WO2003040373A3 - Bacteries coryneformes generatrices de composes chimiques - Google Patents

Bacteries coryneformes generatrices de composes chimiques Download PDF

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Publication number
WO2003040373A3
WO2003040373A3 PCT/EP2002/008464 EP0208464W WO03040373A3 WO 2003040373 A3 WO2003040373 A3 WO 2003040373A3 EP 0208464 W EP0208464 W EP 0208464W WO 03040373 A3 WO03040373 A3 WO 03040373A3
Authority
WO
WIPO (PCT)
Prior art keywords
lysine
production
genetically modified
corynebacterium glutamicum
glutamicum strains
Prior art date
Application number
PCT/EP2002/008464
Other languages
English (en)
Other versions
WO2003040373A2 (fr
Inventor
Brigitte Bathe
Caroline Kreutzer
Bettina Moeckel
Georg Thierbach
Original Assignee
Degussa
Brigitte Bathe
Caroline Kreutzer
Bettina Moeckel
Georg Thierbach
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Degussa, Brigitte Bathe, Caroline Kreutzer, Bettina Moeckel, Georg Thierbach filed Critical Degussa
Priority to AU2002325923A priority Critical patent/AU2002325923A1/en
Priority to BR0211723-1A priority patent/BR0211723A/pt
Priority to EP02760293A priority patent/EP1414970A2/fr
Priority to CA002455878A priority patent/CA2455878A1/fr
Priority to US10/358,405 priority patent/US7160711B2/en
Publication of WO2003040373A2 publication Critical patent/WO2003040373A2/fr
Publication of WO2003040373A3 publication Critical patent/WO2003040373A3/fr
Priority to US11/612,208 priority patent/US20070111291A1/en
Priority to US12/565,533 priority patent/US20100159523A1/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C12N15/77—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Corynebacterium; for Brevibacterium
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/08—Lysine; Diaminopimelic acid; Threonine; Valine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/15—Corynebacterium

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  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

L'invention porte sur des bactéries coryneformes qui, en plus d'une copie au moins, présente au site naturel (locus) d'un cadre de lecture ouvert (ORF), d'un gène ou d'un allèle, codant pour la synthèse d'une protéine ou d'un ARN, produisent, dans chaque cas une deuxième copie et éventuellement une troisième ou une quatrième copie présentes dans chaque cas dans un deuxième site ou éventuellement dans un troisième ou une quatrième site, sous une forme intégrée au chromosome. L'invention porte également sur un procédé de préparation de composés chimiques par fermentation de ces bactéries.
PCT/EP2002/008464 2001-08-06 2002-07-30 Bacteries coryneformes generatrices de composes chimiques WO2003040373A2 (fr)

Priority Applications (7)

Application Number Priority Date Filing Date Title
AU2002325923A AU2002325923A1 (en) 2001-08-06 2002-07-30 Production of l-lysine by genetically modified corynebacterium glutamicum strains
BR0211723-1A BR0211723A (pt) 2001-08-06 2002-07-30 Bactérias corineformes que produzem compostos quìmicos i
EP02760293A EP1414970A2 (fr) 2001-08-06 2002-07-30 Bacteries coryneformes generatrices de composes chimiques
CA002455878A CA2455878A1 (fr) 2001-08-06 2002-07-30 Bacteries coryneformes generatrices de composes chimiques
US10/358,405 US7160711B2 (en) 2001-08-06 2003-02-05 Coryneform bacteria which produce chemical compounds I
US11/612,208 US20070111291A1 (en) 2001-08-06 2006-12-18 Coryneform Bacteria Which Produce Chemical Compounds I
US12/565,533 US20100159523A1 (en) 2001-08-06 2009-09-23 Coryneform Bacteria Which Produce Chemical Compounds I

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US30987801P 2001-08-06 2001-08-06
US60/309,878 2001-08-06

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US10/358,405 Continuation-In-Part US7160711B2 (en) 2001-08-06 2003-02-05 Coryneform bacteria which produce chemical compounds I

Publications (2)

Publication Number Publication Date
WO2003040373A2 WO2003040373A2 (fr) 2003-05-15
WO2003040373A3 true WO2003040373A3 (fr) 2003-12-18

Family

ID=23200067

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2002/008464 WO2003040373A2 (fr) 2001-08-06 2002-07-30 Bacteries coryneformes generatrices de composes chimiques

Country Status (6)

Country Link
EP (1) EP1414970A2 (fr)
CN (1) CN100554426C (fr)
AU (1) AU2002325923A1 (fr)
BR (1) BR0211723A (fr)
CA (1) CA2455878A1 (fr)
WO (1) WO2003040373A2 (fr)

