WO2003070969A3 - Inhibition de l'expression du gene bcl2 induite par interference arn au moyen de petits acides nucleiques interferents (sina) - Google Patents
Inhibition de l'expression du gene bcl2 induite par interference arn au moyen de petits acides nucleiques interferents (sina) Download PDFInfo
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- WO2003070969A3 WO2003070969A3 PCT/US2003/004908 US0304908W WO03070969A3 WO 2003070969 A3 WO2003070969 A3 WO 2003070969A3 US 0304908 W US0304908 W US 0304908W WO 03070969 A3 WO03070969 A3 WO 03070969A3
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- Prior art keywords
- bcl2
- nucleic acid
- gene expression
- rna
- bcl
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- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1135—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against oncogenes or tumor suppressor genes
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- A—HUMAN NECESSITIES
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- A61P37/00—Drugs for immunological or allergic disorders
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- C12N2310/00—Structure or type of the nucleic acid
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- C12N2310/111—Antisense spanning the whole gene, or a large part of it
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- C12N2310/00—Structure or type of the nucleic acid
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- C12N2310/31—Chemical structure of the backbone
- C12N2310/317—Chemical structure of the backbone with an inverted bond, e.g. a cap structure
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- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/318—Chemical structure of the backbone where the PO2 is completely replaced, e.g. MMI or formacetal
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C12N2310/321—2'-O-R Modification
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- C12N2310/00—Structure or type of the nucleic acid
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- C12N2310/32—Chemical structure of the sugar
- C12N2310/322—2'-R Modification
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- C12N2310/00—Structure or type of the nucleic acid
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- C12N2310/33—Chemical structure of the base
- C12N2310/332—Abasic residue
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/34—Spatial arrangement of the modifications
- C12N2310/346—Spatial arrangement of the modifications having a combination of backbone and sugar modifications
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/50—Physical structure
- C12N2310/53—Physical structure partially self-complementary or closed
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Abstract
Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2003569860A JP2005517452A (ja) | 2002-02-20 | 2003-02-18 | 短干渉核酸(siNA)を用いるBCL2遺伝子発現のRNA干渉媒介性阻害 |
CA002463595A CA2463595A1 (fr) | 2002-02-20 | 2003-02-18 | Inhibition de l'expression du gene bcl2 induite par interference arn au moyen de petits acides nucleiques interferents (sina) |
EP03709164A EP1442143A4 (fr) | 2002-02-20 | 2003-02-18 | Inhibition de l'expression du gene bcl2 induite par interference arn au moyen de petits acides nucleiques interferents (sina) |
AU2003213119A AU2003213119A1 (en) | 2002-02-20 | 2003-02-18 | RNA INTERFERENCE MEDIATED INHIBITION OF BCL2 GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA) |
