WO2005033254A1 - 体脂肪燃焼促進用香料組成物 - Google Patents
体脂肪燃焼促進用香料組成物 Download PDFInfo
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- WO2005033254A1 WO2005033254A1 PCT/JP2004/011813 JP2004011813W WO2005033254A1 WO 2005033254 A1 WO2005033254 A1 WO 2005033254A1 JP 2004011813 W JP2004011813 W JP 2004011813W WO 2005033254 A1 WO2005033254 A1 WO 2005033254A1
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- Prior art keywords
- fat
- body fat
- oil
- juniper oil
- present
- Prior art date
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/13—Coniferophyta (gymnosperms)
- A61K36/14—Cupressaceae (Cypress family), e.g. juniper or cypress
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q13/00—Formulations or additives for perfume preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/06—Preparations for care of the skin for countering cellulitis
Definitions
- the present invention relates to a fragrance composition. More specifically, the present invention relates to a fragrance composition used for the purpose of increasing brown adipose tissue in the body, promoting the burning of body fat, or suppressing the accumulation of body fat or reducing body fat. About. Furthermore, the present invention relates to a perfumed product having the above-mentioned effects by containing these flavor compositions. Background art
- Obesity causes not only beauty but also lifestyle-related diseases such as hypertension, hypertension, and diabetes. In advanced countries that are in a state of being bored, medical costs are increasing. Problem.
- Obesity is induced when the amount of energy taken exceeds the amount of energy consumed.
- a method of reversing the above and resolving obesity there is a method of using a fat substitute or a non-absorbable fat to suppress the absorption of fat and reduce the energy intake (for example, see Patent Document 1 and the like).
- Various methods have been proposed for preventing obesity by promoting the metabolism of fats inherent in living bodies.
- oolong tea polyphenol As substances that promote the metabolism of body fat, for example, oolong tea polyphenol, capsaicin, and hydroxycunic acid contained in garcinia are known.
- Oolong tea polyphenols increase fat excretion and give rise to the activation of lipolytic enzyme lipase when given to rats fed a high-fat diet.
- hydroxycunic acid inhibits the synthesis of fat (see the section of the prior art in Patent Document 2).
- plant-derived components containing capsaicin and caffeine have the effect of promoting fat metabolism and promoting fat decomposition (see Non-Patent Documents 1 and 2 and the like).
- Patent Document 1 U.S. Pat.No. 3,600,186
- Patent Document 2 Japanese Patent Application Laid-Open No. 2002-326932
- Patent Document 3 JP 2002-193824 A
- Non-Patent Document 1 Yoshida et al., J. Nutr. Sci. Vitaminol 1988 Dec .; 34 (6) 587-594
- Non-Patent Document 2 Yoshioka et al., J. Nutr. Sci. Vitaminol 1990 Apr .; 36 (2) 173-178
- the present invention provides a fragrance composition that promotes the burning of body fat in accordance with the needs of the art. Specifically, the present invention provides a fragrance composition capable of increasing brown fat tissue in the body by smelling a fragrance, a fragrance composition capable of promoting body fat burning by smelling a scent, and It is another object of the present invention to provide a fragrance composition which can suppress or reduce fat accumulation based on any of these functions. Furthermore, an object of the present invention is to provide a perfumed product having the above function by containing such a fragrance composition.
- juniper oil increased the amount of brown adipose tissue in the body, and the effect of fat was increased. It has been found that it has the effect of promoting fat burning.
- juniper oil or a fragrance composition having the same, and products perfumed with the juniper oil are used to suppress fat accumulation or reduce body fat, thereby preventing obesity. We were convinced that it could be used effectively for the solution.
- the present invention has been completed based on power and knowledge.
- the present invention is a fragrance composition used for various purposes described below: Item 1. A force of juniper oil or a fragrance composition for increasing brown adipose tissue containing the same. Item 2. A fragrance composition for promoting body fat combustion comprising or containing juniper oil. Item 3. A fragrance composition for suppressing body fat accumulation or reducing body fat amount, comprising or containing juniper oil.
- the present invention is a perfumed product used for various purposes described below:
- Item 4 A perfumed product containing juniper oil for increasing brown adipose tissue.
