WO2002085204A1 - Outil de mesure de l'arteriosclerose - Google Patents

Outil de mesure de l'arteriosclerose Download PDF

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Publication number
WO2002085204A1
WO2002085204A1 PCT/JP2002/003982 JP0203982W WO02085204A1 WO 2002085204 A1 WO2002085204 A1 WO 2002085204A1 JP 0203982 W JP0203982 W JP 0203982W WO 02085204 A1 WO02085204 A1 WO 02085204A1
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Prior art keywords
blood
blood flow
air pressure
cuff
capillaries
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PCT/JP2002/003982
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English (en)
Japanese (ja)
Inventor
Masao Itoh
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Combi Corporation
Media Cross Co., Ltd
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Publication date
Application filed by Combi Corporation, Media Cross Co., Ltd filed Critical Combi Corporation
Priority to JP2002582789A priority Critical patent/JPWO2002085204A1/ja
Publication of WO2002085204A1 publication Critical patent/WO2002085204A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
    • A61B5/02007—Evaluating blood vessel condition, e.g. elasticity, compliance
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
    • A61B5/026—Measuring blood flow
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
    • A61B5/021—Measuring pressure in heart or blood vessels
    • A61B5/022—Measuring pressure in heart or blood vessels by applying pressure to close blood vessels, e.g. against the skin; Ophthalmodynamometers

Definitions

  • the present invention relates to an arteriosclerosis degree measuring apparatus, and more particularly to an arteriosclerosis degree measuring apparatus capable of non-invasively and routinely measuring blood viscosity and vasodilatory reaction.
  • blood includes healthy blood and unhealthy blood.
  • unhealthy blood has a high blood viscosity and is called “slimey” blood.
  • Healthy blood has a low blood viscosity and is called “smooth” blood.
  • red blood cells and white blood cells usually have dimensions slightly larger than the diameter of the capillaries, and usually deform themselves and pass through the capillaries, but the blood sugar level and fat in the blood If it is high, self-deformability is low, making it difficult to pass through capillaries and increasing blood viscosity. These are usually described as "blood is hard”.
  • Red blood cell agglutination also occurs when you drink less water, making your blood thicker. Red blood can also be caused by stress, excessive smoking or aging. It is said that spheres tend to aggregate.
  • blood viscosity causes thrombosis, arteriosclerosis, high blood pressure, diabetes, myocardial infarction and cerebral infarction, and is one of the important causes of lifestyle-related diseases.
  • vegetables and fruits that make the blood smooth on a daily basis, and fish and shellfish that contain a large amount of DHA, EPA, etc. are introduced and studied.
  • nitric oxide NO
  • nitric oxide relaxes the smooth muscle of the blood vessel, thereby dilating the blood vessel. It is known that when blood vessels are dilated in this manner, blood easily passes through the blood vessels, so that stress on blood vessels due to muddy blood is alleviated.
  • nitric oxide acts to suppress platelets and blood cells in blood from adhering to endothelial cells in blood vessels, thereby keeping endothelial cells in blood vessels smooth. I have. Therefore, when blood platelets adhere to endothelial cells of blood vessels without releasing nitric oxide, the inner diameter of the blood vessels becomes thinner. This makes it difficult for the blood to pass through the blood vessels, easily forming thrombi, and causing arteriosclerosis. From this, it can be understood that a blood vessel having a larger dilation response, that is, a higher flexibility is a healthy blood vessel.
  • vasodilatory reaction is one of the important causes of lifestyle-related diseases as well as the blood viscosity.
  • An arterial stiffness measuring device for measuring blood viscosity and dilation reaction of blood vessels is conventionally known.
  • Blood viscosity 7? 47i: r-P / 8-l-Q
  • the blood viscosity determined by Poisset's law is 5.68 to 4.41 in the morning and 3.99 at night in healthy volunteers after blood collection and examination using the Hess method. .
  • the measurement site to which the method described in this publication can be applied is limited to the large and middle arteries where there is a blood flow velocity distribution in the blood vessel. It's not easy.
  • Live Blood Analysis which uses a CCD camera and a microscope to observe live blood cells, has become widespread.
