WO2003086359A1 - Comprime oral a base de polyphenol de the permettant de prevenir et de traiter les caries dentaires, et procede de preparation associe - Google Patents

Comprime oral a base de polyphenol de the permettant de prevenir et de traiter les caries dentaires, et procede de preparation associe Download PDF

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Publication number
WO2003086359A1
WO2003086359A1 PCT/CN2003/000264 CN0300264W WO03086359A1 WO 2003086359 A1 WO2003086359 A1 WO 2003086359A1 CN 0300264 W CN0300264 W CN 0300264W WO 03086359 A1 WO03086359 A1 WO 03086359A1
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Prior art keywords
tablet
preventing
mannitol
xylitol
tea polyphenols
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PCT/CN2003/000264
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English (en)
French (fr)
Inventor
Jiang Yu
Youqiu Chu
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Jiang Yu
Youqiu Chu
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Priority to AU2003236124A priority Critical patent/AU2003236124A1/en
Publication of WO2003086359A1 publication Critical patent/WO2003086359A1/zh

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/0216—Solid or semisolid forms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A61K8/738—Cyclodextrins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9789—Magnoliopsida [dicotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0063—Periodont
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses

Definitions

  • the invention relates to a pharmaceutical tablet for preventing and treating dental caries and a technical field for preparing the pharmaceutical tablet. Background technique
  • Tea polyphenols are green tea extracts.
  • tea polyphenols are clinically effective drugs that can inhibit the growth of oral cariogenic bacteria, streptococcus mutans, and remote streptococci.
  • toothpaste, coatings and gargles made of fluorine, which have relatively short residence time in the mouth and a period of acting on the teeth Disadvantages, it is not conducive to effective inhibition of the above-mentioned various oral bacteria. If toothpaste, coating agent and gargle are often used anytime and anywhere, there are disadvantages such as inconvenience and elegance.
  • 94113979. 4 discloses an anti-caries caramel and its manufacturing method.
  • the formula also contains tea polyphenols, but it is very unscientific to use milk sugar as a carrier for the prevention and treatment of dental caries, because of milk sugar or sugar itself It is one of the factors that easily cause dental caries, and it cannot be used by diabetics.
  • the content of tea polyphenols in this patent is low, so its effect on inhibiting various oral bacteria is relatively poor.
  • the invention provides a tea polyphenol containing tablet for preventing and treating dental caries and a preparation method thereof, which solves the problem that the existing toothpaste, coating agent and gargle all have a short residence time in the oral cavity and a short period of action on the teeth. It is not conducive to the effective inhibition of various oral bacteria, and the problem that milk sugar as a carrier for the prevention and treatment of dental caries has certain side effects on the teeth.
  • a tea polyphenol tablet for preventing and treating dental caries which is a medicine (in parts by weight) made of the following raw materials with the following weight ratio:
  • a method for preparing a tea polyphenol containing tablet for preventing dental caries taking a certain amount of ⁇ -cyclodextrin and adding 2-5 times the amount of purified water to homogenize; adding a certain amount of tea polyphenols and grinding into a paste in a grinder Shape, low temperature drying to clathrate; take a certain amount of xylitol, mannitol and natural food additives into a micronizer for processing to 400-600 mesh and set aside, at this time, the above mixed materials Put them into a mixer and mix them together. Put a certain amount of 95% alcohol to make a soft material. Use a nylon sieve to make granules. Then put the granules in a drying box to dry below 60 ⁇ . The lubricant is placed in the mixing hopper together and pressed into a national standard tablet-like form.
  • Tea polyphenols tablet for caries treatment which is a medicine (in parts by weight) made of the following raw materials with the following weight ratio:
  • the tea polyphenol tablet for preventing dental caries is a medicament (in parts by weight) made of the following raw materials with the following weight ratio:
  • the tea polyphenol containing tablet for preventing dental caries is a medicine (in parts by weight) made of the following raw materials with the following weight ratio:
  • Natural food additives 9. 5-10 Lubricants 0.9 9-1. 1 ⁇
  • Tea polyphenol tablets for preventing dental caries are pure tea polyphenols.
  • the medicament is in the form of a tablet or a block.
  • the fineness of the powder of xylitol, mannitol and natural food additive mixture is 450-500 mesh.
  • the fineness of the xylitol, mannitol and natural food additive mixture is 500 mesh.
  • the tea polyphenol containing tablet for preventing and treating caries according to the present invention and a preparation method thereof are medicaments (in parts by weight) made of the following raw materials with the following weight ratios:
  • a method for preparing a tea polyphenol containing tablet for preventing dental caries taking a certain amount of ⁇ -cyclodextrin and adding 2-5 times the amount of purified water to grind, adding a certain amount of tea polyphenols, and grinding into a paste in a grinder.
  • Shape dried at low temperature to be clathrate; take a certain amount of xylitol, mannitol, natural food additives
  • the powder processing machine is processed into 500 meshes before use. At this time, the separately processed mixed materials are put into the mixer and mixed together, and a certain amount of 95% alcohol is used to make a soft material, which is made with a nylon sieve.
  • the granules are placed in a drying box to dry below 60 ° F. The dried granules are put into a mixing hopper together with a certain amount of lubricant and pressed into a national standard tablet-like form.
  • the invention can produce beneficial effects: Because it is in the form of a tablet, it is convenient and elegant when used often anytime, anywhere; because it contains a large amount of tea polyphenols, it can effectively inhibit oral cariogenic bacteria
  • streptococcus mutans and remote streptococci because its raw material fineness is processed to more than 500 mesh, its hardness is longer and its content time is longer, so the time spent in the mouth and the period of action on the teeth are relatively Longer, it is beneficial for effective inhibition of various oral bacteria, and its treatment effect is ideal; because it does not contain sugars, it can also be used by diabetics; Furthermore, it contains a delicate taste, smoothness and no Grainy.

