WO2004012496A2 - Procede d'obtention d'un insaponifiable d'avocat riche en lipides furaniques - Google Patents
Procede d'obtention d'un insaponifiable d'avocat riche en lipides furaniques Download PDFInfo
- Publication number
- WO2004012496A2 WO2004012496A2 PCT/FR2003/002379 FR0302379W WO2004012496A2 WO 2004012496 A2 WO2004012496 A2 WO 2004012496A2 FR 0302379 W FR0302379 W FR 0302379W WO 2004012496 A2 WO2004012496 A2 WO 2004012496A2
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- WO
- WIPO (PCT)
- Prior art keywords
- unsaponifiable
- obtaining
- declaration
- furan lipids
- rich
- Prior art date
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Classifications
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- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11B—PRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
- C11B1/00—Production of fats or fatty oils from raw materials
- C11B1/06—Production of fats or fatty oils from raw materials by pressing
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11B—PRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
- C11B1/00—Production of fats or fatty oils from raw materials
- C11B1/02—Pretreatment
- C11B1/04—Pretreatment of vegetable raw material
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11B—PRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
- C11B1/00—Production of fats or fatty oils from raw materials
- C11B1/10—Production of fats or fatty oils from raw materials by extracting
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11B—PRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
- C11B3/00—Refining fats or fatty oils
- C11B3/12—Refining fats or fatty oils by distillation
Definitions
- the present invention relates to a process for obtaining an avocado unsaponifiable agent rich in furan lipids.
- the avocado comprises, in a known manner, specific lipids of the furan type, the main component of which is • a linoleic furan:
- R is a linear C 11 -C 19 hydrocarbon chain, preferably C ⁇ 3 -C 17 saturated or comprising one or more ethylenic or acetylenic unsaturations.
- the unsaponifiable is the fraction of a fatty substance which, after prolonged action of an alkaline base, remains insoluble in water and can be extracted by an organic solvent.
- Five main groups of substances are present in most unsaponifiables of vegetable oils: saturated or unsaturated hydrocarbons, aliphatic or terpene alcohols, sterols, tocopherols, carotenoid and xanthophilic pigments.
- Patent FR 91 08301 describes a process for obtaining an avocado unsaponifiable material from an avocado oil enriched in one of its fractions, called H, corresponding in fact to these same furan lipids.
- the preparation of such an unsaponifiable matter rich in furan lipids, the content of which can vary from 30 to 60%, is essentially conditioned by controlled heating of the fresh fruit, previously sliced into thin strips, at a temperature between 80 and 120 ° C. , and for a period preferably chosen between 24 to 48 hours.
- the heat treatment can be preceded by dehydration of the fruit, but preferably it is carried out concomitantly with the drying of the fruit. This heat treatment allows, after extraction, to obtain an avocado oil rich in furan lipids.
- the unsaponifiable fraction is obtained according to a conventional saponification process, supplemented by a liquid-liquid extraction step.
- This method has the first drawback of having to heat to a relatively high temperature, at least equal to 80 ° C., for fairly long times, 1 to 2 days, fruit strips rich in lipids which are easily oxidizable under these conditions.
- this type of heat treatment causes in plant food materials, secondary reactions of degradation well known to those skilled in the art, such as the Maillard reactions, which cause unwanted browning of the products, and the appearance of often unpleasant flavors and aromas.
- this type of heat treatment carried out in air, without prior inerting, can be accompanied by significant chemical modifications, in particular in the presence of heat-sensitive substrates such as lipids (e.g. unsaturated fatty acids) and their unsaponifiable fraction (e.g. Vitamin E) .
- heat-sensitive substrates such as lipids (e.g. unsaturated fatty acids) and their unsaponifiable fraction (e.g. Vitamin E) .
- the thermal processes will favor the thermo-oxidation of the substrates, the radical reactions responsible for the appearance of peroxides, but also of intra or intermolecular condensation reactions at the origin of the formation of heavy products.
- the Applicant has thus developed a process, making it possible to obtain, with a high yield, an unsaponifiable material of avocado rich in furan lipids, that is to say a content varying from 50 to 80%, having low contents of heavy products and in peroxides.