  • the blood cell status is shown in the blood magnified about 10,000 times by this CCD camera and microscope, and the red blood cell aggregation and white blood cell status are confirmed alive. it can.
  • This blood cell analysis is excellent because it can confirm the muddy state of blood as an image, but since there are various patterns in blood, it is difficult to judge the state of blood without a specialist, and it can be used easily at home Not a device. In particular, it must be used for laboratory-level use, since blood collection must be performed before microscopic observation.
  • the Micro Channel aray Flow Analyzer which uses a semiconductor microfabrication technology to artificially create capillaries on a glass substrate, allows the collected blood to pass through the capillaries, and measures blood viscosity based on the transit time:
  • the MC-FAN method has been developed. Yuji Kikuchi et al., "Cell microrheology measuring device MC-FANJ cells 30 (7), 281-284 (1998).
  • a capillary diverged from an arteriole to a capillary artery travels at a right angle toward the skin surface where the capillaries, such as the fingertips, concentrate, and then inverts on the skin surface and is connected to the capillary vein.
  • the brachial artery is compressed by the cuff above the systolic blood pressure and occluded for 1 minute.Then, the air pressure in the cuff is released, and the blood fills the entire capillary, so that the capillary tube becomes a capillary tube.
  • a significant difference was found between the group of diabetic patients and the group of healthy subjects in the time required for the blood cell velocity at the connected tip to recover. The reason that such a significant difference was found is that it is likely that it will take time for the diabetic patients to recover blood velocity in the terminal capillary due to high blood viscosity.
  • an arteriosclerosis degree measuring device for measuring the dilation reaction of blood vessels by measuring the diameter of the blood vessel.
  • This measuring device first measures a predetermined blood vessel diameter in a normal state using an echo. Subsequently, after the brachial artery is insufflated with a cuff for 5 minutes, the air pressure of the cuff is released to congest the blood, and the predetermined blood vessel diameter is measured using the echo. Then, the blood vessel diameter is compared between the normal state and the time of hyperemia after the end of ischemia, and the expansion response of the blood vessel is measured from the rate of increase in the blood vessel diameter.
  • the dilatation reaction of the blood vessel is measured by using an echo.
  • the echo is a dog-based apparatus, it is difficult to use it in a general household. Disclosure of the invention
  • An object of the present invention is to provide an arterial stiffness measuring device capable of easily and noninvasively measuring blood viscosity and a dilation reaction of a blood vessel to easily measure the degree of arteriosclerosis.
  • the arterial stiffness measuring device is characterized in that a cuff for compressing and closing an arterial site supplying blood to a capillary blood vessel by air pressure, and an air pressure of this cuff
  • a pneumatic pressure control means for controlling, a blood flow state detecting means for detecting a blood flow state in a capillary blood vessel compressed by the cuff, and an air pressure control means and a blood flow state detecting means, respectively connected to the cuff
  • a central processing unit for controlling the compression and release of the arterial site supplying blood to the capillaries, measuring the blood flow recovery time by the blood flow state detecting means, and calculating the blood viscosity.
  • the blood viscosity can be measured non-invasively, and the blood viscosity can be easily measured and managed at home.
  • the feature of the arteriosclerosis measuring device of the present invention according to claim 2 is that Another feature is that the air pressure control means further includes a timer for setting a time during which air pressure is applied to the cuff by the air pressure control means in order to occlude an arterial site supplying blood to the capillaries for a predetermined time.
  • a feature of the arterial stiffness measuring device of the present invention according to claim 3 is that the device further includes a recovery time measuring timer for measuring the blood flow recovery time.
  • the blood flow recovery time can be accurately measured by the recovery time measurement timer.
  • a feature of the arterial stiffness measuring device of the present invention according to claim 4 is that the blood flow state detecting means is constituted by a photoelectric pulse wave meter. Then, by adopting such a configuration, it is possible to detect the blood flow recovery state based on the pulse wave amplitude value.
