WO2003080585A1 - Derive aminobenzamide - Google Patents
Derive aminobenzamide Download PDFInfo
- Publication number
- WO2003080585A1 WO2003080585A1 PCT/JP2003/003656 JP0303656W WO03080585A1 WO 2003080585 A1 WO2003080585 A1 WO 2003080585A1 JP 0303656 W JP0303656 W JP 0303656W WO 03080585 A1 WO03080585 A1 WO 03080585A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- group
- substituted
- amino
- methyl
- benzamide
- Prior art date
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- PXBFMLJZNCDSMP-UHFFFAOYSA-N 2-Aminobenzamide Chemical class NC(=O)C1=CC=CC=C1N PXBFMLJZNCDSMP-UHFFFAOYSA-N 0.000 title description 4
- 150000001875 compounds Chemical class 0.000 claims abstract description 126
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims abstract description 51
- 206010012601 diabetes mellitus Diseases 0.000 claims abstract description 37
- 229910052757 nitrogen Inorganic materials 0.000 claims abstract description 29
- 150000003839 salts Chemical class 0.000 claims abstract description 28
- 125000001072 heteroaryl group Chemical group 0.000 claims abstract description 18
- 125000004432 carbon atom Chemical group C* 0.000 claims abstract description 14
- 125000002950 monocyclic group Chemical group 0.000 claims abstract description 9
- 125000002619 bicyclic group Chemical group 0.000 claims abstract description 7
- 125000003368 amide group Chemical group 0.000 claims abstract description 5
- 229910052799 carbon Inorganic materials 0.000 claims abstract description 5
- 125000000008 (C1-C10) alkyl group Chemical group 0.000 claims abstract description 4
- -1 carbamoyloxy group Chemical group 0.000 claims description 366
- AJDIZQLSFPQPEY-UHFFFAOYSA-N 1,1,2-Trichlorotrifluoroethane Chemical group FC(F)(Cl)C(F)(Cl)Cl AJDIZQLSFPQPEY-UHFFFAOYSA-N 0.000 claims description 50
- 125000004076 pyridyl group Chemical group 0.000 claims description 35
- 125000000335 thiazolyl group Chemical group 0.000 claims description 31
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 27
- 125000001113 thiadiazolyl group Chemical group 0.000 claims description 26
- 125000003710 aryl alkyl group Chemical group 0.000 claims description 24
- 125000003118 aryl group Chemical group 0.000 claims description 24
- 125000005843 halogen group Chemical group 0.000 claims description 24
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 21
- 125000003277 amino group Chemical group 0.000 claims description 20
- 125000001425 triazolyl group Chemical group 0.000 claims description 20
- 125000000714 pyrimidinyl group Chemical group 0.000 claims description 19
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims description 18
- 125000002971 oxazolyl group Chemical group 0.000 claims description 17
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 17
- 125000002883 imidazolyl group Chemical group 0.000 claims description 16
- 239000003795 chemical substances by application Substances 0.000 claims description 15
- UGCSPKPEHQEOSR-UHFFFAOYSA-N 1,1,2,2-tetrachloro-1,2-difluoroethane Chemical group FC(Cl)(Cl)C(F)(Cl)Cl UGCSPKPEHQEOSR-UHFFFAOYSA-N 0.000 claims description 13
- 125000004122 cyclic group Chemical group 0.000 claims description 13
- 230000001225 therapeutic effect Effects 0.000 claims description 13
- 125000006700 (C1-C6) alkylthio group Chemical group 0.000 claims description 12
- 125000003545 alkoxy group Chemical group 0.000 claims description 12
- 125000001786 isothiazolyl group Chemical group 0.000 claims description 12
- 125000004433 nitrogen atom Chemical group N* 0.000 claims description 12
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 claims description 11
- 125000005110 aryl thio group Chemical group 0.000 claims description 11
- 125000001164 benzothiazolyl group Chemical group S1C(=NC2=C1C=CC=C2)* 0.000 claims description 11
- 125000001624 naphthyl group Chemical group 0.000 claims description 11
- 230000000069 prophylactic effect Effects 0.000 claims description 11
- 229920006395 saturated elastomer Polymers 0.000 claims description 11
- 125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 claims description 10
- 125000004739 (C1-C6) alkylsulfonyl group Chemical group 0.000 claims description 9
- 239000004480 active ingredient Substances 0.000 claims description 9
- 125000000842 isoxazolyl group Chemical group 0.000 claims description 9
- 125000004391 aryl sulfonyl group Chemical group 0.000 claims description 8
- 125000003373 pyrazinyl group Chemical group 0.000 claims description 8
- 125000003831 tetrazolyl group Chemical group 0.000 claims description 8
- 125000004454 (C1-C6) alkoxycarbonyl group Chemical group 0.000 claims description 7
- 208000008589 Obesity Diseases 0.000 claims description 7
- 125000004104 aryloxy group Chemical group 0.000 claims description 7
- 125000003785 benzimidazolyl group Chemical group N1=C(NC2=C1C=CC=C2)* 0.000 claims description 7
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 7
- 125000002541 furyl group Chemical group 0.000 claims description 7
- 235000020824 obesity Nutrition 0.000 claims description 7
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical group [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims description 6
- 125000004093 cyano group Chemical group *C#N 0.000 claims description 6
- 125000005493 quinolyl group Chemical group 0.000 claims description 6
- 125000003354 benzotriazolyl group Chemical group N1N=NC2=C1C=CC=C2* 0.000 claims description 5
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims description 5
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 claims description 5
- 125000004514 1,2,4-thiadiazolyl group Chemical group 0.000 claims description 4
- 125000004520 1,3,4-thiadiazolyl group Chemical group 0.000 claims description 4
- 125000005236 alkanoylamino group Chemical group 0.000 claims description 4
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims description 4
- 125000005099 aryl alkyl carbonyl group Chemical group 0.000 claims description 4
- 125000002102 aryl alkyloxo group Chemical group 0.000 claims description 4
- 125000004193 piperazinyl group Chemical group 0.000 claims description 4
- 125000000168 pyrrolyl group Chemical group 0.000 claims description 4
- FVQDAMVODWHNOJ-VIFPVBQESA-N (2s)-2-(carboxymethylamino)-3-phenylpropanoic acid Chemical group OC(=O)CN[C@H](C(O)=O)CC1=CC=CC=C1 FVQDAMVODWHNOJ-VIFPVBQESA-N 0.000 claims description 3
- 125000004738 (C1-C6) alkyl sulfinyl group Chemical group 0.000 claims description 3
- 125000004890 (C1-C6) alkylamino group Chemical group 0.000 claims description 3
- 239000012190 activator Substances 0.000 claims description 3
- 125000004414 alkyl thio group Chemical group 0.000 claims description 3
- 125000003435 aroyl group Chemical group 0.000 claims description 3
- 125000004541 benzoxazolyl group Chemical group O1C(=NC2=C1C=CC=C2)* 0.000 claims description 3
- 239000003610 charcoal Substances 0.000 claims description 3
- 125000001070 dihydroindolyl group Chemical group N1(CCC2=CC=CC=C12)* 0.000 claims description 3
- 125000003838 furazanyl group Chemical group 0.000 claims description 3
- 125000002632 imidazolidinyl group Chemical group 0.000 claims description 3
- 125000001041 indolyl group Chemical group 0.000 claims description 3
- 125000003386 piperidinyl group Chemical group 0.000 claims description 3
- 125000000719 pyrrolidinyl group Chemical group 0.000 claims description 3
- 125000000147 tetrahydroquinolinyl group Chemical group N1(CCCC2=CC=CC=C12)* 0.000 claims description 3
- 125000001951 carbamoylamino group Chemical group C(N)(=O)N* 0.000 claims description 2
- 125000000904 isoindolyl group Chemical group C=1(NC=C2C=CC=CC12)* 0.000 claims description 2
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 claims description 2
- 125000004309 pyranyl group Chemical group O1C(C=CC=C1)* 0.000 claims description 2
- 125000001183 hydrocarbyl group Chemical group 0.000 claims 16
- 125000004429 atom Chemical group 0.000 claims 1
- 125000003943 azolyl group Chemical group 0.000 claims 1
- 125000001589 carboacyl group Chemical group 0.000 claims 1
- 125000002843 carboxylic acid group Chemical group 0.000 claims 1
- 125000000000 cycloalkoxy group Chemical group 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 claims 1
- 150000002367 halogens Chemical class 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract description 72
- 230000000694 effects Effects 0.000 abstract description 17
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract description 6
- 206010012689 Diabetic retinopathy Diseases 0.000 abstract description 4
- 208000007342 Diabetic Nephropathies Diseases 0.000 abstract description 3
- 208000032131 Diabetic Neuropathies Diseases 0.000 abstract description 3
- 206010063547 Diabetic macroangiopathy Diseases 0.000 abstract description 3
- 208000033679 diabetic kidney disease Diseases 0.000 abstract description 3
- 239000001257 hydrogen Substances 0.000 abstract description 3
- 102000030595 Glucokinase Human genes 0.000 abstract description 2
- 108010021582 Glucokinase Proteins 0.000 abstract description 2
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 description 133
- 238000004992 fast atom bombardment mass spectroscopy Methods 0.000 description 115
- 238000002360 preparation method Methods 0.000 description 111
- 238000005481 NMR spectroscopy Methods 0.000 description 51
- OKKJLVBELUTLKV-MZCSYVLQSA-N Deuterated methanol Chemical compound [2H]OC([2H])([2H])[2H] OKKJLVBELUTLKV-MZCSYVLQSA-N 0.000 description 42
- 238000006243 chemical reaction Methods 0.000 description 42
- 150000002430 hydrocarbons Chemical group 0.000 description 42
- KXDAEFPNCMNJSK-UHFFFAOYSA-N Benzamide Chemical group NC(=O)C1=CC=CC=C1 KXDAEFPNCMNJSK-UHFFFAOYSA-N 0.000 description 37
- 238000000034 method Methods 0.000 description 34
- 125000006239 protecting group Chemical group 0.000 description 29
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 27
- 125000000217 alkyl group Chemical group 0.000 description 27
- 239000000243 solution Substances 0.000 description 27
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 25
- 239000008103 glucose Substances 0.000 description 25
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 24