Description

防治龋齿的茶多酚含片及其制备方法 技术领域
本发明涉及防治龋齿病症的药物含片及其制备该药物含片技术领域。 背景技术
茶多酚是绿茶提取物。对于口腔疾病，在临床上茶多酚是能够有效抑 制口腔致龋菌、变形链球菌、边远链球菌生长的药物。 目前， 在国际国内 对于防治龋齿病症以及保护牙齿，大都采用氟通过制成的牙膏，涂敷剂及 含漱剂来完成，其均存在在口腔中停留时间及作用于牙齿的周期相对较短 的缺点，它不利于对上述各种口腔菌的有效抑制。若经常随时随地使用牙 膏、 涂敷剂及含漱剂又存在不很方便、 不很雅观的缺点。 中国专利
94113979. 4 公开了一种防龋齿奶糖及其制造方法， 其配方中也含有茶多 酚的成份，但是它以奶糖作为防治龋齿病症药物的载体很不科学，因奶糖 或者糖类本身就是容易引发龋齿病症的因素之一，并且糖尿病患者则无法 使用； 再者， 该专利中茶多酚在其中的含量较低， 故它所起到抑制有关各 种口腔菌的作用相对比较差。
发明的公开
本发明提供了一种防治龋齿的茶多酚含片及其制备方法，它解决了现 有牙膏、涂敷剂及含漱剂均存在的在口腔中停留时间及作用于牙齿周期较 短、而不利于对各种口腔菌的有效抑制， 以及奶糖作为防治龋齿病症药物 的载体本身对牙齿有一定副作用的问题。
本发明的目的是通过以下技术方案实现的：一种防治龋齿的茶多酚含 片， 它是包括下述重量配比的原料制成的药剂（以重量份计）：
茶多酚 1-7 木糖醇 25-45
甘露醇 20-40 β -环糊精 15-25
天然食品添加剂 7-12 润滑剂 0. 5-2
一种防治龋齿的茶多酚含片的制备方法， 取一定量的 β -环糊精加 2-5倍量的纯化水研匀； 加入一定量的茶多酚后置研磨机内研磨为糊状， 低温干燥为包合物； 取一定量的木糖醇、甘露醇、天然食品添加剂置入微 粉处理机内处理为 400-600目后待用，此时，将上述分别处理后的混合物 料一同置入混合机内混合， 并置入一定量的 95%酒精制成软材， 用尼龙筛 制成颗粒， 再将该颗粒置入烘干箱中 60Ό以下干燥， 干燥后的颗粒与一 定量的润滑剂一同置入混料斗中， 并压制为国家标准的含片状。
为进一步实现本发明的目的还可通过以下技术方案来完成：所述的防 治龋齿的茶多酚含片，它是包括下述重量配比的原料制成的药剂（以重量 份计） ：
茶多酚 2-6 木糖醇 28 - 40
甘露醇 23-36 β -环糊精 17-22
天然食品添加剂 8 - 11 润滑剂 0. 8-1. 6
所述的防治龋齿的茶多酚含片:它是包括下述重量配比的原料制成的 药剂 （以重量份计） ：