Families Citing this family (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7160711B2 (en) * 2001-08-06 2007-01-09 Degussa Ag Coryneform bacteria which produce chemical compounds I
US6844176B1 (en) 2001-10-16 2005-01-18 Degussa Ag Alleles of the lysC gene from corynebacteria
DE10359594A1 (de) 2003-12-18 2005-07-28 Basf Ag PEF-TU-Expressionseinheiten
DE102004035067A1 (de) * 2004-07-20 2006-02-16 Basf Ag P1-35-Expressionseinheiten
DE102005013676A1 (de) 2005-03-24 2006-09-28 Degussa Ag Allele des zwf-Gens aus coryneformen Bakterien
DE102005023829A1 (de) 2005-05-24 2006-11-30 Degussa Ag Allele des opcA-Gens aus coryneformen Bakterien
DE102005047596A1 (de) 2005-10-05 2007-04-12 Degussa Ag Verfahren zur fermentativen Herstellung von L-Aminosäuren unter Verwendung coryneformer Bakterien
DE102006026328A1 (de) * 2006-06-02 2008-01-03 Evonik Degussa Gmbh Verfahren zur Herstellung eines L-Lysin enthaltenden Futtermitteladditivs
KR100830289B1 (ko) * 2007-01-18 2008-05-16 씨제이제일제당 (주) Ｌ－아르기닌 생산 변이주 및 이의 제조방법
DE102007005072A1 (de) 2007-02-01 2008-08-07 Evonik Degussa Gmbh Verfahren zur fermentativen Herstellung von Cadaverin
JP2011067095A (ja) 2008-01-10 2011-04-07 Ajinomoto Co Inc 発酵法による目的物質の製造法
KR100987281B1 (ko) * 2008-01-31 2010-10-12 씨제이제일제당 (주) 개량된 프로모터 및 이를 이용한 ｌ-라이신의 생산 방법
DE102008001874A1 (de) 2008-05-20 2009-11-26 Evonik Degussa Gmbh Verfahren zur Herstellung von L-Aminosäuren
DE102009030342A1 (de) 2009-06-25 2010-12-30 Evonik Degussa Gmbh Verfahren zur fermentativen Herstellung von organisch chemischen Verbindungen
DE102010003419B4 (de) 2010-03-30 2019-09-12 Evonik Degussa Gmbh Verfahren zur fermentativen Herstellung von L-Ornithin
DE102010025124A1 (de) 2010-06-25 2011-12-29 Forschungszentrum Jülich GmbH Verfahren zur Herstellung von D-Aminosäuren, Mikroorganismus, sowie Vektor
EP2479279A1 (fr) 2011-01-20 2012-07-25 Evonik Degussa GmbH Procédé de fabrication fermentative d'acides aminés contenant du soufre
KR101922742B1 (ko) 2011-02-22 2019-02-20 바스프 에스이 카다베린의 생산을 위한 방법 및 재조합 미생물
DE102011006716A1 (de) 2011-04-04 2012-10-04 Evonik Degussa Gmbh Mikroorganismus und Verfahren zur fermentativen Herstellung einer organisch-chemischen Verbindung
JP2014131487A (ja) 2011-04-18 2014-07-17 Ajinomoto Co Inc Ｌ−システインの製造法
DE102011118019A1 (de) 2011-06-28 2013-01-03 Evonik Degussa Gmbh Varianten des Promotors des für die Glyzerinaldehyd-3-phosphat-Dehydrogenase kodierenden gap-Gens
IN2014CN04002A (fr) 2011-11-02 2015-10-23 Ajinomoto Kk
MY173771A (en) 2011-11-11 2020-02-20 Ajinomoto Kk A method for producing a target substance by fermentation
EP2628792A1 (fr) 2012-02-17 2013-08-21 Evonik Industries AG Cellule dotée d'une activité ppGppase moindre
EP2631298A1 (fr) 2012-02-22 2013-08-28 Evonik Industries AG Procédé biotechnologique et procédé de production de butanol et d'acide butyrique
WO2013160124A1 (fr) 2012-04-27 2013-10-31 Evonik Industries Ag Aloha-isopropylmalate synthases résistant à la rétroaction
EP2674489A1 (fr) 2012-06-15 2013-12-18 Evonik Industries AG Production d'acide 2-hydroxyisobutyrique biotechnologique
PL2700715T3 (pl) 2012-08-20 2019-03-29 Evonik Degussa Gmbh Sposób fermentacyjnego wytwarzania L-aminokwasów z zastosowaniem ulepszonych szczepów z rodziny Enterobacteriaceae
DE102012016716A1 (de) 2012-08-22 2014-02-27 Forschungszentrum Jülich GmbH Verfahren zur Herstellung von Vektoren enthaltend ein für in seiner feedback-Inhibierung gemindertes oder ausgeschaltetes Enzym kodierendes Gen und deren Verwendung für die Herstellung von Aminosäuren und Nukleotiden
EP2762571A1 (fr) 2013-01-30 2014-08-06 Evonik Industries AG Microorganisme et procédé de fabrication par fermentation d'acides aminés
EP2811028B1 (fr) 2013-06-03 2017-02-01 Evonik Degussa GmbH Procédé de production de L-valine en utilisant des Corynebactéries recombinantes comprenant l'opéron ilvBN inductible par le propionate
CN103374540B (zh) * 2013-08-13 2015-04-22 廊坊梅花生物技术开发有限公司 谷氨酸棒杆菌及其应用
EP2940144A1 (fr) 2014-04-30 2015-11-04 Evonik Degussa GmbH Procédé de production de L-lysine en utilisant une bactérie alcaliphile
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EP2940039A1 (fr) 2014-04-30 2015-11-04 Evonik Degussa GmbH Procédé de production d'acides aminés L dans des corynebactéries en utilisant un système de fission de la glycine
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US20200239897A1 (en) 2017-06-07 2020-07-30 Zymergen Inc. Promoters from corynebacterium glutamicum and uses thereof in regulating ancillary gene expression
EP3415622A1 (fr) 2017-06-14 2018-12-19 Evonik Degussa GmbH Procédé de production de produits chimiques fins au moyen d'une corynebactérie sécrétant des alpha-1,6-glucosidases modifiées
KR102011994B1 (ko) 2017-06-30 2019-08-20 씨제이제일제당 주식회사 신규한 아스파토키나제 변이체 및 이를 이용한 l-아미노산의 제조방법
CN109536428B (zh) * 2018-12-07 2022-08-30 武汉远大弘元股份有限公司 一种产l-异亮氨酸的基因工程菌及其构建方法和应用
CN111471638B (zh) * 2020-05-22 2021-11-23 江南大学 一株产l-高丝氨酸的谷氨酸棒杆菌突变株的构建与应用
CN113994002B (zh) * 2021-05-07 2022-06-03 Cj第一制糖株式会社 新型启动子及其用途
CN114181288B (zh) * 2022-02-17 2022-05-03 北京中科伊品生物科技有限公司 制备l-缬氨酸的方法及其所用的基因与该基因编码的蛋白质

