WO2004112815A1 - メラニン産生促進剤及びメラニン産生促進用組成物 - Google Patents

メラニン産生促進剤及びメラニン産生促進用組成物 Download PDF

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Publication number
WO2004112815A1
WO2004112815A1 PCT/JP2004/006436 JP2004006436W WO2004112815A1 WO 2004112815 A1 WO2004112815 A1 WO 2004112815A1 JP 2004006436 W JP2004006436 W JP 2004006436W WO 2004112815 A1 WO2004112815 A1 WO 2004112815A1
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Prior art keywords
melanin production
composition
extract
promoting
hair
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PCT/JP2004/006436
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English (en)
French (fr)
Japanese (ja)
Inventor
Kenji Sakamoto
Toshiyuki Mukaiyama
Keishi Hata
Kazuyuki Hori
Saori Takahashi
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Sakamoto Bio Co., Ltd.
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Publication date
Application filed by Sakamoto Bio Co., Ltd. filed Critical Sakamoto Bio Co., Ltd.
Priority to BRPI0410251-7A priority Critical patent/BRPI0410251A/pt
Priority to KR1020057021403A priority patent/KR101112006B1/ko
Priority to CN2004800123491A priority patent/CN1784215B/zh
Publication of WO2004112815A1 publication Critical patent/WO2004112815A1/ja

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/63—Steroids; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9706—Algae
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9789—Magnoliopsida [dicotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9794—Liliopsida [monocotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/04—Preparations for care of the skin for chemically tanning the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00—Preparations for care of the hair
    • A61Q5/06—Preparations for styling the hair, e.g. by temporary shaping or colouring
    • A61Q5/065—Preparations for temporary colouring the hair, e.g. direct dyes
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2200/00—Function of food ingredients
    • A23V2200/30—Foods, ingredients or supplements having a functional effect on health
    • A23V2200/318—Foods, ingredients or supplements having a functional effect on health having an effect on skin health and hair or coat

Definitions

  • the present invention relates to the use of an extract of Akinonokeshi and a fatty acid ester represented by palmitoyl diol as an active ingredient thereof, which promotes melanin production in melanocytes and prevents gray hair on hair.
  • the present invention relates to a melanin production promoter, which can improve and blacken skin with respect to skin, and a composition for promoting melanin production such as cosmetics, medicines, and foods.
  • the color tone of hair and skin depends on the amount of melanin pigment present in hair and skin.
  • Melanin is biosynthesized by tyrosinase catalysis from tyrosine via dopa in pigment-producing cells (melanocytes) present in the hair bulb and epidermal basal layer.
  • Patent Document 1 JP-A-2000-169348
  • Patent Document 2 Japanese Patent Application Laid-Open No. 2002-47130
  • Patent Document 3 JP 2002-212039 A
  • Patent Document 4 JP-A-2002-3381
  • Non-Patent Document 1 Keiji Hata et al., Biological and Pharmaceutical Bulletin, 2000, Vol. 23, No. 8, p. 96 2—967
  • Non-patent Document 2 Keishi Hata et al., Journal of Natural Products. 2002, 65, p. 645—648
  • the present invention has been made in view of the above circumstances, and an object of the present invention is to provide a substance which has an excellent action of promoting melanin production, is effective in preventing and improving white hair, and is effective in darkening skin. It is to provide a composition used.
  • the present invention relates to an extract of Akinonogeshi or the following general formula:
  • R represents an acinole group having 12 to 22 carbon atoms
  • R represents a melanin production promoter comprising a fluor fatty acid ester or an isomer thereof.
  • the present invention relates to the extract of Akinonogeshi or the following general formula:
  • R represents an acyl group having 12 to 22 carbon atoms.
  • a melanin production promoter containing, as an active ingredient, a diol fatty acid ester and / or an isomer thereof.