- This process includes the following successive steps:
- a step of concentrating the oil in its unsaponifiable fraction then a heat treatment at a temperature which can vary from 80 to 150 ° C., optionally under an inert atmosphere, followed
- avocado having undergone prior processing is meant the co-products resulting from the extraction processes of fresh avocado oils, in particular those resulting from the so-called centrifugation processes. Mention may in particular be made, as “avocado having undergone prior processing”, of i) the avocado milks obtained by pressing the pulps, or ii) the products for settling the pulps partially de-oiled by centrifugation, products generally present at the outlet of centrifugal colanders, or else the centrifuge bases produced during separation.
- avocado cake co-produced during the cold pressing of the fruits ( fresh or dried) or liquid-solid extraction of avocado oil from fresh or dried fruit, using an organic solvent, can also constitute as it is, an alternative raw material usable in the part of the present invention.
- avocado pits can potentially constitute a source of lipids and be used in the context of the present invention.
- step (1) of the process More generally means by dehydration, carried out in step (1) of the process, all of the techniques known to those skilled in the art and which make it possible to extract water from a compound.
- these techniques mention may be made of drying under a stream of hot air or under a controlled atmosphere (eg nitrogen), at atmospheric pressure or under vacuum, in a thick layer or a thin layer, but also the microwave drying, spray drying, freeze drying and osmotic dehydration in solution
- the extraction step (2) can be carried out by any means known to those skilled in the art, preferably by simple cold pressing or with a solvent at low temperature.
- the heat treatment step implemented in step (3) a. or b. can be done in the presence or not of an acid catalyst.
- Acid catalysts in the broad sense are understood to be so-called homogeneous inorganic and organic catalysts such as hydrochloric, sulfuric, acetic or paratoluenesulfonic acids but also, and preferably, heterogeneous solid catalysts such as silica, alumina, silica-aluminas , zirconia, zeolites, acid resins.
- acid aluminas with large specific surfaces will be chosen, that is to say at least equal to 200 m 2 / g.
- Preferred for the implementation of the process of the invention are catalysts of the acid aluminas type.
- this heat treatment is carried out under a continuous stream of nitrogen.
- the heat treatment temperature is between 80 and 130 ° C.
- the concentration step of step (3) a. or (3) b. can be cold crystallization or molecular distillation.
- Molecular distillation can be carried out at a temperature between 180 and 260 ° C while maintaining a pressure between 10 - " ⁇ and 10 - 9 mmHg.
- This step of molecular distillation of the unsaponifiable matter is preferably carried out using a device chosen from molecular distillers of the centrifugal type and molecular devices of the scraped film type.
- Centrifugal type molecular stills are known to those skilled in the art.
- application EP 493 144 describes a molecular still of this type.
- the product to be distilled is spread in a thin layer on the heated surface (hot surface) of a conical rotor rotating at high speed.
- the distillation chamber is placed under vacuum. Under these conditions, there is evaporation and not boiling, from the hot surface, of the constituents of the unsaponifiable, the advantage being that the oil and the unsaponifiable (these products being reputed to be fragile) are not degraded during evaporation.
- Scraped film type molecular stills also known to those skilled in the art, include a distillation chamber with a rotating scraper, allowing continuous spreading over the surface evaporation (hot surface) of the product to be distilled.
- the product vapors are condensed by means of a refrigerated finger, placed in the center of the distillation chamber.
- the peripheral feed and vacuum systems are very close to those of a centrifugal distiller (feed pumps, vacuum and vane vacuum pumps, etc.). • The recovery of residues and distillates in glass flasks is done by gravitational flow.
- Step (4) of saponification of the oil or oily extract can be carried out in the presence of potassium hydroxide or sodium hydroxide in an alcoholic, preferably ethanolic, medium, followed by one or more extraction (s).
- Extraction with an appropriate organic solvent (liquid-liquid extraction) in order to separate the soaps from fatty acids and the unsaponifiable compounds is particularly suitable.
- the suitable organic solvent can be, for example chosen from the group of alkanes, halogenated alkanes, aromatic solvents, ethers such as methyltertiobutyl ether (MTBE) and ethyl ether, or any other suitable solvent immiscible with the hydro-alcoholic solution.