  • a feature of the arterial stiffness measuring device of the present invention according to claim 5 is that the central processing unit moves a plurality of pulse wave maximum amplitude values measured by the photoelectric pulse wave meter simultaneously with the start of the recovery time measurement timer. Control is performed so that the moving average value is compared with the average value in normal conditions within a certain deviation while averaging, and when both match, the evening is terminated and the elapsed time is used as the blood flow recovery time. Is to do. By employing such a configuration, the blood flow recovery time can be accurately calculated based on the pulse wave amplitude value.
  • a feature of the arterial stiffness measuring device is that the blood flow state detecting means is constituted by a laser Doppler blood flow meter or a laser Doppler blood flow velocity meter. By adopting such a configuration, it is possible to detect the blood flow recovery state based on the blood flow amount or the blood flow velocity.
  • a feature of the arterial stiffness measuring apparatus of the present invention according to claim 7 is that the central processing unit is configured to measure the blood flow rate or the blood flow rate measured by a laser doppler blood flow meter or a laser doppler blood flow velocity meter simultaneously with the start of the recovery time measurement.
  • Moving averages of the maximum values of blood flow velocity are compared with each other, and it is compared whether the moving average value is within a certain deviation from the average value at normal time. Is set to be the recovery time. By employing such a configuration, the blood flow recovery time can be accurately calculated based on the blood flow or the blood flow velocity.
  • the arterial stiffness measuring device of the present invention is characterized in that: a cuff for closing an arterial site that supplies blood to a capillary blood vessel by air pressure, and an air pressure control means for controlling the air pressure of the cuff; A photoplethysmogram in a capillary blood vessel blocked by the cuff is measured by a photoplethysmograph, and a blood wave level of blood in the capillary is detected by a pulse wave in a direct frequency band of the photoplethysmogram.
  • a blood level detecting means, and an air pressure control means presses and releases an arterial site supplying blood to the capillaries, and the blood level detecting means provides a photoplethysmogram of the capillaries at normal time and at the time of hyperemia after ischemia. Measuring the difference in blood level between the normal time and the time of congestion after ischemia, calculating the increase in blood volume from the difference in blood level, and calculating the blood flow rate from the increase in blood volume. Pressurized component is calculated, in that it has a central processing equipment to measure vasodilation from the increase in the blood flow.
  • the blood level is the amount of absorbance indicating the ratio of absorption and absorption of near-infrared light by oxidized and reduced hemoglobin flowing through the capillaries of the fingertips.
  • the blood volume is a blood volume per unit time, and it is considered that the blood volume increases if hemoglobin, that is, red blood cells, increases. It can be said that there is a correlation between the level and the blood volume. Therefore, it is thought that if the blood level rises, the blood volume will also increase.
  • the blood flow is the flow of blood per unit time
  • the blood volume is proportional to the blood flow, and the blood flow increases as the blood volume increases. Therefore, it is considered that the increase in blood flow can be calculated from the increase in blood level.
  • the blood level detecting means By adopting such a configuration, not only the waveform of the photoplethysmogram but also the difference in absorbance between normal and blood congestion can be detected by the blood level detecting means. The difference in blood level can be measured. From the difference in blood level, the amount of increase in blood flow can be finally calculated to measure the vasodilatory response.
  • a feature of the arterial stiffness measuring device according to the present invention according to claim 9 is that, in order to occlude an arterial site supplying blood to the capillaries with the cuff for a certain period of time, the air pressure control means applies air pressure to the cuff. The point is that you have to set the evening time. By employing such a configuration, the arterial site supplying blood to the capillaries by the timer can be accurately closed for a certain period of time.
  • FIG. 1 is a diagram showing a configuration of an embodiment of an arteriosclerosis measuring apparatus according to the present invention. Diagram,
  • FIG. 2 is a front view showing an example of a measurement state of blood viscosity by the arterial stiffness measuring device of FIG. 1,
  • FIG. 3 is a front view showing another example of the measurement state of blood viscosity by the arteriosclerosis degree measuring device of FIG.