茶多酚 3 - 5 木糖醇 32 - 38
甘露醇 25-32 β -环糊精 18-21
天然食品添加剂 9 - 10 润滑剂 0. 9-1. 2
所述的防治龋齿的茶多酚含片:它是包括下述重量配比的原料制成的 药剂 （以重量份计） ：
茶多酚 4-5 木糖醇 35-38
甘露醇 27-30 β -环糊精 18-20
天然食品添加剂 9. 5-10 润滑剂 0. 9-1. 1 ― 所述的防治龋齿的茶多酚含片:它是包括下述重量配比的原料制成的 药剂 （以重量份计） ：
茶多酚 4. 5 木糖醇 36. 7
甘露醇 28. 78 β -环糊精 19. 4
天然食品添加剂 9. 62 润滑剂 1
防治龋齿的茶多酚含片， 所说的茶多酚为纯茶多酚。
所说的药剂是片剂或块型。
所述的防治龋齿的茶多酚含片的制备方法， 木糖醇、甘露醇、天然食 品添加剂混合物料的微粉细度为 450-500目。
所述的防治龋齿的茶多酚含片的制备方法，木糖醇、甘露醇、天然食 品添加剂混合物料的微粉细度为 500目。
实施发明的最佳方式
本发明的防治龋齿的茶多酚含片及其制备方法，它是包括下述重量配 比的原料制成的药剂 （以重量份计） ：
茶多酚 4. 5 木糖醇 36. 7
甘露醇 28. 78 β -环糊精 19. 4
天然食品添加剂 9. 62 润滑剂 1
一种防治龋齿的茶多酚含片的制备方法， 取一定量的 β -环糊精加 2-5倍量的纯化水研匀， 加入一定量的茶多酚后置研磨机内研磨为糊状， 低温干燥为包合物； 取一定量的木糖醇、甘露醇、天然食品添加剂置入微 粉处理机内处理为 500目后待用；此时，将上述分别处理后的混合物料一 同置入混合机内混合， 并置入一定量的 95%酒精制成软材， 用尼龙筛制成 颗粒， 再将该颗粒置入烘干箱中 60Ό以下干燥， 干燥后的颗粒与一定量 的润滑剂一同置入混料斗中， 并压制为国家标准的含片状。
本发明未详细描述的的技术部分均为公知技术。
工业应用性
本发明能够产生的有益效果： 因它采取含片的形式， 所以它在经常 随时随地使用时既方便又雅观； 因它内含茶多酚的量较大，所以它能够有 效抑制口腔致龋菌、变形链球菌及边远链球菌的生长； 因它的原料细度被 处理为 500 目以上， 其硬度较大及含化时间较长， 故在口腔中所停留的 时间以及作用于牙齿的周期相对较长， 它有利于对各种口腔菌的有效抑 制， 其治疗效果比较理想； 因它不含糖类物质， 所以糖尿病患者也可以使 用； 再者， 它含化时口感细腻、 润滑、 无任何颗粒感。

