are polycarbonate resins, polyester resins such as polyethylene terephthalate and polybutylene terephthalate, ABS resins, polystyrene resins, polyacrylic resins, polyurethane resins, polyamide resins, and polyacetic acid resins. Fats, poly-Shi-Dani Bulure resin and poly-Shi-Dai Breweryden resin.
- the solubility parameter (SP value) of the polar resin is preferably 9-13, and more preferably 9.5-12.
- solubility parameter 1 is a value calculated using the group parameter of Small by the group contribution method described in “Polymer Handbook”, published by John Wiley & Son, “Polymer Handbook”, 1999, 4th edition, section VII, pages 682-685). .
- the solubility parameter of a copolymer composed of 75% by mass of styrene and 25% by mass of acrylonitrile is one of the solubility parameter of polystyrene 9.03 (cal / cm 3 ) ⁇ and the solubility parameter of polyacrylo-tolyl 12.71.
- Equation (1) Substituting into equation (1) using (. & 17 ⁇ 11 3 ) 1/2 gives a value of 9.95 (calZcm 3 ) 1/2 .
- the solubility parameter ⁇ s of the vinyl polymer obtained by polymerizing the vinyl monomer in two or more steps and changing the type of the vinyl monomer in each step is finally determined. It was determined that additivity was established by the value obtained by dividing the total mass of the obtained vinyl polymer by the mass of the vinyl polymer obtained in each step, that is, the mass fraction. That is, the polymer is polymerized in the q step, and can be calculated by the following equation (2) from the solubility parameter ⁇ i of the polymer obtained in each step and its mass fraction Wi. [0053] [Equation 2]
- polymerization is performed in two stages, and in the first stage, 50 parts by mass of a copolymer consisting of 75% by mass of styrene and 25% by mass of acrylonitrile is obtained, and in the second stage, 50 parts by mass of a polymer of methyl methacrylate is obtained. If obtained, the polymer obtained in this two-stage polymerization
- the water of the polybutadiene composite molded product having a reduced contact angle with water after being subjected to ozone treatment, electron beam treatment, corona discharge treatment, plasma discharge treatment, ultraviolet treatment, ultraviolet laser treatment and chemical treatment When a high adhesive strength is obtained at the time of approaching the contact angle and adhering the solvent with a polar solvent, the following effect is obtained.
- solubility parameter When the solubility parameter is less than 9, the adhesive force by the polar solvent is insufficient, which is not preferable. On the other hand, if it exceeds 13, drug adsorption becomes strong and it is not suitable for connector use.
- Examples of the polar resin satisfying such a solubility parameter include the above-mentioned preferred polar resins.
- Examples of the polar resin molded product used in the present invention include a connector and an infusion set auxiliary tool made of the above various polar resins.
- the method for bonding a polybutadiene molded product of the present invention comprises the steps of (1) first treating the polybutadiene molded product with ozone to introduce a polar group described below into the surface of the polybutadiene molded product.
- the step (1) is a means for reducing the water contact angle on the surface of the polybutadiene molded product. Any method may be used as long as it is ozone treatment, corona discharge treatment, plasma discharge treatment, excimer laser treatment, electron beam treatment, ultraviolet treatment, or chemical treatment.
- Ozonation is performed by exposing a polybutadiene molded article to ozone.
- the exposure method can be performed by an appropriate method such as a method of maintaining the polybutadiene molded article in an atmosphere in which ozone is present for a predetermined time or a method of exposing the molded article to an ozone stream for a predetermined time.
- ozone can be generated by supplying an oxygen-containing gas such as air, oxygen gas, or oxygenated air to an ozone generator (such as an ultraviolet irradiation device).
- an ozone generator such as an ultraviolet irradiation device.
- the obtained ozone-containing gas is introduced into a container, a tank, or the like holding a polybutadiene molded product to perform ozone treatment.
- Various conditions such as the ozone concentration in the ozone-containing gas, the exposure time, and the exposure temperature can be appropriately determined according to the type of the polar resin molded article and the purpose of the surface modification.
- the conditions of the ozone treatment differ depending on the shape of the polybutadiene molded product and the like.
- Oxygen or air flow can be used to generate ozone at a concentration of 200mgZl at a flow rate of 20-2, OOOmlZmin, and can be treated at a temperature of 0-80 ° C for 1 minute and 24 hours.
