Classifications

• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
  • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
  • A61L2/16—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using chemical substances
  • A61L2/18—Liquid substances or solutions comprising solids or dissolved gases
• • A—HUMAN NECESSITIES
  • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
  • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
  • A01N27/00—Biocides, pest repellants or attractants, or plant growth regulators containing hydrocarbons
• • A—HUMAN NECESSITIES
  • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
  • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
  • A01N31/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic oxygen or sulfur compounds
  • A01N31/02—Acyclic compounds
• • A—HUMAN NECESSITIES
  • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
  • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
  • A01N35/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having two bonds to hetero atoms with at the most one bond to halogen, e.g. aldehyde radical
  • A01N35/02—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having two bonds to hetero atoms with at the most one bond to halogen, e.g. aldehyde radical containing aliphatically bound aldehyde or keto groups, or thio analogues thereof; Derivatives thereof, e.g. acetals
• • A—HUMAN NECESSITIES
  • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
  • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
  • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
  • A01N43/02—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms
  • A01N43/24—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with two or more hetero atoms
  • A01N43/32—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with two or more hetero atoms six-membered rings
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K31/00—Medicinal preparations containing organic active ingredients
  • A61K31/12—Ketones
  • A61K31/121—Ketones acyclic
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
  • A61L11/00—Methods specially adapted for refuse
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
  • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
  • A61L2/16—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using chemical substances
  • A61L2/23—Solid substances, e.g. granules, powders, blocks, tablets
  • A61L2/235—Solid substances, e.g. granules, powders, blocks, tablets cellular, porous or foamed
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
  • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
  • A61P31/02—Local antiseptics
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
  • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
  • A61P31/10—Antimycotics
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
  • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
  • A61P31/12—Antivirals
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
  • A61P33/00—Antiparasitic agents
  • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
  • A61P33/00—Antiparasitic agents
  • A61P33/14—Ectoparasiticides, e.g. scabicides
• • C—CHEMISTRY; METALLURGY
  • C02—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
  • C02F—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
  • C02F1/00—Treatment of water, waste water, or sewage
  • C02F1/72—Treatment of water, waste water, or sewage by oxidation
  • C02F1/722—Oxidation by peroxides
• • C—CHEMISTRY; METALLURGY
  • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
  • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
  • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
  • C11D3/39—Organic or inorganic per-compounds
  • C11D3/3947—Liquid compositions
• • C—CHEMISTRY; METALLURGY
  • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
  • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
  • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
  • C11D3/48—Medical, disinfecting agents, disinfecting, antibacterial, germicidal or antimicrobial compositions
• • C—CHEMISTRY; METALLURGY
  • C02—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
  • C02F—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
  • C02F2303/00—Specific treatment goals
  • C02F2303/04—Disinfection

Definitions

• dialkyl ketone peroxide as a biocidal agent: sterilizer, antiseptic, disinfectant and parasiticide.
• the invention relates to new biocidal agents, specifically with the use of dialkyl ketone peroxide as a sterilizing, antiseptic, disinfectant and parasiticidal agent, without toxicity or ecotoxicity, in all types of fields such as medicine, veterinary, industry, home, etc.
• the invention contemplates the use of dialkyl peroxide ketone as a sterilizing, antiseptic, disinfectant and parasiticidal agent, the use of sterilizing, antiseptic, disinfectant or parasiticidal compositions comprising said dialkyl ketone peroxide, and sterilization and disinfection methods comprising the application of said compositions.
• ionizing radiation is an economical method used to sterilize heat sensitive materials; however, it is not used for culture media or protein solutions because it produces alterations of the components.
• ultraviolet radiation poorly penetrating is used to sterilize surfaces.
• antiseptic agents there may be mentioned alcohols, iodine, ionic and amphoteric agents, organ-mercurial agents and some dyes.
• Iodine is an oxidizing agent that is used as a skin disinfectant, although it is irritating and is only effective as a sporicide at high concentrations.
• Ionic and amphoteric agents are odorless antiseptics that do not stain, are not corrosive to metals and are not toxic, as well as being stable and cheap. However, they are not sporicidal or tuberculicidal even in high concentrations.