- a halogenated alkane will be chosen, in particular 1, 2-dichloroethane.
- the extraction solution obtained is preferably then centrifuged, filtered and then washed with water to remove the residual traces of alkalinity. Finally, the extraction solvent is evaporated carefully to recover the unsaponifiable matter.
- additional operations known to those skilled in the art, such as a deodorization step.
- Example 1 Process of advanced heat treatment of the fruit:
- 50 kg of fresh avocados are cut into thin strips 2 to 5 mm thick, including the core, using a disc slicer.
- the drying tool is a thermo-regulated oven with a current of hot air.
- the sliced avocados are spread over a thickness of 4 to 5 cm on stepped shelves.
- the drying temperature is set at 85 ° C, its duration is 48 hours.
- the fruits are crushed and then subjected to cold pressure. This operation is carried out on a small Komet laboratory press.
- the extracted oil is then filtered on a buchner, then stored under nitrogen away from light and moisture.
- the oil obtained is then distilled in a molecular scraper with a scraped film, of the Leybold KDL 4 type, at a temperature of 230 ° C. and under a vacuum of 10 "3 mm of mercury.
- the distillate yield of this operation is 9 , 2%.
- the distillate obtained is saponified for 4 hours, at reflux, in the presence of 175 g of 50% potassium hydroxide and 875 g of ethanol.
- the mixture is cooled to 30 ° C., then diluted by adding demineralized water.
- the hydroalcoholic solution (SHA) obtained is then extracted in the separatory funnel with 1,2-dichloroethane.
- the organic phases are then combined and dried over anhydrous sodium sulfate.
- the dissolved unsaponifiable fraction is finally recovered after evaporation of the solvent and drying under vacuum. This step is carried out in a rotary evaporator, at 70 ° C, under a vacuum of 1 mm of mercury, for 2 hours. 126 g of unsaponifiable fraction of avocado are thus recovered, which is then stored under nitrogen for analysis.
- Example 2 Process of advanced heat treatment of the oil: 50 kg of fresh avocados are cut into thin strips 2 to 5 mm thick, including the core, using a disc slicer.
- the drying tool is a thermo-regulated oven with a current of hot air.
- the sliced avocados are spread over a thickness of 4 to 5 cm on stepped shelves.
- the drying temperature is set at 70 ° C, its duration is 48 hours.
- the fruits are crushed and then subjected to cold pressure. This operation is carried out on a small Komet laboratory press.
- the extracted oil is then filtered on a log burner, then stored under nitrogen away from light and moisture.
- This oil is then heated to 85 ° C, for 48 hours, under a continuous stream of nitrogen, in a glass reactor equipped with mechanical stirring.
- the oil obtained is then distilled in a molecular scraper with a scraped film, of the Leybold KDL 4 type, at a temperature of 230 ° C. and under a vacuum of 10 ⁇ 3 mm of mercury.
- the distillate yield from this operation is 9.4%.
- 50 kg of fresh avocados are cut into thin strips 2 to 5 mm thick, including the core, using a disc slicer.
- the drying tool is a thermo-regulated oven with a current of hot air.
- the sliced avocados are spread over a thickness of 4 to 5 cm on stepped shelves.
- the drying temperature is set at 70 ° C, its duration is 48 hours.
- the fruits are crushed and then subjected to cold pressure. This operation is carried out on a small Komet laboratory press.
- the extracted oil is then filtered on a log burner, then stored under nitrogen away from light and moisture.
- This distillate is then heated to 85 ° C, for 48 hours, under a continuous stream of nitrogen, in a glass reactor equipped with mechanical stirring.
- the oil obtained is saponified for 4 hours, at reflux, in the presence of 175 g of 50% potassium hydroxide and 875 g of ethanol.
- the mixture is cooled to 30 ° C., then diluted by adding demineralized water.
- the hydro-alcoholic solution (SHA) obtained is then extracted in the separatory funnel with 1, 2-dichloroethane.
- Table 1 comparison of the various methods for obtaining the unsaponifiable fraction of avocado / Influence of the nature of the heat treatment
- Example 4 Process for advanced heat treatment of the distillate in the presence of a catalyst:
- 50 kg of fresh avocados are cut into thin strips 2 to 5 mm thick, including the core, using a disc slicer.