- treatment with an ozone concentration of 10-80 mgZl at room temperature for about 20-30 minutes is appropriate.
- an ozone concentration of about 120 mgZl and a treatment at room temperature for about 30 minutes to 6 hours are appropriate.
- the generated ozone concentration when using air is about 50% of that when using oxygen.
- Electron beam treatment [0063] Electron beam treatment:
- an electron beam irradiation device equipped with an electron beam accelerator instead of the above ozone generator, and irradiate the surface of the polybutadiene molded product to be treated with an electron beam generated by the electron beam accelerator. It is implemented by.
- the above electron beam irradiation device include, for example, a device capable of irradiating a uniform electron beam in a curtain form from a linear filament (for example, , An elect opening curtain type device) or the like can be used.
- the electron beam irradiation dose at this time is usually 0.5 Mrad or more, preferably 1.5 Mrad or more, and more preferably 3 Mrad or more.
- the electron beam irradiation dose is set with respect to the line speed of the processed film on the entrance side of the electron beam irradiation apparatus, and the upper limit is not particularly limited, but is usually about 20 Mrad.
- the corona treatment is performed, for example, by passing a polybutadiene molded article to be treated into a corona atmosphere generated in an inert gas using a known corona discharge treatment device.
- the corona discharge density at this time is usually 10 (W. min. Zm 2 ) or more, preferably 30 to 300 (W-min. Zm 2 ).
- the inert gas include argon, helium, krypton, neon, xenon, and a simple gas of nitrogen or a mixed gas of two or more thereof. Nitrogen is particularly preferred in the industry.
- the inert gas may contain oxygen when the oxygen concentration in the gas is 1% by volume or less, preferably 0.1% by volume or less, more preferably 0.01% by volume or less.
- Plasma processing includes low-pressure plasma processing and atmospheric-pressure plasma processing.
- the low-pressure plasma treatment consists of electronically exciting the above-mentioned inert gas with a plasma jet at a power of 200 to 1,000 W at a low pressure of 0.1 to 5 Torr, removing charged particles, and electrically This can be achieved by contacting a neutral, excited inert gas with the polybutadiene article to be treated.
- the processing time at this time is 10-60 seconds, preferably 20-40 seconds.
- an alternating current of 3 to 5kHz2 to 3000V is applied between the electrodes in the above-described inert gas to generate an excited inert gas similar to that in the low-pressure plasma processing. It can be carried out by bringing the excited inert gas into contact with the polybutadiene molded article to be treated.
- the processing time at this time is 10 to 60 seconds, preferably 20 to 40 seconds.
- UV laser treatment
- the ultraviolet laser light there is a laser having an oscillation wavelength of 180 to 360 nm, preferably 190 to 250 nm, and an excimer laser is preferable.
- excimer laser Gases include KrF, KrCl, ArF, ArCl, F, etc.
- an ArF laser has an oscillation wavelength of 192 nm and a photon energy of 148 Kcal. Therefore, a CH bond having a binding energy of 100-l lOKcal can be cleaved, and hydrogen excited by excimer laser irradiation is easily extracted, and instead, for example, a carbonyl group is generated by oxygen in air coexisting. , A carboxyl group, a hydroxyl group and the like can be introduced.
- the chemical treatment is a process for etching or deteriorating a polybutadiene molded product or a process for introducing a functional group to the surface.
- a peroxide treatment such as hydrogen peroxide
- examples include treatment with an inorganic acid such as nitric acid, hydrochloric acid, sulfuric acid, chromic acid, and potassium permanganate solution, and treatment with a solution of aluminum chloride, sodium chloride, and the like in toluene.
- the conditions for chemical treatment are as follows: 2-50% by mass of nitric acid, hydrochloric acid, sulfuric acid, chromic acid or potassium permanganate in an acidic, neutral or basic solvent (including water) and a polybutadiene molded product. Immerse for 5 minutes and 48 hours to oxidize. If necessary, a method of heating to 30-50 ° C can be adopted.
- the above-mentioned ozone treatment, electron beam treatment, corona discharge treatment, plasma discharge treatment, ultraviolet laser treatment, or chemical treatment can be used alone or in combination! it can.
- the ultraviolet laser treatment is performed in the presence of ozone to reduce the water contact angle of the polybutadiene molded article.
- the water contact angle on the surface of the polybutadiene molded article can be reduced by the above-mentioned step (1).
