WO2004009639A1 - 単鎖抗体およびその利用 - Google Patents
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- WO2004009639A1 WO2004009639A1 PCT/JP2003/009140 JP0309140W WO2004009639A1 WO 2004009639 A1 WO2004009639 A1 WO 2004009639A1 JP 0309140 W JP0309140 W JP 0309140W WO 2004009639 A1 WO2004009639 A1 WO 2004009639A1
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- UYTPUPDQBNUYGX-UHFFFAOYSA-N guanine Chemical class O=C1NC(N)=NC2=C1N=CN2 UYTPUPDQBNUYGX-UHFFFAOYSA-N 0.000 description 1
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- 235000010994 magnesium phosphates Nutrition 0.000 description 1
- FPYJFEHAWHCUMM-UHFFFAOYSA-N maleic anhydride Chemical class O=C1OC(=O)C=C1 FPYJFEHAWHCUMM-UHFFFAOYSA-N 0.000 description 1
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- PYWVYCXTNDRMGF-UHFFFAOYSA-N rhodamine B Chemical class [Cl-].C=12C=CC(=[N+](CC)CC)C=C2OC2=CC(N(CC)CC)=CC=C2C=1C1=CC=CC=C1C(O)=O PYWVYCXTNDRMGF-UHFFFAOYSA-N 0.000 description 1
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- 229910052709 silver Inorganic materials 0.000 description 1
- 239000004332 silver Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
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- 238000002415 sodium dodecyl sulfate polyacrylamide gel electrophoresis Methods 0.000 description 1
- 235000010339 sodium tetraborate Nutrition 0.000 description 1
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- ANRHNWWPFJCPAZ-UHFFFAOYSA-M thionine Chemical compound [Cl-].C1=CC(N)=CC2=[S+]C3=CC(N)=CC=C3N=C21 ANRHNWWPFJCPAZ-UHFFFAOYSA-M 0.000 description 1
- 229940104230 thymidine Drugs 0.000 description 1
- FUSNMLFNXJSCDI-UHFFFAOYSA-N tolnaftate Chemical compound C=1C=C2C=CC=CC2=CC=1OC(=S)N(C)C1=CC=CC(C)=C1 FUSNMLFNXJSCDI-UHFFFAOYSA-N 0.000 description 1
- 238000006257 total synthesis reaction Methods 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- BSVBQGMMJUBVOD-UHFFFAOYSA-N trisodium borate Chemical compound [Na+].[Na+].[Na+].[O-]B([O-])[O-] BSVBQGMMJUBVOD-UHFFFAOYSA-N 0.000 description 1
- 238000004506 ultrasonic cleaning Methods 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
- C07K16/1203—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria
- C07K16/1228—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
- C07K16/1235—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia from Salmonella (G)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2318/00—Antibody mimetics or scaffolds
- C07K2318/10—Immunoglobulin or domain(s) thereof as scaffolds for inserted non-Ig peptide sequences, e.g. for vaccination purposes
Abstract
Description
Claims
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU2003248081A AU2003248081A1 (en) | 2002-07-18 | 2003-07-18 | Single chain antibody and utilization thereof |
EP03765324A EP1541588A4 (en) | 2002-07-18 | 2003-07-18 | SINGLE CHAIN ANTIBODIES AND USE THEREOF |
US10/522,000 US20060172344A1 (en) | 2002-07-18 | 2003-07-18 | Single chain antibody and use thereof |
CA002492996A CA2492996A1 (en) | 2002-07-18 | 2003-07-18 | Single chain antibody and utilization thereof |
JP2004522758A JP4330532B2 (ja) | 2002-07-18 | 2003-07-18 | 単鎖抗体およびその利用 |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2002210067 | 2002-07-18 | ||
JP2002-210067 | 2002-07-18 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2004009639A1 true WO2004009639A1 (ja) | 2004-01-29 |
Family
ID=30767711
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/JP2003/009140 WO2004009639A1 (ja) | 2002-07-18 | 2003-07-18 | 単鎖抗体およびその利用 |
Country Status (6)
Country | Link |
---|---|
US (1) | US20060172344A1 (ja) |
EP (1) | EP1541588A4 (ja) |
JP (1) | JP4330532B2 (ja) |
AU (1) | AU2003248081A1 (ja) |
CA (1) | CA2492996A1 (ja) |
WO (1) | WO2004009639A1 (ja) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2006051901A1 (ja) * | 2004-11-12 | 2006-05-18 | Cellfree Sciences Co., Ltd. | 無細胞タンパク質合成方法 |