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 21
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 21
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 18
- 239000000203 mixture Substances 0.000 description 17
- 230000002829 reductive effect Effects 0.000 description 16
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 15
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 15
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 14
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 14
- 239000002253 acid Substances 0.000 description 13
- 239000002585 base Substances 0.000 description 13
- 239000008280 blood Substances 0.000 description 13
- 210000004369 blood Anatomy 0.000 description 13
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 12
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 12
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 11
- 239000003814 drug Substances 0.000 description 11
- 230000003213 activating effect Effects 0.000 description 10
- 150000001408 amides Chemical class 0.000 description 10
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 10
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 9
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical group C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 9
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 9
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 description 9
- 229940079593 drug Drugs 0.000 description 9
- 238000000746 purification Methods 0.000 description 9
- 238000003786 synthesis reaction Methods 0.000 description 9
- GOJUJUVQIVIZAV-UHFFFAOYSA-N 2-amino-4,6-dichloropyrimidine-5-carbaldehyde Chemical group NC1=NC(Cl)=C(C=O)C(Cl)=N1 GOJUJUVQIVIZAV-UHFFFAOYSA-N 0.000 description 8
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 8
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 description 8
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 description 8
- 238000009472 formulation Methods 0.000 description 8
- 210000004185 liver Anatomy 0.000 description 8
- NEPIZAVYXKHUCD-UHFFFAOYSA-N n-(4-methyl-1,3-thiazol-2-yl)benzamide Chemical compound CC1=CSC(NC(=O)C=2C=CC=CC=2)=N1 NEPIZAVYXKHUCD-UHFFFAOYSA-N 0.000 description 8
- 239000002904 solvent Substances 0.000 description 8
- 125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 description 7
- 229910052783 alkali metal Inorganic materials 0.000 description 7
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 7
- 230000002218 hypoglycaemic effect Effects 0.000 description 7
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical group CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 7
- 208000001072 type 2 diabetes mellitus Diseases 0.000 description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 7
- 125000006091 1,3-dioxolane group Chemical group 0.000 description 6
- JGFZNNIVVJXRND-UHFFFAOYSA-N N,N-Diisopropylethylamine (DIPEA) Chemical compound CCN(C(C)C)C(C)C JGFZNNIVVJXRND-UHFFFAOYSA-N 0.000 description 6
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 6
- 125000005153 alkyl sulfamoyl group Chemical group 0.000 description 6
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 description 6
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 description 6
- 239000003153 chemical reaction reagent Substances 0.000 description 6
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- 125000003396 thiol group Chemical group [H]S* 0.000 description 6
- NGNBDVOYPDDBFK-UHFFFAOYSA-N 2-[2,4-di(pentan-2-yl)phenoxy]acetyl chloride Chemical compound CCCC(C)C1=CC=C(OCC(Cl)=O)C(C(C)CCC)=C1 NGNBDVOYPDDBFK-UHFFFAOYSA-N 0.000 description 5
- GWRSATNRNFYMDI-UHFFFAOYSA-N 4-[(9-cyclopentyl-7,7-difluoro-5-methyl-6-oxo-8h-pyrimido[4,5-b][1,4]diazepin-2-yl)amino]-2-fluoro-5-methoxy-n-(1-methylpiperidin-4-yl)benzamide Chemical compound FC=1C=C(NC=2N=C3N(C4CCCC4)CC(F)(F)C(=O)N(C)C3=CN=2)C(OC)=CC=1C(=O)NC1CCN(C)CC1 GWRSATNRNFYMDI-UHFFFAOYSA-N 0.000 description 5
- NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonia chloride Chemical compound [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 description 5
- 108090000790 Enzymes Proteins 0.000 description 5
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- 125000002252 acyl group Chemical group 0.000 description 5
- 239000007864 aqueous solution Substances 0.000 description 5
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- 238000010998 test method Methods 0.000 description 5
- OISVCGZHLKNMSJ-UHFFFAOYSA-N 2,6-dimethylpyridine Chemical compound CC1=CC=CC(C)=N1 OISVCGZHLKNMSJ-UHFFFAOYSA-N 0.000 description 4
- VHYFNPMBLIVWCW-UHFFFAOYSA-N 4-Dimethylaminopyridine Chemical compound CN(C)C1=CC=NC=C1 VHYFNPMBLIVWCW-UHFFFAOYSA-N 0.000 description 4
- QMHIMXFNBOYPND-UHFFFAOYSA-N 4-methylthiazole Chemical compound CC1=CSC=N1 QMHIMXFNBOYPND-UHFFFAOYSA-N 0.000 description 4
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- ZRALSGWEFCBTJO-UHFFFAOYSA-N Guanidine Chemical compound NC(N)=N ZRALSGWEFCBTJO-UHFFFAOYSA-N 0.000 description 4
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- 108700040460 Hexokinases Proteins 0.000 description 4
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- 241000699670 Mus sp. Species 0.000 description 4
- JLTDJTHDQAWBAV-UHFFFAOYSA-N N,N-dimethylaniline Chemical compound CN(C)C1=CC=CC=C1 JLTDJTHDQAWBAV-UHFFFAOYSA-N 0.000 description 4
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- SMWDFEZZVXVKRB-UHFFFAOYSA-N Quinoline Chemical compound N1=CC=CC2=CC=CC=C21 SMWDFEZZVXVKRB-UHFFFAOYSA-N 0.000 description 4
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- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 4
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 4
- 239000000654 additive Substances 0.000 description 4
- 150000001340 alkali metals Chemical class 0.000 description 4
- 150000003936 benzamides Chemical class 0.000 description 4
- 210000004027 cell Anatomy 0.000 description 4
- 238000004587 chromatography analysis Methods 0.000 description 4
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- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 description 4
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- 230000004153 glucose metabolism Effects 0.000 description 4
- AWJUIBRHMBBTKR-UHFFFAOYSA-N isoquinoline Chemical compound C1=NC=CC2=CC=CC=C21 AWJUIBRHMBBTKR-UHFFFAOYSA-N 0.000 description 4
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- CTSLXHKWHWQRSH-UHFFFAOYSA-N oxalyl chloride Chemical compound ClC(=O)C(Cl)=O CTSLXHKWHWQRSH-UHFFFAOYSA-N 0.000 description 4
- 125000001147 pentyl group Chemical group C(CCCC)* 0.000 description 4
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 description 4
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 4
- 125000000246 pyrimidin-2-yl group Chemical group [H]C1=NC(*)=NC([H])=C1[H] 0.000 description 4
- 238000010898 silica gel chromatography Methods 0.000 description 4
- 229910052708 sodium Inorganic materials 0.000 description 4
- 239000011734 sodium Substances 0.000 description 4
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 4
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 4
- GETQZCLCWQTVFV-UHFFFAOYSA-N trimethylamine Chemical compound CN(C)C GETQZCLCWQTVFV-UHFFFAOYSA-N 0.000 description 4
- WSLDOOZREJYCGB-UHFFFAOYSA-N 1,2-Dichloroethane Chemical compound ClCCCl WSLDOOZREJYCGB-UHFFFAOYSA-N 0.000 description 3
- 125000000339 4-pyridyl group Chemical group N1=C([H])C([H])=C([*])C([H])=C1[H] 0.000 description 3
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 3
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- ZUOUZKKEUPVFJK-UHFFFAOYSA-N phenylbenzene Natural products C1=CC=CC=C1C1=CC=CC=C1 ZUOUZKKEUPVFJK-UHFFFAOYSA-N 0.000 description 1
- 125000000109 phenylethoxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])O* 0.000 description 1
- 125000003356 phenylsulfanyl group Chemical group [*]SC1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 description 1
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- 229910000105 potassium hydride Inorganic materials 0.000 description 1
- LPNYRYFBWFDTMA-UHFFFAOYSA-N potassium tert-butoxide Chemical compound [K+].CC(C)(C)[O-] LPNYRYFBWFDTMA-UHFFFAOYSA-N 0.000 description 1
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- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 description 1
- 125000002572 propoxy group Chemical group [*]OC([H])([H])C(C([H])([H])[H])([H])[H] 0.000 description 1
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- XGVXKJKTISMIOW-ZDUSSCGKSA-N simurosertib Chemical compound N1N=CC(C=2SC=3C(=O)NC(=NC=3C=2)[C@H]2N3CCC(CC3)C2)=C1C XGVXKJKTISMIOW-ZDUSSCGKSA-N 0.000 description 1
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- 125000004213 tert-butoxy group Chemical group [H]C([H])([H])C(O*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
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- 125000001973 tert-pentyl group Chemical group [H]C([H])([H])C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
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- HPGGPRDJHPYFRM-UHFFFAOYSA-J tin(iv) chloride Chemical compound Cl[Sn](Cl)(Cl)Cl HPGGPRDJHPYFRM-UHFFFAOYSA-J 0.000 description 1
- OGIDPMRJRNCKJF-UHFFFAOYSA-N titanium oxide Inorganic materials [Ti]=O OGIDPMRJRNCKJF-UHFFFAOYSA-N 0.000 description 1
- 125000003944 tolyl group Chemical group 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- HSMVPDGQOIQYSR-KGENOOAVSA-N triflumizole Chemical compound C1=CN=CN1C(/COCCC)=N/C1=CC=C(Cl)C=C1C(F)(F)F HSMVPDGQOIQYSR-KGENOOAVSA-N 0.000 description 1
- HRXKRNGNAMMEHJ-UHFFFAOYSA-K trisodium citrate Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O HRXKRNGNAMMEHJ-UHFFFAOYSA-K 0.000 description 1
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/426—1,3-Thiazoles
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- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- C—CHEMISTRY; METALLURGY
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/44—Acylated amino or imino radicals
- C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Definitions
- the present invention relates to a dalcokinase activator containing an aminobenzamide amide derivative as an active ingredient, and further relates to a novel aminobenzamide derivative or a salt thereof.