- the water contact angle is the contact angle when a drop of water is gently placed on a treated plate-shaped polybutadiene molded product, and is a commercially available automatic contact angle meter, for example, an automatic contact angle meter manufactured by Kyowa Interface Science Co., Ltd. Can be measured.
- the water contact angle of the polybutadiene molded product treated in the step (1) is usually 80 degrees or less, preferably 75 degrees or less, and more preferably 10 degrees to 70 degrees. If it exceeds 80 ° C, the adhesion to the polar resin molded product will be poor, and the problem that a polar solvent cannot be used will occur.
- the polar resin has a water contact angle of usually 80 ° to 20 °, preferably 78 ° to 30 °, more preferably 75 ° to 40 °.
- the difference (A CA) between the water contact angle (CA) of the polybutadiene molded product with reduced water contact angle obtained in the step (1) and the water contact angle (CA) of the polar resin molded product is usually , +
- the solubility parameter of polybutadiene itself is usually 8.3-8.5, preferably 8.4, but the solubility parameter of the polybutadiene molded product after the treatment in step (1) is Usually, it rises from 9.0 to 12.0, preferably 9.3 to 11.0, and approaches the solubility parameter of the polar resin described above. Therefore, it can be said that in the step (1), the adhesiveness is improved by approximating the solubility parameter of the polybutadiene and the polar resin.
- step (1) is applied to the polybutadiene molded article when the polybutadiene molded article and the polar resin molded article are bonded to each other.
- step (1) is applied to the polar resin molded article. This is also possible.
- the polybutadiene molded product having a reduced water contact angle is bonded to the polar resin molded product by the treatment of the step (1).
- Adhesion methods include solvent adhesion, ultrasonic adhesion, high-frequency adhesion, and adhesion using an adhesive that does not impair transparency during adhesion (UV-curable acrylic-type instant adhesives, cyano acrylate-type instant adhesives). And the like, but solvent bonding is preferred.
- the solvent bonding is to bond both using a polybutadiene molded product and an organic solvent soluble in Z or a polar resin molded product.
- an organic solvent common to polybutadiene molded products and polar resin molded products may be used, or an organic solvent soluble in each may be used individually.
- organic solvent for adhesion examples include tetrahydrofuran, cyclohexane, toluene, cyclohexanone, methyl ethyl ketone, acetone, and ethyl acetate.
- Conditions for this bonding include immersion of the bonding portion between the polybutadiene molded product and the polar resin molded product in a bonding solvent, spraying of the bonding solvent, and application of the bonding solvent with a brush, end cloth, or the like. Can be implemented.
- the polybutadiene molded product and the polar resin molded product may be subjected to roughing treatment using an organic solvent having the same bonding or a combination of individual organic solvents. desirable.
- a polybutadiene molded product such as a tube treated by ozone treatment or the like and a polar resin molded product such as a connector are adhered to each other to form a bonding portion. Is strongly adhered to obtain a polybutadiene composite molded article.
- the infusion set 10 includes a connection member (connector) 15 for coupling to the infusion discharge tube 14 in the infusion bag 12, a first tube T1 for connecting the connection member 15 to the drip tube 11, It has a second tube T2 for connecting the drop tube 11 and the puncture needle 13, a clamp 18 for adjusting the infusion rate, and a cap 16 for enclosing the puncture needle 13.
- connection member (connector) 15 for coupling to the infusion discharge tube 14 in the infusion bag 12
- a first tube T1 for connecting the connection member 15 to the drip tube 11
- It has a second tube T2 for connecting the drop tube 11 and the puncture needle 13, a clamp 18 for adjusting the infusion rate, and a cap 16 for enclosing the puncture needle 13.
- Reference numeral 19 denotes a joining member for connecting the second tube T2 and the puncture needle 13.
- the puncture needle 13 may be a hollow stainless steel having a puncture blade at its tip. Metal needles and synthetic resin needles are used. Further, a roller barrel is used as the clamp 18, and the roller clamp is provided with a roller 17 movably provided, and the second tube T2 is moved by moving the roller 17 to the puncture needle 13 side. The flow path becomes narrower, and the infusion rate can be adjusted. A filter (not shown) is stored in the drip tube 11 in case a foreign substance is contained in an infusion solution or the like. As the puncture needle 13, a conventionally used puncture needle is used.
