WO2005020794A8 - Test de prediction de chimiosensibilite au taxane - Google Patents

Test de prediction de chimiosensibilite au taxane

Info

Publication number
WO2005020794A8
WO2005020794A8 PCT/US2004/027661 US2004027661W WO2005020794A8 WO 2005020794 A8 WO2005020794 A8 WO 2005020794A8 US 2004027661 W US2004027661 W US 2004027661W WO 2005020794 A8 WO2005020794 A8 WO 2005020794A8
Authority
WO
WIPO (PCT)
Prior art keywords
expression
taxane
cell
cancer cell
chemosensitivity
Prior art date
Application number
PCT/US2004/027661
Other languages
English (en)
Other versions
WO2005020794A2 (fr
WO2005020794A3 (fr
Inventor
Naoto T Ueno
Hideki Ishihara
Tamotsu Sudo
Tomoko Matsushima
Original Assignee
Univ Texas
Sysmex Corp
Naoto T Ueno
Hideki Ishihara
Tamotsu Sudo
Tomoko Matsushima
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Texas, Sysmex Corp, Naoto T Ueno, Hideki Ishihara, Tamotsu Sudo, Tomoko Matsushima filed Critical Univ Texas
Priority to JP2006524833A priority Critical patent/JP5052133B2/ja
Priority to EP04782204A priority patent/EP1664076A4/fr
Publication of WO2005020794A2 publication Critical patent/WO2005020794A2/fr
Publication of WO2005020794A8 publication Critical patent/WO2005020794A8/fr
Publication of WO2005020794A3 publication Critical patent/WO2005020794A3/fr

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5011—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing antineoplastic activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
    • C12Q1/485—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase involving kinase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Food Science & Technology (AREA)
  • Epidemiology (AREA)
  • Pathology (AREA)
  • Toxicology (AREA)
  • Genetics & Genomics (AREA)
  • Cell Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • General Physics & Mathematics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

L'invention concerne un procédé pour déterminer la chimiosensibilité d'une cellule cancéreuse à un taxane, ledit procédé consistant à évaluer, dans une cellule cancéreuse, l'effet du taxane sur le niveau d'expression ou sur l'activité d'une ou plusieurs molécules impliquées dans le cycle cellulaire. Ce procédé fait appel à un système d'analyseur automatisé qui évalue des paramètres du cycle cellulaire (molécules) tels que l'activité kinase de CDK1, l'expression de CDK1, l'activité kinase de CDK2, l'expression de CDK2, de MAD2, de la cycline B1, de la cycline E, de p21, et de CDK6. L'invention concerne en outre un procédé pour obtenir un profil de cycle cellulaire d'une cellule cancéreuse sensible à un taxane.
PCT/US2004/027661 2003-08-25 2004-08-25 Test de prediction de chimiosensibilite au taxane WO2005020794A2 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2006524833A JP5052133B2 (ja) 2003-08-25 2004-08-25 タキサン化学受容性予測試験法
EP04782204A EP1664076A4 (fr) 2003-08-25 2004-08-25 Test de prediction de chimiosensibilite au taxane

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US49765503P 2003-08-25 2003-08-25
US60/497,655 2003-08-25

Publications (3)

Publication Number Publication Date
WO2005020794A2 WO2005020794A2 (fr) 2005-03-10
WO2005020794A8 true WO2005020794A8 (fr) 2005-08-18
WO2005020794A3 WO2005020794A3 (fr) 2005-10-20

Family

ID=34272593

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/027661 WO2005020794A2 (fr) 2003-08-25 2004-08-25 Test de prediction de chimiosensibilite au taxane

Country Status (4)