  • FIG. 4 is a positive diagram showing still another example of a measurement state of blood viscosity by the arteriosclerosis degree measuring device of FIG. 1,
  • FIG. 5 is a graph showing a change state of pulse wave amplitude at the time of measurement by the arteriosclerosis measuring device of FIG. 1,
  • FIG. 6 is a block diagram showing a measurement sequence by the arteriosclerosis measuring device of FIG. 1,
  • Fig. 7 is a graph showing the blood viscosity of patients with diabetes, hypercholesterolemia and hyperlipidemia and healthy subjects,
  • FIG. 8 is a graph showing an example of a change in blood viscosity in one day
  • FIG. 9 is a front view showing an example of a measurement object of another embodiment of an arteriosclerosis measuring apparatus according to the present invention.
  • FIG. 10 is a graph showing the waveform and amplitude state of the photoplethysmogram at the time of measurement by the arteriosclerosis measuring device of FIG. 9,
  • FIG. 11 is a graph showing the percentage of increase in blood flow measured by the arteriosclerosis measuring device of FIG. 9,
  • FIG. 12 is a chart showing the average value of the numerical values shown in the graph of FIG. BEST MODE FOR CARRYING OUT THE INVENTION
  • FIG. 1 shows an embodiment of an arteriosclerosis measuring device according to the present invention.
  • the blood viscosity measuring device as the arteriosclerosis measuring device shown in FIG. 1 is a cuff for compressing and closing a blood vessel by air pressure. Have one.
  • This cuff 1 is designed to be attached to a capillary vessel in which blood flow velocity distribution does not occur in a blood vessel in order to calculate an accurate measurement result.
  • the cuff 1 is connected to air pressure control means 2, and controls the air pressure required by the cuff 1 and releases the air pressure from the cuff 1 by the air pressure control means 2.
  • a CPU 3 as a central processing unit having a memory 4 is connected to the air pressure control means 2, and the air pressure control means 2 is controlled by a timer (not shown) provided in the CPU 3. The time for applying air pressure to the cuff 1 can be set. Other functions of the PU 3 will be described later.
  • the average value of the recovery time Treco (s) until the pulse wave when the air pressure is released from the cuff 1 recovers to the normal state, that is, a large number of diabetes The average value of the recovery time Treco (s) measured in patients with cholesterol and hyperlipidemia is stored for each generation with the statistical distribution deviation of soil ⁇ according to its size.
  • the recovery time Treco (s) of a healthy person with the same number of patients as the above-mentioned patients is also statistically processed and stored in the memory 4.
  • the statistical distribution of healthy individuals there is a case where there is a high aging dependency. In these statistical distributions, it is better to separate the two groups separately and store them in the memory 4 for the state of blood viscosity. Easy to judge.
  • the CPU 3 is connected to a photoelectric pulse wave meter 5 as an example of a blood flow state detecting means for detecting a blood flow state in a capillary blood vessel compressed by the cuff 1.
  • the photoplethysmograph 5 can optically measure the state of the pulse wave of the blood flow in the capillaries compressed by the cuff 1.
  • a laser Doppler blood flow meter or a laser Doppler blood flow velocity meter may be used as another example of the blood flow state detecting means.
  • blood flow blood volume x blood flow velocity
  • the laser Doppler blood flow meter has the same index value as the blood velocity in the laser Doppler blood flow velocity meter.
  • the CPU 3 is connected to a recovery time measuring timer 6 for measuring a time required for the pulse wave of the blood flow in the capillary blood vessel released from the compression by the cuff 1 to return to a normal state. I have.
  • a printer 7 for printing the measurement result and a display 8 for displaying the measurement result are connected to the CPU 3 respectively.
  • a memory card 9 for inputting measurement results to a personal computer (not shown) or the like is detachably mounted on the CPU 3.
  • the cuff 1 is wound around a part of a human body in which an artery part supplying blood to a capillary is running. Examples of the site where the cuff 1 is wound are shown in FIGS. 2 to 4, respectively.
  • FIG. 2 shows a state in which a cuff 1 is wound around the bottom of the fifth metacarpal bone of the third or fourth finger of the left hand, and a sac-shaped photoplethysmograph 5 is attached to the distal end.
  • 1 shows a state in which the blood viscosity is measured by the blood viscosity measuring device.
  • a LAN interface cable 11 is led out of the main body 10 of the blood viscosity measurement device.