- Item 5 A perfumed product containing juniper oil for promoting body fat burning.
- Item 6 A perfumed product containing juniper oil for suppressing body fat accumulation or reducing body fat mass.
- the present invention relates to a fragrance composition used for the purpose of increasing brown adipose tissue, promoting body fat burning, suppressing accumulation of body fat, or reducing the amount of body fat.
- Each of these flavor compositions is characterized by containing mosquito made of juniper oil or juniper oil.
- Juniper oil is a juniper (Juniperus L .: Juniperus communis L.) belonging to the family Cypress.
- juniper oil is known to have various useful effects in addition to bactericidal and disinfecting effects and diuretic effects (eg, tonic effect, carminative effect, detoxification effect, stomachic effect, anti-neuropathy effect, It is used for the treatment of various diseases (aroma therapy) based on this, such as rheumatic, aphrodisiac, astringent, blood purifying, antispasmodic, and menstrual effects.
- diseases aroma therapy
- Juniper oil can be prepared by steam distillation of juniper berries as described above, but can also be obtained commercially. Juniper oil prepared by distilling berries and other parts such as twigs together is also included in the juniper oil targeted by the present invention.
- the fragrance composition of the present invention may be composed of only juniper oil or the fragrance composition of the present invention. It may contain components other than the essential oils as long as the effect is obtained. Components other than essential oils include other essential oils, flavors, and bases and additives used in the preparation of flavor compositions.
- the essential oil used in combination with the juniper oil is not limited, but in addition to the resulting fragrance composition exhibiting the effects of the present invention, the juniper oil may be an essential oil belonging to middle notes. It is preferred to take this into account. Preferred examples thereof include benzoic oil, orange oil, grapefruit oil, cypress oil, sandalwood oil, geranim oil, frank oil, bergamot oil, melissa oil, lime oil, lemongrass oil, rosemary oil, lavender oil, and the like. be able to.
- the content ratio of juniper oil may be, for example, 0.1 to 99, as long as the effect of the present invention is exhibited. % (w / w).
- the shape of the fragrance composition of the present invention is not particularly limited.
- a solution dissolved in a lower alcohol having 16 carbon atoms such as ethanol, propyl alcohol or isopropyl alcohol, which is used as a usual solvent for fragrance, and a polyhydric alcohol such as propylene glycol or glycerin; gum arabic or gum tragacanth Emulsified with glycerin fatty acid esters, sucrose fatty acid esters, etc .; natural gums such as gum arabic; materials known as excipients for flavors such as gelatin and dextrin Coated powder; solubilized (dispersed) using a surfactant or the like; solubilized (dispersed); microcapsules obtained by treatment with a known encapsulating agent; And can be prepared according to a conventional method.
- a sustained release can be imparted by inclusion with a known excipient such as cyclodextrin.
- the fragrance composition of the present invention composed of or containing juniper oil can increase brown adipose tissue in the body by smelling its scent.
- Brown adipose tissue is an energy consuming organ that burns energy in the body and produces heat. Therefore, according to the fragrance composition of the present invention, it is considered that the energy metabolism can be activated and the fat burning in the body can be promoted with increasing the amount of brown fat tissue in the body. And as a result, it suppresses fat accumulation in the body and makes it hard to get fat It is possible to make a constitution.
- the fragrance composition of the present invention comprising or containing juniper oil reduces the amount of neutral fat in blood by smelling its scent. Free fatty acids tend to increase. Also, as shown in Test Example 3, the amount of white adipose tissue decreases by smelling the scent. Therefore, it is considered that according to the flavor composition of the present invention, fat metabolism in the body can be promoted to reduce accumulated body fat.
- the flavor composition of the present invention is intended to increase brown adipose tissue in the body, promote body fat burning, promote body fat metabolism, or suppress accumulation of body fat or decrease the amount of body fat. Can be used.
- the fragrance composition of the present invention can be blended with various products as a fragrance having the above function.
- the present invention also provides a perfumed product containing the perfume composition of the present invention.
- the fragrance product refers to a fragrance composition containing the fragrance composition of the present invention for the purpose of fragrance or containing the fragrance composition of the present invention as a result.
