WO2004089532A1 - Dreidimensionaler chip - Google Patents
Dreidimensionaler chip Download PDFInfo
- Publication number
- WO2004089532A1 WO2004089532A1 PCT/EP2004/003720 EP2004003720W WO2004089532A1 WO 2004089532 A1 WO2004089532 A1 WO 2004089532A1 EP 2004003720 W EP2004003720 W EP 2004003720W WO 2004089532 A1 WO2004089532 A1 WO 2004089532A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- carrier
- molecules
- units
- chip
- chip according
- Prior art date
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Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
- B01L3/5085—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates
- B01L3/50857—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates using arrays or bundles of open capillaries for holding samples
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5025—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures for parallel transport of multiple samples
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00279—Features relating to reactor vessels
- B01J2219/00306—Reactor vessels in a multiple arrangement
- B01J2219/00313—Reactor vessels in a multiple arrangement the reactor vessels being formed by arrays of wells in blocks
- B01J2219/00319—Reactor vessels in a multiple arrangement the reactor vessels being formed by arrays of wells in blocks the blocks being mounted in stacked arrangements
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00351—Means for dispensing and evacuation of reagents
- B01J2219/00427—Means for dispensing and evacuation of reagents using masks
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00351—Means for dispensing and evacuation of reagents
- B01J2219/00427—Means for dispensing and evacuation of reagents using masks
- B01J2219/0043—Means for dispensing and evacuation of reagents using masks for direct application of reagents, e.g. through openings in a shutter
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00457—Dispensing or evacuation of the solid phase support
- B01J2219/00475—Sheets
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00585—Parallel processes
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00596—Solid-phase processes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00603—Making arrays on substantially continuous surfaces
- B01J2219/00639—Making arrays on substantially continuous surfaces the compounds being trapped in or bound to a porous medium
- B01J2219/00641—Making arrays on substantially continuous surfaces the compounds being trapped in or bound to a porous medium the porous medium being continuous, e.g. porous oxide substrates
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00603—Making arrays on substantially continuous surfaces
- B01J2219/00664—Three-dimensional arrays
- B01J2219/00668—Two-dimensional arrays within three-dimensional arrays
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00603—Making arrays on substantially continuous surfaces
- B01J2219/00673—Slice arrays
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/0068—Means for controlling the apparatus of the process
- B01J2219/00702—Processes involving means for analysing and characterising the products
- B01J2219/00707—Processes involving means for analysing and characterising the products separated from the reactor apparatus
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00718—Type of compounds synthesised
- B01J2219/0072—Organic compounds
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00718—Type of compounds synthesised
- B01J2219/0072—Organic compounds
- B01J2219/00722—Nucleotides
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00718—Type of compounds synthesised
- B01J2219/0072—Organic compounds
- B01J2219/00725—Peptides
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/06—Auxiliary integrated devices, integrated components
- B01L2300/069—Absorbents; Gels to retain a fluid
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0809—Geometry, shape and general structure rectangular shaped
- B01L2300/0819—Microarrays; Biochips
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- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
- C40B40/04—Libraries containing only organic compounds
- C40B40/06—Libraries containing nucleotides or polynucleotides, or derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
- C40B40/04—Libraries containing only organic compounds
- C40B40/10—Libraries containing peptides or polypeptides, or derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
- C40B60/14—Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries
Definitions
- the invention relates to a chip for examining biological samples and a method for producing these chips and claims the priority of German patent application 103 16 689.0, to which reference is made in terms of content.
- Biochips have recently been used extensively, for example in gene analysis, mutation detection or the study of protein / protein interactions, and - generally - in the diagnosis of diseases or the assessment of the corresponding genetic disposition.
- the known chips consist of a carrier and the "Targef 'molecules immobilized on the carrier (hereinafter also referred to as reference molecules).
- the reference molecules are selected depending on the purpose of the investigation.
- the principle of the biochip is the interaction between the known reference molecule and one more unknown Detect sample molecule - for example from a patient or another biological material - and draw conclusions for the purpose of the investigation from this detection.
- the sample molecules must first hybridize with the reference molecules.
- protein chips protein-protein interactions are examined, for example the interactions between an immobilized antigen as a reference molecule and an antibody from the patient sample. The interactions that are carried out are often made visible by means of fluorescent or isotope labels. The evaluation of the chips presupposes that the position of the reference molecules on the chip is known.
- biochips Compared to other methods of detection, biochips have the particular advantage that they allow a complex question to be dealt with.
- the determination of the samples on the carrier also enables a largely automated evaluation of the results, which is supported by the possibilities of information technology. Nevertheless, the known biochips have not yet achieved the desired level of sensitivity and specificity.
- sensitivity is understood to mean the smallest concentration of sample molecules that can still be detected using the chip according to the invention.
- the present invention is based on the idea of using a porous material as a carrier of the biochip and immobilizing the reference molecules on this porous material.
- the manufacturing processes are all based on arranging these polymers in such a way that they represent a three-dimensional chip.
