529931 A7 ____B7_ 五、發明說明（ί ) [技術領域] 本發明係關於一種動脈硬化度測定裝置，特別是，關 於一種動脈硬化度測定裝置其能夠非侵襲性且日常性地測 定血液黏度或血管擴張反應。 [習知技術與發明欲解決之課題] 一般，血液有健康血液與不健康血液。其中，不健康 血液其黏度高，稱爲「黏稠」的血液。相對於此，健康血 液其血液黏度低，稱爲「順暢」的血液。 成爲黏稠血液的原因之一，是血漿中含有多量之膽固 醇或脂質’由於血液黏度上升，被稱爲「血液充脂」。另 一個原因是，因紅血球或血小板凝集而不易通過微血管， 會表現出「血液很濃」的現象。 又，通常，紅血球或白血球之大小僅比微血管之口徑 稍大，通常係作自我變形以通過微血管內，惟當血液中之 血糖値或脂肪變高會使自我變形能力降低，結果變得不易 通過微血管，使血液黏度升高。該種情形通常會表現出「 血液很硬」的現象。 紅血球之凝集在水分攝取不足時也會發生，使血變濃 。其它，壓力或吸煙過多或是年齡增長亦被認爲會使紅血 球容易凝集。 因血液黏度爲產生血栓或動脈硬化、高血壓、糖尿病 、心肌梗塞、腦梗塞之原因，故爲生活習慣病之重要原因 參數之一。又，飮食生活上，也有很多日常生活上使血液 _____A_____ 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） ·I ------------------------------訂---------線"^^1 (請先閱讀背面之注意事項再填寫本頁) 529931 A7 _____B7______ 五、發明說明（y) 變得順暢的蔬菜或水果、含有多量DHA、EPA等之魚貝類 被介紹和硏究。 再者’血液黏度右變局’則血管之內皮細胞中’對應 於血液黏度之摩擦應力會提高。一旦出現此種情況，則相 應於該摩擦應力做爲生理活性物質之一的一氧化氮(NO)會 被釋出至血管。一氧化氮會使血管平滑肌鬆驰，藉此使血 管擴張。血管一擴張，則因血液變得容易通過血管內，於 是黏稠血液對血管之壓力可以緩和下來。又，前述一氧化 氮因具有抑制血液內之血小板或血球癒合於血管之內皮細 胞之作用，故已知可保持血管之內皮細胞在平滑的狀態。 因此，當不能放出一氧化氮下而血小板等癒合於血管之內 皮細胞時，血管之內徑會變細，又因血管無法擴張，使黏 稠血液通過血管變得困難，容易產生血栓，這也是動脈硬 化產生之原因。因此，可了解擴張反應大，亦即柔軟性高 , 之血管爲健康的。 像這樣，血管之擴張反應，和前述血液黏度同樣也是 生活習慣病之重要原因參數之一。 且，已知先前已有用於測定血液黏度或血管擴張反應 之動脈硬化度測定裝置。529931 A7 ____B7_ V. Description of the Invention (Technical Field) The present invention relates to an arteriosclerosis measurement device, and more particularly, to an arteriosclerosis measurement device which can non-invasively and routinely measure blood viscosity or vasodilation reaction. [Problems to be Solved by the Conventional Technology and Invention] Generally, there are healthy blood and unhealthy blood. Among them, unhealthy blood has a high viscosity and is called "thick" blood. In contrast, healthy blood has a low blood viscosity and is called "smooth" blood. One of the reasons for the thick blood is that blood plasma contains a large amount of cholesterol or lipids', which is called "blood filling" because of the increase in blood viscosity. Another reason is that it is difficult for blood cells to pass through the microvessels due to agglutination of red blood cells or platelets. Also, usually, the size of red blood cells or white blood cells is only slightly larger than the caliber of microvessels. They are usually self-deformed to pass through the microvessels. However, when the blood sugar level or fat in the blood increases, the self-deformation ability is reduced and the result becomes difficult to pass. Micro blood vessels increase blood viscosity. This situation usually shows a "hard blood" phenomenon. Agglutination of red blood cells also occurs when there is insufficient water intake, making the blood thicker. In addition, stress or excessive smoking or aging are also thought to make red blood cells more likely to agglutinate. Because blood viscosity is the cause of thrombosis or arteriosclerosis, hypertension, diabetes, myocardial infarction, and cerebral infarction, it is one of the important causes of lifestyle disorders. In addition, there are many blood in daily life _____A_____ This paper size applies the Chinese National Standard (CNS) A4 specification (210 X 297 mm) · I ------------- ----------------- Order --------- line " ^^ 1 (Please read the notes on the back before filling this page) 529931 A7 _____B7______ 5 2. Description of the invention (y) Vegetables or fruits that become smooth, fish and shellfish containing a large amount of DHA, EPA, etc. are introduced and studied. Furthermore, if the "blood viscosity changes right", the frictional stress corresponding to blood viscosity in endothelial cells of blood vessels will increase. Once this occurs, nitric oxide (NO), which is one of the physiologically active substances corresponding to the frictional stress, is released to the blood vessels. Nitric oxide relaxes vascular smooth muscle, thereby dilating the blood vessels. As the blood vessels dilate, the blood becomes easier to pass through the blood vessels, so the pressure of the thick blood on the blood vessels can be eased. In addition, since the aforementioned nitric oxide has the effect of inhibiting the blood platelets or blood cells from healing to the endothelial cells of blood vessels, it is known that the endothelial cells of blood vessels can be kept in a smooth state. Therefore, when the nitric oxide cannot be released and the platelets and other endothelial cells heal in blood vessels, the inner diameter of the blood vessels will become thinner, and because the blood vessels cannot expand, it will be difficult for viscous blood to pass through the blood vessels, and blood clots will easily occur. This is also an artery Causes of hardening. Therefore, it can be understood that the dilation response is large, that is, the softness of blood vessels is healthy. As such, the dilation response of blood vessels, as well as the aforementioned blood viscosity, is also one of the important cause parameters of lifestyle diseases. Also, arteriosclerosis measuring devices for measuring blood viscosity or vasodilation response have been previously known.
血液黏度一般係以波耳塞尤(Poiseuille)之法則求算。 血液黏度?7 =4 7Γ r · P/8 · 1 · Q (r··血管半徑、P:鏈2點間之血壓差、1:自測定部位起 算之血管之全長、Q:血液流量） 由該波耳塞尤之法則求算出之血液黏度於採血後以黑 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） ——1----------------訂---------線·. (請先閱讀背面之注意事項再填寫本頁) A7 529931 _______B7____ 五、發明說明（ή;) 司法（Hess’s Law)等檢查，在健康正常者，早上約爲 5.68〜4.41，晚上約 3.99。 然而，血液黏度一般而言，若以波耳塞尤之法則，至 少須測定2點間之血壓差，否則無法計算。故，先前有分 別測定血壓差及血流速度，做爲非侵襲性動脈硬化度測定 裝置爲過大之裝置。 但，近年來有不以測定血壓差爲前提之非侵襲性血液 黏度測定方法被提出。 即，如特開平11-316180號公報中所揭示，已知有使 用超音波裝置之回音，求出數點假定爲牛頓流之血流速度 ，以那比葉史托克司(Navier-Stokes)之微分方程式同時求得 血液黏度與壓力梯度之方法。 惟，該公報記載方法可適用之測定部位因僅限於血管 內具有血流速度分布之大、中動脈，若考慮測定部位或測 定技術，在家中不易使用。 另一方面，雖然採取1滴血液不能說是非侵襲性的， 但使用CCD照相機與顯微鏡對活體血液細胞進行觀察之血 液細胞分析(Live Blood Analysis)也普及起來。 在以CCD照相機與顯微鏡放大約1萬倍之血液中，血 球的狀態會被照出，可於活體下確認紅血球之凝集與白血 球之狀態。該血液細胞分析在可將血液之黏稠狀態以畫像 的方式確認方面很出色，但因血液有各種樣式，若非專家 很難判斷血液的狀態，不是在家中可以很方便使用的。特 別是，必須先採血再以顯微鏡觀察，故可說是設定在硏究 —— _______________ ___________ fi _____ __— -- 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） ------------0^--------訂---------線# (請先閱讀背面之注意事項再填寫本頁) 529931 A7 _____ B7 _ 五、發明說明（+ ) 室水準使用之裝置。 再者，最近使用半導體微細加工技術，已開發出於玻 璃基板上製造出人造微血管，使採取之血液通過微血管， •以其通過時間測量血液黏度之Micro Channel Array Flow Analyzer，MC:FAN法。參照菊池佑二等人「細胞微流變量 測定裝置 MC-FAN」細胞 30(7)，281-284(1998)。 該方法因爲採血與裝置之處理規模大故侷限於實驗機 構內利用。但若考慮將血液黏度以流過人工微血管之時間 來表示，則與後述本發明中使用生體內微血管血流量以測 定血液黏度之非侵襲性裝置可認爲在原理上很接近。 一般，自細動脈分往微動脈之微血管，係朝向指尖等 之微血管集中之皮膚表面以直角進入之後，在皮膚表面反 向，而連接於微靜脈血管。 近年在德國之硏究（Influence of metabolic control and duration of disease on microvascular dysfunction in diabetes assessed by laser Doppler anemonetry: M.F. Meyer, H. Schatz Exp Clin Endocrimol Diabetes 106(1998) 395-403, Germany)中使用雷射都卜勒血流速度計在單一微血管內之 血球水平之移動速度中，雖微血管本身之血管運動速度會 重覆，但可見到與心搏同步之速度變動。 故若紅血球等之變形能力降低，或是發生紅血球凝集 等，則單一微血管級之血球速度被推測會因血液黏度上升 使最大速度振幅値減低。 另一方面，比較糖尿病患者1型及2型中10年以上及 ____2_ ____ 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） H· 1^— I ί ·ϋ ϋ H4 n n ϋ · tm§ i l I I It 一 口，fl n n n n n>i ϋ I I (請先閱讀背面之注意事項再填寫本頁) 529931 B7 五、發明說明（（） 10年以下之群體與健康正常者群體，其最大血球速度沒有 明顯之差異。如此，最大血球速度沒有明顯之差異據判斷 是因爲最大血球速度有個人差異，且在心搏周期左右之時 間內誤差太大以致於看不出差異。 對此，將上腕動脈以環套壓迫至最高血壓使其閉塞1 分鐘後，解除環套之空氣壓，使血液充血至全體微血管以 使微動血管之連接至微靜血管前端之血流速度回復爲止之 時間上，糖尿病人群體與健康正常者群體有明顯差異。產 生明顯差異之原因推測爲糖尿病患者之血液黏度高，故末 端之微血管內血球速度要回復比較花時間。 此外，在瑞典之硏究（Skin Capillary is More Impaired in the Toes of Diabetes Than Non-diabetic Patients Vascular Disease :G. Jorneskog5K. Brismar, B. Fagrell: DIABETIC MEDICINE, 1995;12:36-41· Sweden)中，使用腳之拇指以顯 微環套同樣測定被閉塞後回復時間之實驗中，糖尿病患者 與健康正常者有明顯差異。 另外，血管擴張反應方面，已知有習知之藉測定血管 徑以測定血管擴張反應之動脈硬化度測定裝置。 該裝置起先係對平常狀態之既定之血管徑以回音器進 行測定。接著，將上腕動脈以環套阻血5分鐘後，解除環 套之空氣壓使其充血，用前述回音器測定前述既定之血管 徑。並且，比較平常時與阻血結束後充血時之血管徑，由 血管徑之增加比例來測定血管擴張反應。 但是’前述之動脈硬化度測定裝置中使用回音器以測 --^____ 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公爱） (請先閱讀背面之注意事項再填寫本頁) — 訂---------線- 529931 A7 _______B7_ 五、發明說明（V ) 疋血管之擴張反應，惟回音器係很大的裝置，對一般家庭 之使用上有困難。 本發明之目的爲提供一種動脈硬化度測定裝置，其可 以簡單又非侵襲性的方式測定血液黏度或血管擴張反應以 測得動脈硬化度。 [用以解決課題之手段] 爲達成前述目的，申請專利範圍第1項中本發明之動 脈硬化度測定裝置其特徵爲，具有：環套，係藉由空氣壓 來將對微血管供給血液之動脈部位加以壓迫而使其閉塞； 空氣壓控制機構，係用以控制該環套之空氣壓；血流狀態 檢測機構，係用以檢測由該環套所阻血之微血管內之血流 狀態；中央處理裝置，係與該空氣壓控制機構及血流狀態 檢測機構分別連接，用以控制該環套所致之對微血管供給 血液之動脈部位的壓迫及解除，且量測該血流狀態檢測機 構所得之血流回復時間，並運算血液黏度。藉採用這樣的 構成，可以非侵襲性地測定血液黏度。 申請專利範圍第2項中本發明之動脈硬化度測定裝置 其特徵爲，係進一步具有計時器，該計時器係用以設定以 該空氣壓控制機構對環套作用空氣壓之時間’來使得對微 血管供給血液之動脈部位受環套的作用而閉塞一定時間。 藉採用這樣的構成’可以藉計時器正確的使對微血管供給 血液之動脈部位閉塞一定時間。 申請專利範圍第3項中本發明之動脈硬化度測定裝置 本紙張尺度適用中國國家標準（CNS)A4規格（210 x 297公釐） •——：-----------------訂---------線Φ (請先閱讀背面之注意事項再填寫本頁) A7 529931 B7_______ 五、發明說明（7 ) 其特徵爲，係進一步具有用以量測該回復時間之回復時間 量測計時器。