  • R in the fluoric acid fatty acid ester represented by the above general formula is preferably an acyl group having 14 to 18 carbon atoms. More preferably, it is an acyl group having 14 to 18 carbon atoms having a saturated hydrocarbon, and particularly preferably a palmitoyl group.
  • the present invention is also a composition for promoting melanin production, comprising the melanin production promoter.
  • the present invention relates to the extract of Akinonogeshi or the following general formula:
  • R represents an asinole group having 12 to 22 carbon atoms.
  • a composition for promoting melanin production comprising a diol fatty acid ester and / or an isomer thereof.
  • R in the fluor fatty acid ester represented by the above general formula is preferably an acyl group having 14 to 18 carbon atoms. More preferably, it is a C14-C18 acyl group having a saturated hydrocarbon, and particularly preferably a palmitoinole group.
  • the composition for promoting melanin production may be a composition for preventing gray hair or a composition for darkening skin.
  • composition is preferably a cosmetic, pharmaceutical or food containing quasi-drugs.
  • a novel melanin production promoter and a composition having a melanin production promotion effect can be obtained.
  • cosmetics, pharmaceuticals, and foods having an excellent effect of preventing and improving white hair and darkening skin by promoting melanin production can be obtained.
  • the extract of Akinonokeshi according to the present invention can be obtained by an extraction method generally used for plant extraction using Akinonokeshi, that is, a method of extracting Akinonokeshi with a solvent.
  • the Akinonogeshi used in the present invention is a plant of the genus Aactinidae (Lactuca indica) of the Asteraceae family. It is an annual plant, widely distributed in East and Southeast Asia, and can be found throughout Japan. It is a large plant with a height of about 60cm 2m. It grows in sunny places on wastelands, riverbanks, abandoned fields and fields. 9-October: A yellow-white flower blooms on the top of the stem in October. Akinonogeshi has a Japanese name that includes the word "Nogeshi". Its taxonomic genus is different from that of Nogeshi and Ononigeshi, which belong to the same Asteraceae family. It is said that the name came from blooming similar flowers. Akinonogeshi has long been used as a feed for livestock, and is highly safe and powerful as a plant.
  • Akinonogeshi whole plants, leaves, stems, roots, flowers, seeds and the like are used. In particular, it is preferable to use whole plants in terms of effectiveness, extraction efficiency, and the like.
  • the form of Akinonogeshi used to obtain the extract may be, for example, raw as cut, finely cut, dried, or dried and finely chopped or crushed. The force is not limited to these, and other forms can be used as long as the effects of the present invention are not impaired.
  • the extract is formed into a form having high extraction efficiency such as drying and pulverization and then subjected to solvent extraction.
  • the solvent used for the extraction is not particularly limited, but, for example, alcohols such as ethanol, methanol, isopropanol, and 1,3-butylene glycol, hexane, heptane, and cyclohexane.
  • examples thereof include hydrocarbons such as xane, esters such as ethyl acetate, ketones such as acetone, and water.
  • These solvents can be used alone or as a mixture of two or more.
  • ethanol, methanol, or a mixed solvent thereof is preferred for exhibiting the effectiveness of the present invention.
  • the extraction means such as immersion in a solvent and reflux of the solvent are used.
  • the extraction temperature is not particularly limited, and is usually in the range of room temperature to the boiling point of the solvent under normal pressure.
  • the extraction time is not particularly limited, and the extraction is performed at an arbitrary time.
  • solvent After extraction solids such as extraction residues are removed from the extract by filtration, centrifugation, or the like, and then the extract is obtained by removing the extraction solvent.
  • R in the fluoric acid fatty acid ester and its isomer represented by is an acyl group having 12 to 22 carbon atoms, and preferably an acyl group having 14 to 18 carbon atoms.
  • the hydrocarbon constituting the acyl group may contain an unsaturated bond such as a double bond, and may be linear or branched.
  • Specific examples of the acyl group include a lauroyl group, a myristoyl group, a palmito inole group, a stearoyl group, an oleoyl group, an isostearyl group, a behenyl group, and a linoleyl group.