- each of the joining member 15, the drip tube 11, and the joining member 19 corresponds to a “connector having a tube connecting portion”, and is made of a polar resin such as polycarbonate, polyester, transparent ABS, and vinyl chloride. Used.
- tubes Tl and T2 soft tubes having transparency are suitable. Specifically, soft vinyl chloride resin which has been conventionally used and low crystallinity of about 5 to 25% are used. Syndiotactic 1,2-polybutadiene having a degree of crystallinity, and a syndiotactic 1,2-polybutadiene of the present invention having a degree of crystallinity of 5% or more, preferably about 5 to 25%. Butadiene treated with ozone is used.
- the ends of the tubes Tl and T2 and the tube connecting portions of the connecting member 15, the drip tube 11, and the connecting member 19 are solvent bonding, ultrasonic wave, It is firmly fixed by adhesion or high frequency bonding.
- the tube of ozone-treated syndiotactic 1,2-polybutadiene is bonded to the connector made of polycarbonate, the two can be firmly adhered to each other and there is no liquid leakage.
- the solvent adhesion includes tetrahydrofuran, cyclohexane, cyclohexanone, methyl ethyl ketone, acetone, ethyl acetate, toluene and the like as described above.
- a medical member comprising a tube and a connector having a tube joint is also applied as a component to a medical device such as a component of the above-mentioned infusion set or a catheter for drug administration. can do.
- a medical device such as a component of the above-mentioned infusion set or a catheter for drug administration. can do.
- the haze was measured with a Gardner HAZE meter.
- a 2mm-thick press-formed sheet produced at a molding temperature of 150 ° C was punched out using a JIS No. 3 dumbbell, and stress was measured using Shimadzu's universal tensile tester AGlOkNE to determine flexibility.
- RB810 test piece (20 mm wide x 100 mm long x 2 mm thick) manufactured by feJSR was ozone treated.
- the distance to the test piece surface was set to 20 cm and the irradiation time was set to 3 minutes for the mercury lamp power.
- the intensity of ultraviolet light having a wavelength of 254 nm is 18 mWZcm 2
- the integrated light amount is 7 jZcm 2 .
- the contact angle of 1 IX 1 of distilled water dropped on the test piece was measured using a G1 type contact angle measuring device manufactured by Elma Corporation.
- test pieces RB810 manufactured by JSR Corporation, width 20 mm x length 1 OOmm x thickness 2 mm
- various connector pieces width 20 mm x length
- various connector pieces width 20 mm x length
- the test piece with the solvent bonded was heat-treated at 50 ° C for 24 hours, returned to room temperature, and allowed to stand for 2 hours, and then the shear strength was measured using Shimadzu's universal tensile tester AGlOkNE.
- Example 1 shows Example 1 and Comparative Example 1.
- ozone treatment was performed on a test piece of RB. It can be seen that the absorption of the carboxylic group exists at 1,720 cm- 1 .
- the addition of a polar group improves the contact angle to 32 degrees, makes it more compatible with cyclohexanone, a polar solvent, and makes it possible to bond with polycarbonate, a polar resin, and exhibits sufficient adhesion. I understand.
- Example 2 shows Example 2 and Comparative Example 2.
- Example 2 an ozone treatment was performed on a test piece of RB. It can be seen that the absorption of the carboxylic group exists at 1,720 cm- 1 .
- the addition of a polar group improves the contact angle to 32 degrees, makes it more compatible with the polar solvent cyclohexanone, and makes it possible to bond with the polar resin, transparent ABS. Understand the contents.
- Example 3 shows Example 3 and Comparative Example 3.
- ozone treatment was performed on a test piece of RB. It can be seen that the absorption of the carboxylic group exists at 1,720 cm- 1 .
- the addition of the polar group improves the contact angle to 32 degrees, makes it more compatible with the polar solvent cyclohexanone, and makes it possible to adhere to the polar resin, polyester, and develops sufficient adhesive strength! /, Understand the contents.
- Example Comparative Example 4 Table 1 shows Example 1 and Comparative Example 4.
- ozone treatment was performed on a test piece of RB. It can be seen that the absorption of the carboxylic group exists at 1,720 cm- 1 .
- the addition of a polar group improves the contact angle to 32 degrees, makes it more compatible with cyclohexanone, a polar solvent, and makes it possible to bond with polycarbonate, a polar resin, and exhibits sufficient adhesion. I understand. Further, it can be seen that there is no drug adsorption property which is important for infusion tube use, and there is no drug loss.