藉採用這樣的構成’可以藉回復時間量測計 時器正確的量測血流回復時間。 申請專利範圍第4、5項中本發明之動脈硬化度測定裝 置其特徵爲，前述血流狀態檢測機構係由光電脈波量測器 所構成。藉採用這樣的構成’可以根據脈波振幅値檢測血 流回復狀態。 申請專利範圍第6、7項中本發明之動脈硬化度測定裝 置其特徵爲，該中央處理裝置係控制成：於該回復時間量 測計時器之啓動的同時將由光電脈波量測計所量測到之脈 波最大振幅値做複數個移動平均’並比較移動平均値與平 常時之平均値是否在某個偏差以內爲一致，當兩者爲一致 時乃使得計時器停止，並將經過的時間當作血流回復時間 。藉採用這樣的構成，可以根據脈波振幅値正確的運算血 流回復時間。 申請專利範圍第8、9項中本發明之動脈硬化度測定裝 置其特徵爲，前述血流狀態檢測機構係由雷射都卜勒血流 計或是雷射都卜勒血流速度計所構成。藉採用這樣的構成 ，可以根據血流量或血流速度檢測血流回復狀態。 申請專利範圍第10、11項中本發明之動脈硬化度測 定裝置其特徵爲，該中央處理裝置係控制成：於該回復時 間量測計時器之啓動的同時將由雷射都卜勒血流計或雷射 都卜勒血流速度計所量測到之血流量或血流速度最大値做 複數個移動平均，並比較移動平均値與平常時之平均値是 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） (請先閱讀背面之注意事項再填寫本頁) Μ --訂！--------線一 529931 A7 _一― _ B7_____ 五、發明說明（3 ) (請先閱讀背面之注意事項再填寫本頁) 否在某個偏差以內爲一致，當兩者爲一致時乃使得計時器 停止，並將經過的時間當作回復時間。藉採用這樣的構成 ，可以根據血流量或血流速度正確的運算血流回復時間。 申請專利範圍第12項中本發明之動脈硬化度測定裝置 其特徵爲，具有：環套，係藉由空氣壓來將對微血管供給 血液之動脈部位加以壓迫而使其閉塞；空氣壓控制機構， 係用以控制該環套之空氣壓；血液水平檢測機構，係利用 光電脈波量測計來量測該環套所阻血之微血管內之光電脈 波，以該光電脈波中之直流之頻帶脈波來檢測該微血管內 血液之血液水平；中央處理裝置，係藉該空氣壓控制機構 將對該微血管供給血液之動脈部位加以壓迫及解除，並以 該血液水平檢測機構來量測平常時及阻血後充血時之該微 血管之光電脈波，由該光電脈波檢測平常時及阻血後充血 時之血液水平之差，由該.血液水平之差來運算血液量之增 加量，再由該血液量之增加量來運算血流量之增加量，再 由該血流量之增加量來測定血管擴張反應。 此處，血液水平係指以吸光度表示流過指尖微血管之 氧化及還原血紅素其吸收近紅外線之比例。又，本發明之 血液量因係每單位時間之血液量，故只要血紅素即紅血球 增加，則認爲血液量會增加，可說是血液水平與血液量有 相關關係。又，血流量因係在每單位時間之血液流量，故 血液量與血流量有成正比，血液量增加則血流量亦增加。 故認爲由血液水平之增加可運算出血流量之增加量。而且 ，藉習知之血管擴張反應測定法使用回音以測定擴張之血 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） A7 529931 ___ B7______ 五、發明說明（f ) 管徑，已判明血流量若增加則血管會擴張很多，故藉測定 血液水平可以量測血管之擴張度。 爲正確測定血液量，如習知之僅以光電脈波量測定交 流部分是不行的，必須正確地測定直流部分。 而且，藉這樣的構成，以血液水平檢測手段不僅能夠 檢測光電脈波之波形，還可檢測平常時與充血時其吸光度 之差，故可由吸光度之差測定血液水平之差，並由該血液 水平之差運算最終血流量之增加程度以測定血管擴張反應。 申請專利範圍第13項中本發明之動脈硬化度測定裝置 其特徵爲，係進一步具有計時器，該計時器係用以設定以 該空氣壓控制機構對環套作用空氣壓之時間，來使得對微 血管供給血液之動脈部位受環套的作用而閉塞一定時間。 藉採用這樣的構成，可以藉計時器將對微血管供給血液之 動脈部位加以正確地閉塞一定的時間。 [發明實施之形態] 圖1表示本發明之動脈硬化度測定裝置之實施形態， 作爲圖1之動脈硬化度測定裝置之血液黏度測定裝置具有 以空氣壓壓迫血管並使其閉塞之環套1。爲正確運算測定 結果，該環套1被裝設於血管內不會產生血流速度分布之 微血管。 前述環套1被連接於空氣壓控制機構2,藉該空氣壓 控制機構2對環套1供給必要之空氣壓的同時，進行由環 套1解除空氣壓之控制。又，空氣壓控制機構2上連接有 --------------------訂---------線 (請先閱讀背面之注意事項再填寫本頁) 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） 529931 A7 ______B7__ 五、發明說明（\。） 具備記憶體4之CPU3以作爲中央處理裝置，藉裝在CPlj3 之計時器（未圖示）可設定前述空氣壓控制機構2對環套1 作用空氣壓的時間。該CPU3之其他機能將於後述。 此外，前述CPU3之記憶體4可記憶由環套丨解除空 氣壓時脈波回復到平常時狀態之回復時間TreC0(s)平均値 ，亦即，事先對多數糖尿病、高膽固醇症、高脂血症患者 所測定之回復時間TreC〇(S)平均値以年齡別依其大小以土 σ之統計分布偏差範圍來記憶。又，另一方面，以與前述 患者同樣程度之人數規模對健康正常者之回復時間 Treco(s)亦同樣的進行統計處理，而記憶於記憶體4中。特 別是，因爲健康正常者之統計分布有時會和年齡增加有很 高的依存性，在統計分布中乃將2個群體分別記憶於記憶 體4中對血液黏度狀態之判斷會較容易。 前述CPU3上連接有光電脈波量測計5，以當成血流 狀態檢測機構之一例以檢測被前述環套1壓迫之微血管中 之血流狀態。該光電脈波量測計5可將被前述環套1壓迫 之微血管中之血流脈波狀態以光學方式量測。再者，做爲 檢測前述血流狀態之機構之其他例也可使用雷射都卜勒血 流計或雷射都卜勒血流速度計。此處，因具有血流量=血液 量X血流速度的關係，使用雷射都卜勒血流計或雷射都卜 勒血流速度計之血液速度皆爲同樣的指標値。 又，前述CPU3上連接有回復時間量測計時器6，以 量測自被前述環套1壓迫到解除之微血管內之血流脈波回 到平常時狀態所須要之時間。 — - 1 ^ —— 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） (請先閱讀背面之注意事項再填寫本頁) --------訂---------線- A7 529931 ___B7___ 一 五、發明說明（丨\ ) 又，前述CPU3上分別連接有列印測定結果之印表機 7及顯示測定結果之顯示器8。再者’前述CPU3上裝設有 可插拔之記憶卡9’以將測定結果輸入不圖示之個人電腦 等。 前述環套1之內部被捲繞在可行經對微血管供給血液 之動脈之人體的部位。環套1所捲繞部位之例分別表示在 圖2至圖4中。 圖2表示將環套1捲繞在左手第3指或第4指基第5 中手骨底部，利用前端部裝有囊狀光電脈波量測計5之前 述圖1之血液黏度測定裝置測定血液黏度之狀態。再者’ 由血液黏度測定裝置本體1〇有LAN界面之纜線11被導出 〇 又，圖3表示將環套1捲繞在左手手腕，將左手第3 指或第4指前端部裝設囊狀光電脈波量測計5，以利用圖1 之血液黏度測定裝置測定血液黏度之狀態。 又，圖4表示將環套1捲繞在左手上腕部，將左手第 3指或第4指前端部裝設囊狀光電脈波量測計5，以利用圖 1之血液黏度測定裝置測定血液黏度之狀態。 再者，除圖2、圖3及圖4以外，只要內部可行經對 微血管供給血液之動脈部位，則足大拇指之中足骨底部等 其他部位亦可。 其次，說明由前述構成所形成之本發明實施形態。又 ，本說明係說明如圖2所示之將環套1捲繞在左手第3指 或第4指基第5中手骨底部之實施形態。 ____________L4—---- 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） ---I--I--I I · I----I I ' — III — — — — (請先閱讀背面之注意事項再填寫本頁) 529931 A7 ________B7 __ 五、發明說明（γ) 圖5表示環套1使用前後以光電脈波量測計所量測到 之脈波振幅狀態。又，圖6爲以步驟順序顯示實施形態之 作用。 圖1及圖2爲將空氣壓作用於左手第4指基第5中手 骨底部前之η個平常時脈波最大振幅値或僅以Trest秒平 均，如圖5所示，以求出脈波最大振幅値之平均値 VmaxAV(圖 6-ST1) 〇 此時，作用於環套1之適當空氣壓雖僅需設定在比被 測定者之最高血壓値高數十mmHg即可，但時有作用於環 套1之空氣壓究竟多大數値爲適當並不淸楚之情況。在此 種情況下，可採行一面將環套1之空氣壓上升時使得脈波 振幅之最大値成爲下降一定値Vmin之點作爲最適環套壓 之方法（圖6-ST2)。 之後，藉CPU3所控制之空氣壓控制機構2將空氣壓 作用於環套1，並如圖5所示讓動脈微血管閉塞一定時間 Toe(圖6-ST3)。該時間Toe比如可設定爲60秒左右。 以環套1將微血管閉塞Toe時間後，將作用於環套1 之空氣壓急速解除，使閉塞之動脈血再度流入如網狀分布 之微血管。該脈波在回復過程中，若血液黏性狀態增大時 ，紅血球等變形能力會降低，血球不易通過微血管時應該 會比較耗時。 圖5中爲決定該回復時間Treco，當環套1之空氣壓 被解除的同時，CPU3將對n個脈波振幅之最大値作移動 平均，或配合時間常數以一定時間Tmov內取到之脈波最 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） ----------會--------^---------線·. (請先閱讀背面之注意事項再填寫本頁) 529931 A7 _______B7____ 五、發明說明（（々） 大値之數m作移動平均。同時亦起動回復時間測定計時器 (圖 6-ST4)。 以CPU3對該移動平均値VmaxMOV與先前每隔1秒 所求得之平常時脈波最大値之平均値VmaxAV進行比較， 並運算其差分値（圖6-ST5)。檢測出該算出之差分値收斂到 某個既定偏差値5以內之時點，於該時點由CPU3之指令 使回復時間計時器6停止。且回復時間計時器6至此所量 測之時間被以回復時間Treco⑷保存。又，該回復時間 Ti*eco(s)係直接顯示於顯示器9(圖6-ST6)。 並且，以將實際所量測之回復時間TreC〇(s)與事先記 憶於記憶體4之做爲統計分布値之回復時間Treco(s)進行 相對比較的方式，使用印表機7印字於紙上（圖6-ST7)。 圖7表示在前述之記憶體中所記憶之於多數糖尿病、 高膽固醇症、高脂血症患者所測定之回復時間TreC〇(s)平 均値與在與患者同程度人數規模之健康正常者中所測定之 回復時間TreC〇(S)之平均値。特別是，健康正常者之統計 分布中，回復時間，TreC〇(S)與年齡增加有很高的依存性， 越是高齡者其。暝暢性」會降低。另一方面，患者之統計 分布中，回復時間TreC〇(S)與年齡增加沒有觀察到依存性 ，同樣是血液變成「黏稠」的狀態。 又，如圖8所示，將1日中回復時間Treco(s)之變化依 回復時間TreC〇(S)之大小重新以血液之「順暢性」、「黏稠 」之易懂之表現法做爲血液黏度之標準進行相對評價，則有 激勵平時攝取使血液變成順暢之食物的作用（圖6-ST8)。 --------訂---------- (請先閱讀背面之注意事項再填寫本頁) 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） 529931 A7 _____B7_____ 五、發明說明（V&) 亦即，一般被認爲早上之血液黏度高’夜間會變低’ 故已知有睡前喝水以使在睡眠期間會升商的血液能維持在 低黏度之健康法。又’ 一般認爲當壓力蓄積時血液黏度會 升高。故，除與前述糖尿病等日常血液黏度高之患者群作 相對比較之外，掌握本身1日中之血液黏度相對變化範圍 也很重要。 此外，血液黏度和血壓一樣長期掌握很重要。故將數 天分彙整之回復時間TreC〇(s)與測定時間一起保存於記憶 卡9，並轉存到個人電腦等較高階之數據處理機構。或是 ，也可透過LAN界面之纜線11以直接連線下載至個人電 腦（圖 6-ST9)。 又，將前述於1日數次測定之回復時間TreC〇(s)記憶 於記憶體4，與測定時間一同以印表機7印於紙上作爲血 液體檢表也很要緊（圖6-ST10)。 如以上所說明，以本實施形態之血液黏度測定裝置， 因可簡單且非侵襲性的測定血液黏度，故在家中亦可測定 並管理血液黏度。 再者，本發明不限定於前述實施形態，依需要可作各 種變更。比如說，前述實施形態中，說明以光電脈波量測 計作爲血流狀態檢測機構依據脈波振幅値來檢測血流回復 時間’但當然也可以如前述以雷射都卜勒血流計或雷射都 卜勒血液流量計作爲血流狀態檢測機構依據脈波振幅値以 檢測血流回復時間。 再者，本實施形態中，係以配置於血液黏度測定裝置 ----- -12______— 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公爱〉 ：——：---------9--------訂---------線· (請先閱讀背面之注意事項再填寫本頁) 529931 A7 ________— B7 _ 五、發明說明（“） 上之CPU作爲一個中央處理裝置以控制環套空氣壓，及接 收來自光電脈波量測計之訊號，但不限定於此。比如，血 液*占度測疋裝置亦可由自動阻血裝置(作爲控制環套空氣壓 之空氣控制機構）及血流狀態檢測機構（當成檢測微血管血 流狀態之血流狀態檢測機構)所構成，在該自動阻血裝置及 血流狀態測定裝置上分別配置中央處理裝置。 其次，參照圖9至圖12對本發明中動脈效果測定裝置 之第2實施形態作說明。 如圖9所示’作爲本實施形態中動脈效果測定裝置之 血管擴張反應測定裝置21具有作爲空氣壓控制機構之自動 阻血裝置22，該自動阻血裝置22上連接有藉空氣壓壓迫 血管並使其閉塞之環套23。本實施形態中，前述環套23 雖裝設在前腕部’但只要是可壓迫動脈之部位，上腕部、 手腕、指根、足頸皆可。 又’該自動阻血裝置22具有作爲第1中央處理裝置之 CPU24及使前述CPU24動作之啓動按鈕25，與設定前述 自動阻血裝置22對環套23供給空氣壓之時間之計時器26 〇 又’該自動阻血裝置22在對前述環套23加入可壓迫 前腕部動脈並使微血管閉塞程度之空氣壓的同時，並可進 行由前述環套23解除空氣壓之控制。本實施形態中，若押 下啓動按鈕25則會對前述環套23加入250mmHg之壓力 ，維持5分鐘後，將前述環套23之空氣壓解除。 又，該自動阻血裝置22上設有環套壓顯示盤27以即 本紙張尺度適用中國國家標準（CNS)A4規格（21〇 X 29/公爱) 賴 (請先閱讀背面之注意事項再填寫本頁)Blood viscosity is generally calculated using Poiseuille's law. Blood viscosity? 7 = 4 7 r r · P / 8 · 1 · Q (r ·· vascular radius, P: blood pressure difference between two points in the chain, 1: full length of blood vessels from the measurement site, Q: blood flow) The blood viscosity calculated by the Porcelain's law is applied to the Chinese National Standard (CNS) A4 specification (210 X 297 mm) on a black paper scale after blood collection. ---- 1 ------------ ---- Order --------- Line ·. (Please read the notes on the back before filling this page) A7 529931 _______B7____ V. Description of the invention (price;) Judgment (Hess's Law) and other inspections, in Healthy people are about 5.68 to 4.41 in the morning and 3.99 in the evening. However, in general, the viscosity of blood must be measured at least between two points if the law of Bolsei is used, otherwise it cannot be calculated. Therefore, the blood pressure difference and blood flow velocity were previously measured separately as non-invasive arteriosclerosis measurement devices which were too large. However, in recent years, non-invasive blood viscosity measurement methods have not been proposed based on the measurement of blood pressure differences. That is, as disclosed in Japanese Patent Application Laid-Open No. 11-316180, it is known that echoes using an ultrasonic device are used to obtain a number of blood flow velocities that are assumed to be Newtonian. Differential equation method to obtain blood viscosity and pressure gradient at the same time. However, the measurement site to which the method described in this publication is applicable is limited to large and middle arteries with blood flow velocity distribution in blood vessels, and it is not easy to use it at home if the measurement site or measurement technique is considered. On the other hand, although taking one drop of blood cannot be said to be non-invasive, live blood analysis using a CCD camera and a microscope to observe living blood cells has become popular. The state of the blood cells