WO2003002991A3 - Vorrichtung zur fotometrischen messung mehrerer proben - Google Patents
Vorrichtung zur fotometrischen messung mehrerer proben Download PDFInfo
- Publication number
- WO2003002991A3 WO2003002991A3 PCT/EP2002/007120 EP0207120W WO03002991A3 WO 2003002991 A3 WO2003002991 A3 WO 2003002991A3 EP 0207120 W EP0207120 W EP 0207120W WO 03002991 A3 WO03002991 A3 WO 03002991A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- light
- samples
- evaluation
- control device
- photometric measurement
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
- G01N21/251—Colorimeters; Construction thereof
- G01N21/253—Colorimeters; Construction thereof for batch operation, i.e. multisample apparatus
Landscapes
- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
Abstract
Eine Vorrichtung zur fotometrischen Messung mehrerer Proben (12), die jeweils von einer zugeordneten Lichtquelle (14) bestrahlt werden, wobei das von den Proben (12) veränderte Licht von einer optischen Einrichtung (19) aufgefangen und als Summe des von allen Proben (12) abgestrahlten Lichtes wenigstens einem Sensor (27) zur Intensitätsmessung und Auswertung in einer diesem nachgeschalteten Auswerteinrichtung (32) zugeführt wird, wobei die Lichtquellen (14) von einer Ansteuereinrichtung (31) einzeln steuerbar sind und die Auswerteinrichtung (32) sowie die Ansteuereinrichtung (31) derart gesteuert sind, dass die Auswerteinrichtung (32) das Licht jeder Probe (12) getrennt von dem Licht anderer Proben ermittelt, ist dadurch gekennzeichnet, dass die Ansteuereinrichtung (31) die Lichtquellen (14) mit unterschiedlichen Signalen moduliert, welche der Auswerteinrichtung (32) vorgegeben sind, um mit deren Hilfe die Lichtsignale der einzelnen Proben (12) aus dem vom Sensor (27) empfangenen Summensignal zu ermitteln.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/476,848 US7102131B2 (en) | 2001-06-29 | 2002-06-27 | Device for photometric measurement of several samples |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10131687.9 | 2001-06-29 | ||
DE10131687A DE10131687A1 (de) | 2001-06-29 | 2001-06-29 | Vorrichtung zur Durchführung von Nukleinsäure-Amplifikationsreaktionen bei gleichzeitiger Verfolgung der Bildung von Amplifikationsprodukten |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2003002991A2 WO2003002991A2 (de) | 2003-01-09 |
WO2003002991A3 true WO2003002991A3 (de) | 2003-10-30 |
Family
ID=7690107
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2002/007120 WO2003002991A2 (de) | 2001-06-29 | 2002-06-27 | Vorrichtung zur fotometrischen messung mehrerer proben |
Country Status (3)
Country | Link |
---|---|
US (1) | US7102131B2 (de) |
DE (1) | DE10131687A1 (de) |
WO (1) | WO2003002991A2 (de) |
Families Citing this family (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7521719B2 (en) * | 2004-08-13 | 2009-04-21 | Paul Steven Schranz | Light emitting and image sensing device and apparatus |
DE102004056787A1 (de) * | 2004-11-24 | 2006-06-01 | Heinrich-Heine-Universität Düsseldorf | Vorrichtung und Verfahren zur Messung von Fluoreszenz in mehreren Reaktionsräumen |
EP1681556B1 (de) | 2005-01-18 | 2007-04-11 | Roche Diagnostics GmbH | Fluoreszenzabbildung mittels Telezentrizität |
EP1681555B1 (de) | 2005-01-18 | 2007-03-21 | Roche Diagnostics GmbH | Fluoreszenzabbildung mittels telezentrischer Anregungs- und Abbildungsoptiken |
WO2006077763A1 (ja) * | 2005-01-20 | 2006-07-27 | Ube Industries, Ltd. | 非水電解液及びそれを用いたリチウム二次電池 |
DE102005027407B3 (de) * | 2005-06-13 | 2006-11-09 | Eppendorf Ag | Thermocycler |