  • Fig. 3 shows the blood viscosity measurement shown in Fig. 1 with the cuff 1 wrapped around the left wrist and a sac-shaped photoelectric pulse wave meter 5 attached to the tip of the third or fourth finger of the left hand. This shows a state where the blood viscosity is being measured by the device.
  • Fig. 4 shows a blood viscosity measurement device of Fig. 1 in which a cuff 1 is wound around the upper arm of the left hand and a sac-shaped photoelectric pulse wave meter 5 is attached to the tip of the third or fourth finger of the left hand. Indicates a state in which the blood viscosity is measured.
  • FIG. 5 shows a state of the pulse wave amplitude value measured by the photoelectric pulse wave meter 5 before and after using the cuff 1.
  • FIG. 6 shows the operation of the embodiment in the order of steps.
  • the appropriate air pressure applied to the cuff 1 should be set so that the systolic blood pressure value of the subject is increased by several tens of mmHg, but in some cases, what kind of air pressure is applied to the cuff 1 It is often unclear whether the values are appropriate. In such a case, there is a method in which the point where the maximum value of the pulse wave amplitude falls by a constant value Vmin while increasing the air pressure of the cuff 1 is set as the optimum cuff pressure (Fig. 6-ST2).
  • the air pressure acting on the cuff 1 is rapidly released, and the occluded arterial blood flows again into the capillaries that are wrapped in a mesh.
  • the viscous state of the blood increases and the deformability of, for example, red blood cells decreases, and the blood cells become difficult to pass through the capillaries.
  • the CPU 3 averages the maximum value of the n pulse wave amplitudes or adjusts the time constant at the same time as the air pressure of the cuff 1 is released. Therefore, the moving average is performed at a few meters of the maximum value of the pulse wave captured within a certain time Tmov. At the same time, start the recovery time measurement timer ( Figure: 6-ST4).
  • This moving average value VmaxMOV is compared with the average value of the maximum pulse wave value VniaxAV at normal times, which was previously obtained every second, at the CPU 3, and the difference value is calculated (Fig. 6—ST5). .
  • the point in time at which the calculated difference value falls within a predetermined deviation value ⁇ is detected, and at this point, the recovery time timer 6 is stopped by an instruction from the CPU 3. Then, the time measured by the recovery time timer 6 is stored as the recovery time Treco (s). Also, this recovery: time Treco (s) is immediately displayed on display 9 (FIG. 6—ST 6).
  • Figure 7 shows the average recovery time Treco (s) measured in a large number of patients with diabetes, hypercholesterolism, and hyperlipidemia stored in memory 4 described above, and a similar number of patients.
  • Recovery time of Treco (s) measured in healthy subjects It shows the average value.
  • the recovery time Treco (s) is highly age-dependent, and the older the elderly, the lower the “smoothness” of blood.
  • the recovery time Treco (s) does not show any age dependence, and the blood is uniformly in a “slime” state.
  • the recovery time Treco (s) for several days is stored in the memory card 9 together with the measurement time so that it can be transferred to a higher-level data processing means such as a personal computer.
  • the program may be downloaded directly to a personal computer via the LAN interface cable 11 directly (FIG. 6—ST 9).
  • the blood viscosity measuring device of the present embodiment the blood viscosity Can be measured simply and non-invasively, so that blood viscosity can be measured and managed at home.
  • the blood flow state detecting means is described as detecting the blood flow recovery time based on the pulse wave amplitude value by the photoelectric pulse wave meter.
  • the blood flow or the blood flow recovery time is detected based on the blood flow or the blood flow velocity by using a laser Doppler blood flow velocity meter.
  • operations such as controlling the air pressure of the cuff and receiving a signal from the photoplethysmograph are performed by a CPU as one central processing unit provided in the blood viscosity measurement device. But not limited to.
  • a blood viscosity measurement device is divided into an automatic blood-blocking device as air control means for controlling the air pressure of the cuff, and a blood flow state detection device as a blood flow state detection means for detecting the state of blood flow in the capillaries.
  • a central processing unit may be provided in each of the automatic blood ischemia device and the blood flow condition measuring device.