is illuminated in the blood that is put about 10,000 times with a CCD camera and a microscope, and the state of agglutination of red blood cells and the state of white blood cells can be confirmed in a living body. This blood cell analysis is excellent in that the viscous state of blood can be confirmed by a picture. However, because there are various types of blood, it is difficult for an expert to judge the state of the blood, and it is not convenient to use at home. In particular, blood must be collected first and then observed under a microscope, so it can be said that it is set to research-_______________ ___________ fi _____ __---This paper size applies the Chinese National Standard (CNS) A4 specification (210 X 297 mm)- ---------- 0 ^ -------- Order --------- Line # (Please read the notes on the back before filling this page) 529931 A7 _____ B7 _ 5. Description of the invention (+) The device used in the room is standard. In addition, recently, using semiconductor microfabrication technology, the Micro Channel Array Flow Analyzer (MC: FAN method) has been developed to manufacture artificial microvessels on a glass substrate and pass the collected blood through the microvessels. Refer to the "Cell Microfluidic Variable Measuring Device MC-FAN" by Kikuchi Yuji et al. 30 (7), 281-284 (1998). This method is limited to use in experimental institutions because of the large scale of blood collection and device processing. However, if the blood viscosity is considered to be expressed by the time flowing through the artificial microvessels, it is considered to be very close in principle to the non-invasive device for measuring blood viscosity using the microvascular blood flow in vivo in the present invention described later. Generally, the microvessels that divide from the arterioles to the arterioles are connected to the surface of the skin at right angles after the skin surface where the microvessels such as fingertips are concentrated enters, and are connected to the microvenous vessels. Laser in recent years (Influence of metabolic control and duration of disease on microvascular dysfunction in diabetes assessed by laser Doppler anemonetry: MF Meyer, H. Schatz Exp Clin Endocrimol Diabetes 106 (1998) 395-403, Germany) The Doppler flow velocity meter in the blood cell level movement speed in a single microvessel, although the microvessel's blood vessel velocity will repeat, it can be seen that the velocity changes in synchronization with the heartbeat. Therefore, if the deformability of red blood cells or the like is reduced, or red blood cell agglutination occurs, the blood cell velocity of a single microvascular level is estimated to decrease the maximum velocity amplitude due to an increase in blood viscosity. On the other hand, comparison of type 1 and type 2 diabetes patients with more than 10 years and ____2_ ____ This paper size applies the Chinese National Standard (CNS) A4 specification (210 X 297 mm) H · 1 ^ — I ί · ϋ ϋ H4 nn ϋ · tm§ il II It, fl nnnn n > i ϋ II (Please read the notes on the back before filling this page) 529931 B7 V. Invention Description (() Groups under 10 years and healthy normal groups, There is no significant difference in its maximum blood cell velocity. In this way, it is judged that there is an individual difference in the maximum blood cell velocity, and the error is so large that the difference between the cardiac cycle is so small that no difference can be seen. After compressing the upper carotid artery with the cuff to the highest blood pressure for 1 minute, the air pressure of the cuff is released, and the blood is congested to all the microvessels, so as to restore the blood flow velocity connecting the micromotor vessels to the front of the microstatic vessels There is a significant difference between the diabetic population and the healthy normal population. The reason for the significant difference is presumed to be that the blood viscosity of the diabetic patients is high, so the microvascular blood cells at the end It takes time to reply. In addition, Skin Capillary is More Impaired in the Toes of Diabetes Than Non-diabetic Patients Vascular Disease: G. Jorneskog5K. Brismar, B. Fagrell: DIABETIC MEDICINE, 1995; 12: 36-41 · Sweden), using the thumb of a foot to measure the recovery time after occlusion using a micro-loop, the diabetic patient is significantly different from a healthy person. In addition, the vasodilator response is known An arteriosclerosis measuring device for measuring the vasodilation response by measuring the diameter of a blood vessel. The device first measures a predetermined diameter of a blood vessel in a normal state by using an echophone. Then, the upper carotid artery is blocked with a cuff for 5 minutes, and then the cuff is released. The blood pressure was used to make the blood congested, and the predetermined blood vessel diameter was measured using the echo. The blood vessel dilation response was measured by comparing the blood vessel diameter between normal time and blood congestion after the end of hemostasis. However, 'the aforementioned artery The echometer is used to measure the hardness measurement device-^ ____ This paper size applies to China National Standard (CNS) A4 Grid (210 X 297 public love) (Please read the precautions on the back before filling in this page) — Order --------- line- 529931 A7 _______B7_ 5. Description of the invention (V) The vasodilation reaction, However, the echo device is a large device, which is difficult for ordinary families to use. The object of the present invention is to provide an arteriosclerosis measuring device which can measure blood viscosity or vasodilation reaction in a simple and non-invasive way to measure Arteriosclerosis. [Means to solve the problem] In order to achieve the foregoing object, the arteriosclerosis measuring device of the present invention in the first scope of the patent application is characterized by having a loop, which is an artery that supplies blood to microvessels by air pressure. The part is compressed to occlude it; the air pressure control mechanism is used to control the air pressure of the cuff; the blood flow state detection mechanism is used to detect the blood flow state in the microvessels blocked by the cuff; the central processing The device is respectively connected with the air pressure control mechanism and the blood flow state detection mechanism, and is used to control the compression and release of the arterial portion of the microvascular supply blood caused by the loop, and measure the blood flow state detection mechanism. Blood flow recovery time and calculation of blood viscosity. With this configuration, blood viscosity can be measured non-invasively. The arteriosclerosis measuring device of the present invention in item 2 of the scope of the patent application is further characterized by a timer, which is used to set the time for the air pressure control mechanism to apply air pressure to the loop to make the The arterial site where the microvascular supply blood is occluded by the cuff for a certain period of time. By adopting such a structure ', the arterial site supplying blood to the microvessel can be accurately occluded by the timer for a certain period of time. The scope of the patent application for item 3 of the device for measuring arteriosclerosis of the present invention The paper size is applicable to the Chinese National Standard (CNS) A4 (210 x 297 mm) • ——: ------------ ----- Order --------- Line Φ (Please read the precautions on the back before filling this page) A7 529931 B7_______ V. Description of the invention (7) It is characterized by further A timer for measuring the response time. By adopting such a structure ', it is possible to accurately measure the blood flow recovery time by using a recovery time measurement timer. The arteriosclerosis measuring device of the present invention in claims 4 and 5 is characterized in that the aforementioned blood flow state detection mechanism is composed of a photoelectric pulse wave measuring device. By adopting such a structure ', it is possible to detect the state of blood flow recovery based on the pulse wave amplitude 値. The arteriosclerosis measuring device of the present invention in item 6 and 7 of the scope of the patent application is characterized in that the central