- Dalcokinase (ATP: Dhe exose 6-phosphotran sferaze, EC 2.7.1.1.1) is one of four mammalian hexokinase types (hexokinase IV). It is. Hexokinase is the very first enzyme in the glycolytic pathway, catalyzing the glucose-to-glucose-6-phosphate reaction. Glucokinase is mainly expressed in the liver and kidney cells and plays an important role in whole body glucose metabolism by controlling the rate-limiting step of glucose metabolism in those cells. . The darcokinase in the liver and in the liver of the lentil have different N-terminal 15 amino acid sequences due to differences in splicing, but have the same enzymatic properties.
- dalcokinase acts as a glucose sensor in cells and liver of the gut.
- Recent results from dalcokinase-engineered mice have shown that dalcokinase does indeed play an important role in systemic glucose homeostasis. Mice with disrupted dalcokinase gene die shortly after birth, whereas mice overexpressing dalcokinase have low blood glucose levels. It becomes.
- the response of S-extracted beta cells to hepatocytes depends on the increase in glucose concentration, but all correspond to the direction of lowering blood glucose. Spleen cells will secrete more insulin, and the liver will take up and store sugar as glycogen, while reducing sugar release.
- dalcokinase acts as a glucose sensor in humans and plays an important role in glucose homeostasis.
- blood glucose control using the glycokinase sensor system may be possible in many type II diabetes patients. Since the darcokinase activator is expected to have an action to promote the secretion of insulin by pancreatic pancreatic cells and an action to enhance the uptake of glucose and suppress the release of glucose in the liver, it is considered to be useful as a therapeutic agent for patients with type I diabetes.
- VMH Ventrom dial hypot a1 amus
- Approximately 20% of neurons in VMH are called glucose-responsible neurons, and have long been thought to play an important role in weight control.
- glucose is administered to the brain of rats, food intake is reduced, whereas when glucose metabolism is suppressed by intracerebral administration of a glucose analog, dalcosamine, overeating occurs.
- glucose responsive bite is activated in response to a physiological change in glucose concentration (5-20 mM), but its activity is suppressed when glucose metabolism is suppressed by dalcosamine or the like.
- VHM darcokinase A mechanism similar to dalcokinase, similar to the secretion of insulin by secretory basal cells, is assumed for the Vulk's concentration detection system. Therefore, substances that activate VHM darcokinase in addition to liver and kidney beta cells have no effect on blood sugar correction. In addition, it may be able to correct obesity, which is a problem in many type II diabetics.
- compounds having a darcokinase activating action can be used as therapeutic and / or prophylactic agents for diabetes, or as diabetics such as retinopathy, nephropathy, neurosis, ischemic heart disease, and arterial infarction. It is useful as a therapeutic and / or prophylactic agent for chronic complications of the present invention, and as a therapeutic and / or prophylactic agent for obesity.
- the above compound does not have an amino group in the benzamide skeleton, and is structurally different from the compound according to the present invention.
- the use of the compound represented by the above formula (I ⁇ ) relates to a CDK inhibitor ⁇ an anticancer agent and the like.
- the diabetes used as the use according to the present invention is described in WO00 / 26202. There is no description, nor is there any description suggesting this.
- the compound (IV) does not have a nitrogen atom next to the carbon atom bonded to the nitrogen atom of the NH group of the carbamoyl group, and is structurally different from the present compound.
- the use of the compound (V) relates to Factor Xa, but is different from the diabetes used in the present application.
- WO 00/39118 which discloses the compound (IV)
- compound (IV) is also useful as a therapeutic and / or prophylactic agent for diabetes, and there is no description suggesting this. Equation (V)
- the above compound (V) has a piperazinyl group on the side of the amido group on the side of the proponyl group, and is clearly structurally different from the present invention. Further, these compounds are related to a Factor Xa inhibitor, and are clearly different from the diabetic used in the compound of the present invention in terms of use. There is no suggestion that it is useful.
- the compound has a nitro group on the benzamide skeleton and is structurally different from the compound of the present application having an amino group.
- the compound represented by the formula (VII) has a methoxy group in R 1 , and has a benzamide skeleton. Since it has no amino group, it is structurally different from the present compound. Disclosure of the invention
- An object of the present invention is to provide a therapeutic and / or prophylactic agent for diabetes which binds to dalcokinase to increase the activity of dalcokinase, and to stimulate the satiety center by activating dalcokinase.
- a therapeutic and / or prophylactic agent for diabetes which binds to dalcokinase to increase the activity of dalcokinase, and to stimulate the satiety center by activating dalcokinase.
- the compound according to the present invention has advantages such as being superior to existing diabetic drugs, and being able to develop new medicinal properties which are not possessed by existing diabetic drugs. There is.
- the present inventors have conducted intensive studies to develop a novel diabetic drug having a new drug effect, having a drug effect higher than that of the existing diabetic drug by a mechanism of action different from that of the above-mentioned existing drug.
- the compound represented by the formula (I) has a dalcokinase activating action, and have completed the present invention. That is, the present invention
- R 1 represents one S ( ⁇ ) p-A, -S- ( ⁇ ) d-B or one-D (where p and Q are the same or different and are 0 to 2 indicates the integer
- a is shows the C 1 one C 10 alkyl group which may a straight optionally substituted with R 1Q, B and D, their respective independently optionally substituted with R 1Q shows the R 12
- R 2 represents a hydrogen atom, a halo gen atom or R 1Q optionally substituted straight or branched C 1 -C 6 alkyl group
- X 1 and X 2 are each independently N Or CH (however, X 1 and X 2 are not simultaneously N), and represented by the formula (II)
- R 1Q represents a hydrocarbon group which may be substituted with R 11 or R 11
- R 11 is a hydrogen atom, an amino group, a carbamoyl group, a carbamoylamino group, a carbamoyloxy group, a carboxyl group, a cyano group , Sulfamoyl group, trifluoromethyl group, halogen atom, hydroxy group, formyl group, linear C1-C6 alkyl group, cyclic C3-C9 hydrocarbon group, aralkyl group, N-aralkylamino group, N, N Diaralkylamino group, aralkyloxy group, aralkylcarbonyl group, N-aralkyl group,
- R 1 () of A represents a hydrocarbon group which may be substituted with R 111 or R 111
- R 12 of B may be a phenyl group which may be substituted with R 1G.
- R 1Q of B represents a hydrocarbon group which may be substituted with R 111 or R 111
- R 12 of D represents R a phenyl group which may be substituted with 1Q
- ⁇ Indicates a hydrocarbon group which may be substituted with ⁇ or 111 , and R 1Q of the heteroaryl group represented by formula (II) may be substituted with R 112 or R 112.
- the heteroaryl group of the formula (II) is a thiazolyl group, an imidazolyl group, A ryl group, 1,2,4-thiadiazolyl group, 1,3,4-thiadiazolyl group, triazolyl group, oxazolyl group, isoxazolyl group, pyrazinyl group, pyridyl group, pyrimidinyl group, pyridothiazolyl group or benzothiazolyl group;
- R 1Q of A is a hydrocarbon group which may be substituted with R 113 or R 113
- R 12 of B may be a phenyl group which may be substituted with R 1Q , Imidazolyl, oxazolyl, thiazolyl, thiadiazolyl, triazolyl, tetrazolyl, pyridyl, pyrimidinyl, ethylenedioxyphenyl, methylenedioxyphenyl or pyridothiazolyl
- R 1Q of B Is a hydrocarbon group which may be substituted with R 113 or R 113
- R 12 of D may be a phenyl group, a naphthyl group, a pyridyl group, an ethylenedioxyphenyl which may be substituted with R 1 Q a group or a methylenedioxy O carboxymethyl-phenylalanine group, a R 1Q is R 113, or which may be optional
- the heteroaryl group of the formula (II) is a thiazolyl group.
- R 1Q of A is R 113 or a hydrocarbon group optionally substituted with R 113
- R 12 of B is R 1 .
- a phenyl group, imidazolyl group, oxazolyl group, thiazolyl group, thiadiazolyl group, triazolyl group, pyridyl group, pyrimidinyl group, ethylenedioxyphenyl group, methylenedioxyphenyl group or pyridothiazolyl group which may be substituted with R 1Q of R is R 113 or a hydrocarbon group optionally substituted with R 113
- R 12 of D is R 1 .
- R 1Q of R 2 is a hydrocarbon group which may be substituted with R 113 or R 113
- R 113 is a hydrogen atom, a propyloxyl group, a trifluoromethyl Group, halogen atom, hydroxy group, linear C 1 -C 6 alkyl group, cyclic saturated C 3 -C 9 hydrocarbon group, C 1 -C 6 alkoxy group, C 1 -C 6 alkoxycarbonyl group, A C 1 -C 6 alkylthio group or a C 1 -C 6 alkylsulfonyl group; and
- R 1Q of (II) is R 114 or a hydrocarbon group which may be substituted with R 114 , and R 114 is a hydrogen atom, a carboxyl group, a trifluoromethyl group, a halogen atom, a hydroxy group, an aryl group A compound which is an arylthio group, a linear C 1 -C 6 alkyl group, a C 1 -C 6 alkylthio group, a C 1 -C 6 alkoxy group or a C 1 -C 6 alkoxycarbonyl group,
- a glucokinase activator comprising the compound according to any of (1) to (10) as an active ingredient
- a therapeutic or Z or preventive agent for diabetes mellitus comprising the compound according to any one of (1) to (10) as an active ingredient
- a therapeutic and / or prophylactic agent for diabetes or obesity comprising the compound according to any one of (1) to (10) as an active ingredient,
- a therapeutic and / or Z- or prophylactic agent for obesity comprising as an active ingredient the compound according to any of (1) to (10).
- aryl group examples include a hydrocarbon ring aryl group having 6 to 14 carbon atoms such as a phenyl group, a naphthyl group, a biphenyl group, and an anthryl group.