- the drying tool is a thermo-regulated oven with a current of hot air.
- the sliced avocados are spread over a thickness of 4 to 5 cm over stepped shelves.
- the drying temperature is set at 70 ° C, its duration is 48 hours.
- the fruits are crushed and then subjected to cold pressure. This operation is carried out on a small Komet laboratory press.
- the extracted oil is then filtered on a log burner, then stored under nitrogen away from light and moisture.
- the oil obtained is then distilled in a molecular still with a scraped film, of the Leybold KDL 4 type, at a temperature of 230 ° C. and under a vacuum of 10 ⁇ 3 mm of mercury.
- the distillate yield from this operation is 9.9%.
- the heat-treated distillate is filtered and saponified for 4 hours, at reflux, in the presence of 175 g of 50% potassium hydroxide and 875 g of ethanol .
- the mixture is cooled to 30 ° C., then diluted by adding demineralized water.
- the hydro-alcoholic solution (SHA) obtained is then extracted in the separatory funnel with 1,2-dichloroethane.
- the organic phases are then combined and dried over anhydrous sodium sulfate.
- the dissolved unsaponifiable fraction is finally recovered after evaporation of the solvent and vacuum drying. This step is carried out in a rotary evaporator, at 70 ° C, under a vacuum of 1 mm of mercury, for 2 hours. 126 g of unsaponifiable fraction of avocado are thus recovered, which is then stored under nitrogen for analysis.
- Example 5 Process for advanced heat treatment of the distillate in the absence of catalyst:
- 50 kg of fresh avocados are cut into thin strips 2 to 5 mm thick, including the core, using a disc slicer.
- the drying tool is a thermo-regulated oven with a current of hot air.
- the sliced avocados are spread over a thickness of 4 to 5 cm on stepped shelves.
- the drying temperature is set at 70 ° C, its duration is 48 hours.
- the fruits are crushed and then subjected to cold pressure. This operation is carried out on a small Komet laboratory press.
- the oil extracted is then filtered on b ⁇ chner, then stored under nitrogen away from light and moisture.
- the oil obtained is then distilled in a molecular still with a scraped film, of the Leybold KDL 4 type, at a temperature of 230 ° C. and under a vacuum of 10 ⁇ 3 mm of mercury.
- the distillate yield from this operation is 9.9%.
- This distillate is then heated to 85 ° C for 2 hours under a continuous stream of nitrogen, and in a glass reactor equipped with mechanical stirring.
- the heat-treated distillate is saponified for 4 hours, at reflux, in the presence of 175 g of 50% potassium hydroxide and 875 g of ethanol.
- the mixture is cooled to 30 ° C., then diluted by adding demineralized water.
- the hydro-alcoholic solution (SHA) obtained is then extracted in the separatory funnel with 1,2-dichloroethane.
- Furan lipid content 70.1%
- 50 kg of fresh avocados are cut into thin strips 2 to 5 mm thick, including the core, using a disc slicer.
- the drying tool is a thermo-regulated oven with a current of hot air.
- the sliced avocados are spread over a thickness of 4 to 5 cm on stepped shelves.
- the drying temperature is set at 65 ° C, its duration is 72 hours.
- the fruits are crushed and then subjected to cold pressure. This operation is carried out on a small Komet laboratory press.
- the oil extracted is then filtered on b ⁇ chner, then stored under nitrogen away from light and moisture.
- the oil obtained is then distilled in a molecular scraper with a scraped film, of the Leybold KDL 4 type, at a temperature of 230 ° C. and under a vacuum of 10 "3 mm of mercury.
- the distillate yield of this operation is 9 , 1%.
- the distillate obtained is saponified for 4 hours, at reflux, in the presence of 175 g of 50% potassium hydroxide and 875 g of ethanol.
- the mixture is cooled to 30 ° C., then diluted by adding demineralized water.
- the hydroalcoholic solution (SHA) obtained is then extracted in the separatory funnel with 1, 2-dichloroethane.
- the organic phases are then combined and dried over anhydrous sodium sulfate.