processing device is controlled to be measured by a photoelectric pulse wave meter when the recovery time measurement timer is started. Measure the maximum amplitude of the pulse wave, make a plurality of moving averages, and compare the moving average with the usual average. Whether the two are within a certain deviation is consistent. When the two are consistent, the timer stops and the elapsed time passes. Time is treated as blood flow recovery time. With this configuration, the blood flow recovery time can be accurately calculated based on the pulse wave amplitude. The arteriosclerosis measuring device according to the present invention in claims 8 and 9 is characterized in that the blood flow state detection mechanism is composed of a laser Doppler blood flow meter or a laser Doppler blood flow velocity meter. . By adopting such a configuration, the blood flow recovery state can be detected based on the blood flow rate or the blood flow velocity. The arteriosclerosis measuring device of the present invention in the scope of application patents Nos. 10 and 11 is characterized in that the central processing device is controlled so that the laser doppler blood flow meter will be activated simultaneously with the activation of the recovery time measurement timer. The blood flow or blood flow velocity measured by the laser doppler blood flow velocity meter is the largest, and a plurality of moving averages are compared, and the moving average is compared with the average in normal times. This paper applies the Chinese national standard (CNS) ) A4 size (210 X 297 mm) (Please read the notes on the back before filling this page) Μ-Order! -------- Line 1 529931 A7 _1 _ _ B7_____ V. Description of the invention (3) (Please read the precautions on the back before filling this page) Whether it is consistent within a certain deviation, when the two are When they match, the timer stops and the elapsed time is used as the reply time. By adopting such a structure, the blood flow recovery time can be accurately calculated based on the blood flow rate or the blood flow velocity. The arterial sclerosis measuring device of the present invention in item 12 of the scope of the patent application is characterized in that it has: a cuff, which compresses the arterial site supplying blood to the blood vessels by air pressure, and occludes it; an air pressure control mechanism, It is used to control the air pressure of the loop; the blood level detection mechanism is to measure the photoelectric pulse wave in the micro blood vessels blocked by the loop with a photoelectric pulse wave meter, and the frequency band of direct current in the photoelectric pulse wave Pulse wave to detect the blood level of the blood in the microvessel; the central processing device is to use the air pressure control mechanism to compress and release the arterial part that supplies blood to the microvessel, and use the blood level detection mechanism to measure the normal and The photoelectric pulses of the microvessels during congestion after hemostasis are detected by the photoelectric pulses. The difference in blood levels between normal time and congestion after hemostasis is calculated from the difference in blood levels, and then the blood volume is calculated. The amount of increase in blood volume is used to calculate the increase in blood flow, and the increase in blood flow is used to determine the vasodilation response. Here, the blood level refers to the ratio of oxidized and reduced heme which absorbs near-infrared rays flowing through the microvessels of the fingertips in terms of absorbance. In addition, since the blood volume of the present invention is the blood volume per unit time, as long as the hemoglobin, that is, red blood cells, increases, the blood volume is considered to increase, and it can be said that the blood level is related to the blood volume. In addition, since the blood flow is the blood flow per unit time, the blood volume is proportional to the blood flow. As the blood volume increases, the blood flow also increases. Therefore, it is thought that the increase in blood flow can be calculated from the increase in blood level. Moreover, the echo of the conventional vasodilation response measurement method is used to determine the dilated blood. The paper size applies the Chinese National Standard (CNS) A4 specification (210 X 297 mm) A7 529931 ___ B7______ 5. Description of the invention (f) It is determined that if the blood flow increases, the blood vessels will expand a lot, so the blood vessel expansion can be measured by measuring the blood level. In order to measure the blood volume correctly, it is not possible to measure the AC portion only with the photoelectric pulse wave volume. It is necessary to measure the DC portion correctly. Moreover, with such a configuration, the blood level detection means can detect not only the waveform of the photoelectric pulse wave, but also the difference in absorbance between normal time and congestion. Therefore, the difference in blood level can be measured from the difference in absorbance, and the blood level can be determined from the difference in absorbance. The difference is calculated as the final increase in blood flow to determine the vasodilator response. The thirteenth arteriosclerosis measuring device of the present invention in item 13 of the scope of the patent application is further characterized by a timer, which is used to set the time for the air pressure to be applied to the loop by the air pressure control mechanism to make the The arterial site where the microvascular supply blood is occluded by the cuff for a certain period of time. By adopting such a configuration, the arterial portion supplying blood to the microvessel can be accurately occluded by the timer for a certain period of time. [Mode for Carrying Out the Invention] Fig. 1 shows an embodiment of the arteriosclerosis measuring device of the present invention. The blood viscosity measuring device as the arteriosclerosis measuring device of Fig. 1 includes a cuff 1 for compressing and occluding a blood vessel with air pressure. In order to correctly calculate the measurement result, the loop 1 is installed in a micro blood vessel which does not generate a blood flow velocity distribution in a blood vessel. The aforementioned sleeve 1 is connected to an air pressure control mechanism 2, and the air pressure control mechanism 2 is used to supply the necessary air pressure to the sleeve 1 while controlling the release of the air pressure by the sleeve 1. In addition, the air pressure control mechanism 2 is connected with a -------------------- order --------- line (please read the precautions on the back before (Fill in this page) This paper size applies the Chinese National Standard (CNS) A4 specification (210 X 297 mm) 529931 A7 ______B7__ 5. Description of the invention (\.) CPU3 with memory 4 is used as a central processing device and borrowed from CPlj3 A timer (not shown) can set the time for the air pressure control mechanism 2 to apply air pressure to the ring 1. Other functions of the CPU3 will be described later. In addition, the memory 4 of the aforementioned CPU 3 can memorize the average recovery time TreC0 (s) of the pulse wave returning to the usual state when the air pressure is released from the loop, that is, for most diabetes, hypercholesterolemia, hyperlipidemia The average recovery time TreC0 (S) measured by the patients was memorized by the age and the range of the statistical distribution deviation of soil σ according to their size. On the other hand, the response time Treco (s) of healthy people with the same number of patients as the aforementioned patients is also statistically processed and stored in the memory 4. In particular, because the statistical distribution of healthy people sometimes has a high dependence on increasing age, in the statistical distribution, it is easier to judge the blood viscosity state by memorizing the two groups in memory 4 respectively. The above-mentioned CPU 3 is connected with a photoelectric pulse wave measuring meter 5 as an example of a blood flow state detecting mechanism to detect a blood flow state in a micro blood vessel which is oppressed by the aforementioned sleeve 1. The photoelectric pulse wave measuring meter 5 can optically measure