Country Link
US (1) US20050136177A1 (fr)
EP (1) EP1664076A4 (fr)
JP (1) JP5052133B2 (fr)
WO (1) WO2005020794A2 (fr)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030213168A1 (en) * 2002-04-01 2003-11-20 Anthony Hesse Compositions, methods and devices for enhancing landscaping materials
WO2005100680A2 (fr) * 2004-04-06 2005-10-27 Thi International, Llc Appareil et procede de traitement du paillis
US20090226894A1 (en) * 2004-12-08 2009-09-10 Aventis Pharmaceuticals Inc. Method for measuring resistance or sensitivity to docetaxel
JP5046574B2 (ja) * 2005-06-30 2012-10-10 シスメックス株式会社 抗がん剤治療の有効性予測方法
US7682785B2 (en) * 2005-06-30 2010-03-23 Sysmex Corporation Method for predicting effectiveness of chemotherapy using anticancer agent
JP2007259846A (ja) 2006-02-28 2007-10-11 Sysmex Corp 悪性腫瘍の性質の判定方法
JP5111902B2 (ja) * 2007-03-14 2013-01-09 シスメックス株式会社 癌の診断支援装置
JP2009240238A (ja) * 2008-03-31 2009-10-22 Sysmex Corp アンスラサイクリン系抗がん剤に対するがん細胞の感受性の判定方法及び判定装置
CN102597762B (zh) * 2009-10-30 2016-08-03 学校法人庆应义塾 抗癌剂感受性判定标记
EP2591121B1 (fr) * 2010-07-05 2018-01-24 Lonza Ltd Lignée cellulaire productrice
ES2620582T3 (es) * 2011-01-21 2017-06-29 Basilea Pharmaceutica Ag Uso de BUBR1 como un biomarcador de la respuesta de fármacos a furazanobencimidazoles
US9671405B2 (en) 2012-09-19 2017-06-06 Cornell University Identifying taxane sensitivity in prostate cancer patients
WO2017065277A1 (fr) 2015-10-14 2017-04-20 日東紡績株式会社 Méthode de détermination de lignées cellulaires humaines sensibles à un médicament par une méthode d'analyse utilisant une mesure de l'activité de deux types de protéine kinase
CA3201131A1 (fr) * 2020-12-31 2022-07-07 Catherine M. Shachaf Systemes et procedes d'evaluation de remodelage tissulaire