  • FIG. 9 a second embodiment of the arteriosclerosis measuring apparatus according to the present invention will be described with reference to FIGS. 9 to 12.
  • FIG. 9 a second embodiment of the arteriosclerosis measuring apparatus according to the present invention will be described with reference to FIGS. 9 to 12.
  • the vasodilatory reaction measuring device 21 as the arteriosclerosis degree measuring device has an automatic blood ischemic device 22 as air pressure control means. Is connected to a cuff 23 for compressing and closing a blood vessel by air pressure.
  • This cuff 23 is designed to be attached to an artery site that supplies blood to capillaries. In the present embodiment, the cuff 23 is attached to the forearm, but the artery is compressed. Any part that can be cut off may be the upper arm, wrist, finger base, ankle, etc.
  • the automatic blood ischemia device 22 includes a CPU 24 as a first central processing unit, a start button 25 for operating the CPU 24, and the automatic blood ischemia device 2.2 that applies air pressure to the cuff 23. It has a timer 26 for setting the supply time.
  • the automatic blood ischemia device 22 applies air pressure to the extent that the cuff 23 can compress the artery of the forearm and occlude the capillaries, and controls the air pressure to be released from the cuff 23. It is supposed to do.
  • a pressure of 25 OmmHg is applied to the buffer 23, and after maintaining for 5 minutes, the air pressure of the cuff 23 is released. I have.
  • the pressure supplied to the cuff 2 3 the pressure supplied to the cuff 2 3 .
  • the cuff pressure display panel 27 for immediately displaying the force, and the pressure of 25 O mmH to the cuff 23 were supplied.
  • a time display panel 28 for displaying the elapsed time later is provided.
  • the vasodilator reaction measuring device 21 has a blood level detecting device 30 as a blood level detecting means for measuring a photoelectric pulse wave to detect a blood level.
  • 0 has a sac-shaped photoplethysmograph 31 for detecting photoplethysmograms in capillaries.
  • the detection of the photoplethysmogram of the capillary blood vessel is performed because the velocity distribution of the blood flow does not occur in the blood vessel as described in the first embodiment, so that the accurate detection result of the photoplethysmogram is calculated. This is because they can do this.
  • the photoelectric pulse wave meter 31 is mounted on the tip of the second finger of the right hand.
  • the photoplethysmograph 31 uses a light-emitting element (not shown) to generate oxyhemoglobin and Light that is absorbed by reduced hemoglobin is irradiated, and of this light, light that has passed through the capillaries is received by a light receiving element (not shown). At this time, the light receiving element receives light that is not absorbed by the oxidized and reduced hemoglobin flowing in the capillaries, and the photoelectric pulse wave meter 31 absorbs the light by the oxidized and reduced hemoglobin. Photoplethysmograms are measured based on the measured absorbance.
  • the blood level detection device 30 receives a pulse wave of a DC frequency band among the frequency bands of the photoplethysmogram measured by the photoplethysmograph 31 as a DC signal, and outputs the pulse wave via an amplifier. It is made to amplify.
  • the photoelectric pulse wave meter 31 measures the amplitude of the photoelectric pulse wave by measuring the DC frequency band of the photoelectric pulse wave.
  • the blood level detecting device 30 has a CPU 32 as a second central processing unit provided with a memory (not shown).
  • the CPU 32 can measure not only the waveform of the photoplethysmogram but also the difference in absorbance of light absorbed by oxidized and reduced hemoglobin, etc., based on the DC signal from the photoplethysmograph 31. To detect the blood level.
  • the CPU 32 calculates an increase in blood flow from a comparison value between the blood level after normal and the blood level at the time of hyperemia after ischemia, and measures the dilation response of the blood vessel based on the increase in blood flow. It is supposed to.
  • a printer (not shown) for printing the measurement result and a display (not shown) for displaying the measurement result are connected to the blood level detection device 30 respectively.
  • a memory card 33 for inputting a measurement result to, for example, a personal computer (not shown) or the like is detachably attached to the blood level detection device 30.
  • the blood The level detecting device 30 is provided with a LAN interface 34 for connecting a LAN cable for network connection to a personal computer.