  • R is more preferably a C14-C18 acyl group having a saturated hydrocarbon, and the hydrocarbon may be linear or branched, but is preferably linear.
  • the hydrocarbon may be linear or branched, but is preferably linear.
  • an acyl group having 16 carbon atoms having a saturated hydrocarbon is preferred.
  • palmitoyl groups are most preferred.
  • the fluor fatty acid ester represented by the above general formula (hereinafter simply referred to as fluor fatty acid) It is called an ester. ) And isomers thereof can be obtained, for example, by a method of acylating a fluor.
  • acylation although it is carried out in a usual manner, it is permissible to carry out an asinolelation reaction on a plant containing a rule or an extract thereof.
  • the extract can be used in the form of an extract obtained by removing the solvent from the solvent extract of the plant, that is, in the form of an extract.
  • an extract diluent obtained by arbitrarily diluting the extract with a solvent or an extract concentrate obtained by removing an arbitrary amount of the solvent and concentrating the extract can be used as an extract diluent obtained by arbitrarily diluting the extract with a solvent or an extract concentrate obtained by removing an arbitrary amount of the solvent and concentrating the extract.
  • an operation such as deodorization can be performed after the operation of the present invention is performed as long as the effects of the present invention are not impaired.
  • palmitoyl diol having a palmitoyl group as R of the diol fatty acid ester is a component contained in the above-mentioned akinonogeshi. It can be obtained by isolating from the Aquinococcus extract of the invention by a known method. For example, the power that can be isolated and obtained by repeating fractionation of an Aquinonogeshi extract by column chromatography or the like is not limited thereto. The present inventors have found for the first time that palmitoylrubeol in the present invention is present in Akinonogeshi.
  • the extract of Akinonogeshi used for the isolation of palmitoylrubeol is a dry extract obtained by removing the solvent from the solvent extract of Akinonogeshi, that is, it is used in the form of an extract.
  • the extract obtained by extraction can be used as it is, or it can be used as an extract diluent obtained by arbitrarily diluting the extract with a solvent or an extract concentrate obtained by removing an arbitrary amount of the solvent and concentrating the extract. You can also. Further, it can be used after an operation such as deodorization is added as long as the effect of the present invention is not impaired.
  • Palmitoylrubeol preferably used in the present invention can be obtained by other means, such as isolation from a plant other than Akinonogeshi containing palmitoylnorreol, in addition to the extraction from Akinonogeshi. it can.
  • the extract of Akinonoki, the fatty acid fatty acid ester and isomers thereof according to the present invention have an excellent melanin production promoting action as described later. Therefore, they are useful as melanin production promoters.
  • This melanin production enhancer is useful for extracting the novel functions of Akinonogeshi extract and diol fatty acid esters and isomers thereof. It is a new and useful use based on the discovery, and exhibits a function as a melanin production promoter by containing an extract of Aquinonoki-shi or a fluor fatty acid ester and / or an isomer thereof as an active ingredient.
  • the melanin production promoter promotes the production of melanin in melanocytes, and exhibits functions such as prevention of gray hair or improvement of gray hair, ie, darkening, and browning of skin.
  • the melanin production promoter of the present invention can be applied to various fields having a very wide range of applications.
  • Examples of the field include cosmetics, quasi-drugs, pharmaceuticals, foods, and the like, and these are suitable.
  • the use form of the extract of Akinonokishi and the fatty acid ester of the chlorophyll and the isomers thereof are as follows.
  • a dried extract from which the solvent has been removed that is, in the form of an extract
  • it can be used as it is in the form of an extract obtained by extraction with a solvent, and the extract is optionally diluted with a solvent
  • the extract diluent and the solvent can be used as an extract concentrate after removing an arbitrary amount of the solvent.
  • deodorization deodorized substance
  • purification refined substance
  • the extract-dried product may be dissolved in a solvent at an arbitrary concentration and used as a solution of the extract-dried product. Further, the product may be further purified by column chromatography or the like, and used as a fraction, or as an active ingredient.