- Product It is not particularly limited as long as it has these properties, but specific flavored products include, for example, fragrances, cosmetics, inhalants, detergents for textile products, textile products, foods, pharmaceuticals, and pharmaceutical departments. Foreign goods or daily necessities (miscellaneous goods) can be cited.
- fragrance for example, those conventionally used as fragrances for indoors, toilets, automobiles, entrances, bathrooms, closets, textiles such as clothing, and closets, etc. Things.
- those having a deodorizing effect are also included in the fragrance.
- Various flavor forms are used, such as solid, semi-solid (jelly, gel, etc.), liquid, and aerosol forms.
- Cosmetic products include, in addition to cosmetics, biological cleansing agents such as stones, bath additives, fredrance such as perfumes, toothpastes, liquid toothpastes, mouthwashes, mouse pets, and mouth fresheners. Included. Specific examples of cosmetics include creams, emulsions, cosmetic powders, body lotions, and the like. Cosmetics, hair styling, hair washing, stone, body soap, antiperspirant, shampoo, rinse, perfume, lotion, lipstick, lip balm, sunscreen, massage oil, massage cream, skin care oil and the like.
- Examples of inhaled administration agents include those that generate fragrance near the nose by spraying or volatilization of fragrance components and intentionally inhale fragrance. For example, nasal drops, sprays, inhalants, etc. It is.
- the food for example, contains the flavor composition of the present invention, and increases the caloric content of brown adipose tissue in the body, promotes the combustion of body fat, promotes the metabolism of body fat, or suppresses the accumulation of body fat or body fat. Examples include those taken for the purpose of reducing the amount.
- the scent stays in the mouth for a relatively long time and the scent is inhaled through the mouth, or the scent component is inhaled before entering the mouth.
- Specific examples include confectionery such as gum, candy, gummies, and troches; frozen desserts and desserts such as yogurt and ice cream; soft drinks such as tea: refreshing agents in the mouth; and supplements.
- Examples of the detergent for textile products include anionic, cationic, nonionic or zwitterionic detergents, textile softeners, textile softener products, and dryer softener products. No.
- textile products include clothing such as underwear and outerwear, handkerchiefs, rugs, snacks and bags, and small articles.
- Quasi-drugs include toothpastes, liquid toothpastes, mouthwashes, mouse pets, mouthwashes, cataplasms and the like, and daily necessities (miscellaneous goods) include kitchen detergents and endothermic products. Patches such as cooling jewel sheets are included.
- the content of the fragrance composition of the present invention in the flavored product is not particularly limited, and may be appropriately selected from the range of 0.1 to 99% (w / w) in terms of the content of juniper oil. Can be. However, since the effect of the fragrance composition of the present invention is affected by individual differences such as age, gender, psychological condition, physical condition, and body fat mass, the fragrance composition of less than 0.1% (WZW). In some cases, a perfumed product containing is used. Preferably it is 1 to 50% (wZw), more preferably 3 to 30% (w / w).
- the fragrance base is generally in the form of a solid, liquid, semi-solid (jelly, gel, etc.), aerosol, or the like.
- examples include water, ethanol, solid or liquid anionic, cationic, nonionic activators, polymeric agents, oils and fats, guar gum, xanthan gum, gum arabic, diurane gum, carrageenan, gelatin, agar, etc. .
- a holding carrier such as a solid polymer (for example, polystyrene, polypropylene), calcium silicate or the like.
- components such as bases and additives conventionally used in cosmetics can be contained in the cosmetics.
- the base is not particularly restricted but includes, for example, water, ethanol, talc, gelatin and the like.
- the additives are not particularly limited, but include, for example, humectants, emollients, preservatives, and solubilizers.
- the perfume composition of the present invention is dissolved in an alcohol (eg, ethyl alcohol) or an aqueous alcohol by using the perfume composition according to the present invention without any addition. It can be used in the condition.
- the perfume can be blended with the fragrance composition of the present invention at a rate of 0.1-99 (w / w)% in terms of the juniper oil content.
- the mixing ratio of water and alcohol can be in the range of 50: 50-0: 100 (volume ratio).
- the colon may contain solubilizers, softeners, humetatans, thickeners, bacteriostats, or other materials commonly used in cosmetics.