- the “lower alkyl group” preferably means a linear or branched alkyl group having 1 to 6 carbon atoms, for example, a methyl group, an ethyl group, a propyl group, an isopropyl group, a butyl group, an isobutyl group, a sec-butyl group.
- Cycloalkyl group means a monocyclic saturated hydrocarbon group having 3 to 9 carbon atoms, and examples thereof include a cyclopropyl group, a cyclobutyl group, a cyclopentyl group, a cyclohexyl group, and a cycloheptyl group.
- “Lower alkoxy group” means a group in which a hydrogen atom of a 7K acid group is substituted with the lower alkyl group, for example, a methoxy group, an ethoxy group, a propoxy group, and an isopropoxy group.
- the “aralkyl group” means the lower alkyl group having the aryl group, and examples thereof include a benzyl group, an 11-phenylethyl group, a 2-phenylethyl group, an 11-naphthylmethyl group, and a 2-naphthylmethyl group. .
- aralkylamino group means a group in which a hydrogen atom of an amino group is mono-substituted with the aralkyl group, and examples thereof include a benzylamino group and a phenethylamino group.
- Diaralkylamino group means a group in which hydrogen atoms of the same or different amino groups are di-substituted by the above-mentioned aralkyl group.
- dibenzylamino group N-benzyl-2-phenylethylamino And the like.
- aralkyl molybamoyl group refers to a group in which a hydrogen atom bonded to the nitrogen atom of a molybmoyl group is monosubstituted with the aralkyl group, and is preferably, for example, a benzylcarbamoyl group or a phenylethylcarbamoyl group. .
- Alkylsulfamoyl group means a group in which the hydrogen atom of NH 2 of the alkylsulfamoyl group is mono-substituted with the alkyl group, for example, methylsulfamoyl group, ethylsulfamoyl group, isopropylsulfamoyl group. Moils and the like are preferred.
- Dialkylsulfamoyl group means a group in which the hydrogen atom of NH 2 of the alkylsulfamoyl group is disubstituted with the same or different alkyl group, for example, a dimethylsulfamoyl group, And a moyl group and a methylethylsulfamoyl group.
- Heteroaryl group means a 4- to 7-membered monocyclic ring having 1 to 3 heteroatoms selected from the group consisting of oxygen, sulfur and nitrogen in the heteroaryl group, or A bicyclic heteroaryl group in which the monocyclic heteroaryl group is condensed with a benzene ring or a pyridin ring, such as a furyl group, a phenyl group, a pyrrolyl group, an imidazolyl group, a pyrazolyl group, a thiazolyl group, and a thiadiazolyl group.
- Examples include a zolyl group, a benzothiazolyl group, an oxazolopyridyl group, a pyridothiazolyl group, an isothiazolopyridyl group, and a benzochenyl group.
- Halogen atom means, for example, a fluorine atom, a chlorine atom, a bromine atom, an iodine atom and the like.
- lower alkyl group refers to a group that is monosubstituted with the lower alkyl group, for example, methylcarbamoyl group, engineered carbamoyl group, propyl group, and isopropyl group.
- methylcarbamoyl group engineered carbamoyl group, propyl group, and isopropyl group.
- sec-butylcarbamoyl group tert-butylcarbamoyl group and the like.
- di-lower alkylcarbamoyl group refers to a disubstituted disubstituted with the same or different lower alkyl group.
- examples of the “di-lower alkylsubstituted rubamoyl group” include dimethylcarbamoyl and And a rucarbamoyl group, an ethylmethyl carbamoyl group, a dipropyl rubamoyl group, a methyl propyl rubamoyl group, and a diisopropyl rubumbyl group.
- lower alkylamino group means an amino group mono-substituted by the lower alkyl group, for example, a methylamino group, an ethylamino group, a propylamino group, an isopropylamino group, a butylamino group, a sec-butylamino group or a tert-amino group. And a butylamino group.
- di-lower alkylamino group means an amino group di-substituted by the same or different lower alkyl groups, such as dimethylamino, getylamino, dipropylamino, methylpropylamino or diisopropylamino. No.
- the “aralkylamino group” means a group in which a hydrogen atom of an amino group is mono-substituted with the aralkyl group, and examples thereof include a benzylamino group, a phenylethylamino group and a 2-phenylethylamino group.
- Can be "Diaralkylamino group” means a group in which a hydrogen atom of an amino group is disubstituted with the aralkyl group, and examples thereof include a dibenzylamino group, a diphenylethylamino group, and a benzylphenylethylamino group.
- the aralkyl groups may be the same or different.
- the “aralkyloxy group” means a group in which the aralkyl group and an oxygen atom are bonded, and examples thereof include a benzyloxy group, a phenylethyloxy group, and a 2-phenylethyloxy group.
- aralkylcarbonyl group means a group in which the aralkyl group and the carbonyl group are bonded, and examples thereof include a benzylcarbonyl group and a phenylethylcarbonyl group.
- the “aralkyl molybmoyl group” means a group in which a hydrogen atom of a molybmoyl group is mono-substituted with the aralkyl group. Examples thereof include a benzylcarbamoyl group, a phenylethylcarbamoyl group, and a 2-phenylphenylcarbamoyl group. And the like.
- arylthio group means a group in which a hydrogen atom of a thiol group is substituted with the above aryl group, and examples thereof include a phenylthio group, a naphthylthio group, and a biphenylthio group.
- arylamino group means a group in which a hydrogen atom of an amino group is monosubstituted with the above aryl group, and examples thereof include a phenylamino group, a naphthylamino group, and a biphenylamino group.
- aryloxy group means a group in which a hydrogen atom of a hydroxyl group is substituted with the above aryl group, and examples thereof include a phenyloxy group, a naphthyloxy group, and a biphenyloxy group.
- arylsulfonyl group means a group in which the aryl group and a sulfonyl group are bonded, and examples thereof include a phenylsulfonyl group and a naphthylsulfonyl group.
- arylsulfonyloxy group means a group in which a hydrogen atom of a hydroxyl group is substituted with the above-mentioned arylsulfonyl group, and examples thereof include a phenylsulfonyloxy group and a biphenylsulfonyloxy group. .
- Arylsulfonylamino group means that the hydrogen atom of an amino group is It means a group mono-substituted by a ruphonyl group, and examples thereof include a phenylsulfonylamino group, a naphthylsulfonylamino group, and a biphenylsulfonylamino group.
- arylsulfamoyl group means a group in which a hydrogen atom of a sulfamoyl group is monosubstituted with an aryl group, and examples thereof include a phenylsulfamoyl group, a naphthylsulfamoyl group, and a biphenylsulfamoyl group.
- arylcarbamoyl group means a group in which a hydrogen atom of a carbamoyl group is monosubstituted with an aryl group, and examples thereof include a phenylcarbamoyl group, a naphthylcarbamoyl group, and a biphenylcarbamoyl group. .
- the “aroyl group” means a group in which the above aryl group and a carbonyl group are bonded, and examples thereof include a phenylcarbonyl group and a naphthylcarbonyl group.
- Aloxy group means a group in which the above-mentioned arylo group is bonded to an oxygen atom, and includes, for example, a phenylcarpoxy group, a naphthylcarpoxy group and the like.
- Alkanoyl group means a group in which the above-mentioned alkyl group and carbonyl group are bonded, and examples thereof include a methylcarbonyl group, an ethylcarbonyl group, a propylcarbonyl group, and an isopropylpropylcarbonyl group.
- alkanoylamino group means a group in which the above-mentioned alkanoyl group is bonded to an amino group, and examples thereof include a methylcarbonylamino group, an ethylcarbonylamino group, and an isopropylpropylamino group.
- alkylthio group means a group in which the alkyl group and a sulfur atom are bonded, and examples thereof include a methylthio group, an ethylthio group, a propylthio group, and an isopropylthio group.
- alkylsulfamoyl group means a group in which a hydrogen atom of a sulfamoyl group is mono-substituted with the above-mentioned alkyl group. Examples thereof include a methylsulfamoyl group, an ethylsulfamoyl group, a propylsulfamoyl group, and an isopropylsulfamoyl group. Moyl groups and the like.
- Dialkylsulfamoyl group means a group in which a hydrogen atom of a sulfamoyl group is disubstituted with the above-mentioned alkyl group, and examples thereof include a dimethylsulfamoyl group, a methylsulfamoyl group, and a methylethylsulfamoyl group. And the alkyl groups may be the same or different.
- alkylsulfinyl group means a group in which the alkyl group and the sulfinyl group are bonded, and examples thereof include a methylsulfinyl group, an ethylsulfinyl group, and an isopropylsulfinyl group.
- alkylsulfonyl group means a group in which the alkyl group and the sulfonyl group are bonded, and examples thereof include a methylsulfonyl group, an ethylsulfonyl group, a propylsulfonyl group, and an isopropylsulfonyl group.
- alkylsulfonylamino group means a group in which a hydrogen atom of an amino group is monosubstituted with the alkylsulfonyl group, for example, a methylsulfonylamino group, an ethylsulfonylamino group, a propylsulfonylamino group or And an isopropylpropylsulfonylamino group.
- Alkoxycarbonyl group means a group in which a hydrogen atom of a carboxyl group is substituted with the above-mentioned alkyl group, and examples thereof include a methoxycarbonyl group, an ethoxycarbonyl group, a propylcarbonyl group, and an isopropylpropyl group.
- “Hydrocarbon group” refers to a straight-chain alkyl group having 1 to 6 carbon atoms, or one or two, preferably one, of the carbon atoms constituting the straight-chain alkyl group. May be replaced by a nitrogen atom, a sulfur atom or an oxygen atom, or Z and the carbon atoms in the linear alkyl group having 1 to 6 carbon atoms are bonded by a double bond or a triple bond. Good. The number of the double bond or triple bond is preferably 1 or 2, and more preferably 1.
- hydrocarbon group specifically, for example, a methyl group, an ethyl group, a propyl group, an isopropyl group or a butyl group, or the following formula (VIII)
- cyclic C 3 -C 9 hydrocarbon group means a group in which a saturated or unsaturated hydrocarbon group having 3 to 9 carbon atoms forms a ring structure among the hydrocarbon groups.