  • the diol fatty acid ester and its isomer contain the fluoric acid fatty acid ester and / or its isomer as an active ingredient, and the melanin production promoting action (function) is effectively exerted.
  • It may be used in the form of a plant or an extract thereof containing a concentration of a diol fatty acid ester and / or an isomer thereof.
  • the extract may be in the form of a solvent extract, a concentrated solution thereof, or an extract (extract) obtained by purifying the extract (extract) to an arbitrary amount containing a diol fatty acid ester and / or an isomer thereof. Any form may be used as long as it satisfies the above conditions.
  • the melanin production promoter of the present invention can be added to a composition as a melanin production promotion component to form a new and useful composition having a melanin production promotion action, that is, a composition for promoting melanin production. .
  • the composition for promoting melanin production in the present invention It works especially on hair and skin. In the case of hair, it blackens the hair and is effectively used, for example, as a composition for preventing gray hair. In the skin, the skin is blackened (browned), and is effectively used as a skin blackening composition.
  • the composition is not particularly limited and is optional. Examples thereof include cosmetics, quasi-drugs, pharmaceuticals, foods, and the like, and these are suitable.
  • compositions include cosmetics for promoting melanin production, medicinal products for promoting melanin production, foods for promoting melanin production, cosmetics for preventing white hair, pharmaceuticals for preventing white hair, foods for preventing white hair, cosmetics for darkening the skin, Drugs for skin darkening, foods for skin darkening, and the like.
  • the extract of Akinonokeshi in terms of an extracted dry product
  • the content of diol fatty acid ester and its isomer amount, applications, dosage form varies depending formulation purposes such as, in general, preferable than the total amount of the composition in 0.1 00001- 20 mass 0/0 force Mashigu ⁇ a 0. 0001- 10 mass% is there.
  • the dosage in the case of a drug can be appropriately changed based on the age and weight of the patient, the route of application, the degree of progression of the disease, and the treatment performed in parallel, and is specified. However, it is generally about 1-10 ml (liquid) or 1-20 mg (taliform, ointment, etc.) per day, administered once or twice or three times a day. Can, but is not limited to.
  • composition for promoting melanin production according to the present invention, cosmetics, pharmaceuticals, foods and the like are blended with other components usually used in cosmetics, pharmaceuticals, foods and the like as long as the effects of the present invention are not impaired. be able to.
  • a specific component contained in the component may cover a plurality of components.
  • an oil component a surfactant, a humectant, Polyhydric alcohols, thickeners, water-soluble polymers, film-forming agents, water-insoluble polymers, powders, pigments, dyes, lakes, lower alcohols, ultraviolet absorbers, sequestering agents, organic amines, pH adjusters And medicinal ingredients, sugars, other hair or skin darkening ingredients, preservatives, antioxidants, fragrances, water and the like.
  • oil components include jojoba oil, olive oil, apogado oil, castor oil, coconut oil, tallow, and hard oil. Oils and derivatives thereof, waxes such as liquid lanolin, carnaupa wax, beeswax and lanolin, liquid paraffin, squalane, vaseline, microcrystalline wax, hydrocarbons such as solid paraffin, stearic acid, behenic acid, etc.
  • Higher fatty acids higher alcohols such as cetyl alcohol, stearyl alcohol and cetostearyl alcohol, glyceryl trioctanoate, isopropyl myristate, diisostearyl malate, glyceryl tri-2-ethyl glyceryl hexate, diglyceryl diisostearate, triglyceride Esters such as trimethylolpropane 2-ethylhexanoate, trimethylolpropane trioctanoate, di-2-ethylhexyl sebacate, dimethylpolysiloxane, methylphenylpolysiloxane, decamethylcyclope And silicone oils such as n-siloxane.