• Organ-mercurial compounds meanwhile, are highly toxic. Hydrogen peroxide is a weak antiseptic, with oxidative capacity and free radical forming, which is being used in gaseous form as surface disinfectant or decontaminant of biological cabinets because it does not possess the toxic and carcinogenic properties of ethylene oxide and formaldehyde. Finally, certain dyes, such as acridine or triphenylmethane derivatives, are also used as antiseptics.
• sterilizing agents and / or disinfectants chlorine and derivatives, aldehydes, phenolic compounds and ethylene oxide may be mentioned.
• Chlorine, hypochlorites and chloramines are disinfectants well known in the state of the art.
• the most commonly used chlorinated product in disinfection is sodium hypochlorite, which is active on all bacteria, including spores, and is also effective in a wide range of temperatures.
• the bactericidal activity of sodium hypochlorite is due to hypochlorous acid (HCIO) and Cl 2 that are formed when the hypochlorite is diluted in water. Its activity is influenced by the presence of organic matter, since there may be substances in the medium capable of reacting with chlorinated compounds that decrease their effective concentration and of forming organic compounds with carcinogenic properties. In addition, chlorine is irritating and corrosive on certain materials.
• Aldehydes are alkylating agents that are used as disinfectants and sterilizers, being sporicidal.
• Glutaraldehyde is the only effective cold sterilizer, but it is quite toxic and classified as a carcinogen.
• Gaseous formaldehyde is used to decontaminate buildings, environments, etc., although it has the disadvantage of being very irritating and losing activity in refrigerated environments.
• Phenolic compounds are commonly used disinfectants. Phenol is not usually used as a disinfectant because of its unpleasant smell, because it is very irritating and because of the residue that remains after surface treatment. The most commonly used phenol derivatives are hexachlorophen and cresols that are very effective at low concentrations against vegetative forms of bacteria, although they are not effective against spores. Also, ethylene oxide is a disinfectant agent used in gas sterilization, usually in the pharmaceutical industry. It serves to sterilize heat sensitive material but is very dangerous because it is highly flammable and explosive, as well as being carcinogenic.
• Dialkyl ketone peroxides have long been known in the state of the art.
• methyl ethyl ketone peroxide is widely known for its use in the polymer industry for curing unsaturated polyester resins (see, for example, US Patent 4,931,514, US patent application US 2002/0137972 or international patent application WO 9518180).
• composition has been described as a fuel additive comprising a ketone peroxide, such as methyl ethyl ketone peroxide, acetone peroxide or a mixture of both (see US patent application US 4,482,352).
• a ketone peroxide such as methyl ethyl ketone peroxide, acetone peroxide or a mixture of both (see US patent application US 4,482,352).
• dialqullcetone peroxides per se as sterilizing agents, antiseptics, disinfectants or parasiticides is not known.
• dialkyl ketone peroxides can be used per se as sterilizing, antiseptic, disinfectant or parasiticidal agents without harmful effects, both toxicologically and environmentally, which is very rare in known disinfectants and parasiticides. in the state of the art and something totally unknown in the case of sterilizers.
• the object of the present invention is to provide the use of said dialkyl ketone peroxides, or isomers thereof, as sterilizing agents, antiseptics, disinfectants or non-toxic parasiticides and of a very wide spectrum of action as to the type of organisms on which it acts (bacteria, viruses, fungi, spores, mycobacteria, protozoa, algae, prions, parasites, etc.), and regarding the type of applications in which they are used (human and animal therapy, hygiene, packaging, medical and industrial instruments, surfaces and sanitary environments, premises, surfaces in general, industrial facilities, cooling towers, sanitary hot water circuits, water purification for human or animal consumption, etc.).
• An object of the present invention is to provide the use of a dialkyl ketone peroxide, or an isomer or a mixture of isomers thereof, as a sterilizing, antiseptic, disinfectant and parasiticidal agent.
• Another object of the present invention is to provide the use of a composition comprising said dialkyl ketone peroxide, or an isomer or a mixture of isomers thereof, as a sterilizing, antiseptic, disinfectant or parasiticidal agent.