the state of blood flow pulse waves in the microvessels which are oppressed by the aforementioned sleeve 1. Furthermore, as another example of the mechanism for detecting the aforementioned blood flow state, a laser Doppler flow meter or a laser Doppler flow velocity meter may be used. Here, since there is a relationship of blood flow = blood volume x blood flow velocity, the blood velocity using the laser Doppler flow meter or the laser Doppler flow velocity meter is the same index 値. In addition, the CPU 3 is connected with a recovery time measurement timer 6 to measure the time required for the blood flow pulses in the microvessels that have been oppressed to be released by the loop 1 to return to the normal state. —-1 ^ —— This paper size is applicable to China National Standard (CNS) A4 (210 X 297 mm) (Please read the precautions on the back before filling this page) -------- Order --- ------ Line- A7 529931 ___B7___ One or five. Description of the invention (丨 \) In addition, the aforementioned CPU 3 is connected to a printer 7 for printing the measurement results and a display 8 for displaying the measurement results. Furthermore, "the CPU 3 is provided with a removable memory card 9" to input the measurement result to a personal computer or the like (not shown). The inside of the aforementioned cuff 1 is wound around a part of the human body that can pass through arteries that supply blood to microvessels. Examples of the winding positions of the ferrule 1 are shown in Figs. 2 to 4 respectively. Fig. 2 shows that the loop 1 is wound around the bottom of the third or fourth finger base of the left hand, and measured with the blood viscosity measuring device of Fig. 1 using a capsule-type photoelectric pulse wave meter 5 at the front end. The state of blood viscosity. Furthermore, the cable 11 with a LAN interface is derived from the blood viscosity measuring device main body 10, and FIG. 3 shows that the loop 1 is wound around the left wrist, and a capsule is attached to the front end of the third or fourth finger of the left hand. The shape photoelectric pulse wave measuring meter 5 is used to measure the state of blood viscosity using the blood viscosity measuring device of FIG. 1. In addition, FIG. 4 shows that the cuff 1 is wound around the wrist of the left hand, and a capsule-shaped photoelectric pulse wave meter 5 is installed at the front end of the third or fourth finger of the left hand to measure blood using the blood viscosity measuring device of FIG. 1. The state of viscosity. Furthermore, in addition to Figs. 2, 3, and 4, as long as internally available arterial sites can supply blood to microvessels, other sites such as the bottom of the foot bones in the thumb can be used. Next, an embodiment of the present invention formed by the aforementioned configuration will be described. In addition, this description is to describe the embodiment in which the collar 1 is wound around the bottom of the third or fourth finger base of the left hand as shown in Fig. 2. ____________ L4 —---- This paper size applies to China National Standard (CNS) A4 (210 X 297 mm) --- I--I--II · I ---- II '— III — — — — ( (Please read the precautions on the back before filling this page) 529931 A7 ________B7 __ V. Description of the Invention (γ) Figure 5 shows the pulse wave amplitude state measured by the photoelectric pulse wave meter before and after the loop 1 is used. Fig. 6 shows the effects of the embodiment in the order of steps. Figures 1 and 2 show the maximum amplitudes of n normal pulses in front of the base of the hand bone in the fifth finger base of the left hand in the fifth finger, or averaged only in Trest seconds, as shown in Figure 5, to obtain the pulse The average of the maximum amplitude of the wave 値 VmaxAV (Figure 6-ST1). At this time, although the appropriate air pressure acting on the sleeve 1 need only be set to tens of mmHg higher than the subject's maximum blood pressure 但, but sometimes It is not unreasonable how much the air pressure acting on the collar 1 is appropriate. In this case, you can use the method to increase the air pressure of the loop 1 so that the maximum amplitude of the pulse wave becomes a certain decrease Vmin as the optimal loop pressure (Figure 6-ST2). After that, the air pressure control mechanism 2 controlled by the CPU 3 applies air pressure to the cuff 1 and occludes the arterial microvessels for a certain period of time, as shown in Fig. 5 (Fig. 6-ST3). The time Toe can be set to about 60 seconds, for example. After the microvessels are occluded with the cuff 1 for the Toe time, the air pressure acting on the cuffs 1 is quickly released, so that the occluded arterial blood flows into the microvessels with a reticular distribution again. During the recovery of this pulse wave, if the viscosity of blood increases, the deformability of red blood cells will decrease, and it will be time-consuming when blood cells do not easily pass through the microvessels. Figure 5 is to determine the recovery time Treco. When the air pressure of the loop 1 is released, the CPU 3 will take a moving average of the maximum amplitudes of n pulse waves, or match the time constant to the pulses obtained within a certain time Tmov. Wave most paper size is applicable to China National Standard (CNS) A4 (210 X 297 mm) ---------- Yes -------- ^ --------- Line .. (Please read the precautions on the back before filling in this page) 529931 A7 _______B7____ 5. Description of the invention ((々) The number of large m is moving average. At the same time, the timer for measuring the recovery time is started (Figure 6-ST4) The CPU3 compares this moving average 値 VmaxMOV with the average 値 VmaxAV of the usual maximum pulse wave 每隔 obtained every 1 second, and calculates the difference 値 (Figure 6-ST5). The calculated difference is detected値 Converge to a certain deviation 値 5, at which point the response time timer 6 is stopped by the instruction of CPU3. And the time measured by the response time timer 6 so far is saved as the recovery time Treco⑷. Also, the The response time Ti * eco (s) is directly displayed on the display 9 (Figure 6-ST6). The measured recovery time TreC0 (s) is compared with the recovery time Treco (s) stored in memory 4 as a statistical distribution in advance, and the printer 7 is used to print on the paper (Figure 6-ST7). FIG. 7 shows the average recovery time TreC (s) measured in most of the patients with diabetes, hypercholesterolemia, and hyperlipidemia memorized in the aforementioned memory, and among the healthy normal persons on the same scale as the number of patients The average of the measured recovery time TreC0 (S). In particular, in the statistical distribution of healthy people, the recovery time, TreC0 (S) has a high dependence on the increase in age, the older the person is. On the other hand, in the statistical distribution of patients, there is no dependence on the recovery time TreC0 (S) and increasing age, and the blood becomes "thick". Also, as shown in Figure 8, The change in the response time Treco (s) in the first day according to the size of the recovery time TreC0 (S) was used to evaluate the blood's "smoothness" and "thickness" as a standard for blood viscosity. Then there is an incentive to take blood normally The role of smooth food (Figure 6-ST8). -------- Order ---------- (Please read the precautions on the back before filling this page) This paper size is applicable to China National Standard (CNS) A4 specification (210 X 297 mm) 529931 A7 _____B7_____ V. Description of the invention (V &) That is, it is generally considered that the blood viscosity in the morning is 'lower at night', so it is known to drink before bedtime Water in order to keep blood that will rise during sleep to maintain a low viscosity health method. It is also generally believed that blood viscosity increases when pressure builds up. Therefore, in addition to making a comparative comparison with the above-mentioned patient group with high daily blood viscosity such as diabetes, it is also important to grasp the relative change range of blood viscosity in one day. In addition, blood viscosity is as important as blood pressure over time. Therefore, the recovery time TreC0 (s), which is collected for several days, is stored in the memory card 9 together with the measurement