DE102005027555B3 (de) * | 2005-06-14 | 2006-10-05 | Eppendorf Ag | Thermocycler |
US7791728B2 (en) * | 2005-08-11 | 2010-09-07 | Hewlett-Packard Development Company, L.P. | System for optically analyzing a substance with a selected single-wavelength |
DE102005043834A1 (de) * | 2005-09-13 | 2007-03-22 | Eppendorf Ag | Vorrichtung zur Durchführung von Real-Time PCR-Reaktionen |
DE102005046583A1 (de) | 2005-09-28 | 2007-03-29 | Eppendorf Ag | Laborvorrichtung zur gleichzeitigen Durchführung von Reaktionen in einer Mehrzahl von Proben |
KR100797388B1 (ko) | 2005-12-01 | 2008-01-28 | 한국전자통신연구원 | 양방향 위성통신 시스템에서 비캡슐화 데이터 통신을 위한 적응형 패킷 스케줄링 장치 및 수신 장치와, 송신 방법 및 수신 방법 |
DE102006036171B4 (de) * | 2006-07-28 | 2008-10-09 | Analytik Jena Ag | Anordnung und Verfahren zur mehrkanaligen Fluoreszenzmessung in PCR-Proben |
DE102006048346A1 (de) * | 2006-10-12 | 2008-04-17 | Eppendorf Ag | Verfahren zur Vorrichtung zur quantitativen Echtzeitanalyse von fluoreszierenden Proben |
US7414724B2 (en) * | 2006-11-17 | 2008-08-19 | Eppendorf Ag | Light diffuser used in a testing apparatus |
DE102006056596A1 (de) * | 2006-11-30 | 2008-06-05 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Vorrichtung zum ortstaufgelösten Detektieren von Fluoreszenzsignalen |
EP1962084A1 (de) | 2007-02-21 | 2008-08-27 | Roche Diagnostics GmbH | Gerät zur Emission und Detektion von Lichtstrahlen |
EP2193356B1 (de) * | 2007-08-29 | 2014-07-23 | Eppendorf Ag | Vorrichtung und verfahren für die radiometrische messung mehrerer proben |
DE102007062250A1 (de) * | 2007-12-21 | 2009-06-25 | Evotec Ag | Vorrichtung zur Untersuchung chemischer und/oder biologischer Proben |
EP2108699B1 (de) | 2008-04-08 | 2014-06-25 | F.Hoffmann-La Roche Ag | Vorrichtung zur analytischen Verarbeitung und Detektion |
DE102008001322A1 (de) * | 2008-04-22 | 2009-10-29 | Linos Photonics Gmbh & Co. Kg | System zur optischen Analyse von Probenarrays |
EP2148187A1 (de) * | 2008-07-25 | 2010-01-27 | Roche Diagnostics GmbH | Anregungs- und Abbildungsoptik für die Fluoreszenzdetektion |
GB0817991D0 (en) * | 2008-10-02 | 2008-11-05 | Enigma Diagnostics Ltd | Fluorescence based detection methods and apparatus |
GB201005704D0 (en) * | 2010-04-06 | 2010-05-19 | It Is Internat Ltd | Improvements in systems for chemical and/or biochemical reactions |
US9096892B1 (en) | 2011-02-04 | 2015-08-04 | K2 Biomicrosystems, LLC | Nucleic acid amplification and monitoring apparatus |
GB2500177A (en) * | 2012-03-07 | 2013-09-18 | Valeport Ltd | Fluorometer with beamsplitter |
US20140373643A1 (en) * | 2013-06-25 | 2014-12-25 | Dale D. Timm, Jr. | Internally illuminated heating and/or chilling bath |
DE102014108143A1 (de) * | 2014-06-10 | 2015-12-10 | Kist Europe-Korea Institute of Science and Technologie Europe Forschungsgesellschaft mbh | An optical system for detecting fluorescent or luminescent signals of at least two samples |
DE102016200271A1 (de) | 2016-01-13 | 2017-07-13 | Institut Dr. Foerster Gmbh & Co. Kg | Vorrichtung zur Erzeugung und Messung einer Emission |
JP6630947B2 (ja) * | 2017-09-01 | 2020-01-15 | ウシオ電機株式会社 | マイクロプレートリーダー |
TWI660218B (zh) * | 2018-02-22 | 2019-05-21 | 致茂電子股份有限公司 | 自動化螢光檢測系統 |
Citations (5)
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US4343991A (en) * | 1979-05-25 | 1982-08-10 | Olympus Optical Co., Ltd. | Sample detector |
US5038258A (en) * | 1989-03-02 | 1991-08-06 | Carl-Zeiss-Stiftung | Illuminating arrangement for illuminating an object with incident light |
US5294799A (en) * | 1993-02-01 | 1994-03-15 | Aslund Nils R D | Apparatus for quantitative imaging of multiple fluorophores |