- Comparative Example 4 uses PVC and has excellent adhesive strength because of compatibility with polar solvents and polar resins even without ozone treatment. However, it is not preferable because it has a high drug-adsorbing property, which is important as an infusion tube, and the remaining amount of the drug decreases (loss). It is not preferable because the plasticizer contained in PVC has a risk of causing various obstacles to the human body.
- Example 1 shows Example 1 and Comparative Example 5.
- ozone treatment was performed on a test piece of RB. It can be seen that the absorption of the carboxylic group exists at 1,720 cm- 1 .
- the addition of a polar group improves the contact angle to 32 degrees, makes it more compatible with cyclohexanone, a polar solvent, and makes it possible to bond with polycarbonate, a polar resin, and exhibits sufficient adhesion. I understand.
- Comparative Example 5 which uses PE, has no polarity and therefore has poor compatibility with polar solvents and polar resins, and poor adhesive strength. In addition, transparency and flexibility, which are important for an infusion tube, are poor and are not preferable. [0095] [Table 1]
- the present invention it is useful for medical applications, is free from liquid leakage at the joint, is excellent in flexibility and hardness, is excellent in steam sterilization resistance, is recyclable, and has a Shiridani bull system. It is possible to provide a medical member mainly composed of syndiotactic 1,2-polybutadiene and a medical device using the same, which are environmentally friendly because they do not contain fat.
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- Engineering & Computer Science (AREA)
- Mechanical Engineering (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Polymers & Plastics (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Crystallography & Structural Chemistry (AREA)
- Manufacturing & Machinery (AREA)
- Materials Engineering (AREA)
- Materials For Medical Uses (AREA)
- Treatments Of Macromolecular Shaped Articles (AREA)
- Lining Or Joining Of Plastics Or The Like (AREA)
- Adhesives Or Adhesive Processes (AREA)
Abstract
Description
Claims
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP20040807653 EP1698654A4 (en) | 2003-12-26 | 2004-12-24 | METHOD FOR BONDING AN ARTICLE FORMED FROM POLYBUTADIENE, ARTICLE FORMED FROM POLYBUTADIENE COMPOSITE THUS MANUFACTURED, MEDICAL ELEMENT, AND NECESSARY FOR PERFUSER FLUID |
US10/583,865 US20080226930A1 (en) | 2003-12-26 | 2004-12-24 | Method For Adhering Polybutadiene Formed Article, Polybutadiene Composite Formed Article Manufactured Thereby, Medical Member, and Infusion Fluid Set |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2003-433773 | 2003-12-26 | ||
JP2003433773 | 2003-12-26 |
Publications (1)
Publication Number | Publication Date |
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WO2005063859A1 true WO2005063859A1 (ja) | 2005-07-14 |
Family
ID=34736529
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/JP2004/019296 WO2005063859A1 (ja) | 2003-12-26 | 2004-12-24 | ポリブタジエン成形品の接着方法、これより得られるポリブタジエン複合成形品、医療用部材、および輸液セット |
Country Status (5)
Country | Link |
---|---|
US (1) | US20080226930A1 (ja) |
EP (1) | EP1698654A4 (ja) |
KR (1) | KR20060123391A (ja) |
CN (1) | CN1898304A (ja) |
WO (1) | WO2005063859A1 (ja) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
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CN101357552B (zh) * | 2007-07-30 | 2011-06-15 | 比亚迪股份有限公司 | 一种用于光固化涂层表面的印刷方法 |
JP5391772B2 (ja) * | 2009-03-26 | 2014-01-15 | 富士ゼロックス株式会社 | 記録装置 |
US9782542B2 (en) * | 2009-10-01 | 2017-10-10 | Momentive Performance Materials Inc. | Self-lubricating pharmaceutical syringe stoppers |