Family Cites Families (100)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US299082A (en) * 1884-05-20 Mechanical movement
US3812615A (en) * 1972-06-01 1974-05-28 Celanese Corp Method of coating soil with an agricultural mulch
US3932319A (en) * 1972-07-28 1976-01-13 Union Carbide Corporation Blends of biodegradable thermoplastic dialkanoyl polymer, a naturally occurring biodegradable product, a plastic additive and a filler
US3871130A (en) * 1972-10-18 1975-03-18 Gen Foods Corp Plant husbandry
US3881278A (en) * 1972-11-29 1975-05-06 Conwed Corp Method of making mulch composition
US4000992A (en) * 1974-11-27 1977-01-04 Cole Jr Howard W Dust suppression with small bubble foam in cyclone
US4067140A (en) * 1976-04-07 1978-01-10 Thomas John C Mulch and process of making same
US4210289A (en) * 1978-12-26 1980-07-01 Arnoldy Adrian F Tub grinder control
US4379168B1 (en) * 1980-03-14 1990-01-23 Pesticides containing d-limonene
US4339890A (en) * 1980-07-18 1982-07-20 Bruce E. Koenig Dry seeding mulch and process of making same
US4337117A (en) * 1980-08-13 1982-06-29 Texon Inc. Decay resistant material
US4369597A (en) * 1981-03-24 1983-01-25 Ronald B. Leep Pelletized mint mulch and method of making
SE454496B (sv) * 1983-04-15 1988-05-09 Teknikgruppen Ab Maskin for kvistning av tred
CA1223852A (fr) * 1983-09-08 1987-07-07 Douglas D. Hamilton Dechiqueteuse de residus
US4635862A (en) * 1984-05-17 1987-01-13 Nelmor Co., Inc. Rotary comminutor
US4587123A (en) * 1984-06-28 1986-05-06 Price Jacqueline S Compositions and methods for reducing pest infestation
US4571360A (en) * 1985-03-22 1986-02-18 Union Carbide Corporation Foam composition used in paper treatment
US4732817A (en) * 1986-04-21 1988-03-22 Lotz W Robert Wood preservation
US4804683A (en) * 1986-08-08 1989-02-14 Colgate-Palmolive Company N-alkyl neotridecanamide insect repellents
US4736781A (en) * 1986-08-26 1988-04-12 Morbark Industries, Inc. Stump disintegrator
US4759930A (en) * 1987-06-09 1988-07-26 Granirer Marc S Insect killing compositions and method of killing insects employing a synergistic mixture of pyrethrum, eucalpytus, rosemary and peppermint
US4816220A (en) * 1987-07-10 1989-03-28 Sukomal Roychowdhury Deodorant composition for abating the odor of organic refuse
US5082188A (en) * 1987-08-28 1992-01-21 Sterling Grinding Company, Inc. Apparatus for processing material
US4932156A (en) * 1988-11-09 1990-06-12 Becker-Underwood, Inc. Method of controlling the color of mulch
WO1990005936A1 (fr) * 1988-11-18 1990-05-31 Murai Optical Co., Ltd. Monture de lunettes
JPH02142709A (ja) * 1988-11-24 1990-05-31 Kurita Water Ind Ltd 有害生物防除剤
US5133500A (en) * 1988-12-02 1992-07-28 Virgil Simpson Marking foam system for agricultural equipment
US5082500A (en) * 1989-05-10 1992-01-21 Newastecon, Inc. Sprayable composition
US4990373A (en) * 1989-09-29 1991-02-05 Rusmar Incorporated Membrane-forming foam composition and method
US5096616A (en) * 1989-09-29 1992-03-17 Rusmar Incorporated Method of providing a foam barrier between a substrate and the atmosphere and compositions therefor
US5074992A (en) * 1989-09-29 1991-12-24 Fuel Harvesters Equipment, Inc. Woodwaste processing system with contaminate separation
US5396731A (en) * 1990-03-07 1995-03-14 Byrne; Steven E. Mulch pads and methods
US5080534A (en) * 1990-04-23 1992-01-14 Goodson & Associates Low water materials transportation
FI85117C (fi) * 1990-04-27 1992-03-10 Rauma Repola Oy Foerfarande foer skaerning av flis och flisningsanordning.
US5079036A (en) * 1990-07-27 1992-01-07 Betz Laboratories, Inc. Method of inhibiting freezing and improving flow and handleability characteristics of solid, particulate materials