- a fragrance component which is in harmony with the fragrance composition of the present invention is further added and modulated to obtain a finish such as a top note, a middle note, or a base note.
- a finish such as a top note, a middle note, or a base note.
- Appropriate combinations of notes can be used to create formulations that produce an attractive aroma over time.
- the inhalation preparation may contain components such as bases and additives conventionally used in inhalation preparations, in addition to the fragrance composition of the present invention.
- the gas used in the conventional inhalation administration agent can be used.
- the scented product of the present invention contains juniper oil as a scent component. Obedience
- the perfumed product of the present invention the amount of brown adipose tissue in the body can be increased. And, along with that, it is thought that it is possible to activate energy metabolism and promote fat burning in the body. As a result, it is possible to suppress the accumulation of fat in the body and create a constitution that makes it difficult to gain fat. Further, it is considered that the flavoring product of the present invention can promote fat metabolism in the body and reduce accumulated body fat.
- the flavoring product of the present invention can be used for the purpose of increasing brown adipose tissue in the body, promoting the burning of body fat, promoting the metabolism of body fat, or suppressing the accumulation of body fat or reducing the amount of body fat. .
- the fragrance composition and perfumed product of the present invention containing juniper oil as an active ingredient it is possible to increase brown adipose tissue in the body. Along with this, it is thought that energy metabolism can be activated to promote fat burning in the body. As a result, it is possible to suppress the accumulation of fat in the body and create a constitution that makes it difficult to gain fat. Further, it is considered that the fragrance composition and perfumed product of the present invention containing juniper oil as an active ingredient can promote fat metabolism in the body and reduce accumulated body fat.
- the flavoring product of the present invention can be used for the purpose of increasing brown adipose tissue in the body, promoting the burning of body fat, promoting the metabolism of body fat, or suppressing the accumulation of body fat or reducing the amount of body fat. it can.
- odor paper (7 mm x 50 mm, manufactured by Daiichi Pharmaceutical Co., Ltd.), and the odor emitted from the odor paper is naturally inhaled by rats. This was done by placing it in the upper part of the rat breeding cage for 5 days. During the test, rats were allowed food and water ad libitum, and food intake was recorded.
- Table 1 The results are shown in Table 1, together with the total food intake (total food consumption g) of the rats for 5 days.
- the weight gain (g) shown in Table 1 indicates the weight gain of each rat as compared to the weight measured before the test.
- Each measured value in Table 1 is the standard deviation of the mean of the measured values for the rats (6 rats) in each group.
- grapefruit oil activates the sympathetic nerve by smelling its scent, thereby activating metabolism and reducing body weight.
- juniper oil was much more effective at reducing triglyceride in blood than such grapefruit oil.
- the juniper oil inhalation group consumes more food than the grapefruit oil inhalation group, the fat reduction rate of triglyceride in blood is markedly higher, as shown in the figure. Energy use) has been promoted.
- Table 2 shows the results. Table 2 also shows the results of the ratio of the weight of the brown adipose tissue to the weight of the adipose tissue [(brown adipose tissue weight / body weight) ⁇ 100 (%)] in each rat group.
- Each measured value in Table 2 is the average soil standard deviation of the measured values for each rat (6 rats) in each group.
- the results are shown in Table 3.
- the measured values in Table 3 are the average standard deviation of the measured values for each rat (8 rats) in each group.
- Test Example 4 Weight Change of White Adipose Tissue The change in the weight of white adipose tissue when Wistar male rats were smelled with juniper oil was examined. Specifically, as in Test Example 2, randomly selected Wistar male rats (6 weeks old, weighing 125-145 g) were divided into two groups (each group: 6), and In rats, the aroma emitted from juniper oil was spontaneously inhaled for 8 days (Juniper oil inhalation group), and rats in Group 2 were spontaneously inhaled with dipropylene glycol for 8 days as a control (non-inhalation group). During the test, as in Test Example 2, rats were allowed to freely eat food and water.
- Table 4 shows the results.
- the measured values in Table 4 are the mean ⁇ standard deviation of the measured values for each rat (6 rats) in each group.
- Perfumed products containing the fragrance composition of the present invention shown in the following formulation examples were prepared.