time, and transferred to a higher-level data processing organization such as a personal computer. Alternatively, you can also download directly to the personal computer through the cable 11 of the LAN interface (Figure 6-ST9). It is also important to memorize the recovery time TreC0 (s) measured several times a day in the memory 4 and print it on the paper with the printer 7 as the blood test meter together with the measurement time (Fig. 6-ST10). As described above, the blood viscosity measuring device of this embodiment can measure blood viscosity simply and non-invasively, so it can also measure and manage blood viscosity at home. In addition, the present invention is not limited to the foregoing embodiments, and various changes can be made as necessary. For example, in the foregoing embodiment, it was explained that the photoelectric pulse wave measurement is used as the blood flow state detection mechanism to detect the blood flow recovery time based on the pulse wave amplitude 値. Of course, as described above, a laser Doppler flow meter or As a blood flow state detection mechanism, the laser Doppler blood flow meter detects the blood flow recovery time based on the pulse wave amplitude 値. Moreover, in this embodiment, it is arranged in the blood viscosity measuring device ----- -12 ______— This paper size is applicable to the Chinese National Standard (CNS) A4 specification (210 X 297 public love): ——: --- ------ 9 -------- Order --------- Line · (Please read the notes on the back before filling in this page) 529931 A7 ________— B7 _ 5. Description of the invention (") The CPU above acts as a central processing device to control the air pressure of the loop and receive signals from the photoelectric pulse wave meter, but it is not limited to this. For example, the blood * occupancy measurement device can also be an automatic blood block device (As an air control mechanism that controls the air pressure of the loop) and a blood flow state detection mechanism (as a blood flow state detection mechanism that detects the microvascular blood flow state). The automatic blood blocking device and the blood flow state measurement device are respectively arranged at the center. Processing device. Next, a second embodiment of the arterial effect measurement device according to the present invention will be described with reference to FIGS. 9 to 12. As shown in FIG. Of air pressure control mechanism A dynamic blood blocking device 22 is connected to a cuff 23 that compresses and occludes a blood vessel by air pressure. In this embodiment, although the cuff 23 is installed on the forearm ', as long as it can compress the artery The upper wrist, wrist, finger base, and foot and neck can be used. The automatic blood blocking device 22 includes a CPU 24 as a first central processing device, an activation button 25 for operating the CPU 24, and a ring for setting the automatic blood blocking device 22. The timer 26 for the time when the air pressure is supplied from the sleeve 23. The automatic blood blocking device 22 can add the air pressure to the aforementioned cuff 23 to compress the anterior wrist artery and occlude the microvessels. Release the air pressure control. In this embodiment, if the start button 25 is pressed, a pressure of 250 mmHg is added to the aforementioned sleeve 23, and after maintaining for 5 minutes, the air pressure of the aforementioned sleeve 23 is released. Moreover, the automatic blood blocking device 22 There is a ring sleeve pressure display disc 27 on the paper, which is applicable to the Chinese national standard (CNS) A4 specification (21 × 29 / public love). Lai (Please read the precautions on the back before filling this page)
529931 A7 ___B7 _ 五、發明說明（A ) 時顯示對環套23供給之壓力，及時間顯示盤28以顯示對 環套23供給25OmmHg壓力後所經過之時間。 又，前述血管擴張反應測定裝置21具有血液水平檢測 裝置30以測定光電脈波而作爲檢測血液水平之血液水平檢 測機構，該血液水平檢測裝置30具有可檢測微血管之光電 脈波之囊狀光電脈波量測計31。此處，因爲在檢測微血管 之光電脈波時係如前述第1實施形態中所述不會產生血管 內血流速度分布，故可以正確運算光電脈波之檢測結果。 本實施形態中，前述光電脈波量測計31係裝在右手第2指 之前端部。且，該光電脈波量測計31係藉未圖示之發光元 件照射被氧化血紅素及還原血紅素所吸收之光線，並將其 中透過微血管之光以未圖示之受光元件吸收。此時受光元 件會接受未被微血管內流動之氧化、還原血紅素吸收之光 ，前述光電脈波量測計31依據氧化、還原血紅素等在吸收 光之程度內之吸光度以量測光電脈波。 又，血液水平檢測裝置30會將光電脈波量測計31所 量測到之光電脈波頻帶中直流之頻帶以直流訊號接受，並 以放大器放大。此時’光電脈波量測計31藉測定光電脈波 頻帶中直流之頻帶，可測定光電脈波之振幅。 又，血液水平檢測裝置30具有CPU32以作爲具備記 憶體(未圖示)之第2中央處理裝置。該CPU32不僅可測定 來自前述光電脈波量測計31之直流訊號所產生之光電脈波 波形，並可測定被氧化、還原血紅素等所吸收之光其吸光 度之差，藉此可檢測血液水平。 ΐ紙張尺度適用中國國家標準（CNS)A4規格（210 X 29^公爱) ' --------------------訂---------線 (請先閱讀背面之注意事項再填寫本頁) 529931 A7 _______B7____ 五、發明說明（J ) 又，前述CPU32由平常時血液水平與阻血後充血時之 血液水平的比較値運算血流量之增加程度，並藉血流量之 增加程度測定血管之擴張反應。 又，前述血液水平檢測裝置30上分別連接有列印測定 結果之印表機(未圖示)與顯示測定結果之顯示器(未圖示）。 又，前述血液水平檢測裝置30上裝設有可插拔之記憶卡 33以將測定結果輸入個人電腦（未圖示）。再者，前述血液 水平檢測裝置30上設有可連接LAN纜線之LAN界面34 以對個人電腦做網路連接。 其次，對第2實施形態之作用加以說明。 首先，將環套23裝設於前腕部，並將光電脈波量測計 31裝設於右手第2指之前端部。 其次，對前述環套23供給空氣壓前之平常時，以血液 水平檢測裝置30花3分鐘檢測右手第2指之前端部微血管 血液水平。· 接著，壓下前述自動阻血裝置22之啓動按鈕25，對 環套23供給250mmHg之空氣壓，使前述前腕部之動脈阻 血5分鐘後，使前述環套23之空氣壓急速解除，以使血液 流入被阻血之動脈及微血管而充血。此時，前述微血管在 擴張約1分鐘的同時，因前述微血管之血流量亦增加約1 分鐘，乃以前述血液水平檢測裝置30檢測包含其後充血狀 態在內之環套23解除後數分鐘之間（本實施形態中爲5分 鐘)之前述微血管之血液水平。 圖10爲顯示第2實施形態中使用血管擴張反應測定裝 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐〉 --------------------訂·-------- (請先閱讀背面之注意事項再填寫本頁) 529931 A7 _ B7___ 五、發明說明（1¾ ) 置21檢測血液水平之例子之圖。如圖10所示，若將動脈 阻血，因爲瘀血，血液水平會急速上升。之後，血液流動 隨著瘀血消除，血液水平會緩緩下降至平常時之値附近。 此時因沒有脈動故無法檢測脈波。接著，將環套之空氣壓 解除使之充血，則因血液急速流入故血液水平會在一瞬間 急速上升，但是因流出之血液量較所提供者爲多，故血液 水平會急速下降。之後，血液會隨著脈動流入，故血液水 平會隨著此脈動之波形而緩緩上升，並在充血後1分鐘左 右出現正確之脈波。 且，前述血液水平檢測裝置30之CPU32當將平常時 血液水平平均値當成R，而正確脈波出現後之充血時血液 水平平均値當成OC時，係以 D=(OC-R)/RxlOO[%] 來運算血流量增加程度之比例D。該血流量增加程度 之比例D被記憶在前述血液水平檢測裝置30之CPU32之 記憶體內。 又，圖11爲使用第2實施形態之血管擴張反應測定裝 置21運算血流量增加程度之比例D於4日期間求出數次 血流量增加程度之比例D數値之例子之圖形。如圖11所 示可了解，血流量增加程度之比例D隨日有所不同，且1 日當中依時間也會不同。 因此，前述血液水平檢測裝置30之CPU32會運算數 日間1日中數次血流量增加程度之比例D，並將該等比例 D記憶於前述記憶體內。並如圖12所示，前述CPU32會 _____21__ 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） - - - -------豐--------訂---------線· (請先閱讀背面之注意事項再填寫本頁) 529931 A7 _B7 > p··11 - - — — ^—i ι "** 11111 "" 111 11 1 1 _ 五、發明說明（if )529931 A7 ___B7 _ 5. In the description of the invention (A), the pressure supplied to the collar 23 is displayed, and the time display panel 28 is used to display the time elapsed after the pressure of 25OmmHg is supplied to the collar 23. The vasodilation response measurement device 21 includes a blood level detection device 30 as a blood level detection means for detecting a blood pulse level, and the blood level detection device 30 includes a sac-shaped photoelectric pulse capable of detecting a photoelectric pulse wave of a microvessel.波 量 测测 31。 Wave measurement gauge 31. Here, since the detection of the photoelectric pulse wave of the microvessel is as described in the first embodiment, the blood flow velocity distribution in the blood vessel is not generated, so that the detection result of the photoelectric pulse wave can be calculated accurately. In this embodiment, the aforementioned photoelectric pulse wave measuring meter 31 is mounted on the front end of the second finger of the right hand. In addition, the photoelectric pulse wave measuring device 31 irradiates light absorbed by oxidized heme and reduced heme by a light-emitting element (not shown), and absorbs light passing through the microvessels by a light-receiving element (not shown). At this time, the light receiving element will receive light that is not absorbed by the oxidized and reduced heme flowing in the microvessels. The aforementioned photoelectric pulse wave measurement meter 31 measures the photoelectric pulse wave based on the absorbance of the oxidized and reduced heme to the extent that it absorbs light. . In addition, the blood level detecting device 30 receives a direct-current frequency band in the photoelectric pulse-wave frequency band measured by the photoelectric pulse wave measuring meter 31 as a direct-current signal and amplifies it with an amplifier. At this time, the 'photoelectric pulse wave measuring meter 31 can measure the amplitude of the photoelectric pulse wave by measuring the DC frequency band in the photoelectric pulse wave band. The blood level detection device 30 includes a CPU 32 as a second central processing unit including a memory (not shown). The CPU 32 can not only measure the photoelectric pulse wave waveform generated by the DC signal from the aforementioned photoelectric pulse wave measuring meter 31, but also measure the difference in absorbance of light absorbed by the oxidized and reduced