  • the cuff 23 is attached to the forearm, and the photoplethysmograph 31 is attached to the tip of the second finger of the right hand.
  • the blood level of the capillary at the tip of the second finger of the right hand is detected for 3 minutes using the blood level detection device 30.
  • FIG. 10 is a graph showing an example of detecting a blood level using the vasodilator response measuring apparatus 21 according to the second embodiment.
  • Fig. 10 when the artery is blocked, the blood level rises rapidly due to congestion. Thereafter, as blood flows and stasis resolves, blood levels gradually drop to near normal values. At this time, no pulse wave is detected because there is no pulsation. Subsequently, when the air pressure in the cuff is released and congested, the blood level rapidly rises for a moment due to the rapid inflow of blood, but the blood level rapidly increases because the amount of blood flowing out is greater than the amount supplied. Descend. Then the blood is pulsed As blood flows in, the blood level gradually rises while following this pulsation waveform, and an accurate pulse wave appears about 1 minute after congestion.
  • the CPU 32 of the blood level detecting device 30 sets the average value of the blood level at normal time to R, and sets the average value of the blood level at the time of congestion after an accurate pulse wave appears to OC.
  • the rate of increase D in the flow rate is
  • Is calculated by The increase rate D of the blood flow is stored in the memory of the CPU 32 of the blood level detection device 30.
  • FIG. 11 shows the ratio of the increase in the blood flow several times in four days when the ratio D of the increase in the blood flow was calculated using the vasodilator measurement apparatus 21 according to the second embodiment.
  • Fig. 11 is a graph showing an example of a numerical value when D is plotted. As shown in Fig. 11, the rate of increase in blood flow D varies depending on the day, and also varies depending on the time of day. You can see that.
  • the CPU 32 of the blood level detecting device 30 calculates the ratio D of the increase in the blood flow several times a day for several days, and stores these ratios D in the memory. Then, the CPU 32 obtains an average value or the like of the respective ratios D as shown in FIG. 12 from the ratios D of the increase in the blood flow, and measures the dilation response of the blood vessel based on the average values. .
  • the rate of increase D in the blood flow for a certain number of days is stored in the memory card 33, and the personal computer or the like is connected to the memory card 33 using the memory card 33 or through the LAN interface 34 cable.
  • the data of the ratio D of the increase in the blood flow is transferred, and the average value of the ratio D is obtained by data processing means such as a personal computer. It may measure the expansion response.
  • the increase rate D of the blood flow rate measured several times a day can be stored in the memory and printed on paper using a printer.
  • a pulse wave in the DC frequency band of the photoelectric pulse wave can be detected by the blood level detecting device. It is possible to detect not only the waveform but also the difference in the absorbance of the light irradiated to oxidized and reduced hemoglobin during normal time and during hyperemia. Thus, the blood level can be measured, and the blood flow can be finally calculated from the blood level to measure the dilation reaction of the blood vessel.
  • CPUs 24 and 32 as central processing units are provided in each of the automatic blood ischemia device 22 and the blood level detection device 30.
  • One central processing unit having the functions of the two CPUs may be provided in one vasodilatory reaction measuring device.
  • standard values of the vasodilatory response for each age such as the tenth, the twentys, and the thirties are determined, and these standard values are calculated.
  • the CPU of the blood level detection device may be stored in advance, and the arterial stiffness may be measured based on these standard values.
  • the blood level detection device 30 is configured to receive, as a DC signal, a pulse wave in the DC frequency band among the photoelectric pulse waves from the photoelectric pulse wave meter 31, but is not limited thereto. .
  • a photoelectric pulse wave meter as a blood flow state detecting means in the first embodiment, an AC signal as well as a DC signal can be received, and a DC signal and an AC signal can be received. It may have a switching switch for switching the reception of the data.