- the dissolved unsaponifiable fraction is finally recovered after evaporation of the solvent under vacuum and at low temperature. This step is carried out in a rotary evaporator, at 70 ° C, under a vacuum of 1 mm of mercury, for 2 hours. 105 g of unsaponifiable fraction of avocado are thus recovered, which is then stored under nitrogen for analysis.
- the furan lipid content of the unsaponifiable fraction of avocado obtained is extremely low (considerably less than 10%).
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- Oil, Petroleum & Natural Gas (AREA)
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- Natural Medicines & Medicinal Plants (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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- Polymers & Plastics (AREA)
- Epidemiology (AREA)
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- Alternative & Traditional Medicine (AREA)
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- Rheumatology (AREA)
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- Orthopedic Medicine & Surgery (AREA)
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- Pain & Pain Management (AREA)
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- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
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Abstract
Description
Claims
Priority Applications (11)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU2003273485A AU2003273485C1 (en) | 2002-07-29 | 2003-07-28 | Method for producing an avocado unsaponifiable rich in furan lipids |
US10/522,907 US7371420B2 (en) | 2002-07-29 | 2003-07-28 | Method for producing an avocado unsaponifiable rich in furan lipids |
DE60325603T DE60325603D1 (de) | 2002-07-29 | 2003-07-28 | Gewinnungsverfahren einer unverseifbaren avocadofraktion mit einem höheren furanlipidengehalt |
JP2004525478A JP4303680B2 (ja) | 2002-07-29 | 2003-07-28 | アボカド由来のフラン脂質に富んだ不けん化物を得るプロセス |
EP03755645A EP1530430B1 (fr) | 2002-07-29 | 2003-07-28 | Procede d'obtention d'un insaponifiable d'avocat riche en lipides furaniques |
CA2493979A CA2493979C (fr) | 2002-07-29 | 2003-07-28 | Procede d'obtention d'un insaponifiable d'avocat riche en lipides furaniques |
MXPA05001238A MXPA05001238A (es) | 2002-07-29 | 2003-07-28 | Procedimiento para la obtencion de un material no saponificable rico en lipidos de furano a partir de aguacate. |
BRPI0313538-1A BR0313538B1 (pt) | 2002-07-29 | 2003-07-28 | Processo de obtenção de um insaponificável de abacate rico em lipídeos furânicos |
IL166567A IL166567A (en) | 2002-07-29 | 2005-01-30 | A method of making a substance rich in furan-lipid that does not turn into soap |
ZA2005/01330A ZA200501330B (en) | 2002-07-29 | 2005-02-15 | Method for producing an avocado unsaponifiable rick in furan lipids |
HK05109967.5A HK1076359A1 (en) | 2002-07-29 | 2005-11-08 | Method for producing an avocado unsaponifiable rich in furan lipids |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FRPCT/FR02/02715 | 2002-07-29 | ||
PCT/FR2002/002715 WO2004016106A1 (fr) | 2002-07-29 | 2002-07-29 | Procede d'obtention d'un insaponifiable d'avocat riche en lipides furaniques |
US10/206,792 US6994875B2 (en) | 2002-07-29 | 2002-07-29 | Process for obtaining a furan lipid-rich unsaponifiable material from avocado |
US10/206,792 | 2002-07-29 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2004012496A2 true WO2004012496A2 (fr) | 2004-02-12 |
WO2004012496A3 WO2004012496A3 (fr) | 2004-04-08 |
Family
ID=31497203
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/FR2002/002715 WO2004016106A1 (fr) | 2002-07-29 | 2002-07-29 | Procede d'obtention d'un insaponifiable d'avocat riche en lipides furaniques |