US5105577A (en) * 1991-04-19 1992-04-21 Hedges Gary W Artificial mulch chips
US5207391A (en) * 1991-07-09 1993-05-04 Anderson Robert R Tub grinder
FR2679101B1 (fr) * 1991-07-17 1993-11-26 Quinoleine Derives Procede de protection de semences vegetales et dispositif permettant la mise en óoeuvre du procede.
US5225095A (en) * 1991-08-02 1993-07-06 Chubb National Foam, Inc. Foam concentrate
US5215786A (en) * 1991-08-20 1993-06-01 Rusmar Incorporated Composition for providing a foam barrier between a substrate and the atmosphere and the method of use
US5192587A (en) * 1991-08-23 1993-03-09 Kurtz Bros., Inc. Method for coloring wood chips
US5228738A (en) * 1991-09-26 1993-07-20 Tokiwa Chemical Industries, Co., Ltd. Windshield glass molding for vehicles
US5181663A (en) * 1992-02-03 1993-01-26 Dorscht John P Tub grinder with screen portion
US5314126A (en) * 1992-02-12 1994-05-24 Alvarez Oscar E Hammer mill apparatus
US5413286A (en) * 1992-04-27 1995-05-09 Tramor, Inc. Waste processing machine
US5300438A (en) * 1992-07-06 1994-04-05 Augspurger Engineering Composting apparatus
US5302017A (en) * 1992-08-07 1994-04-12 Construction Forms, Inc. Rotating mixing drum with replaceable liner for mixing aggregate and binder
US5323975A (en) * 1993-03-03 1994-06-28 Fulghum Industries, Inc. Wood chipping apparatus
US5419502A (en) * 1993-04-14 1995-05-30 Wood Technology, Inc. Tub grinder systems and methods for comminuting waste wood
US5394912A (en) * 1993-08-04 1995-03-07 Real Search Inc. Wood fibre debris processor
US5649578A (en) * 1994-03-07 1997-07-22 Leguin; Dana Wood pulverizer with improved hammers and anvils
US5494514A (en) * 1994-06-14 1996-02-27 Goodson & Associates, Inc. Weather resistant soil cement
US5509256A (en) * 1994-06-29 1996-04-23 Groth; Ernest F. Fibrous material packaging machine
NL9401542A (nl) * 1994-09-22 1996-05-01 Inst Voor Agrotech Onderzoek Afdekmateriaal voor land- en tuinbouwgrond.
US6210955B1 (en) * 1994-10-05 2001-04-03 Gas Research Institute Foam transport process for in-situ remediation of contaminated soils
DE19500960C1 (de) * 1995-01-14 1995-08-31 Inter Wood Maschinen Langholzzerspaner
US5732827A (en) * 1995-03-03 1998-03-31 Portec Inc. Screening apparatus
US5713525A (en) * 1995-03-31 1998-02-03 Wood Technology, Inc. Horizontal comminuting machine particularly for recyclable heavy wood randomly carrying non-shatterable foreign pieces
US5881959A (en) * 1995-05-04 1999-03-16 Cmi Corporation Materials grinder with infeed conveyor and anvil
US5863003A (en) * 1995-07-26 1999-01-26 Smith; Leward M. Waste processing machine
US5834298A (en) * 1995-08-01 1998-11-10 Sloan-Kettering Institute For Cancer Research Gene encoding the human homolog of MAD2
US5890665A (en) * 1995-09-20 1999-04-06 Arasmith; Stanley Dale Pulverizing, filtering, and transporting apparatus
US6048458A (en) * 1995-12-01 2000-04-11 Eastern Power Limited Apparatus and method for waste recycling and conversion
US5649580A (en) * 1996-03-05 1997-07-22 U.S. Natural Resources, Inc. Assembly for infeed table
US5720440A (en) * 1996-03-29 1998-02-24 Diamond Z Manufacturing Cover rotating drum grinding machine
US5866201A (en) * 1996-05-20 1999-02-02 Blue; David Solid/liquid rotational mixing system
US5711795A (en) * 1996-08-23 1998-01-27 Battelle Memorial Institute Compressible and moldable toy sand composition
US5782580A (en) * 1996-10-15 1998-07-21 Atlantic Richfield Company Soil remediation method
US6199318B1 (en) * 1996-12-12 2001-03-13 Landec Corporation Aqueous emulsions of crystalline polymers for coating seeds