• Another object of the present invention is to provide a method of sterilization, disinfection, asepsis or deworming that comprises the application of said composition.
• the invention provides the use of dialkyl ketone peroxide, or an isomer or a mixture of isomers thereof, as a sterilizing, antiseptic, disinfectant and parasiticidal agent.
• the term "sterilizing agent” refers to any chemical substance that eliminates all forms of life, including spores.
• antiseptic agent refers to any chemical substance that prevents the growth or action of microorganisms, either by destroying them or inhibiting their growth and activity, being a substance that is applied to a human or animal body.
• disinfectant agent refers to any chemical substance that destroys the vegetative forms but not necessarily the resistance forms of pathogenic microorganisms, being a substance that is applied to inanimate objects.
• parasiticidal agent refers to any physical or chemical agent to fight against parasitic organisms, eliminating them, repelling or attracting them, including products used directly or indirectly for human or veterinary hygiene. In particular, it refers to insecticidal, arachnicidal and carried agents.
• agents can be considered biocidal agents, since they are active substances, or preparations containing one or more active substances, intended to destroy, repel or inactivate harmful or harmful organisms, to prevent their action, or to combat them by any means, by means of chemical or biological action
• dialkyl ketone peroxide is used as a bactericidal, virucidal, fungicidal, sporicidal, mycobactericidal, protocidal, algicidal, prionicidal, insecticidal, arachnicidal or acaricidal agent.
• the dialkyl ketone peroxide of the present invention may be dialkyl peroxide.
• (C1-C20) ketone or an isomer or a mixture of isomers thereof, preferably dialkyl (C1-C6) ketone peroxide, or an isomer or a mixture of isomers thereof.
• dialkyl ketone peroxide refers to compounds of formula (I): R 1 HO-O-C-O-OH
• R1 and R2 independently represent a (C1-C20) alkyl group, preferably a (C1-C6) alkyl group.
• Said alkyl groups may be linear or branched, saturated or unsaturated, unsubstituted or substituted by various inorganic or organic groups.
• One of the preferred dialkyl ketone peroxides within the scope of the present invention is methyl ethyl ketone peroxide, or an isomer or a mixture of isomers thereof.
• dialkyl ketone peroxide dialkyl ketone peroxide
• that of an isomer or mixture of isomers thereof is contemplated.
• isomer refers to any possible isomer, be it a polymerization Isomer, a structural isomer or a stereoisomer (an enantiomer, in case there is one or more chiral carbons, or a diastereoisomer), etc.
• the stereoisomers D, L and meso are also known.
• dialkyl ketone peroxide in another particular embodiment, applies to very diverse fields, such as: human and animal therapy, human and animal hygiene, washing and disinfection of healthy or injured skin in man or in animals, packaging, wrapping, medical and industrial instruments, surfaces and sanitary environments, premises, surfaces in general, industrial facilities, cooling towers, air conditioning ducts, machinery and food production facilities, agricultural facilities, sanitary hot water circuits , water purification for human or animal consumption, or any other industrial, domestic, environmental, agricultural, forestry, urban, pharmaceutical, civil, military, police, scientific, technological, spatial, geological, sanitary or preventive application in which they are demonstrated useful the biocidal properties of dialkyl ketone peroxide.
• dialkyl ketone peroxide can be used as a bactericidal, virucidal, fungicidal, sporicidal, mycobactericidal, protoid, algicidal, prionicidal or parasiticidal agent, by topical application on infected or infested skin, in different formulations and pharmaceutical forms. , among which we can mention the ointment, cream, lotion, solution, ointment, powder, solid bar, suspension, emulsion, fogging or spraying.
• dialkyl ketone peroxide can also be used as a bactericidal, virucidal, fungicidal, sporicidal, mycobactericidal, protoid, algicidal, prionicidal or parasiticidal agent, by enteral or parenteral, oral application, rectal, vaginal, intramuscular, intradermal, intravenous or intraarterial, in order to fight bacterial, mycobacterial, fungal, viral, prionic, protozoal infections, etc.