JP2007526460A (ja) * | 2004-03-03 | 2007-09-13 | バイエル・テクノロジー・サービシーズ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | 細胞集団のタンパク質発現プロファイルの作成のための分析用プラットフォームおよび方法 |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2005015212A1 (en) * | 2003-08-07 | 2005-02-17 | Cellfree Sciences Co., Ltd. | Reagent for producing a protein chip |
BR112016030740A2 (pt) | 2014-07-01 | 2018-02-20 | Pfizer Inc. | diacorpos heterodiméricos biespecíficos e seus usos |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1995004069A1 (en) * | 1993-07-30 | 1995-02-09 | Affymax Technologies N.V. | Biotinylation of proteins |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5914254A (en) * | 1993-08-02 | 1999-06-22 | Celtrix Pharmaceuticals, Inc. | Expression of fusion polypeptides transported out of the cytoplasm without leader sequences |
GB0111459D0 (en) * | 2001-05-10 | 2001-07-04 | Isis Innovation | Universal fluorescent sensors |
AU2005302453A1 (en) * | 2004-10-29 | 2006-05-11 | Medimmune, Llc | Methods of preventing and treating RSV infections and related conditions |
-
2003
- 2003-07-18 US US10/522,000 patent/US20060172344A1/en not_active Abandoned
- 2003-07-18 EP EP03765324A patent/EP1541588A4/en not_active Withdrawn
- 2003-07-18 AU AU2003248081A patent/AU2003248081A1/en not_active Abandoned
- 2003-07-18 WO PCT/JP2003/009140 patent/WO2004009639A1/ja active Application Filing
- 2003-07-18 CA CA002492996A patent/CA2492996A1/en not_active Abandoned
- 2003-07-18 JP JP2004522758A patent/JP4330532B2/ja not_active Expired - Fee Related
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1995004069A1 (en) * | 1993-07-30 | 1995-02-09 | Affymax Technologies N.V. | Biotinylation of proteins |
US5723584A (en) * | 1993-07-30 | 1998-03-03 | Affymax Technologies N.V. | Biotinylation of proteins |
Non-Patent Citations (9)
Title |
---|
BECKETT D. ET AL.: "A minimal peptide substrate in biotin holoenzyme synthetase-catalyzed biotinylation", PROTEIN SCI., vol. 8, no. 4, 1999, pages 921 - 929, XP002971557 * |
DUFFY S. ET AL.: "Site-specific, enzymatic biotinylation of recombinant protein in spodoptera frugiperda cells using biotin acceptor peptides", ANAL. BIOCHEM., vol. 262, no. 2, 1998, pages 122 - 128, XP002215966 * |
HIRAYASU KAWASAKI ET AL.: "Kokassei o yusuru tansa kotai no musaibo gosei", SEIKAGAKU (P3-207), vol. 74, no. 8, 25 August 2002 (2002-08-25), pages 870, XP002974131 * |
JIANG X. ET AL.: "Expression of Fab fragment of catalyticantibody 6D9 in an escherichia coli in vitro coupled transcription/translation system", FEBS LETT., vol. 514, no. 2-3, March 2002 (2002-03-01), pages 290 - 294, XP004347714 * |
LUO D. ET AL.: "Expression of a fusion protein of scFv-biotin mimetic peptide for immunoassay", J. BIOTECHNOL., vol. 65, no. 2-3, 1998, pages 225 - 228, XP004144926 * |
MADIN K. ET AL.: "A highly efficient and robust cell-free protein synthesis system propeared from wheat embryos: plants apparently contain a suicide system directed at ribosomes", PROC. NATL. ACAD. SCI. USA, vol. 97, no. 2, 2000, pages 559 - 564, XP002906354 * |
RYABOVA L.A. ET AL.: "Functional antibody production using cell-free translation: effects of protein disulfide isomerase and chaperones", NAT. BIOTECHNOL., vol. 15, no. 1, 1997, pages 79 - 84, XP002041753 * |
See also references of EP1541588A4 * |
ZHANG H. ET AL.: "A human monoclonal antimelanoma single-chain Fv antibody derived from tumor-infiltrating lymphocytes", CANCER RES., vol. 55, no. 16, 1995, pages 3584 - 3591, XP002971556 * |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2007526460A (ja) * | 2004-03-03 | 2007-09-13 | バイエル・テクノロジー・サービシーズ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | 細胞集団のタンパク質発現プロファイルの作成のための分析用プラットフォームおよび方法 |
WO2006051901A1 (ja) * | 2004-11-12 | 2006-05-18 | Cellfree Sciences Co., Ltd. | 無細胞タンパク質合成方法 |
Also Published As
Publication number | Publication date |
---|---|
EP1541588A4 (en) | 2007-09-12 |
JPWO2004009639A1 (ja) | 2005-11-17 |
CA2492996A1 (en) | 2004-01-29 |
JP4330532B2 (ja) | 2009-09-16 |
AU2003248081A1 (en) | 2004-02-09 |
US20060172344A1 (en) | 2006-08-03 |
EP1541588A1 (en) | 2005-06-15 |
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