US10/923,516 US20050176025A1 (en) | 2001-05-18 | 2004-08-20 | RNA interference mediated inhibition of B-cell CLL/Lymphoma-2 (BCL-2) gene expression using short interfering nucleic acid (siNA) |
US12/192,878 US20090247613A1 (en) | 2002-02-20 | 2008-08-15 | RNA INTERFERENCE MEDIATED INHIBITION OF B-CELL CLL/LYMPHOMA-2 (BCL2) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA) |
Applications Claiming Priority (16)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US35858002P | 2002-02-20 | 2002-02-20 | |
US60/358,580 | 2002-02-20 | ||
US36312402P | 2002-03-11 | 2002-03-11 | |
US60/363,124 | 2002-03-11 | ||
US38678202P | 2002-06-06 | 2002-06-06 | |
US60/386,782 | 2002-06-06 | ||
US39690502P | 2002-07-18 | 2002-07-18 | |
US60/396,905 | 2002-07-18 | ||
US40678402P | 2002-08-29 | 2002-08-29 | |
US60/406,784 | 2002-08-29 | ||
US40837802P | 2002-09-05 | 2002-09-05 | |
US60/408,378 | 2002-09-05 | ||
US40929302P | 2002-09-09 | 2002-09-09 | |
US60/409,293 | 2002-09-09 | ||
US44012903P | 2003-01-15 | 2003-01-15 | |
US60/440,129 | 2003-01-15 |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US10/923,516 Continuation-In-Part US20050176025A1 (en) | 2001-05-18 | 2004-08-20 | RNA interference mediated inhibition of B-cell CLL/Lymphoma-2 (BCL-2) gene expression using short interfering nucleic acid (siNA) |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2003070969A2 WO2003070969A2 (fr) | 2003-08-28 |
WO2003070969A3 true WO2003070969A3 (fr) | 2004-01-08 |
Family
ID=27761716
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2003/004908 WO2003070969A2 (fr) | 2001-05-18 | 2003-02-18 | Inhibition de l'expression du gene bcl2 induite par interference arn au moyen de petits acides nucleiques interferents (sina) |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP1442143A4 (fr) |
JP (1) | JP2005517452A (fr) |
AU (1) | AU2003213119A1 (fr) |
CA (1) | CA2463595A1 (fr) |
WO (1) | WO2003070969A2 (fr) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9228186B2 (en) | 2002-11-14 | 2016-01-05 | Thermo Fisher Scientific Inc. | Methods and compositions for selecting siRNA of improved functionality |
US9399774B2 (en) | 2010-04-29 | 2016-07-26 | Ionis Pharmaceuticals, Inc. | Modulation of transthyretin expression |
Families Citing this family (60)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19956568A1 (de) | 1999-01-30 | 2000-08-17 | Roland Kreutzer | Verfahren und Medikament zur Hemmung der Expression eines vorgegebenen Gens |
DE10100586C1 (de) | 2001-01-09 | 2002-04-11 | Ribopharma Ag | Verfahren zur Hemmung der Expression eines Ziegens |
US7829693B2 (en) | 1999-11-24 | 2010-11-09 | Alnylam Pharmaceuticals, Inc. | Compositions and methods for inhibiting expression of a target gene |
US8546143B2 (en) | 2001-01-09 | 2013-10-01 | Alnylam Pharmaceuticals, Inc. | Compositions and methods for inhibiting expression of a target gene |
US7423142B2 (en) | 2001-01-09 | 2008-09-09 | Alnylam Pharmaceuticals, Inc. | Compositions and methods for inhibiting expression of anti-apoptotic genes |
US7767802B2 (en) | 2001-01-09 | 2010-08-03 | Alnylam Pharmaceuticals, Inc. | Compositions and methods for inhibiting expression of anti-apoptotic genes |
US7745418B2 (en) | 2001-10-12 | 2010-06-29 | Alnylam Pharmaceuticals, Inc. | Compositions and methods for inhibiting viral replication |
DE10163098B4 (de) | 2001-10-12 | 2005-06-02 | Alnylam Europe Ag | Verfahren zur Hemmung der Replikation von Viren |