• ointment cream, lotion, solution, ointment, powder, solid bar, suspension, emulsion, nebulization, spray, syrup, enema, tablet, capsule, suppository, ovule, elixir or mouthwash.
• dialkyl ketone peroxide is particularly useful in the formulation of products such as dentifrices and mouthwashes, for example, as an antiseptic in a concentration around 0.25% (v / v), with the additional advantage of High whitening power of tooth enamel.
• dialkyl ketone peroxide is used as a high-level sterilizing disinfectant to chemically sterilize non-sterilizable surgical material, especially endoscopes, as well as operating room surfaces and clean rooms.
• Thermally sterilizable materials can also be disinfected, the use of a chemical sterilizer being an alternative route.
• dialkyl ketone peroxide is used as a disinfectant for organic waste, especially hospital or clinical type, before its evacuation, in order to reduce its levels of infectious toxicity and thus improve the level of compliance with the Law on Prevention of Occupational Risks and the Hazardous Waste Law.
• dialkyl ketone peroxide is as an environmental disinfectant to disinfect all types of non-surgical surfaces and materials, such as laboratories, food industry, pharmaceutical, biotechnology, etc.
• Dialkyl ketone peroxide is also used as an antiseptic disinfectant for healthy or injured skin (with bedsores), or as a liquid disinfectant soap for hygienic hand washing with disinfection included.
• the Preparation form is done by adding the product as an ingredient mixed with a liquid soap.
• dialkyl ketone peroxide is as a disinfectant for cooling towers to prevent Legionella in refrigeration circuits. Its use consists in the addition of a certain quantity of the product, depending on the volume of water to be treated.
• a further object of the present invention is to provide the use of a composition comprising dialkyl (C1-C20) ketone peroxide, or an isomer or a mixture of isomers thereof, preferably dialkyl (C1-C6) ketone peroxide, or a isomer or a mixture of isomers thereof, as previously described, in a volume percentage equal to or less than 50%, preferably equal to or less than 20%, as a sterilizing, antiseptic, disinfectant and parasiticidal agent.
• a composition comprising dialkyl (C1-C20) ketone peroxide, or an isomer or a mixture of isomers thereof, preferably dialkyl (C1-C6) ketone peroxide, or a isomer or a mixture of isomers thereof, as previously described, in a volume percentage equal to or less than 50%, preferably equal to or less than 20%, as a sterilizing, antiseptic, disinfectant and parasiticidal agent.
• the use of said composition is provided as a bactericidal, virucidal, fungicidal, sporicidal, mycobactericidal, protoid, algicidal, prionicidal, insecticidal, arachnicidal and acaricidal agent.
• a composition comprising a dialkyl (C1-C20) ketone peroxide, or an isomer or a mixture of isomers thereof, preferably a dialkyl (C1-C6) ketone peroxide, or a isomer or a mixture of isomers thereof, as previously described, in a volume percentage equal to or less than 5%, preferably equal to or less than 0.3%.
• composition comprising methyl ethyl ketone peroxide, or an isomer or a mixture of isomers thereof is used.
• a composition comprising as an excipient water, any organic solvent is used suitable or an oil.
• suitable organic solvents alcohols and, more particularly, an alcohol selected from hexylene glycol, polyethylene glycol, propylene glycol, glycerin-formal, diacetone alcohol, ethanol, n-propanol or isopropanol are preferred.
• composition is carried out by conventional methods, by simple dissolution of the dialkyl ketone peroxide in the suitable solvent by mechanical stirring, preferably in a reactor for one hour.
• Methyl ethyl ketone peroxide is commercially available from numerous suppliers worldwide, since it is a product widely used in the industry.
• One of the commercial products available is Butanox M-50, whose declared concentration of methyl etll ketone peroxide is 33% (w / v), always expressed approximately, with the remaining 67% being phlegmatizing (dimethyl phthalate) .
• any other commercial product can be used in which, in general, the concentration of peroxide varies between 33 and 50% (w / v), the remaining percentage being a phlegmatizer such as dimethyl phthalate or isobutyl phthalate. , or 2,2,4-trimethyl-1,3-pentanediol diisobutyrate, for example.