  • higher alcohols such as cetyl alcohol, stearyl alcohol and cetostearyl alcohol, glyceryl trioctanoate, isopropyl myristate, diisostearyl malate, glyceryl tri-2-
  • Examples of the powder include tanolek, myric, kaolin, silica, zinc white, titanium mica, titanium oxide, iron oxide, and nylon powder.
  • surfactant examples include polyoxyethylene (hereinafter also referred to as P ⁇ ⁇ ⁇ ⁇ E) alkyl ether, POE fatty acid ester, POE sorbitan fatty acid ester, glycerin fatty acid ester, POE hydrogenated castor oil, POE sorbitol fatty acid
  • Nonionic surfactants such as esters and polyoxyalkylene-modified polysiloxanes, anionic surfactants such as sodium palmitate, cationic surfactants such as stearyltrimethylammonium chloride, betaine, amidobetaine, imidazolinium, and sulfobetaine And the like.
  • humectant examples include glycerin, 1,3-butylene glycol, and polyethylene glycol.
  • PEG poly(ethylene glycol)
  • dipropylene glycol poly(ethylene glycol)
  • sorbitol poly(ethylene glycol)
  • Examples of the thickener include water-soluble polymers such as carboxyvinyl polymer, carboxymethyl cellulose, and polybutyl alcohol, and clay minerals such as bentonite.
  • Examples of the ultraviolet absorber include para-aminobenzoic acid (hereinafter abbreviated as PABA), glycerinole PABA, ethyldihydroxypropyl PABA, octyl methoxycinnamate, and 2_ethoxyxetinole ⁇ -methoxycinnamate.
  • PABA para-aminobenzoic acid
  • glycerinole PABA glycerinole PABA
  • ethyldihydroxypropyl PABA ethyldihydroxypropyl PABA
  • octyl methoxycinnamate octyl methoxycinnamate
  • 2_ethoxyxetinole ⁇ -methoxycinnamate 2-ethoxyxetinole ⁇ -methoxycinnamate.
  • 2,4-dihydroxybenzophenone 2-hydroxy-1-methoxybenzophenone, 2-hydroxy-4-methoxy-14-methylbenzophenone, 2-hydroxy-4-methoxy-14-methylbenzophenone sulfone Acid salt, ethyl perocyanate, 2-phenylenoxy 5-methylbenzoxazole, 4-methoxy-l 4-t-butyldibenzoy Noremethane, ethyl hexyl paramethoxy cake, and the like.
  • Examples of sequestering agents include tetrasodium edetate, citric acid and the like.
  • lower alcohols include ethanol and the like.
  • Examples of organic amines include monoethanolamine, triethanolamine and the like.
  • Examples of the pH adjuster include buffers such as sodium lactate-monolactate and sodium citrate-monocitrate.
  • Examples of the medicinal component include pantothenyleethyl ether, glycyrrhizinate, nicotinate, and the like.
  • antioxidants include tocoproles, dibutylhydroxytoluene, propyl gallate and the like.
  • sugars include erythritol, sucrose, hyaluronic acid and the like.
  • preservatives include ethylparaben, butylparaben, sodium benzoate and the like.
  • it can be selected from the components that can be blended with the following pharmaceuticals and foods, and can be blended.
  • components contained in the components may extend over a plurality of components.
  • examples thereof include excipients, stabilizers, and wetting agents. , Emulsifiers, absorption enhancers, pH adjusters, surfactants, diluents, carriers, dissolution aids, flavoring agents, preservatives, fragrances, coloring agents, various additives such as coating agents, water, etc. Is mentioned.
  • Specific examples of these additive components include starch, sugars such as lactose, magnesium sulfate, talc, gelatin, cellulose derivatives such as hydroxypropylcellulose, vegetable oils such as soybean oil and sesame oil, animal oils and synthetic oils, and the like. Examples include gums, alcohols such as ethanol, 1,3-butylene glycol, and polyalkylene glycol.
  • it can also be selected from the above-mentioned cosmetics and components that can be added to the following foods, and can be added.