FR2832154B1 (fr) | 2001-11-09 | 2007-03-16 | Centre Nat Rech Scient | Oligonucleotides inhibiteurs et leur utilisation pour reprimer specifiquement un gene |
DE10202419A1 (de) | 2002-01-22 | 2003-08-07 | Ribopharma Ag | Verfahren zur Hemmung der Expression eines durch eine Chromosomen-Aberration entstandenen Zielgens |
US9657294B2 (en) | 2002-02-20 | 2017-05-23 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA) |
US9181551B2 (en) | 2002-02-20 | 2015-11-10 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA) |
US7951935B2 (en) | 2002-11-14 | 2011-05-31 | Dharmacon, Inc. | siRNA targeting v-myc myelocytomatosis viral oncogene homolog (MYC) |
US9719094B2 (en) | 2002-11-14 | 2017-08-01 | Thermo Fisher Scientific Inc. | RNAi targeting SEC61G |
US9771586B2 (en) | 2002-11-14 | 2017-09-26 | Thermo Fisher Scientific Inc. | RNAi targeting ZNF205 |
US7635770B2 (en) | 2002-11-14 | 2009-12-22 | Dharmacon, Inc. | siRNA targeting protein kinase N-3 (PKN-3) |
US7592442B2 (en) | 2002-11-14 | 2009-09-22 | Dharmacon, Inc. | siRNA targeting ribonucleotide reductase M2 polypeptide (RRM2 or RNR-R2) |
US9719092B2 (en) | 2002-11-14 | 2017-08-01 | Thermo Fisher Scientific Inc. | RNAi targeting CNTD2 |
US7977471B2 (en) | 2002-11-14 | 2011-07-12 | Dharmacon, Inc. | siRNA targeting TNFα |
US7612196B2 (en) | 2002-11-14 | 2009-11-03 | Dharmacon, Inc. | siRNA targeting cyclin-dependent kinase inhibitor 1B (p27, Kip1) (CDKN1B) |
US10011836B2 (en) | 2002-11-14 | 2018-07-03 | Thermo Fisher Scientific Inc. | Methods and compositions for selecting siRNA of improved functionality |
US7691998B2 (en) | 2002-11-14 | 2010-04-06 | Dharmacon, Inc. | siRNA targeting nucleoporin 62kDa (Nup62) |
US9839649B2 (en) | 2002-11-14 | 2017-12-12 | Thermo Fisher Scientific Inc. | Methods and compositions for selecting siRNA of improved functionality |
US8198427B1 (en) | 2002-11-14 | 2012-06-12 | Dharmacon, Inc. | SiRNA targeting catenin, beta-1 (CTNNB1) |
US9879266B2 (en) | 2002-11-14 | 2018-01-30 | Thermo Fisher Scientific Inc. | Methods and compositions for selecting siRNA of improved functionality |
WO2006006948A2 (fr) | 2002-11-14 | 2006-01-19 | Dharmacon, Inc. | Methodes et compositions permettant de selectionner des arnsi presentant une fonctionnalite amelioree |
US7619081B2 (en) | 2002-11-14 | 2009-11-17 | Dharmacon, Inc. | siRNA targeting coatomer protein complex, subunit beta 2 (COPB2) |
US8090542B2 (en) | 2002-11-14 | 2012-01-03 | Dharmacon Inc. | Functional and hyperfunctional siRNA |
GB0306148D0 (en) * | 2003-03-18 | 2003-04-23 | Milner Jo | Regulation of gene expression |
WO2004106511A1 (fr) * | 2003-05-30 | 2004-12-09 | Nippon Shinyaku Co., Ltd. | Arn oligobicatenaire inhibant l'expression de bcl-2 et composition medicinale contenant cet arn |
WO2005061710A1 (fr) * | 2003-12-23 | 2005-07-07 | Santaris Pharma A/S | Composes oligomeres permettant la modulation de bcl-2 |
US20050244869A1 (en) | 2004-04-05 | 2005-11-03 | Brown-Driver Vickie L | Modulation of transthyretin expression |
US7605250B2 (en) | 2004-05-12 | 2009-10-20 | Dharmacon, Inc. | siRNA targeting cAMP-specific phosphodiesterase 4D |
WO2006035432A2 (fr) * | 2004-09-27 | 2006-04-06 | Tel Hashomer Medical Research Infrastructure And Services Ltd. | Silençage genique s'utilisant en dermatologie |
CN103028120B (zh) * | 2005-09-12 | 2015-08-12 | 俄亥俄州立大学研究基金会 | 用于诊断或治疗bcl2相关癌症的组合物和方法 |