- the essential oil extracted from the berries of Juniperus communis (Cypressaceae) (trade name: Juniper Berry Oil, Ogawa Perfume Co., Ltd.) was used as the following juniper oil.
- Polyoxyethylene alkyl ether 0.5 (Sanyo Chemical, Sannonic SS-90)
- Blended components Blended amount (% by weight) Juniper oil 30.0 Isoparaffin (manufactured by NOF Corporation, NAS-4) 70.0 [0068] A mixture of juniper oil and isoparaffin was impregnated into a carrier (Florite RM-90, manufactured by Specialized Keima Corporation) and placed in an unglazed vessel.
- the fragrance composition and the perfumed product of the present invention the effect of increasing brown adipose tissue in the body, or the promotion of body fat burning or body fat metabolism is suppressed, thereby suppressing accumulation of body fat, In addition, the amount of body fat can be reduced. Therefore, according to the present invention, it is possible to provide a fragrance composition and a perfumed product that can be effectively used to improve the energy metabolism and to make the body less fat.
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Abstract
Description
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Application Number | Priority Date | Filing Date | Title |
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JP2003-342657 | 2003-09-30 | ||
JP2003342657A JP3951271B2 (ja) | 2003-09-30 | 2003-09-30 | 体脂肪燃焼促進剤 |
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Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8476227B2 (en) | 2010-01-22 | 2013-07-02 | Ethicon Endo-Surgery, Inc. | Methods of activating a melanocortin-4 receptor pathway in obese subjects |
US9044606B2 (en) | 2010-01-22 | 2015-06-02 | Ethicon Endo-Surgery, Inc. | Methods and devices for activating brown adipose tissue using electrical energy |
US10080884B2 (en) | 2014-12-29 | 2018-09-25 | Ethicon Llc | Methods and devices for activating brown adipose tissue using electrical energy |
US10092738B2 (en) | 2014-12-29 | 2018-10-09 | Ethicon Llc | Methods and devices for inhibiting nerves when activating brown adipose tissue |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2012012385A (ja) * | 2010-05-31 | 2012-01-19 | Shiseido Co Ltd | 交感神経活性化剤、並びにそれを含有する化粧料、食品、及び雑貨 |
ES2702761T3 (es) | 2010-05-31 | 2019-03-05 | Shiseido Co Ltd | Agente de elevación de la temperatura cutánea y composición cosmética, producto alimentario y diversos artículos que contienen dicho agente de elevación de la temperatura cutánea |
KR101454970B1 (ko) | 2012-11-06 | 2014-10-28 | 대구한의대학교산학협력단 | 당귀로부터 추출되는 정유(essential oil) 분획물을 포함하는 체지방 또는 셀룰라이트 감소 및 예방효과를 갖는 아로마 오일 조성물 및 화장료 조성물 |
Citations (2)
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WO2001043736A1 (fr) * | 1999-12-14 | 2001-06-21 | Teikoku Seiyaku Co., Ltd. | Medicaments permettant de soulager l'hemicranie |
JP2003105371A (ja) * | 2001-09-29 | 2003-04-09 | Kobayashi Pharmaceut Co Ltd | 便意を増進する香料組成物及び付香製品 |
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2003
- 2003-09-30 JP JP2003342657A patent/JP3951271B2/ja not_active Expired - Fee Related
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2004
- 2004-08-18 WO PCT/JP2004/011813 patent/WO2005033254A1/ja active Application Filing
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2001043736A1 (fr) * | 1999-12-14 | 2001-06-21 | Teikoku Seiyaku Co., Ltd. | Medicaments permettant de soulager l'hemicranie |
JP2003105371A (ja) * | 2001-09-29 | 2003-04-09 | Kobayashi Pharmaceut Co Ltd | 便意を増進する香料組成物及び付香製品 |
Non-Patent Citations (4)
Title |
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CHAVALI ET AL.: "Increased production of TNF-alpha and decreased levels of dienoic eicosanoids, IL-6 and IL-10 in mice fed menhanden oil and juniper oil diets response to an intraperitoneal lethal dose of LPS", PROSTAGLANDINS, LEUKOTRIENES AND ESSENTIAL FATTY ACIDS, vol. 59, no. 2, 1998, pages 89 - 93, XP002904197 * |
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