PCT/FR2003/002379 WO2004012496A2 (fr) | 2002-07-29 | 2003-07-28 | Procede d'obtention d'un insaponifiable d'avocat riche en lipides furaniques |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/FR2002/002715 WO2004016106A1 (fr) | 2002-07-29 | 2002-07-29 | Procede d'obtention d'un insaponifiable d'avocat riche en lipides furaniques |
Country Status (18)
Country | Link |
---|---|
US (2) | US6994875B2 (fr) |
EP (1) | EP1530430B1 (fr) |
JP (1) | JP4303680B2 (fr) |
KR (1) | KR100915498B1 (fr) |
CN (1) | CN1303913C (fr) |
AR (1) | AR040522A1 (fr) |
AT (1) | ATE418876T1 (fr) |
AU (1) | AU2003273485C1 (fr) |
BR (1) | BR0313538B1 (fr) |
CA (1) | CA2493979C (fr) |
DE (1) | DE60325603D1 (fr) |
ES (1) | ES2319407T3 (fr) |
HK (1) | HK1076359A1 (fr) |
IL (1) | IL166567A (fr) |
MX (1) | MXPA05001238A (fr) |
RU (1) | RU2320712C2 (fr) |
WO (2) | WO2004016106A1 (fr) |
ZA (1) | ZA200501330B (fr) |
Cited By (18)
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---|---|---|---|---|
WO2011012615A2 (fr) | 2009-07-30 | 2011-02-03 | Laboratoires Expanscience | Composition cosmetique pour le traitement de l'acne comprenant un extrait peptidique de schizandra |
WO2011012612A2 (fr) | 2009-07-30 | 2011-02-03 | Laboratoires Expanscience | Extrait du fruit de schizandra sphenanthera et compositions cosmetiques, dermatologiques et nutraceutiques le comprenant |
WO2011064402A2 (fr) | 2009-11-30 | 2011-06-03 | Laboratoires Expanscience | Extrait de graines d'acacia macrostachya et compositions le comprenant |
WO2011064401A2 (fr) | 2009-11-30 | 2011-06-03 | Laboratoires Expanscience | Extrait de graines de vigna unguiculata et compositions le comprenant |
WO2011073281A1 (fr) | 2009-12-16 | 2011-06-23 | Laboratoires Expanscience | Composition comprenant au moins un sucre en c7 pour le traitement de l'alopécie, pour le traitement cosmétique des phanères, et pour le soin des cheveux, cils ou ongles |
WO2012085224A1 (fr) | 2010-12-22 | 2012-06-28 | Laboratoires Expanscience | Extrait de pulpe et/ou de peau d'avocat riche en polyphenols et compositions cosmetiques, dermatologiques et nutraceutiques le comprenant |
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WO2014122326A1 (fr) | 2013-02-11 | 2014-08-14 | Laboratoires Expanscience | Utilisation d'une composition comprenant un perséose d'avocat dans la protection des cellules souches épidermiques |
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Also Published As
Publication number | Publication date |
---|---|
IL166567A0 (en) | 2006-01-15 |
ES2319407T3 (es) | 2009-05-07 |
ATE418876T1 (de) | 2009-01-15 |
KR20050036962A (ko) | 2005-04-20 |
BR0313538A (pt) | 2005-08-16 |
ZA200501330B (en) | 2005-11-30 |
JP4303680B2 (ja) | 2009-07-29 |
RU2320712C2 (ru) | 2008-03-27 |
EP1530430B1 (fr) | 2008-12-31 |
CN1303913C (zh) | 2007-03-14 |
EP1530430A2 (fr) | 2005-05-18 |
IL166567A (en) | 2008-11-26 |
US7371420B2 (en) | 2008-05-13 |
MXPA05001238A (es) | 2005-06-08 |
RU2005105594A (ru) | 2005-09-10 |
AU2003273485B2 (en) | 2007-09-27 |
US6994875B2 (en) | 2006-02-07 |
AR040522A1 (es) | 2005-04-06 |
AU2003273485A1 (en) | 2004-02-23 |
JP2006500340A (ja) | 2006-01-05 |
US20060099323A1 (en) | 2006-05-11 |
AU2003273485C1 (en) | 2008-03-20 |
US20040018258A1 (en) | 2004-01-29 |
CA2493979C (fr) | 2011-11-01 |
WO2004016106A1 (fr) | 2004-02-26 |
DE60325603D1 (de) | 2009-02-12 |
KR100915498B1 (ko) | 2009-09-03 |
AU2003273485B8 (en) | 2007-10-18 |
WO2004012496A3 (fr) | 2004-04-08 |
HK1076359A1 (en) | 2006-01-20 |
CN1678202A (zh) | 2005-10-05 |
BR0313538B1 (pt) | 2014-04-08 |
CA2493979A1 (fr) | 2004-02-12 |
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