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000063388A1 (fr) * 1999-04-19 2000-10-26 Kyowa Hakko Kogyo Co., Ltd. Nouvelle aspartokinase desensibilisee
EP1067192A1 (fr) * 1999-07-07 2001-01-10 Degussa-Hüls Aktiengesellschaft Bactéries corynéformes produisant L-lysine et procédés pour la production de L-lysine
EP1094111A2 (fr) * 1999-10-20 2001-04-25 Degussa-Hüls Aktiengesellschaft Séquences polynucleotidiques codant Pck
EP1108790A2 (fr) * 1999-12-16 2001-06-20 Kyowa Hakko Kogyo Co., Ltd. Nouveaux polynuclétides

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000063388A1 (fr) * 1999-04-19 2000-10-26 Kyowa Hakko Kogyo Co., Ltd. Nouvelle aspartokinase desensibilisee
EP1172437A1 (fr) * 1999-04-19 2002-01-16 Kyowa Hakko Kogyo Co., Ltd. Nouvelle aspartokinase desensibilisee
EP1067192A1 (fr) * 1999-07-07 2001-01-10 Degussa-Hüls Aktiengesellschaft Bactéries corynéformes produisant L-lysine et procédés pour la production de L-lysine
EP1094111A2 (fr) * 1999-10-20 2001-04-25 Degussa-Hüls Aktiengesellschaft Séquences polynucleotidiques codant Pck
EP1108790A2 (fr) * 1999-12-16 2001-06-20 Kyowa Hakko Kogyo Co., Ltd. Nouveaux polynuclétides

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
ISHINO, S. ET AL.: "Nucleotide sequence of the meso-diaminopimelate D-dehydrogenase gene from Corynebacterium glutamicum", NUCLEIC ACIDS RESEARCH, vol. 15, no. 9, 11 May 1987 (1987-05-11), pages 3917, XP001056569 *
KRONEMEYER, W. ET AL.: "Structure of the gluABCD Cluster Encoding the Glutamate Uptake System of Corynebacterium glutamicum", JOURNAL OF BACTERIOLOGY, vol. 177, no. 5, March 1995 (1995-03-01), pages 1152 - 1158, XP002935147 *
SCHÄFER, A. ET AL.: "Small mobilizable multi-purpose cloning vectors derived from the Escherichia coli plasmids pK18 and pK19: selection of defined deletions in the chromosome of Corynebacterium glutamicum", GENE, vol. 145, no. 1, 22 July 1994 (1994-07-22), pages 69 - 73, XP001093898 *

Also Published As

Publication number Publication date
AU2002325923A1 (en) 2003-05-19
EP1414970A2 (fr) 2004-05-06
WO2003040373A2 (fr) 2003-05-15
CN1539015A (zh) 2004-10-20
CN100554426C (zh) 2009-10-28
BR0211723A (pt) 2004-09-21
CA2455878A1 (fr) 2003-05-15

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