- the cyclic C 3 -C 9 hydrocarbon group is preferably a cyclic saturated hydrocarbon group having 3 to 9 carbon atoms.
- the cyclic C 3 -C 9 hydrocarbon group is, for example, a cyclopropyl group, a cyclobutyl group, a cyclopentyl group or a cyclohexyl group. More preferably, it is a butyl group or a pentyl group.
- R 1 represents one S (0) p—A, one S (0) q—B or one-D.
- p and q each independently represent an integer of 0 to 2.
- p and q are each independently preferably 0 or 2, and more preferably 0.
- A is R 1 .
- Examples of the “linear C 1 -C 10 alkyl group” in A include a methyl group, an ethyl group, a propyl group, a butyl group, a pentyl group, and a hexyl group. Of these, a methyl group and an ethyl group , A propyl group or a butyl group is preferable, and a methyl group, an ethyl group, or a propyl group is more preferable.
- linear C 1 -C 10 alkyl group of A may be bonded to the hydrocarbon group of R 1 Q to form a 3 to 7 ring structure.
- the ring structure of A is preferably, for example, a cyclopropyl group, a cyclobutyl group, a cyclopentyl group, a cyclohexyl, a cycloheptyl group or the like. .
- A is, for example, methyl, ethyl, propyl, cyclopropyl, isopropyl, butyl, pentyl, cyclopentyl, cyclohexyl, Chloroheptyl group and the like.
- methyl group, ethyl group, propyl group, isopropyl group, butyl group, cyclopentyl group and cyclohexyl group are preferred, and methyl group, ethyl group, propyl group and isopropyl group are preferred.
- Groups, cyclopentyl groups, cyclohexyl groups and the like are more preferred.
- R 1Q represents R 11 or a linear hydrocarbon group which may be substituted with R 11 .
- R 11 is a hydrogen atom, amino group, sorbamoyl group, rubamoylamino group, rubamoyloxy group, carboxyl group, cyano group, sulfamoyl group, trifluoromethyl group, halogen atom, hydroxy group, formyl group, cyclic C 3 — C 9 Hydrocarbon group, aralkyl group, N-aralkylamino group, N, N-diaralkylamino group, aralkyloxy group, aralkylcarbonyl group, N-aralkyl group, rubylmoyl group, aryl group, perylthio group, N- ⁇ Arylamino, aryloxy, arylsulfonyl, arylsulfonyloxy, N-arylsulfonylamino, arylsulfamoyl, N
- R 111 or a hydrocarbon group optionally substituted with R 111 is preferable, and a hydrocarbon group optionally substituted with R 113 or R 113 is more preferable.
- R 111 is a hydrogen atom, a linear C 1 -C 6 alkyl group, a carbamoyloxy group, a carboxy group, a cyano group, a trifluoromethyl group, a halogen atom, a hydroxy group, a cyclic saturated C 3—C 9 hydride group, aralkyl group, aryl group, arylo group, aroxy group, C 1 -C 6 alkylthio group, C 1 -C 6 alkoxy group or C 1 -C 6 alkoxycarbonyl group, and R 113 is Hydrogen atom, straight-chain CI-C6 alkyl group, propyloxyl group, trifluoromethyl group, halogen atom, hydroxy group, cyclic saturated C3-C9
- A is, for example, methyl, ethyl, propyl, isopropyl, cyclopentyl, cyclohexyl, carbamoyloxymethyl, carbamoyloxethyl, cyanomethyl, cyanoethyl, Cyanopropyl group, hydroxyethyl group, propyloxylmethyl group, propyloxylethyl group, 1,2-dichloroethyl group, 3-bromopropyl group, 2-chloroethyl group, cyclopropylmethyl group, cyclopropylethyl group, cyclopentylmethyl Group, cyclopropylethyl group, phenethyl group, benzyl group, trifluoromethyl group, phenacyl group, ethylthiomethyl group, naphthoylmethyl group, methylthioethyl group, propylthiomethyl group, isopropylthioethyl group
- R 1 B represents an optionally R 1 2 optionally substituted with R 1 D.
- R 12 of B is phenyl, naphthyl, isoxazolyl, isothiazolyl, imidazolyl, oxazolyl, thiazolyl, thiadiazolyl, chenyl, triazolyl, tetrazolyl, pyridyl, pyrazinyl, pyrimidinyl Group, pyridazinyl group, pyrazolyl group, pyrrolyl group, pyraryl group, furyl group, furazanyl group, imidazolidinyl group, tetrahydrofuranyl group, piperazinyl group, piperidinyl group, pyrrolidinyl group, morpholino group, isoquinolyl group, insoindolyl group, indolyl group , Ethylenedioxyphenyl, quinolyl, pyridothiazolyl, dihydroindolyl, tetrahydroquinol
- R 1 2 of B R 1 .
- a midazolyl group, a benzothiazolyl group, a benzotriazolyl group or a pyridothiazolyl group is preferable, and a phenyl group, an imidazolyl group, an oxazolyl group, a thiazolyl group, a thiadiazolyl group, a triazolyl group, a pyridyl group, and a pyrimidinyl group which may be substituted by R 1Q are preferred.
- R 1Q of B is preferably R 111 or a hydrocarbon group optionally substituted with R 111 , and more preferably R 113 or a hydrocarbon group optionally substituted with R 113 .
- R 111 and R 113 have the same meaning as R 111 or R 113 in A described above.
- B is, for example, phenyl, 2-thiazolyl, 4-thiazolyl, 5-thiazolyl, 2-thiadiazolyl, 2-pyridyl, 3-pyridyl, 4-pyridyl, 2-imidazolyl, 2 —Pyrimidinyl group, 4-pyrimidinyl group, 5 monopyrimidinyl group, 4 _isothiazolyl group, 2-oxazolyl group, 4 _oxazolyl group, 5-year-old xazolyl group, 2-phenyl, 3-phenyl group, 2-phenyl group , 3_furyl, triazole-3-yl, 5-tetrazolyl, 5- (1-methyl) tetrazolyl, 2,3-ethylenedioxyphenyl, 3,4-ethylenedioxy Enyl, 2,3-methylenedioxyphenyl, 3,4-methylenedioxyphenyl, benzimidazolyl, benzothiazolyl, 5-benzotriazolyl, 5-
- R 1G and R 12 are as defined above.
- R 12 of D is preferably a phenyl group, a naphthyl group, a pyridyl group, an ethylenedioxyphenyl group or a methylenedioxyphenyl group, and may be substituted with R 1Q phenyl, pyridyl, methylenedioxyf An enyl group or an ethylenedioxyphenyl group is more preferred.
- R 1 Q of D is preferably R 111 or a hydrocarbon group optionally substituted with R 111 , and more preferably R 113 or a hydrocarbon group optionally substituted with R 113. No. Here, R 111 or R 113 has the same meaning as described above.
- R 2 represents a hydrogen atom, a halogen atom or a C 1 -C 6 alkyl group which may be substituted by R 1D .
- R 1Q of R 2 is preferably R 111 or a hydrocarbon group optionally substituted with R 111 , and more preferably R 113 or a hydrocarbon group optionally substituted with R 113 .
- R 111 and R 113 are as defined above.
- D more specifically, for example, phenyl, 1-naphthyl, 2-naphthyl, 2-pyridyl, 3-pyridyl, 4-pyridyl, 3,4-ethylenedioxyf Enyl group, 2,3-ethylenedioxyphenyl group, 2,3-methylenedioxyphenyl group, 3,4-methylenedioxyphenyl group, 4-tolyl group, 3-carbamoylphenyl , 4-carboxyphenyl, 4-carboxyphenyl, 2-cyanophenyl, 4-trifluoromethylphenyl, 4-chlorophenyl, 2-fluoro Phenyl group, 2,4-difluorophenyl group, 3-bromophenyl group, 4-hydroxyphenyl group, 4-methylthiophenyl group, 2-fluoro-4-methylsulfonylphenyl group, 2-methoxy-4-monofluorophenyl group, 2 —Methoxyphenyl Group
- Examples of the monocyclic or bicyclic heteroaryl group of the above formula (II) include 2-thiazolyl, 4-thiazolyl, 2-imidazolyl, 3-isothiazolyl, 1,2,4-thiadiazol — 3-yl group, 1,2,4-thiadiazol-5-yl group, 1,3,4-thiadiazolyl 2-yl group, 2-triazolyl group, 2-oxazolyl group, 3_isoxazolyl group , A virazinyl group, a 2-pyridyl group, a 2-pyrimidinyl group, a 3-pyrido- [3,2-d] [1,3] thiazolyl-2-yl group or a 2-benzothiazolyl group.
- R 112 is, for example, a hydrogen atom, a sulfamoyl group, a sulfoxyl group, a sulfamoyl group, a trifluoromethyl group, a halogen atom, a hydroxy group, an aralkyl group, an aryl group, an arylthio group, or an arylsulfonyl group.
- R 114 examples thereof include a hydrogen atom, a propyloxyl group, a trifluoromethyl group, a halogen atom, a hydroxy group, an aryl group, an arylthio group, a linear C 1 -C 6 alkyl group, a C 1 -C 6 alkylthio group, 1-06 alkoxy group or C 1 -C 6 alkoxyl propyl group.
- R 2 represents a hydrogen atom, a halogen atom or a C 1 -C 6 alkyl group optionally substituted with R 1Q .
- 2 1 ⁇ 1 () may be substituted with R 111 or R 111
- a hydrocarbon group is preferable, and a hydrocarbon group which may be substituted by R 113 or R 113 is more preferable.
- R 111 and R 113 are as defined above.
- R 2 is more preferably a methyl group, an ethyl group, a propyl group, an isopropyl group, a fluorine atom, or a hydrogen atom.
- X 1 and X 2 of the group represented by are CH
- X 1 is preferably a nitrogen atom
- X 2 is preferably CH
- more preferably X 1 and X 2 are both CH. It is good.
- R 1 represents —S— (O) p_A, one S (0) q—B or —O—D.