  • a specific component contained in the component may cover a plurality of components.
  • a sweetener an acidulant, a preservative, and a flavor
  • various additives such as coloring agents, excipients, stabilizers, wetting agents, emulsifiers, absorption promoters, pH adjusters, surfactants, diluents and carriers, and water.
  • specific examples of these additional components include various extracts such as ginseng extract, ginger extract and honey, cyclic oligosaccharides, reduced maltose, trehalose, lactose, and sugars such as fatty acid esters of sucrose.
  • Lifting power S can.
  • it is selected from ingredients that can be blended with the above-mentioned cosmetics and pharmaceuticals, and can be combined with each other.
  • composition of the present invention can be prepared in various forms.
  • cosmetics for example, creams, lotions, emulsions, ointments, solutions, lotions, jewels, foams, essences (cosmetics), foundations, packs' masks, and aerosols can be applied. .
  • the dosage form of the cosmetic includes solution, solubilizing, emulsifying, powder, powder dispersing, oil-liquid, gel, ointment, aerosol, foam, stick, and water.
  • a wide range of dosage forms is possible, such as a two-layer system for one oil and a three-layer system for water-oil-powder.
  • any of oral administration and parenteral administration methods can be adopted, and a pharmaceutical preparation form suitable for each can be adopted.
  • Pharmaceutical preparations include, for example, liquid preparations such as solutions, syrups, injections, liquid inhalants, emulsions, tablets, powders, granules, capsules, ointments, solid inhalants, suppositories, etc. Can be mentioned.
  • Foods are useful as so-called functional foods, and are widely applicable, for example, as confectionery, beverages such as soft drinks, processed vegetables or fruits, livestock meat products, seasonings and the like. Its form is powder, solid product, solution and the like.
  • the composition of the present invention is particularly preferably used as an external preparation for cosmetics, pharmaceuticals and the like.
  • the composition for preventing gray hair includes, for example, creams, lotions, emulsions, ointments, solutions, gels, aerosols, foams, and the like, as hair creams, hair tonics, hair liquids, hair rinses, hair shampoos, hair treatments, and hair. It is preferably used as a product such as a conditioner.
  • the composition for skin darkening it is preferable to use, for example, creams, lotions, emulsions, ointments, jewels, nuts, foams, solutions, essences, sticks, powders, and the like, as products.
  • composition of the present invention can be prepared in any form and dosage form by a conventional method.
  • the whole plant was freeze-dried and powdered using a fiber mixer. This powder 100 ml of methanol was added to lOg, and the mixture was allowed to stand at room temperature for 30 minutes to extract. After the extraction, 0.26 g of an extraction powder (extracted dried product) was obtained by filtration and drying under reduced pressure.
  • the whole freeze-dried Akinonogeshi was ground with a fiber mixer, 3 L of methanol was added to 300 g of the powder, the mixture was allowed to stand for 90 minutes, and the filtrate was dried under reduced pressure to obtain an extraction powder.
  • a fresh 3 L of methanol was added to the filtered Akinonogeshi powder, the mixture was allowed to stand for 90 minutes, and the filtrate was dried under reduced pressure to obtain an extraction powder again. This extraction operation was repeated a total of 5 times, giving a total of 33.7 g of extraction powder.
  • the melanin production promoting action in B16 melanoma cells was evaluated by the following method.
  • a culture of B16 2F2 cells (1 X 10 5 cells / ml) was mixed with an extract of Akinonokishi or a dandelion root extract to a concentration of 20 Aig / ml, and mixed with a 24-well culture plate (0 After culturing at 5 ml / well for 72 hours, the cells were measured for cell number and melanin content.
  • To determine the melanin content of B162F2 cells add IN Na ⁇ H solution (300 ⁇ / ⁇ ) to a 24-well culture plate, leave at room temperature for 60 minutes to dissolve intracellular melanin pigment, and measure the absorbance at 470 nm. And quantified.