Claims

权 利 要 求 书
1、 一种防治龋齿的茶多酚含片， 其特征在于它是包括下述重量配比 的原料制成的药剂（以重量份计）：
茶多酚 1-7 木糖醇 25-45
甘露醇 20-40 β -环糊精 15-25
天然食品添加剂 7-12 润滑剂 0. 5-2
2、 根据权利要求 1所述的防治龋齿的茶多酚含片， 其特征在于它是 包括下述重量配比的原料制成的药剂 （以重量份计） ：
茶多酚 2-6 木糖醇 28-40
甘露醇 23-36 β -环糊精 17 - 22
天然食品添加剂 8-11 润滑剂 0. 8-1. 6
3、 根据权利要求 1所述的防治龋齿的茶多酚含片， 其特征在于它是 包括下述重量配比的原料制成的药剂 （以重量份计） ：
茶多酚 3-5 木稗醇 32 - 38
甘露醇 25-32 β -环糊精 18-21
天然食品添加剂 9-10 润滑剂 0. 9-1. 2
4、 根据权利要求 1所述的防治龋齿的茶多酚含片， 其特征在于它是 包括下述重量配比的原料制成的药剂 （以重量份计） ：
茶多酚 4-5 木糖醇 35-38
甘露醇 27-30 β -环糊精 18-20
天然食品添加剂 9. 5-10 润滑剂 0. 9-1. 1
5、 根据权利要求 1所述的防治龋齿的茶多酚含片， 其特征在于它是 包括下述重量配比的原料制成的药剂 （以重量份计） ：
茶多酚 4. 5 木糖醇 36. 7
甘露醇 28. 78 β -环糊精 19. 4
天然食品添加剂 9. 62 润滑剂 1
6、根据权利要求 1或 2或 3或 4或 5所述的防治龋齿的茶多酚含片， 其特征在于所说的茶多酚为纯茶多酚。
7、根据权利要求 1或 2或 3或 4或 5所述的防治龋齿的茶多酚含片， 其特征在于该含片的剂型为片剂。
8、 一种防治龋齿的茶多酚含片的制备方法， 其特征在于： 取一定量 的 _环糊精加 2-5倍量的纯化水研匀，加入一定量的茶多酚后置研磨机 内研磨为糊状， 低温干燥为包合物； 取一定量的木糖醇、 甘露醇、 天然食 品添加剂置入微粉处理机内处理为 400-600目后待用；此时，将上述分别 处理后的混合物料一同置入混合机内混合，并置入一定量的 95%酒精制成 软材， 用尼龙筛制成颗粒， 再将该颗粒置入烘干箱中 60°C以下干燥， 干 燥后的颗粒与一定量的润滑剂一同置入混料斗中，并压制为国家标准的含 片状。
9、 根据权利要求 8所述的防治龋齿的茶多酚含片及其制备方法， 其 特征在于： 木糖醇、 甘露醇、 天然食品添加剂混合物料的微粉细度为 450-500目。
10、根据权利要求 8所述的防治龋齿的茶多酚含片及其制备方法， 其 特征在于： 木糖醇、 甘露醇、 天然食品添加剂混合物料的微粉细度为 500 百。
PCT/CN2003/000264 2002-04-17 2003-04-14 Comprime oral a base de polyphenol de the permettant de prevenir et de traiter les caries dentaires, et procede de preparation associe WO2003086359A1 (fr)

Priority Applications (1)

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AU2003236124A AU2003236124A1 (en) 2002-04-17 2003-04-14 Tea polyphenol buccal tablet for preventing and treating tooth decay and its preparing method

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CN02110270A CN1377645A (zh) 2002-04-17 2002-04-17 防治龋齿的茶多酚含片及其制备方法
CN02110270.8 2002-04-17

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CN101829209B (zh) * 2010-04-28 2012-12-05 广西大学 果味甜茶茶多酚的制备方法
CN101926430B (zh) * 2010-08-06 2013-01-23 陈森全 一种多酚口腔含片及其制备方法
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CN110339175A (zh) * 2019-08-19 2019-10-18 云南农业大学 一种预防和治疗口腔溃疡的茶多酚含片
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