- one S (O) p—B or one O—D is preferable.
- R 2 is C ⁇ —i which may be substituted by a hydrogen atom, a halogen atom or R 1Q .
- a hydrogen atom or a halogen atom is preferable, and a hydrogen atom is more preferable.
- alkyl group a C 1 -C 6 alkyl group is preferable.
- the halogen atom for R 2 is preferably a fluorine atom, a chlorine atom or a bromine atom, and more preferably a fluorine atom or a chlorine atom.
- the benzamide derivative represented by the formula (I) includes, for example, 2-amino-4 monofluoro-5- (1-methyl-1H-imidazole-2--2- ⁇ "ruthulfanyl-N-thiazole-2-ii" B) benzamide, 2-amino-4-fluoro mouth—5— (1-methyl_1H—imidazole-2-ylusulfanyl) —N— (4-methyl-1-thiazo-1-lu-2-yl) benzamide, 2-amino-5 — (1-Methyl-1H-imidazo-1-yl-2-ylsulfanyl) —N— (4-hydridoxymethyl-thiazol-2-yl) benzamide, 2 _amino-5 _ (1H-imidazo-1-ru-2-ylsulfanyl) ) One N— (4,18 hydroxymethyl methyl) Benzoyl 2-benzyl) benzamide, 2-amino-5-methylsulfanyl
- the benzamide derivative according to the present invention can exist as a pharmaceutically acceptable salt.
- the salt include an acid addition salt and a base addition salt.
- the acid addition salts include hydrohalides such as hydrochloride, hydrofluoride, hydrobromide, and hydroiodide; nitrates, perchlorates, sulfates, phosphates, and charcoal.
- Inorganic acid salts such as acid salts; lower alkyl sulfonates such as methanesulfonate, trifluoromethanesulfonate, and sulfonic acid salts; aryl sulfones such as benzenesulfonate and P-toluenesulfonate Acid salt; fumarate, succinate, ku Organic acid salts such as citrate, tartrate, oxalate and maleate; and acid addition salts which are organic acids such as amino acids such as glutamate and aspartate.
- the base addition salt examples include alkali metal salts such as sodium and potassium, alkaline earth metal salts such as calcium and magnesium, ammonium salts, salts with organic bases such as guanidine, triethylamine, dicyclohexylamine and the like.
- the compound of the present invention may exist as a solvate, preferably a hydrate of the free compound or a salt thereof.
- the compound according to the present invention may have stereoisomers or tautomers such as optical isomers, diastereoisomers, and geometric isomers depending on the mode of the substituent. Needless to say, all of these isomers are included in the compound of the present invention. Furthermore, it goes without saying that any mixture of these isomers is also included in the compounds of the present invention.
- the compound of the present invention Since the compound of the present invention has a dalcokinase activating action, it is useful as a therapeutic and / or prophylactic agent for diabetes and also as a preventive agent for complications of diabetes.
- the complication of diabetes is a disease that is caused by the onset of diabetes. Examples of the complication of diabetes include diabetic nephropathy, diabetic retinopathy, diabetic neuropathy, and diabetes. Arteriosclerosis and the like.
- the compound according to the present invention can be used for any of insulin-dependent diabetes (IDDM, insulindep-endendetabetes me llitus) and insulin-dependent diabetes (NIDDM, non-insulin-dependent endtdiabetes me 11 itus). It is also applicable to diabetes.
- IDDM insulin-dependent diabetes
- NIDDM insulin-dependent diabetes
- Insulin-dependent diabetes mellitus is caused by obesity-induced insulin resistance due to the predisposition to hereditary hypoinsulin secretion and skeletal muscle insulin resistance. It is considered to be mainly adult-onset. It has been proposed that insulin-dependent diabetes be classified into type I and type II according to its predisposition.
- the compound according to the present invention is useful not only for type I insulin-dependent diabetes mellitus, but also for type II diabetes, which was impossible to achieve a sufficient decrease in blood sugar level with conventional diabetic drugs. it is conceivable that.
- type II diabetes the degree of hyperglycemia after eating is remarkably longer than that in healthy subjects, but the compound according to the present invention is also useful for type II diabetes.
- the compound (I) of the present invention can be easily produced using a known reaction means or according to a method known per se.
- the compound of the general formula (I) of the present invention is produced not only by synthesis in a normal liquid phase but also by synthesis using a solid phase such as a combinatorial synthesis method or a parallel synthesis method, which has been remarkably developed in recent years. be able to.
- it can be produced, for example, by the following method.
- Step 1 a carboxylic acid compound (1) or a reactive derivative thereof and R 1 represented by the above formula (II) are used. And reacting it with an amino compound having a monocyclic or bicyclic heteroaryl group which may be substituted with a compound or a salt thereof to produce a compound (3).
- This reaction was performed according to methods described in the literature (eg, Basics and Experiments on Peptide Synthesis, Nobuo Izumiya et al., Maruzen, 1983, Comprehensive Organic Synthesis) (Comprehensive Organic Synthesis), Volume 6, Peramon Press, 1991, etc.), a method based on it, or a combination of these methods with a conventional method to form an ordinary amide.
- the reaction may be performed, that is, using a condensing agent well known to those skilled in the art, or using an ester activation method, a mixed acid anhydride method, an acid chloride method, a carbodiimide method, etc., which can be used by those skilled in the art. Can be performed.
- amide-forming reagents include, for example, thionyl chloride, N, N-dicyclohexylcarbodiimide, 1-methyl-2-bromopyridinium iodide, N, N'-capillonyldiimidazole, diphenylphosphoryl chloride, diphenyl Nilphosphoryl azide, N, N'-disuccinimidyl oleponate, N, N'-disuccinimidyl oxalate, 1-ethyl-3
- Examples of the base used include, for example, trimethylamine, triethylamine, N, N-diisopropylethylamine, N-methylmorpholine, N-methylpyrrolidin, N-methylbiperidine, N, N-dimethylaniline, 1,8 —Diazabic mouth [5.4.0] pendant force— Tertiary aliphatic amines such as 7-ene (DBU), 1,5-azabicyclo [4.3.0] nona—5-ene (DBN)
- aromatic amines such as pyridine, 4-dimethylaminopyridine, picoline, lutidine, quinoline and isoquinoline; among them, for example, tertiary aliphatic amines and the like are preferable; particularly, for example, triethylamine or N, N-diiso Propylethylamine and the like are preferred.
- condensation aid used examples include N-hydroxybenzotriazole hydrate, N-hydroxysuccinimide, N-hydroxy-5-norpolene-2,3-dicarboximide or 3-hydroxy-3,4-dihydro-4-oxo- Examples thereof include 1,2,3-benzotriazole and the like, among which N-hydroxybenzotriazole and the like are preferable.
- the amount of the amino compound (2) to be used varies depending on the type of the compound to be used, the type of solvent and other reaction conditions, but is usually 0.02 to 1 equivalent of the carboxylic acid compound (1) or its reactive derivative. To 50 equivalents, preferably 0.2 to 2 equivalents.
- the reactive derivative include an active ester derivative, an active amide derivative and the like which are usually used in the field of organic chemistry.
- the amount of the amide forming reagent to be used varies depending on the compound to be used, the type of solvent and other reaction conditions, but is usually 1 to 50 equivalents, preferably 1 equivalent to 1 equivalent of the carboxylic acid compound (1) or a reactive derivative thereof. 1 to 5 equivalents.
- the amount of the condensing aid used varies depending on the compound used, the type of solvent and other reaction conditions, but is usually 1 to 50 equivalents, preferably 1 equivalent to 1 equivalent of the carboxylic acid compound (1) or a reactive derivative thereof. 1 to 5 equivalents.
- the amount of the base used varies depending on the compound used, the kind of the solvent and other reaction conditions, but is usually 1 to 50 equivalents, preferably 3 to 5 equivalents.
- the reaction solvent used in this step is, for example, an inert organic solvent, and is not particularly limited as long as the reaction is not hindered.
- methylene chloride, chloroform, 1,2-dichloroethane, acetate nitrile or N, N-dimethylformamide is preferable.
- the reaction temperature is one 1 0 0 D C to solvent boiling point, preferably from 0 to 3 0 ° C.
- the reaction time is 0.5 to 96 hours, preferably 3 to 24 hours.
- the base, the amide-forming reagent, and the condensation auxiliary used in Step 1 can be used alone or in combination of one or more.
- the protecting group can be removed as appropriate.
- the removal of the auxiliary group can be performed by the method described in the literature (Protective glue). Press in Organic Synthesis (Author), TW Green, Second Edition, John Wiley & Sons, 1991, etc. It can be performed by combining with a conventional method.
- the compound (3) thus obtained can be isolated or purified by a known separation and purification means, for example, concentration, reduced pressure concentration, crystallization, solvent extraction, reprecipitation, chromatography, or the like.
- concentration, reduced pressure concentration, crystallization, solvent extraction, reprecipitation, chromatography, or the like for example, concentration, reduced pressure concentration, crystallization, solvent extraction, reprecipitation, chromatography, or the like.
- the next step can be performed.
- Step 2 This step is a method for producing a compound (5) by reacting the amide compound (3) obtained in the above step 1 with the compound (4).
- a base may be added to the reaction system as needed.
- a phenol derivative or a thiol derivative is preferable.
- the phenol derivative or thiol derivative include phenol, thiophenol, thioimidazole, thiotriazole and the like.
- the amount of the compound (4) to be used varies depending on the compound to be used, the kind of the solvent and other reaction conditions, but it is usually 2 to 50 equivalents, preferably 2 to 1 equivalent of the amino derivative (3). To 5 equivalents.