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  • Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)

Abstract

La présente invention concerne un outil de mesure de l'artériosclérose, comprenant : une manchette (1) servant à obstruer, par une pression exercée au moyen d'une pression d'air, une partie d'une artère servant à acheminer le sang vers les capillaires ; un élément de commande de pression d'air (2), servant à commander la pression d'air dans la manchette (1) ; un élément de détection (5) de l'état du débit sanguin, servant à déterminer l'état du débit sanguin dans les capillaires obstrués par la manchette ; et une unité de traitement centrale (3), connectée à l'élément de commande de pression d'air (2) et à l'élément de détection (5) de l'état du débit sanguin, servant à commander la pression et le relâchement des capillaires par la manchette (1), à mesurer le temps de récupération du débit sanguin au moyen de l'élément de détection (5) de l'état de débit sanguin, et à calculer la viscosité sanguine, ladite viscosité sanguine pouvant être mesurée de manière non invasive et ce, même au sein d'une famille, et pouvant être mesurée facilement dans le but de contrôler la viscosité.
PCT/JP2002/003982 2001-04-20 2002-04-22 Outil de mesure de l'arteriosclerose WO2002085204A1 (fr)

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JP2007044261A (ja) * 2005-08-10 2007-02-22 Utsunomiya Univ 血管硬度測定装置
JP2007111244A (ja) * 2005-10-20 2007-05-10 Seiko Instruments Inc 血液循環状態測定装置
JP2007202791A (ja) * 2006-02-02 2007-08-16 Kowa Co 血管脈波測定装置
JP2008295657A (ja) * 2007-05-30 2008-12-11 Yuri Uchiyama 血液粘性度測定装置
JP2009219716A (ja) * 2008-03-17 2009-10-01 Yunekusu:Kk 生体血管状態測定装置
JP2011520581A (ja) * 2008-05-26 2011-07-21 コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ 光学的検出方法及び関節の状態を光学的に検出する装置
JP2014166269A (ja) * 2013-02-28 2014-09-11 Canon Inc 画像処理装置及び画像処理方法
JP2014193349A (ja) * 2013-03-19 2014-10-09 Avita Corp 生理状態を監視するための装置および方法
JP2015054219A (ja) * 2013-09-13 2015-03-23 カシオ計算機株式会社 脱水状態判定装置
WO2015049963A1 (fr) * 2013-10-03 2015-04-09 コニカミノルタ株式会社 Dispositif et procédé de mesure de bio-informations
JP2017196474A (ja) * 2017-07-05 2017-11-02 カシオ計算機株式会社 脱水状態判定装置
US10238306B2 (en) 2006-02-20 2019-03-26 Everist Genomics, Inc. Method for non-evasively determining an endothelial function and a device for carrying out said method

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Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007044261A (ja) * 2005-08-10 2007-02-22 Utsunomiya Univ 血管硬度測定装置
JP2007111244A (ja) * 2005-10-20 2007-05-10 Seiko Instruments Inc 血液循環状態測定装置
JP2007202791A (ja) * 2006-02-02 2007-08-16 Kowa Co 血管脈波測定装置
US10238306B2 (en) 2006-02-20 2019-03-26 Everist Genomics, Inc. Method for non-evasively determining an endothelial function and a device for carrying out said method
JP2008295657A (ja) * 2007-05-30 2008-12-11 Yuri Uchiyama 血液粘性度測定装置
JP2009219716A (ja) * 2008-03-17 2009-10-01 Yunekusu:Kk 生体血管状態測定装置
JP2011520581A (ja) * 2008-05-26 2011-07-21 コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ 光学的検出方法及び関節の状態を光学的に検出する装置
JP2014166269A (ja) * 2013-02-28 2014-09-11 Canon Inc 画像処理装置及び画像処理方法
JP2014193349A (ja) * 2013-03-19 2014-10-09 Avita Corp 生理状態を監視するための装置および方法
JP2015054219A (ja) * 2013-09-13 2015-03-23 カシオ計算機株式会社 脱水状態判定装置
WO2015049963A1 (fr) * 2013-10-03 2015-04-09 コニカミノルタ株式会社 Dispositif et procédé de mesure de bio-informations
JP2017196474A (ja) * 2017-07-05 2017-11-02 カシオ計算機株式会社 脱水状態判定装置

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CN1461201A (zh) 2003-12-10
TW529931B (en) 2003-05-01

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