EP2468891B1 (fr) | 2006-01-05 | 2015-04-29 | The Ohio State University Research Foundation | Procédés à base de micro ARN pour le diagnostic du cancer de la prostate ou de l'estomac. |
EP2369011A1 (fr) | 2006-03-20 | 2011-09-28 | The Ohio State University Research Foundation | Empreintes digitales micro-ARN pendant une mégacaryocytopoïese |
AU2007296055A1 (en) * | 2006-09-15 | 2008-03-20 | Enzon Pharmaceuticals, Inc. | Polymeric conjugates containing positively-charged moieties |
CA2664271A1 (fr) * | 2006-11-27 | 2008-06-12 | Enzon Pharmaceuticals, Inc. | Conjugues d'arn a interference courte polymeres |
JP2010519910A (ja) * | 2007-03-02 | 2010-06-10 | エムディーアールエヌエー,インコーポレイテッド | Bcl2遺伝子の発現を抑制するための核酸化合物およびその使用 |
WO2008124927A1 (fr) * | 2007-04-13 | 2008-10-23 | Vincent Research & Consulting Inc. | Siarn contre la thymidylate synthase et son utilisation dans les schémas de traitement du cancer |
ES2570359T3 (es) | 2007-08-03 | 2016-05-18 | Univ Ohio State Res Found | Regiones ultraconservadas que codifican ARNnc |
US20110118337A1 (en) * | 2008-07-10 | 2011-05-19 | Merck Sharp & Dohme Corp. | Method of Using Compositions Comprising MIR-192 and/or MIR-215 for the Treatment of Cancer |
WO2010021389A1 (fr) * | 2008-08-21 | 2010-02-25 | 協和発酵キリン株式会社 | Acide nucléique capable d'inhiber l'expression de la protéine bcl-2 |
GB2468477A (en) * | 2009-03-02 | 2010-09-15 | Mina Therapeutics Ltd | Double stranded RNA molecule comprising siRNA and miRNA precursors |
US8916533B2 (en) | 2009-11-23 | 2014-12-23 | The Ohio State University | Materials and methods useful for affecting tumor cell growth, migration and invasion |
CN103140582A (zh) | 2010-08-24 | 2013-06-05 | 默沙东公司 | 含有内部非核酸间隔子的单链RNAi试剂 |
WO2012058210A1 (fr) | 2010-10-29 | 2012-05-03 | Merck Sharp & Dohme Corp. | INHIBITION FACILITÉE PAR L'INTERFÉRENCE D'ARN DE L'EXPRESSION D'UN GÈNE AU MOYEN D'ACIDES NUCLÉIQUES INTERFÉRENTS COURTS (siNA) |
EP2637673B1 (fr) | 2010-11-12 | 2016-10-26 | The Ohio State University Research Foundation | Procédés relatifs aux microarn-21 et réparation de désappariement dans le cancer colorectal |
EP2640368B1 (fr) | 2010-11-15 | 2020-12-30 | The Ohio State University Research Foundation | Systèmes mucoadhésifs à libération contrôlée |
AU2012323924A1 (en) | 2011-10-14 | 2014-05-29 | The Ohio State University | Methods and materials related to ovarian cancer |
US9481885B2 (en) | 2011-12-13 | 2016-11-01 | Ohio State Innovation Foundation | Methods and compositions related to miR-21 and miR-29a, exosome inhibition, and cancer metastasis |
JP2015511121A (ja) | 2012-01-20 | 2015-04-16 | ジ・オハイオ・ステート・ユニバーシティ | 浸潤性および予後に関する乳がんバイオマーカーシグネチャー |
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CN113677373A (zh) * | 2019-03-28 | 2021-11-19 | 日东电工株式会社 | RNAi分子 |
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- 2003-02-18 AU AU2003213119A patent/AU2003213119A1/en not_active Abandoned
- 2003-02-18 WO PCT/US2003/004908 patent/WO2003070969A2/fr active Application Filing
- 2003-02-18 EP EP03709164A patent/EP1442143A4/fr not_active Withdrawn
- 2003-02-18 CA CA002463595A patent/CA2463595A1/fr not_active Abandoned
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Also Published As
Publication number | Publication date |
---|---|
AU2003213119A1 (en) | 2003-09-09 |
WO2003070969A2 (fr) | 2003-08-28 |
CA2463595A1 (fr) | 2003-08-28 |
EP1442143A4 (fr) | 2005-02-16 |
JP2005517452A (ja) | 2005-06-16 |
EP1442143A2 (fr) | 2004-08-04 |
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