FI102910B1 (fi) * 1997-01-22 1999-03-15 Bmh Wood Technology Oy Menetelmä ja laitteisto puuhakkeen käsittelemiseksi
US6045070A (en) * 1997-02-19 2000-04-04 Davenport; Ricky W. Materials size reduction systems and process
US6063335A (en) * 1997-03-24 2000-05-16 Henkel Corporation Method for disinfecting surfaces
US5856024A (en) * 1997-04-15 1999-01-05 Parr; Michael J. Decorative particulate material and method of making and using same
EP1012374B1 (fr) * 1997-05-28 2009-07-15 Purecolor Incorporated Teinture minerale pour le bois
IT1291926B1 (it) * 1997-06-06 1999-01-21 Univ Roma Sistema di rivelazione di radiazione infrarossa basato su sensori in silicio amorfo e sue leghe
US6209259B1 (en) * 1997-07-11 2001-04-03 Encap, Llc Seeding treatments
US5910514A (en) * 1997-10-01 1999-06-08 Greenberg; Lee M. Synthetic mulch
GB9721466D0 (en) * 1997-10-09 1997-12-10 Barrier Hygiene Ltd A pesticidal composition
ATE254016T1 (de) * 1997-11-04 2003-11-15 Holzindustrie Preding Ges M B Vorrichtung zur herstellung von kantholz aus rundhölzern
US6029395A (en) * 1998-01-05 2000-02-29 Morgan; Albert W. Biodegradable mulch mat
US20020006613A1 (en) * 1998-01-20 2002-01-17 Shyjan Andrew W. Methods and compositions for the identification and assessment of cancer therapies
US6251058B1 (en) * 1998-01-29 2001-06-26 Petrozyme Technologies, Inc. Treatment of soil contaminated with hazardous residues
ATE238555T1 (de) * 1998-02-18 2003-05-15 Theryte Ltd Krebsbehandlung
GB2335739A (en) * 1998-02-18 1999-09-29 Univ Liverpool Screening anti-cancer agents
US6231865B1 (en) * 1998-03-26 2001-05-15 Safer Gro Laboratories, Inc. Natural pesticide
US6207228B1 (en) * 1998-04-21 2001-03-27 Vincent G. Hundt Concurrent fragmentation and impregnation machine and processing
US6086002A (en) * 1998-06-25 2000-07-11 Frazier; Joan H. Balanced comminuting, vacuum and loading and/or spreading system
US6391349B1 (en) * 1998-07-23 2002-05-21 T-Rex Products, Inc. Glow-in-the-dark terrarium substrate and method of making and using the same
US6136430A (en) * 1998-08-05 2000-10-24 Cargill, Incorporated Disposable water resistant cover for bulk salt
US6048377A (en) * 1999-01-21 2000-04-11 True Pitch, Inc. Top dressing for gardens and lawns
US20010028941A1 (en) * 1999-03-04 2001-10-11 Mieko Sakai Artificial stone
US6245733B1 (en) * 1999-04-30 2001-06-12 James Mosbaugh Porous agglomerations of fused microspheres
US6345772B1 (en) * 1999-07-30 2002-02-12 Case Corporation Field marking system
US6360894B1 (en) * 1999-08-31 2002-03-26 Finlay Hydrascreens Ltd. Double skin trommel
US6338871B1 (en) * 2000-04-30 2002-01-15 Bong Hang Shin Colored silica sand
US6264715B1 (en) * 2000-05-22 2001-07-24 Salem Organic Soils, Inc. Method for making soil conditioner
US6250793B1 (en) * 2000-05-23 2001-06-26 Michael Gian Animal feed additive application utilizing foam
US6376566B1 (en) * 2000-06-14 2002-04-23 Rhodia Inc. Agricultural foam marker compositions and use thereof
US6398140B1 (en) * 2000-09-28 2002-06-04 William H. Stieh Truck mounted chipper vehicle
DE10319483A1 (de) * 2003-04-30 2004-11-18 Brockhues Gmbh & Co. Kg Schnell zerfallendes Pigmentkonzentrat

Also Published As

Publication number Publication date
JP2007503809A (ja) 2007-03-01
EP1664076A4 (fr) 2010-01-13
JP5052133B2 (ja) 2012-10-17
US20050136177A1 (en) 2005-06-23
EP1664076A2 (fr) 2006-06-07
WO2005020794A2 (fr) 2005-03-10
WO2005020794A3 (fr) 2005-10-20

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Free format text: IN PCT GAZETTE 10/2005 UNDER (72, 75) THE ADDRESS OF "UENO, NAOTO, T." SHOULD READ "3251 CHEVY CHASE, HOUSTON, TX 77019 (US)"

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