  • the same experiment was carried out with the same amount of methanol added in place of the extract of Akinonokishi or dandelion root extract.
  • Figure 3 shows the results.
  • the extract of Akinonogeshi induced about three-fold melanin production on B162F2 cells compared to the dandelion root extract.
  • Dandelion root extract increases the amount of soup Even so, melanin production hardly changed.
  • palmitoylrubeol strongly induced melanin production in ⁇ 162F2 cells.
  • the extract of Akinonogeshi in the synthesizing component is the extract of Akinonokeshi (dried extract) obtained in Preparation Example 1 above, except where otherwise specified.
  • the ethanol extract of the whole plant of Akinonogeshi was prepared according to the method of the above Preparation Example. Also, in all of the examples, an excellent melanin production promoting effect was observed, and when used for hair, the effect of preventing graying of hair was observed. When used, the effect of blackening the skin was observed.
  • 1,3-butylene glycol 1.0 methylphenylpolysiloxane 1.0 collagen hydrolyzate 1.0 ethanol ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ - ⁇ ⁇ 0.5 Purified water
  • Acetic acid dl a—tocopherol / re 0. 05
  • Vitamin E derivative appropriate amount
  • Vitamin E derivative appropriate amount
  • a novel melanin production promoter and a composition having a melanin production promoting effect can be obtained. It can be applied to foods, medicines, foods, etc.
  • FIG. 1 is a 1 H-NMR spectrum of palmitoylrubeol.
  • FIG. 2 is a 13 C-NMR spectrum of palmitoylrubeol.
  • Fig. 3 is a view showing the effect of the extract of Akinonogeshi on melanin production.
  • FIG. 4 is a graph showing the effect of palmitoyl lubeol on promoting melanin production.

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PCT/JP2004/006436 2003-05-14 2004-05-13 メラニン産生促進剤及びメラニン産生促進用組成物 WO2004112815A1 (ja)

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BRPI0410251-7A BRPI0410251A (pt) 2003-05-14 2004-05-13 promotor de melanogênese, e, composição promotora de melanogênese
KR1020057021403A KR101112006B1 (ko) 2003-05-14 2004-05-13 멜라닌 생성 촉진제 및 멜라닌 생성 촉진용 조성물
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JP5428000B2 (ja) * 2007-06-27 2014-02-26 株式会社スカイライト・バイオテック ルペオール含有医薬組成物、食品及び飼料
JP6027752B2 (ja) * 2011-02-21 2016-11-16 第一三共ヘルスケア株式会社 ＡＧＥｓ生成抑制剤
JP6142342B2 (ja) * 2013-02-22 2017-06-07 株式会社東洋新薬 アキノノゲシ抽出物の新規な用途
KR101692851B1 (ko) * 2015-10-16 2017-01-05 경상대학교산학협력단 아모르피제니를 유효성분으로 함유하는 피부 미백용 조성물
CN108113927A (zh) * 2018-02-28 2018-06-05 周海英 一种用于化妆品中的具有美白功效的组合物及其制备方法
CN108815066B (zh) * 2018-06-14 2019-10-15 广州植境生物科技有限公司 一种含稷籽提取物的草本护发组合物
WO2020032297A1 (ko) * 2018-08-10 2020-02-13 탑월드(주) 백반증 증상 개선용 조성물 및 이의 제조방법
JP2020143032A (ja) * 2019-03-08 2020-09-10 国立大学法人 東京医科歯科大学 白髪抑制・改善剤、及び、リン酸化ｍｉｔｆ／ｍｉｔｆ産生比増加剤
KR102249072B1 (ko) * 2019-07-11 2021-05-06 인하대학교 산학협력단 치커리 추출물을 유효성분으로 함유하는 백반증 또는 백모증의 예방 또는 치료용 약학적 조성물
CN111387505B (zh) * 2020-04-21 2023-04-07 中国农业科学院都市农业研究所 一种对黑色素合成抑制的生菜提取物及生菜配套栽培方法

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