- the chip according to the invention has the advantage that an enlarged surface is available for the immobilization of the reference molecules.
- the density of the reference molecules per carrier unit can thus be increased.
- porous material can make it possible to warp onto a further solid carrier substance in the sense of a support layer.
- This not only has advantages in terms of production technology and costs, but also enables all-round access of the sample molecules from the test sample to the reference molecules. In contrast to this, access to the sample molecules is only possible on one side with known chips. The easier access improves the sensitivity of the chip.
- One or more polymers from the following group can be selected as the carrier material: polyethylene, polyvinyl chloride, polypropylene, polyethylene terephthalate (PET), polyamide, polyimide, polystyrene, polyvinylidene chloride (PVDC), polycarbonate, cellophane, acetate or polysulfonate.
- Table 1 provides an overview of the advantageous properties of these polymers.
- the chip according to the invention can only consist of one layer of the carrier material.
- the necessary stability of the layer can be achieved by choosing a suitable layer thickness.
- different layers are advantageously combined.
- the layers can consist of the same or different polymers.
- the reference molecules are advantageously immobilized on the polymers before the layers are brought together.
- the reference molecules are immobilized on the carrier by means of the methods known to the person skilled in the art.
- the layers, each with a quality of reference molecules, are referred to below as "carrier units”.
- the chip consists of a multiplicity of carrier units which, like a checkerboard, lie next to one another in the X and Y directions and one above the other in the Z direction.
- the number of different reference molecules made available for the examination can be varied.
- individual carrier units can also be used multiple times - e.g. for control purposes - occur.
- the individual layers of the carrier units can be 0.01 to 1 micrometer.
- the area of the support units can be up to a few square meters.
- the support units may be advantageous to at least partially surround the support units with proppants.
- Additional support means on the top or bottom of the carrier can also be advantageous. These can also consist of permeable or porous material. As a rule, they are not equipped with reference molecules.
- the layers can be connected to one another by means of holding means, for example clips.
- the carriers according to the invention can be produced easily and inexpensively.
- the manufacturing process begins with loading individual polymer layers with reference molecules.
- the number of layers varies depending on the purpose of the examination.
- the layers (carrier units) are placed on top of each other to form a first block and cut, for example, with a microtome at right angles to the layer plane. This initially results in area-like cuts with “bands” of carrier units, each of which contains different reference molecules.
- Cuts from different blocks can be stacked again to form a second block ("multilayer blocks"). This block is also cut into thin layered units perpendicular to the plane of the layers.
- each carrier unit can be determined without any doubt beforehand or can also be traced later.
- the carrier according to the invention can also be produced using a second method.
- This mask has openings through which the carrier materials can be loaded with reagents - for example also with the reference molecules.
- the openings can be cylindrical or conical, for example.
- the mask itself can be produced using the known methods of lithography.
- a device can be used which comprises a mask made of a solid material with a thickness of 400 to 500 ⁇ m. It has conical openings, the upper diameter of which can be 100 ⁇ m and the lower 5 ⁇ m, for example.
- This mask can be displaced in the X and Y directions relative to the support means 4, 2. Other dimensions are also possible.
- the support means consist of 50 to 100 ⁇ m thick plastic units with passages of 5 to 10 ⁇ m.
- the carrier material itself is arranged in receiving means 3, which can be 50 ⁇ m thick in the embodiment shown.
- the receptacles for the carrier material provided in these support means also have a diameter of 5 to 10 ⁇ m. These recesses can consist entirely of the porous carrier material or can be filled with it.
- FIGS. 4 and 5 A schematic representation of the recesses filled with different carrier materials (spherical, rod-shaped or gel-like) can be seen in FIGS. 4 and 5.
- the mask is moved in the X and Y directions relative to the support means. This process is repeated until all the desired carrier units contain the reagent. This creates First, a chip with various carrier units that expand in the X and Y directions. This chip is therefore two-dimensional. To complete the chip, the mask and the support means opposite it, on which the carrier unit is arranged, can be removed. The carrier material is thus again accessible to the sample material from both sides.
- the carriers located in the recesses can, for example, be successively equipped with nucleic acids using the method according to the invention (FIG. 6).
- oligonucleotides are placed over the support in a defined order. This “growth” of the reference molecules on the carrier is also shown in FIG. 7.
- the chips produced in this way can be placed one on top of the other in the Z direction, so that the carrier units are aligned.
- the result is a three-dimensional chip (Fig. 2).
- the evaluation of the carrier according to the invention presupposes that the sample molecules interacting with the reference molecules can be detected within the carrier unit.
- LCSM confocal laser scanning microscopy
- FIG. 3 The use of confocal laser scanning microscopy for evaluating the chip according to the invention is shown schematically in FIG. 3:
- Steps 1 to 4 shown show the recordings of the signals along the Z axis.
- Step 5 shows the movement along the Y axis.
- the laser beam passes through the light-refractive plate to the microscope objective and is thus focused on points with a diameter of 5 to 10 ⁇ m. This stimulates the luminescence in the spot.