• the use of the latter phlegmatizer is particularly advantageous, since it avoids the possible release of phthalates.
• the present invention provides a method of sterilization, disinfection, asepsis or deworming comprising the application of a composition comprising dialkyl (C1-C20) ketone peroxide, or an isomer or a mixture of isomers thereof, preferably peroxide dialkyl (C1-C6) ketone, or an isomer or a mixture of isomers thereof, as previously described, in a volume percentage equal to or less than in a volume percentage equal to or less than 50%, preferably equal or less than 20%, as previously described.
• a composition comprising dialkyl (C1-C20) ketone peroxide, or an isomer or a mixture of isomers thereof, preferably peroxide dialkyl (C1-C6) ketone, or an isomer or a mixture of isomers thereof, as previously described, in a volume percentage equal to or less than in a volume percentage equal to or less than 50%, preferably equal or less than 20%, as previously described.
• a method of sterilization, disinfection, asepsis or deworming comprises the application of a composition comprising dialkyl (C1-C20) ketone peroxide, or an isomer or a mixture of isomers thereof, preferably dialkyl (C1-C6) ketone peroxide, or an isomer or a mixture of isomers thereof, in a percentage in volume equal to or less than 5%, preferably equal to or less than 0.3%.
• a method of sterilization, disinfection, asepsis or deworming comprising the application of a composition comprising methyl ethyl ketone peroxide, or an isomer or a mixture of isomers thereof.
• a method of sterilization, disinfection, asepsis or deworming comprising the application of a composition that uses as water excipient, any suitable organic solvent or an oil.
• suitable organic solvents include alcohols and, more particularly, an alcohol selected from hexylene glycol, polyethylene glycol, propylene glycol, glycerin-formal, diacetone alcohol, ethanol, n-propanol or isopropanol.
• the application of said composition is carried out by conventional methods.
• the mode of use is performed manually by immersion in a bucket or automatically by washing / disinfecting machines.
• the method of use is the contacting by the usual means of the liquid product with the surface to be disinfected.
• these usual means we can mention the fogging by means of a sprayer, the fogging by means of a vaporizer with propellant gases, the dispensing by means of a mechanical propellant (such as liquid soaps), the discharge with or without a dispenser to the hands, to the skin, to a enclosure, canalization or reservoir containing the liquid to be treated, the simple extension by brush, brush, mop or cloth, or by dropper, etc.
• dialkyl peroxide ketone in cooling towers to prevent or combat Legionella, it is recommended to use 5% active ingredient in n-propanol and water to dilute to 1: 50, so that the principle active remains at a concentration of 0.1% (v / v). Also, to apply in domestic hot water circuits, the active substance must be diluted in the circuit at a concentration of 0.1% (v / v). Similarly, for water circuits in food industries, or for water purification, the active substance must be diluted to 0.1% (v / v). Finally, for high level disinfection it is recommended to work with concentrations of 2% (v / v).
• dialkyl ketone peroxide in a concentration of the order of 0.25% (v / v).
• Nv Number of CFU / ml of the bacterial suspension
• N Number of CFU / ml of the bacterial test suspension
• Na Number of CFU / ml in the test mixture ( ⁇ 1.5 x 10 2 or> 3 x 10 3 CFU / ml)
• R Reduction of viability (for there to be a bactericidal effect, R must be greater than 10 5 )
• Nv CFU / ml number of the fungal suspension
• N Number of CFU / ml of the fungal test suspension
• the product of the invention has fungicidal activity for the strains mentioned, Candida albicans ATCC 10321, and Aspergillus niger ATCC 16404.
• the product of the invention at concentrations of 20% and 25% for 30 minutes has a total sporicidal effect, under the specified test conditions. At concentrations of 20% and 25% for 15 minutes the sporicidal effect is not total, although it significantly reduces the number of viable spores.
• a 0.25% (v / v) methyl ethyl ketone peroxide solution was prepared by diluting approximately 33% (w / v) methyl ethyl ketone peroxide M-50 (cell culture medium) in the cell culture medium. Said solution was contacted for 15 minutes at a temperature of 20 ° C with a suspension of poliovirus type 1 ATCC VR-192 (Incubation temperature: 35 ° C).