- Examples of the base used include trimethylamine, triethylamine, N, N-diisopropylethylamine, N-methylmorpholin, N-methylpyrrolidine, N-methylpiperidine, N, N_dimethylaniline, Tertiary aliphatic amines such as 8-diazabicyclo [5.4.0] 7-ene (DBU) and 1,5-azabicyclo [4.3.0] nonane 5-DBN (DBN)
- An aromatic amine such as pyridine, 4-dimethylaminopyridine, picoline, lutidine, quinoline or isoquinoline; an alkali metal such as potassium metal, sodium or lithium; an alkali metal such as sodium hydride or potassium hydride Metal hydrides; alkali metal alkylates, such as butyllithium; potassium-tert-butylate, sodium ethylate or sodium Alkali metal alkoxides such as thiolate; alkali metal hydroxides such as potassium hydro
- tertiary aliphatic amines alkali metal hydrogen Or alkali metal carbonates, especially triethylamine, N, N-diisopropane Preferred are pyrethylamine, sodium hydride or carbonated lime.
- the amount of the base used varies depending on the compound used, the type of solvent and other reaction conditions, but is usually 0 to 50 equivalents, preferably 2 to 10 equivalents, per equivalent of the amide compound (3). It is. One or more of these bases can be used as necessary.
- the inert organic solvent to be used is not particularly limited as long as it does not hinder the reaction.
- Specific examples include methylene chloride, chloroform, 1,2-dichloroethane, trichloroethane, and N , N-dimethylformamide, N, N-dimethylacetamide, ethyl acetate, methyl acetate, acetonitrile, benzene, xylene, water, toluene, 1,4-dioxane, tetrahydrofuran or a mixed solvent thereof.
- the compound (5) thus obtained can be isolated and purified by a known separation and purification means, for example, concentration, concentration under reduced pressure, crystallization, solvent extraction, reprecipitation, chromatography and the like.
- Step 3 is a method for producing the compound (I-11) according to the present invention by reducing the compound (5).
- a method well known to those skilled in the art is used for the reduction reaction used in this step.
- Specific examples of the reduction reaction used in this step include (1) a catalytic reduction method using hydrogen, formic acid, ammonium formate, hydrazine hydrate and a palladium, platinum, nickel catalyst, and (2) hydrochloric acid, ammonium chloride. And (3) a reduction method using methanol and tin chloride.
- the amount of the reducing agent used in the above reduction reaction varies depending on the type of the compound and the solvent to be used and other reaction conditions, but is usually 1 to 50 equivalents, preferably 2 to 20 equivalents per 1 equivalent of the compound (5). It is.
- the reaction solvent to be used is not particularly limited as long as the reaction is not hindered, but, for example, halogenated hydrocarbons such as dichloromethane, chloroform, etc., for example, ethers such as ethyl ether, tert-butyl methyl ether, tetrahydrofuran, etc. Amides such as N, N-dimethylformamide and N, N-dimethylacetamide; sulfoxides such as dimethylsulfoxide; nitriles such as acetonitrile; amides such as methanol, ethanol and propanol. It is possible to use alcohols, for example, aromatic hydrocarbons such as benzene, toluene and xylene, ⁇ , or a mixed solvent thereof.
- halogenated hydrocarbons such as dichloromethane, chloroform, etc.
- ethers such as ethyl ether, tert-butyl methyl ether, tetra
- reaction temperature and the reaction time are not particularly limited, the reaction temperature is about 10 to 10 ° C., preferably about 0 to 50 ° C., about 1 to 20 hours, preferably about 1 to 5 hours. Perform the reaction.
- the compound (1-1) according to the present invention is isolated and purified by a known separation and purification means, for example, concentration, concentration under reduced pressure, crystallization, solvent extraction, reprecipitation, chromatography, or the like.
- the next step can be performed without isolation and purification.
- the compound in each of the above steps may have a protecting group on each substituent.
- the protecting group can be appropriately removed in each step by a known method, a method analogous thereto, or a method combining these with a conventional method.
- an appropriate removal reaction can be performed depending on the compound, the type of reaction, and other reaction conditions.However, when each protecting group is removed individually, it is considered that each protecting group is removed at the same time. A person skilled in the art can select as appropriate.
- Examples of the protecting group include a protecting group for a hydroxy group, a protecting group for an amino group, a protecting group for a carbonyl group, a protecting group for an aldehyde, and a protecting group for a keto group.
- the order of removing the protecting groups is not particularly limited.
- Examples of the hydroxy-protecting group include lower alkylsilyl groups such as tert-butyldimethylsilyl group and tert-butyldiphenylsilyl group, and lower alkoxymethyl groups such as methoxymethyl group and 2-methoxyethoxymethyl group.
- Examples thereof include an aralkyl group such as a benzyl group and a p-methoxybenzyl group, for example, an acyl group such as a formyl group and an acetyl group, and among these, a tert-butyldimethylsilyl group and an acetyl group are particularly preferable.
- an aralkyl group such as a benzyl group and a p-methoxybenzyl group
- an acyl group such as a formyl group and an acetyl group
- a tert-butyldimethylsilyl group and an acetyl group are particularly preferable.
- Examples of the protecting group for an amino group include aralkyl groups such as benzyl group and p-nitrobenzyl group; for example, formyl group and acetyl group; and lower alkoxy groups such as ethoxycarbonyl group and tert-butoxycarponyl group.
- Examples thereof include alkoxycarbonyl groups, for example, benzyloxycarbonyl groups, and aralkyloxycarponyl groups such as p-nitro-2-benzyloxycarbonyl group, among which nitrobenzyl group and tert-butoxy group are particularly preferred.
- a carbonyl group, a benzyloxycarbonyl group and the like are preferable.
- Examples of the protective group for the carbonyl group include lower alkyl groups such as methyl group, ethyl group and tert-butyl group, and aralkyl groups such as benzyl group and p-methoxybenzyl group. Particularly, a methyl group, an ethyl group, a tert-butyl group, a benzyl group and the like are preferable.
- Examples of the protecting group for the keto group include a dimethylketal group, a 1,3-dioxolane group, a 1,3-dioxolane group, a 1,3-dithiane group, and a 1,3-dithiolane group. Evenyl and 1,3-dioxolane groups are more preferred.
- Examples of the protecting group for the aldehyde group include a dimethyl acetal group, a 1,3-dioxolane group, a 1,3-dioxolane group, a 1,3-dithiane group, and a 1,3-dithiolane group. Among them, a dimethyl acetal group and a 1,3-dioxolane group are more preferred.
- a protecting group may be introduced into a functional group in order to efficiently promote the reaction.
- the introduction of these protecting groups can be appropriately selected by those skilled in the art, and the removal of the protecting groups can be performed by a method such as the above-described Protective Group in Organic Synthesis, a method analogous thereto, or a combination of these methods and a conventional method. It can be done by doing.
- the order of removal of the protecting groups can be appropriately selected by those skilled in the art.
- the compound (1-1) thus obtained can be isolated or purified by known separation and purification means, for example, concentration, concentration under reduced pressure, crystallization, reprecipitation, solvent extraction, chromatography, or the like. It can be applied to the next step without performing.
- the compound (1-1) according to the present invention can also be produced by the following steps.
- Protective Groups scan Inorganic method such synthesis of the described, by combine the methods equivalent thereto, or a thereof with an ordinary method, those skilled in the art to appropriately select the protecting group Can do this.
- the compounds (6) and (5 ′) thus obtained can be isolated and purified by known separation and purification means, for example, concentration, concentration under reduced pressure, crystallization, reprecipitation, solvent extraction, or the like, or isolation and purification. It can be applied to the next step without performing.
- the compound (I-11) according to the present invention can be isolated and purified by known separation and purification means, for example, concentration, concentration under reduced pressure, crystallization, reprecipitation, and solvent extraction.
- the removal of the protecting group depends on the type of the protecting group and the stability of the compound, but the removal of the protective group in organic synthesis (Protective Group Organic Synthesis) described above. sis), 2nd edition by TW Green, John Wiley & Sons, 1991, etc.) Can be performed by combining the above. For example, it can be carried out by solubilization using an acid or a base, chemical reduction using a metal hydride complex, or catalytic reduction using a palladium carbon catalyst, Raney Nigel or the like.
- the benzamide compounds provided by the present invention can exist as pharmaceutically acceptable salts. Such salts are described in formula (I) and "Embodiments of the Invention".
- the compound can be produced by a conventional method using the compound represented by the formula (I-11). Specifically, when the compounds (I) and (I-11) have a basic group derived from, for example, an amino group or a pyridyl group in the molecule, the compound is converted to an acid. Can be converted to the corresponding pharmaceutically acceptable salt.
- the acid addition salts include hydrohalides such as hydrochloride, hydrofluoride, hydrobromide, and hydroiodide; nitrates, perchlorates, sulfates, phosphates, and charcoal.
- Inorganic acid salts such as acid salts; lower alkyl sulfonates such as methanesulfonate, trifluoromethanesulfonate and ethanesulfonate; aryl sulfones such as benzenesulfonate and p-toluenesulfonate Acid salts; organic acid salts such as fumarate, succinate, citrate, tartrate, oxalate and maleate; and organic acids such as amino acids such as glutamate and aspartate. Acid addition salts can be mentioned.
- the treatment of the compound with a base is also applicable. It can be converted to a pharmaceutically acceptable salt.
- the base addition salt include, for example, alkali metal salts such as sodium and potassium, alkaline earth metal salts such as calcium and magnesium, ammonium salts, salts with organic bases such as guanidine, triethylamine and dicyclohexylamine.
- the compounds of the present invention may exist as any hydrates or solvates of the free compounds or salts thereof.
- the excellent darcokinase activating action of the compound of the present invention represented by the general formula (I) can be measured by a method described in the literature (for example, Diabetes) Vol. 45, pp. 1671-1677, 1996, etc.) or a method analogous thereto.
- Dalcokinase activity is not measured directly by glucose-6-phosphate. Instead, liposome enzyme glucose-16-phosphate dehydrogenase converts phosphodalconolactone from dalcose-6-phosphate. During production, the extent of darcokinase activity is determined by measuring the amount of Thio-NADH produced.
- Rec omb in an t human liver GK used in this Atsushi was expressed as FLAG fusi on 1 "0S 6111 in £ .co 1i and purified by ANT I FLAG M2 AFF INI TY GEL (Sigma)
- the assay was performed using a flat-bottomed 96-we11 plate at 30 ° C.