- a second light beam is sent through the plate to the detector. The signal and its spatial coordinates are documented. Then the laser moves and focuses on another spot.
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- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Clinical Laboratory Science (AREA)
- Organic Chemistry (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Abstract
Description
Claims
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP04726150A EP1615717A1 (de) | 2003-04-10 | 2004-04-07 | Dreidimensionaler chip |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10316689.0 | 2003-04-10 | ||
DE2003116689 DE10316689A1 (de) | 2003-04-10 | 2003-04-10 | Dreidimensionaler Chip |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2004089532A1 true WO2004089532A1 (de) | 2004-10-21 |
Family
ID=33039027
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2004/003720 WO2004089532A1 (de) | 2003-04-10 | 2004-04-07 | Dreidimensionaler chip |
Country Status (3)
Country | Link |
---|---|
EP (1) | EP1615717A1 (de) |
DE (1) | DE10316689A1 (de) |
WO (1) | WO2004089532A1 (de) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2005018796A1 (en) * | 2003-08-21 | 2005-03-03 | Pamgene B.V. | Microarray support for bioprobe synthesis |
EP1910826A2 (de) * | 2005-06-15 | 2008-04-16 | Arizona Board of Regents, acting for and on behalf of Arizona State University | Mikrostruktur- und mikrodomänen-mikroarrays, verfahrenzur herstellung und verwendung davon |
EP3177707A4 (de) * | 2014-08-08 | 2018-01-24 | Applied Materials, Inc. | Gemusterte abscheidung von flüssigkeitsfilmen für biomedizinische vorrichtungen |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1999013313A1 (en) * | 1997-09-11 | 1999-03-18 | Genovations, Inc. | Method of making high density arrays |
WO1999060170A1 (en) * | 1998-05-21 | 1999-11-25 | Hyseq, Inc. | Linear arrays of immobilized compounds and methods of using same |
WO2001009607A1 (en) * | 1999-07-30 | 2001-02-08 | Large Scale Proteomics, Corp. | Microarrays and their manufacture |
US20020051995A1 (en) * | 2000-10-30 | 2002-05-02 | Rajan Kumar | Stacked arrays |
US20020094533A1 (en) * | 2000-10-10 | 2002-07-18 | Hess Robert A. | Apparatus for assay, synthesis and storage, and methods of manufacture, use, and manipulation thereof |
WO2002081077A2 (en) * | 2001-04-05 | 2002-10-17 | Millennium Pharmaceuticals, Inc. | System for the synthesis of spatially separated libraries of compounds and methods for the use thereof |
-
2003
- 2003-04-10 DE DE2003116689 patent/DE10316689A1/de not_active Withdrawn
-
2004
- 2004-04-07 WO PCT/EP2004/003720 patent/WO2004089532A1/de active Application Filing
- 2004-04-07 EP EP04726150A patent/EP1615717A1/de not_active Withdrawn
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1999013313A1 (en) * | 1997-09-11 | 1999-03-18 | Genovations, Inc. | Method of making high density arrays |
WO1999060170A1 (en) * | 1998-05-21 | 1999-11-25 | Hyseq, Inc. | Linear arrays of immobilized compounds and methods of using same |
WO2001009607A1 (en) * | 1999-07-30 | 2001-02-08 | Large Scale Proteomics, Corp. | Microarrays and their manufacture |
US20020094533A1 (en) * | 2000-10-10 | 2002-07-18 | Hess Robert A. | Apparatus for assay, synthesis and storage, and methods of manufacture, use, and manipulation thereof |
US20020051995A1 (en) * | 2000-10-30 | 2002-05-02 | Rajan Kumar | Stacked arrays |
WO2002081077A2 (en) * | 2001-04-05 | 2002-10-17 | Millennium Pharmaceuticals, Inc. | System for the synthesis of spatially separated libraries of compounds and methods for the use thereof |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2005018796A1 (en) * | 2003-08-21 | 2005-03-03 | Pamgene B.V. | Microarray support for bioprobe synthesis |
EP1910826A2 (de) * | 2005-06-15 | 2008-04-16 | Arizona Board of Regents, acting for and on behalf of Arizona State University | Mikrostruktur- und mikrodomänen-mikroarrays, verfahrenzur herstellung und verwendung davon |
EP1910826A4 (de) * | 2005-06-15 | 2010-01-20 | Univ Arizona State | Mikrostruktur- und mikrodomänen-mikroarrays, verfahren zur herstellung und verwendung davon |
EP3177707A4 (de) * | 2014-08-08 | 2018-01-24 | Applied Materials, Inc. | Gemusterte abscheidung von flüssigkeitsfilmen für biomedizinische vorrichtungen |
Also Published As
Publication number | Publication date |
---|---|
DE10316689A1 (de) | 2004-10-28 |
EP1615717A1 (de) | 2006-01-18 |
DE10316689A8 (de) | 2005-02-10 |
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