EP0902271A2 (de) * | 1997-09-15 | 1999-03-17 | Becton, Dickinson and Company | Vorrichtung und Verfahren zur Analyse von Proben |
WO2001035079A1 (en) * | 1999-11-12 | 2001-05-17 | E. I. Du Pont De Nemours And Company | Fluorometer with low heat-generating light source |
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US4628026A (en) * | 1983-11-15 | 1986-12-09 | Dietlind Gardell | Method and apparatus for automated double fluorochromization analysis in lymphocytotoxicity testing |
US5500188A (en) * | 1984-03-01 | 1996-03-19 | Molecular Devices Corporation | Device for photoresponsive detection and discrimination |
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CA2092373A1 (en) * | 1992-04-24 | 1993-10-25 | Klaus W. Berndt | Methods and apparatus for detecting biological activities in a specimen |
JP2909216B2 (ja) * | 1994-04-29 | 1999-06-23 | パーキン‐エルマー コーポレイション | 核酸増幅生成物のリアルタイム検出装置 |
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US6122042A (en) * | 1997-02-07 | 2000-09-19 | Wunderman; Irwin | Devices and methods for optically identifying characteristics of material objects |
US6097025A (en) * | 1997-10-31 | 2000-08-01 | Ljl Biosystems, Inc. | Light detection device having an optical-path switching mechanism |
US5942432A (en) * | 1997-10-07 | 1999-08-24 | The Perkin-Elmer Corporation | Apparatus for a fluid impingement thermal cycler |
DE19745373A1 (de) * | 1997-10-14 | 1999-04-15 | Bayer Ag | Optisches Meßsystem zur Erfassung von Lumineszenz- oder Fluoreszenzsignalen |
US6369893B1 (en) * | 1998-05-19 | 2002-04-09 | Cepheid | Multi-channel optical detection system |
US6034774A (en) * | 1998-06-26 | 2000-03-07 | Eastman Kodak Company | Method for determining the retardation of a material using non-coherent light interferometery |
EP1983331B1 (de) * | 1999-05-28 | 2011-07-13 | Yokogawa Electric Corporation | Optische Anordnung zur Auswertung eines Biochips |
US6563581B1 (en) * | 2000-07-14 | 2003-05-13 | Applera Corporation | Scanning system and method for scanning a plurality of samples |
-
2001
- 2001-06-29 DE DE10131687A patent/DE10131687A1/de not_active Withdrawn
-
2002
- 2002-06-27 WO PCT/EP2002/007120 patent/WO2003002991A2/de not_active Application Discontinuation
- 2002-06-27 US US10/476,848 patent/US7102131B2/en not_active Expired - Fee Related
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4343991A (en) * | 1979-05-25 | 1982-08-10 | Olympus Optical Co., Ltd. | Sample detector |
US5038258A (en) * | 1989-03-02 | 1991-08-06 | Carl-Zeiss-Stiftung | Illuminating arrangement for illuminating an object with incident light |
US5294799A (en) * | 1993-02-01 | 1994-03-15 | Aslund Nils R D | Apparatus for quantitative imaging of multiple fluorophores |
EP0902271A2 (de) * | 1997-09-15 | 1999-03-17 | Becton, Dickinson and Company | Vorrichtung und Verfahren zur Analyse von Proben |
WO2001035079A1 (en) * | 1999-11-12 | 2001-05-17 | E. I. Du Pont De Nemours And Company | Fluorometer with low heat-generating light source |
Non-Patent Citations (1)
Title |
---|
HAUSER P C ET AL: "A SOLID-STATE INSTRUMENT FOR FLUORESCENCE CHEMICAL SENSORS USING A BLUE LIGHT-EMITTING DIODE OF HIGH INTENSITY", MEASUREMENT SCIENCE AND TECHNOLOGY, IOP PUBLISHING, BRISTOL, GB, vol. 6, no. 8, 1 August 1995 (1995-08-01), pages 1081 - 1085, XP000525059, ISSN: 0957-0233 * |
Also Published As
Publication number | Publication date |
---|---|
DE10131687A1 (de) | 2003-01-16 |
WO2003002991A2 (de) | 2003-01-09 |
US20040141178A1 (en) | 2004-07-22 |
US7102131B2 (en) | 2006-09-05 |
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