US8530536B2 (en) * | 2009-10-01 | 2013-09-10 | Momentive Performance Materials Inc. | Self-lubricating pharmaceutical syringe stoppers |
US9200147B2 (en) * | 2010-06-29 | 2015-12-01 | Eastman Chemical Company | Processes for making cellulose ester compositions |
US20130150501A1 (en) | 2011-12-07 | 2013-06-13 | Eastman Chemical Company | Cellulose esters in highly-filled elastomaric systems |
DE102012008789B4 (de) * | 2012-05-07 | 2021-03-25 | Innovative Oberflächentechnologien GmbH | Polymeroberflächen mit erhöhter Oberflächenenergie und Verfahren zur Herstellung derselben |
KR20160125389A (ko) * | 2014-02-20 | 2016-10-31 | 프레제니우스 헤모케어 네덜란드 비.브이. | 적혈구 제품, 혈장 및 혈소판의 보관을 위한 비-dehp 가소제를 갖는 의료용 컨테이너 및 시스템 구성요소 |
US10077343B2 (en) | 2016-01-21 | 2018-09-18 | Eastman Chemical Company | Process to produce elastomeric compositions comprising cellulose ester additives |
CN112156266A (zh) * | 2020-10-13 | 2021-01-01 | 湖南平安医械科技有限公司 | 一次性使用静脉留置针导管 |
Citations (4)
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JP2000245851A (ja) * | 1999-03-03 | 2000-09-12 | Terumo Corp | 医療用コネクターおよび医療用コネクターを備えた医療用具 |
JP2001162723A (ja) * | 1999-12-08 | 2001-06-19 | Tokai Rubber Ind Ltd | ゴム・ポリアミド複合体及びその製造方法 |
WO2003018685A2 (en) * | 2001-08-24 | 2003-03-06 | Baxter International Inc. | Medical tubing made from polybutadiene |
JP2003190274A (ja) * | 2001-12-28 | 2003-07-08 | Nippon Zeon Co Ltd | 医療用チューブの製造方法 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
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BE524672A (ja) * | 1952-11-29 | 1900-01-01 | ||
US3333634A (en) * | 1965-06-29 | 1967-08-01 | Mobil Oil Corp | Secondary recovery method achieving high macroscopic and microscopic sweep efficiency |
US3928664A (en) * | 1973-01-17 | 1975-12-23 | Du Pont | Ozone treatment of elastomers |
US4144153A (en) * | 1975-10-03 | 1979-03-13 | Takiron Co., Ltd. | Radiation process for producing 1,2-polybutadiene foamed products |
US4422907A (en) * | 1981-12-30 | 1983-12-27 | Allied Corporation | Pretreatment of plastic materials for metal plating |
JPH02305834A (ja) * | 1989-03-15 | 1990-12-19 | Terumo Corp | 耐放射線性ポリブタジエン組成物 |
US5254390B1 (en) * | 1990-11-15 | 1999-05-18 | Minnesota Mining & Mfg | Plano-convex base sheet for retroreflective articles |
JP2000129017A (ja) * | 1998-10-22 | 2000-05-09 | Terumo Corp | 医療用部材およびその製造方法 |
US20050069716A1 (en) * | 2003-09-11 | 2005-03-31 | Sun Sasongko | Composition of coextruded adhesive film to bond non-polar to polar surfaces |
-
2004
- 2004-12-24 CN CNA2004800389669A patent/CN1898304A/zh active Pending
- 2004-12-24 WO PCT/JP2004/019296 patent/WO2005063859A1/ja not_active Application Discontinuation
- 2004-12-24 KR KR1020067012660A patent/KR20060123391A/ko not_active Application Discontinuation
- 2004-12-24 EP EP20040807653 patent/EP1698654A4/en not_active Withdrawn
- 2004-12-24 US US10/583,865 patent/US20080226930A1/en not_active Abandoned
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
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JP2000245851A (ja) * | 1999-03-03 | 2000-09-12 | Terumo Corp | 医療用コネクターおよび医療用コネクターを備えた医療用具 |
JP2001162723A (ja) * | 1999-12-08 | 2001-06-19 | Tokai Rubber Ind Ltd | ゴム・ポリアミド複合体及びその製造方法 |
WO2003018685A2 (en) * | 2001-08-24 | 2003-03-06 | Baxter International Inc. | Medical tubing made from polybutadiene |
JP2003190274A (ja) * | 2001-12-28 | 2003-07-08 | Nippon Zeon Co Ltd | 医療用チューブの製造方法 |
Non-Patent Citations (1)
Title |
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See also references of EP1698654A4 * |
Also Published As
Publication number | Publication date |
---|---|
US20080226930A1 (en) | 2008-09-18 |
EP1698654A1 (en) | 2006-09-06 |
KR20060123391A (ko) | 2006-12-01 |
EP1698654A4 (en) | 2007-05-30 |
CN1898304A (zh) | 2007-01-17 |
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