- DMS DM solution or DMS 1 was added as a control.
- dispensing xture FLAG-GK :, 20 U / m
- the increase in absorbance at 405 nm was measured every 30 seconds for 10 minutes, and the compound was evaluated using the increase in the first 5 minutes.
- FLAG-GK was added so that the absorbance increase after 5 minutes in the presence of 1% DMS0 was between 0.05 and 0.1.
- AC200 was used as a number indicating the GK activity of the compound.
- the definition of AC200 indicates the compound concentration required to increase the OD value by a factor of two (200%) with the ⁇ D value in the DMSO control as 100%.
- the compounds shown in the following Production Examples showed 200% activity at 10 M or less.
- the fact that the compound of the present invention having the GK activating effect represented by the general formula (I) exhibits an excellent hypoglycemic effect is demonstrated, for example, by the following test method. Since the compound included in the present invention exhibited a specific hypoglycemic action, the compound of Production Example 33 included in the present invention was selected, and the hypoglycemic action was examined. Using a mouse, the effect of the administration of the compound on the blood glucose level after the addition of glucose was examined. The test method and results are shown below.
- hypoglycemic effect of the compound according to the present invention is described in the literature (Proc. Natl. Acc. Sci. 1995. 92. 3096-3099) in addition to the method described in the above test method.
- the method can also be carried out by a method according to the above, a method analogous thereto, or a combination of these methods with an ordinary method.
- the compound according to the present invention is useful as a medicament for treating and / or preventing diabetes.
- the benzamide derivative represented by the general formula (I) exhibits a hypoglycemic effect by activating dalcokinase, and thus is used as a therapeutic and / or prophylactic agent for diabetes or as a complication of diabetes.
- it is useful as a preventive drug for diabetic retinopathy, diabetic nephropathy, diabetic arteriosclerosis, diabetic ischemic heart disease and the like.
- the compound represented by the general formula (I) according to the present invention has a dalcokinase activating action, it can be used not only for inulin-dependent diabetes but also for inulin-non-diabetic. It is also useful for dependent diabetes.
- novel aminobenzamide derivative represented by the formula (I) can be administered orally or parenterally.
- the compound according to the present invention can be administered after various pharmaceutical preparations by adding pharmaceutically acceptable additives according to the administration form.
- additives that are commonly used in the field of pharmaceutical preparations can be used as such additives, such as gelatin, lactose, sucrose, titanium oxide, starch, crystalline cellulose, hydroxypropylmethylcellulose, carboxymethylcellulose, and corn.
- Dosage forms to be formulated as a mixture with these additives include solid forms such as tablets, capsules, granules, powders and suppositories; or liquids such as syrups, elixirs and injections Preparations and the like can be mentioned, and these can be prepared according to a method usually used in the field of preparations.
- a liquid preparation it may be in the form of being dissolved or suspended in water or another appropriate medium at the time of use.
- it may be dissolved or suspended in a physiological saline solution or a glucose solution as necessary, and a buffer or a preservative may be added.
- These preparations may contain the compounds according to the invention in a proportion of from 1.0 to 100% by weight, preferably from 1.0 to 60% by weight, of the total drug.
- the dose and frequency of administration vary depending on the sex, age, weight, degree of symptoms, the type and range of the intended treatment effect, etc. of the patient.
- 0.1 to 10 Omg / kg per adult per day is divided into 1 to several times, and for parenteral administration, 0.001 to 1 OmgZkg Is preferably administered one to several times.
- a granule was prepared in the same manner as in Formulation Example 2, and 96 parts of the granule was added with 3 parts of calcium stearate and compression-molded to prepare a tablet having a diameter of 10 mm.
- Formulation Example 4
- novel derivative of the present invention represented by the formula (I) or a pharmaceutically acceptable salt thereof has a dalcokinase activating action, for example, in the treatment and prevention of diabetes or in the prevention of diabetes, for example, diabetic. It is useful for the prevention of complications of diabetes such as nephropathy, diabetic retinopathy, diabetic neuropathy or diabetic arteriosclerosis.
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EP03712941A EP1496052B1 (en) | 2002-03-26 | 2003-03-25 | Novel aminobenzamide derivative |
AU2003221140A AU2003221140B9 (en) | 2002-03-26 | 2003-03-25 | Novel aminobenzamide derivative |
DE60328671T DE60328671D1 (de) | 2002-03-26 | 2003-03-25 | Neue aminobenzamidderivate |
JP2003578340A JP4419571B2 (ja) | 2002-03-26 | 2003-03-25 | 新規アミノベンズアミド誘導体 |
CA002488161A CA2488161A1 (en) | 2002-03-26 | 2003-03-25 | Novel aminobenzamide derivative |
US10/952,471 US7253188B2 (en) | 2002-03-26 | 2004-09-27 | Aminobenzamide derivative |
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WO2004072066A1 (en) * | 2003-02-11 | 2004-08-26 | Prosidion Limited | Tri(cyclo) substituted amide glucokinase activator compounds |
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KR102267630B1 (ko) * | 2019-08-22 | 2021-06-21 | 주식회사 에스엔바이오사이언스 | Ptp-1b 억제활성을 가지는 신규 로바릭산 유도체, 그의 제조방법 및 그 용도 |
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- 2003-03-25 CA CA002488161A patent/CA2488161A1/en not_active Abandoned
- 2003-03-25 AU AU2003221140A patent/AU2003221140B9/en not_active Ceased
- 2003-03-25 JP JP2003578340A patent/JP4419571B2/ja not_active Expired - Fee Related
- 2003-03-25 EP EP03712941A patent/EP1496052B1/en not_active Expired - Fee Related
- 2003-03-25 WO PCT/JP2003/003656 patent/WO2003080585A1/ja active Application Filing
- 2003-03-25 DE DE60328671T patent/DE60328671D1/de not_active Expired - Lifetime
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2004
- 2004-09-27 US US10/952,471 patent/US7253188B2/en not_active Expired - Fee Related
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US7199140B2 (en) | 2001-06-26 | 2007-04-03 | Astrazeneca Ab | Vinyl phenyl derivatives as GLK activators |
US7390908B2 (en) | 2001-08-17 | 2008-06-24 | Astrazeneca Ab | Compounds effecting glucokinase |
US7534593B2 (en) | 2001-12-19 | 2009-05-19 | Hoffmann-La Roche Inc. | Crystals of glucokinase and methods of growing them |
US7812167B2 (en) | 2002-10-03 | 2010-10-12 | Novartis, Ag | Substituted (thiazol-2-yl)-amides or sulfonamides as glucokinase activators useful in the treatment of type 2 diabetes |
US7230108B2 (en) | 2002-11-19 | 2007-06-12 | Astrazeneca Ab | Quinoline derivatives as glucokinase ligands |
WO2004072066A1 (en) * | 2003-02-11 | 2004-08-26 | Prosidion Limited | Tri(cyclo) substituted amide glucokinase activator compounds |
US7582632B2 (en) | 2003-02-11 | 2009-09-01 | Prosidion Limited | Tri(cyclo) substituted amide compounds |
US7214681B2 (en) | 2003-02-11 | 2007-05-08 | Prosidion Limited | Tri(cyclo) substituted amide compounds |
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JP4700684B2 (ja) * | 2004-04-02 | 2011-06-15 | ノバルティス アーゲー | 2型糖尿病の処置に有用なグルコキナーゼアクティベーターとしてのスルホンアミド−チアゾロピリジン誘導体 |
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WO2005095418A1 (en) * | 2004-04-02 | 2005-10-13 | Novartis Ag | Sulfonamide-thiazolpyridine derivatives as glucokinase activators useful the treatment of type 2 diabetes |
US7781451B2 (en) | 2004-04-02 | 2010-08-24 | Novartis Ag | Thiazolopyridine derivatives, pharmaceut ical conditions containing them and methods of treating glucokinase mediated conditions |
US7750020B2 (en) | 2004-04-02 | 2010-07-06 | Novartis Ag | Sulfonamide-thiazolpyridine derivatives as glucokinase activators useful the treatment of Type 2 diabetes |
JP2007530632A (ja) * | 2004-04-02 | 2007-11-01 | ノバルティス アクチエンゲゼルシャフト | 2型糖尿病の処置に有用なグルコキナーゼアクティベーターとしてのスルホンアミド−チアゾロピリジン誘導体 |
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WO2007128761A2 (de) | 2006-05-04 | 2007-11-15 | Boehringer Ingelheim International Gmbh | Verwendungen von dpp iv inhibitoren |
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US8394843B2 (en) | 2006-05-31 | 2013-03-12 | Takeda California, Inc. | Substituted isoindoles as glucokinase activators |
US8008332B2 (en) | 2006-05-31 | 2011-08-30 | Takeda San Diego, Inc. | Substituted indazoles as glucokinase activators |
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US8163779B2 (en) | 2006-12-20 | 2012-04-24 | Takeda San Diego, Inc. | Glucokinase activators |
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US9649344B2 (en) | 2012-07-31 | 2017-05-16 | The Board Of Regents Of The University Of Texas System | Methods and compositions for in vivo induction of pancreatic beta cell formation |
US10293002B2 (en) | 2012-07-31 | 2019-05-21 | The Board Of Regents Of The University Of Texas System | Methods and compositions for in vivo induction of pancreatic beta cell formation |
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Also Published As
Publication number | Publication date |
---|---|
CA2488161A1 (en) | 2003-10-02 |
JPWO2003080585A1 (ja) | 2005-07-21 |
JP4419571B2 (ja) | 2010-02-24 |
EP1496052B1 (en) | 2009-08-05 |
US20050282815A1 (en) | 2005-12-22 |
AU2003221140A1 (en) | 2003-10-08 |
DE60328671D1 (de) | 2009-09-17 |
US7253188B2 (en) | 2007-08-07 |
AU2003221140B9 (en) | 2009-07-30 |
EP1496052A4 (en) | 2007-10-24 |
EP1496052A1 (en) | 2005-01-12 |
AU2003221140B2 (en) | 2009-04-02 |
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