• ASTM E-1053-97 Standard Test Method for Efficacy of Virucidal Agents Intended for Inanimate Environmental Surfaces. ASTM International Pause.
• Disinfectant neutralization method dilution in cell culture medium until reaching the non-cytotoxic dilution: 1: 7,000, with four replicates.
• the results of the virucidal activity of the methyl ethyl ketone peroxide solution are shown in Table 4.
• ECP cytopathic effect
• CTX cytotoxicity
• the product of the invention at a concentration of 0.25% for 15 minutes has a total virucidal effect with a reduction greater than 1 x 10 4 TCID 50 against Poliovirus type 1 under the conditions indicated.
• EXAMPLE 5 Mycobactericidal activity
• Three solutions of 1%, 2% and 4% (v / v) methyl ethyl ketone peroxide were prepared by diluting Butanox M-50 (33% (w / v) methyl ethyl ketone peroxide) in a sodium chloride solution -triptone.
• Each of said solutions was contacted for 5, 15 and 30 minutes at a temperature of 20 ° C with a suspension of Mycobacterium terrae ATCC 15755 incubated at 35 ° C and arranged on a carrier disk in the presence of bovine mucin and serum albumin.
• CFU / ml The average number of colony forming units per ml (CFU / ml) recovered after the exposure of 10 tests of carrier discs was determined with each of the three methyl ethyl ketone peroxide solutions indicated during the indicated times.
• the product of the invention at a concentration of 1% has mycobactericidal effect at 15 and 30 minutes, and at concentrations of 2% and 4% it has Mycobactericidal effect at 5, 15 and 30 minutes.

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• Inorganic Chemistry (AREA)
• Oncology (AREA)
• Hydrology & Water Resources (AREA)
• Tropical Medicine & Parasitology (AREA)
• Virology (AREA)
• Agricultural Chemicals And Associated Chemicals (AREA)
• Apparatus For Disinfection Or Sterilisation (AREA)
• Medicinal Preparation (AREA)
• Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
• Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
• Catching Or Destruction (AREA)

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• 2004
  • 2004-04-16 PT PT04727918T patent/PT1637168E/pt unknown
  • 2004-04-16 EP EP04727918A patent/EP1637168B1/en not_active Expired - Lifetime
  • 2004-04-16 JP JP2006505603A patent/JP2006523657A/ja not_active Withdrawn
  • 2004-04-16 CA CA2522335A patent/CA2522335C/en not_active Expired - Fee Related
  • 2004-04-16 KR KR1020057019731A patent/KR20060009259A/ko not_active Ceased
  • 2004-04-16 AU AU2004229191A patent/AU2004229191B2/en not_active Ceased
  • 2004-04-16 AT AT04727918T patent/ATE421342T1/de not_active IP Right Cessation
  • 2004-04-16 BR BRPI0409752-1A patent/BRPI0409752A/pt not_active Application Discontinuation
  • 2004-04-16 MX MXPA05011035A patent/MXPA05011035A/es active IP Right Grant
  • 2004-04-16 DE DE602004019211T patent/DE602004019211D1/de not_active Expired - Lifetime
  • 2004-04-16 CN CNA2004800169758A patent/CN1809388A/zh active Pending
  • 2004-04-16 RU RU2005135461/15A patent/RU2316355C2/ru not_active IP Right Cessation
  • 2004-04-16 PL PL04727918T patent/PL1637168T3/pl unknown
  • 2004-04-16 US US10/553,158 patent/US20070112062A1/en not_active Abandoned
  • 2004-04-16 ES ES04727918T patent/ES2321192T3/es not_active Expired - Lifetime
  • 2004-04-16 WO PCT/ES2004/000169 patent/WO2004091671A1/es not_active Ceased
• 2010
  • 2010-07-26 US US12/843,253 patent/US20100292343A1/en not_active Abandoned
• 2011
  • 2011-07-06 JP JP2011150060A patent/JP2011246473A/ja active Pending

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