hemoglobin, thereby detecting the blood level. . ΐThe paper size is applicable to China National Standard (CNS) A4 specification (210 X 29 ^ Public Love) '-------------------- Order -------- -Line (please read the precautions on the back before filling this page) 529931 A7 _______B7____ 5. Description of the Invention (J) In addition, the aforementioned CPU32 calculates the increase in blood flow by comparing the blood level at normal time with the blood level at the time of congestion after hemorrhage. The degree of blood flow is measured by the increase in blood flow. The blood level detection device 30 is connected to a printer (not shown) for printing the measurement results and a display (not shown) for displaying the measurement results. The blood level detecting device 30 is provided with a removable memory card 33 to input the measurement result to a personal computer (not shown). Furthermore, the aforementioned blood level detection device 30 is provided with a LAN interface 34 to which a LAN cable can be connected to make a network connection to a personal computer. Next, the effect of the second embodiment will be described. First, the cuff 23 is mounted on the front wrist, and the photoelectric pulse wave meter 31 is mounted on the front end of the second finger of the right hand. Next, in the normal state before the air pressure is supplied to the cuff 23, the blood level detection device 30 detects the blood level of the microvessel at the front end of the second finger of the right hand for 3 minutes. · Next, press the start button 25 of the automatic blood blocking device 22 to supply 250 mmHg of air pressure to the cuff 23 to block the arteries of the forearm for 5 minutes, then quickly release the air pressure of the cuff 23 to make blood Flow into blocked arteries and microvessels and congestion. At this time, while the aforementioned microvessels are dilated for about 1 minute, the blood flow of the aforementioned microvessels is also increased by about 1 minute, which is a few minutes after the cuff 23 including the subsequent congestion state is detected by the aforementioned blood level detecting device 30. (5 minutes in this embodiment) the blood level of the aforementioned microvessels. Fig. 10 shows the measurement of the vasodilator response in the second embodiment. The paper size is in accordance with the Chinese National Standard (CNS) A4 (210 X 297 mm) ---------------- ---- Order · -------- (Please read the precautions on the back before filling out this page) 529931 A7 _ B7___ V. Description of the invention (1¾) An example of setting 21 to test the blood level. As shown in Figure 10, if the arteries are blocked, the blood level will rise rapidly because of the stasis. After that, the blood flow will be eliminated with the stasis, and the blood level will slowly drop to the vicinity of the usual ridge. Pulse wave. Then, if the air pressure of the cuff is released to make it congested, the blood level will rise rapidly due to the rapid inflow of blood, but because the amount of blood flowing out is more than that provided, the blood level will drop rapidly. After that, the blood will flow in with the pulsation, so the blood level will slowly rise with the waveform of this pulsation, and the correct pulse wave will appear about 1 minute after the congestion. Moreover, the CPU 32 of the aforementioned blood level detection device 30 should Normally, blood levels are averaged as R, and The average blood level at the time of congestion after the appearance of the pulse wave is regarded as OC. D = (OC-R) / Rx100 [%] is used to calculate the ratio D of the increase in blood flow. The ratio D of the increase in blood flow is memorized In the memory of the CPU 32 of the blood level detection device 30. Fig. 11 is a graph showing the increase in the blood flow rate using the vasodilation response measurement device 21 of the second embodiment. A graph of an example of the number D of the ratio D. As shown in FIG. 11, it can be understood that the ratio D of the degree of increase in blood flow varies from day to day, and also varies with time during the day. Therefore, the blood level detecting device 30 CPU32 calculates the ratio D of the degree of increase in blood flow several times during the day and stores these ratios D in the aforementioned memory. As shown in Figure 12, the aforementioned CPU32 will _____21__ This paper standard applies Chinese national standards ( CNS) A4 specification (210 X 297 mm)---------------------- Order --------- line · (Please read the precautions on the back first Fill in this page again) 529931 A7 _B7 > p ·· 11--— — ^ —i ι " ** 11111 & quo t; " 111 11 1 1 _ 5. Description of the invention (if)
I 由該等血流量增加程度之比例D求出前述各比例D之平均 値等，依該平均値以測定血管擴張反應。 又，血管擴張反應如同血壓或前述血液黏度一樣必須 長期掌握。因此’亦可將幾天分彙集之血流量增加程度之 比例D保存於前述記憶卡33並用該記憶卡33，或透過 LAN界面34之纜線，轉送血流量增加程度之比例D之資 料到個人電腦等’以該個人電腦等資料處理機構求出前述 各比例D之平均値’以測定血管擴張反應。 又，與前述第1實施形態相同的，亦可將1日數次所 測定到之血流量增加程度之比例D記憶於記憶體並用印表 機列印。 如以上所說明的，以本實施形態之血管擴張反應測定 裝置21，因可用血液水平檢測裝置檢測光電脈波之直流頻 帶之脈波，故不僅能夠檢測光電脈波之波形，還可檢測平 常時與充血時對氧化、還原血紅素所照射之光其吸光度之 差。藉此，可測定血液水平，且由該血液水平運算最終血 流量並測定血管之擴張反應。 因此，可既簡單又非侵襲性地測定血管擴張反應。又 ，因血管擴張反應大時爲柔軟之健康血管，故可藉血管擴 張反應以測定動脈硬化度。其結果是，可在家中輕鬆的測 定動脈硬化度，並依該動脈硬化度日常上留心動脈硬化之 預防。 再者，本發明不限定於前述第2之實施形態，依需要 可作各種變更。 ---22--------- 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） --------------------訂---------線 (請先閱讀背面之注意事項再填寫本頁) 529931 A7 ____B7___ 五、發明說明（W ) 比如，該第2之實施形態中，自動阻血裝置22與血液 水平檢測裝置30雖分別配置有作爲中央處理裝置之 CPU24、32，但不限定於此，亦可在1個血管擴張測定裝 置上配置具備前述2個CPU機能之1個中央處理裝置。 又，因血管黏度隨年齡有所不同，故亦可將10幾歲、 20幾歲、30幾歲等年齡層之血管擴張反應標準値求出，將 該等標準値記憶於血液水平檢測裝置之CPU，並依據該標 準値測定動脈硬化度。 再者，前述血液水平檢測裝置30可由來自光電脈波量 測計之光電脈波中直流之頻帶之脈波作爲直流訊號接收， 但不限定於此。比如，前述第1之實施形態中因也可用光 電脈波量測計作爲血流狀態檢測機構，故也可接收直流訊 號之外的其它交流訊號，且也可爲具有切換直流訊號與交 流訊號接收之開關者。 [發明之效果] 如以上所說明依本發明之動脈硬化度測定裝置，以微 血管內血流速度之回復時間與血液黏度相對比較，可以簡 單且非侵襲性地測定血液黏度。 亦即，本發明之特點在於，具有：以空氣壓來將對微 血管供給血液之動脈部位加以壓迫而使其閉塞之環套、控 制該環套空氣壓之空氣壓控制機構、用以檢測被前述環套 所壓迫之微血管內血流狀態之血流狀態檢測機構、以及中 央處理裝置(分別與前述空氣壓控制機構、血流狀態檢測機 —------- ...... 1- -------- H -..... - _— 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） --------------------訂·-------- (請先閱讀背面之注意事項再填寫本頁) A7 529931 ____B7_____ 五、發明說明（) 構連接，可控制以前述環套對動脈部位(可對微血管供給血 液）之壓迫及解除，且以前述血流狀態檢測機構量測血流回 復時間，來運算血液黏度）。而且，藉採用該種構成，可以 非侵襲性的方式測定血液黏度，在家中亦可簡單地測定血 液黏度並進行管理。 又，若再裝設計時器以設定利用前述空氣壓控制機構 對環套作用空氣壓之時間而藉由前述環套將前述微血管閉 塞一定時間，則可藉計時器將對微血管供給血液之動脈部 位做一定時間正確的閉塞。 再者，若再裝設回復時間量測計時器以量測前述血流 回復時間，則藉回復時間量測計時器可以正確量測血流回 復時間。 再者，若前述血流狀態檢測機構係以光電脈波量測計 構成，則可根據脈波振幅値來檢測血流回復狀態。 再者，前述中央處理裝置若可控制前述回復時間量測 計時器之啓動與同時間光電脈波量測計所量測到之脈波最 大振幅値作複數個移動平均而比較移動平均値與平常時之 平均値是否在某一偏差以內爲一致，並在兩者一致之時刻 使得計時器停止，以其經過時間作爲血流回復時間，則可 依據血流量或血流速度來正確地運算血流回復時間。 又，如依本發明之其他動脈硬化度測定裝置，可以簡 單且非侵襲性的測定血管之擴張反應。又，因血管擴張反 應大時爲柔軟之健康血管，故可藉血管擴張反應以測定動 脈硬化度。其結果是，可在家中輕鬆地測定動脈硬化度， —— ___- ---—- 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） (請先閱讀背面之注意事項再填寫本頁) π裝 I---訂·--------{ A7 529931 ______B7______ 五、發明說明 並依該動脈硬化度留心日常上動脈硬化之預防。 又，藉空氣壓控制機構計時器之設置，可以正確地量 測阻血時間。 [圖示之簡單說明] 圖1係表示本發明動脈硬化度測定裝置之實施形態之 構成方塊圖。 圖2係表示以圖1之動脈硬化度測定裝置測定血液黏 度狀態之一例之前視圖。 圖3係表示以圖1之動脈硬化度測定裝置測定血液黏 度狀態之其他例之前視圖。 圖4係表示以圖1之動脈硬化度測定裝置測定血液黏 度狀態之其他例之前視圖。 圖5係表示以圖1之動脈硬化度測定裝置測定時之脈 波振幅之變化狀態圖。 圖6係表示圖1之動脈硬化度測定裝置之測定順序之 方塊圖。 圖7係表示糖尿病、高膽固醇症、高脂血症患者與健 康正常者中血液黏度之對比圖。 圖8係表示1日當中血液黏度之變遷之一例之圖。 圖9係表示本發明中其他動脈硬化度測定裝置之胃_ 形態之測定狀態之一例之前視圖。 圖10係表示以圖9之動脈硬化度測定裝置測定日寺 電脈波之波形與振幅狀態圖。 __________9^ ______ + 尺度適用中國國家標準（CNS)A4規格（210 X 297公釐) " '^^ __ .---*-----------------訂---------線 (請先閱讀背面之注意事項再填寫本頁) 529931 A7 _B7 _ 五、發明說明（>5) 圖11係表示以圖9之動脈硬化度測定裝置測定時之血 流量增加程度之比例圖。 圖12係表現圖11所示數値平均値之圖表。 [元件符號說明] 1環套 2空氣壓控制機構 3,24,32 CPU 4記憶體 5光電脈波量測計 6回復時間量測計時器 7印表機 8顯示器 9,33記憶卡 10本體 11 LAN纜線 21血管擴張反應測定裝置 22自動阻血裝置 23環套 25啓動按鈕 26計時器 27環套壓顯示盤 28時間顯示盤 30血液水平檢測裝置 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） (請先閱讀背面之注意事項再填寫本頁) ---- 訂---------線， 529931 A7 ____B7 五、發明說明（xMr) 31光電脈波量測計 34 LAN界面 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） --------------------訂---------線 (請先閱讀背面之注意事項再填寫本頁)I From the ratio D of the degree of increase in blood flow, the average 値 and the like of each ratio D are obtained, and the vasodilation response is measured according to the average 値. In addition, the vasodilator response must be grasped for a long time like blood pressure or the aforementioned blood viscosity. Therefore, it is also possible to save the proportion D of the degree of increase in blood flow that is collected in a few days on the aforementioned memory card 33 and use the memory card 33 or the cable of the LAN interface 34 to transfer the data of the proportion D of the degree of increase in blood flow to the individual A computer or the like "calculates the average value of each of the aforementioned ratios D" by a data processing unit such as a personal computer to measure the vasodilation response. Also, similar to the first embodiment, the ratio D of the degree of increase in blood flow measured several times a day may be stored in a memory and printed with a printer. As described above, in the vasodilation response measuring device 21 of this embodiment, since the pulse wave of the DC band of the photoelectric pulse wave can be detected by the blood level detection device, it can detect not only the waveform of the photoelectric pulse wave, but also the normal time. The difference between the absorbance of light irradiated by oxidized and reduced heme during congestion. Thereby, the blood level can be measured, the final blood flow can be calculated from the blood level, and the blood vessel expansion reaction can be measured. As a result, the vasodilation response can be measured in a simple and non-invasive manner. In addition, since the vasodilation response is a soft healthy blood vessel, the vasodilation response can be used to measure the degree of arteriosclerosis. As a result, the degree of arteriosclerosis can be easily measured at home, and the prevention of arteriosclerosis can be routinely monitored according to the degree of arteriosclerosis. The present invention is not limited to the second embodiment described above, and various changes can be made as necessary. --- 22 --------- This paper size applies to China National Standard (CNS) A4 (210 X 297 mm) ------------------ --Order --------- line (please read the precautions on the back before filling this page) 529931 A7 ____B7___ V. Description of the Invention (W) For example, in the second embodiment, the automatic blood blocking device 22 Although the CPUs 24 and 32 serving as the central processing device are arranged separately from the blood level detection device 30, the present invention is not limited to this, and one central processing device having the aforementioned two CPU functions may be arranged on one vasodilation measurement device. In addition, because the blood vessel viscosity varies with age, the vasodilation response standards of the 10-, 20-, and 30-year-old age groups can also be obtained, and these standards can be stored in the blood level detection device. The CPU measures arteriosclerosis according to this standard. In addition, the blood level detection device 30 may receive a pulse wave of a DC frequency band from a photoelectric pulse wave of a photoelectric pulse wave meter as a DC signal, but it is not limited thereto. For example, in the first embodiment described above, since a photoelectric pulse wave measuring device can also be used as a blood flow state detection mechanism, it can also receive AC signals other than DC signals, and it can also switch between receiving DC signals and AC signals. Switcher. [Effect of the Invention] As described above, the arteriosclerosis measuring device according to the present invention can relatively simply and non-invasively measure the blood viscosity by comparing the recovery time of the blood flow velocity in the blood vessel with the blood viscosity. That is, the present invention is characterized in that it has an annulus that compresses and occludes the arterial portion that supplies blood to the blood vessels with air pressure, an air pressure control mechanism that controls the air pressure of the annulus, and detects The blood flow state detection mechanism of the blood flow state in the microvessel compressed by the cuff, and the central processing device (respectively the aforementioned air pressure control mechanism and the blood flow state detection machine ----------- ...... 1 --------- H -.....-_— This paper size applies to China National Standard (CNS) A4 (210 X 297 mm) ------------ -------- Order · -------- (Please read the notes on the back before filling this page) A7 529931 ____B7_____ V. Description of the invention () Structure connection, which can control the above-mentioned loop pair The pressure and release of the arterial site (which can supply blood to the microvessels), and the blood flow recovery time is measured by the aforementioned blood flow state detection mechanism to calculate the blood viscosity). Furthermore, by adopting this configuration, blood viscosity can be measured in a non-invasive manner, and blood viscosity can be easily measured and managed at home. In addition, if a timer is installed to set the time when the air pressure control mechanism applies air pressure to the cuff and the microvessel is occluded by the cuff for a certain time, the arterial part that supplies blood to the microvessel can be used by the timer. Do the correct occlusion for a certain amount of time. Furthermore, if a recovery time measurement timer is further installed to measure the aforementioned blood flow recovery time, the recovery time measurement timer can accurately measure the blood flow recovery time. Furthermore, if the blood flow state detection mechanism is constituted by a photoelectric pulse wave measuring device, the blood flow recovery state can be detected based on the pulse wave amplitude 値. Furthermore, if the central processing device can control the activation of the recovery time measurement timer and the maximum amplitude of the pulse wave measured by the photoelectric pulse wave meter at the same time, make a plurality of moving averages and compare the moving average with normal Whether the average time of time is consistent within a certain deviation, and the timer is stopped at the time when the two are consistent, and the elapsed time is used as the blood flow recovery time, then the blood flow can be correctly calculated according to the blood flow or blood flow velocity Response Time. Further, according to another arteriosclerosis measuring device according to the present invention, it is possible to simply and non-invasively measure the vasodilation response. In addition, since the vasodilation response is a soft healthy blood vessel, the vasodilation response can be used to measure the degree of arterial sclerosis. As a result, the degree of arteriosclerosis can be easily measured at home, —— ___- ------ This paper size applies the Chinese National Standard (CNS) A4 specification (210 X 297 mm) (Please read the precautions on the back first (Fill in this page again) π Pack I --- Order · -------- {A7 529931 ______B7______ V. Description of the invention and pay attention to the prevention of daily upper arteriosclerosis according to the degree of arteriosclerosis. In addition, by setting the timer of the air pressure control mechanism, the blood blocking time can be accurately measured. [Brief description of the figure] Fig. 1 is a block diagram showing the configuration of an embodiment of the arteriosclerosis measuring device of the present invention. Fig. 2 is a front view showing an example of a blood viscosity measurement using the arteriosclerosis measuring device shown in Fig. 1; Fig. 3 is a front view showing another example of the state of blood viscosity measurement by the arteriosclerosis measuring device of Fig. 1; Fig. 4 is a front view showing another example of the blood viscosity measurement using the arteriosclerosis measuring device of Fig. 1; Fig. 5 is a graph showing changes in pulse wave amplitude when measured by the arteriosclerosis measuring device shown in Fig. 1; Fig. 6 is a block diagram showing a measurement procedure of the arteriosclerosis measuring device of Fig. 1. Fig. 7 is a graph showing the comparison of blood viscosity among patients with diabetes, hypercholesterolemia, hyperlipidemia, and healthy individuals. FIG. 8 is a diagram showing an example of changes in blood viscosity during a day. FIG. 9 is a front view showing an example of a measurement state of a stomach shape of another arteriosclerosis measuring device in the present invention. Fig. 10 is a diagram showing the waveform and amplitude of the Nichiji pulse wave measured by the arteriosclerosis measuring device shown in Fig. 9. __________ 9 ^ ______ + Standards apply to China National Standard (CNS) A4 (210 X 297 mm) " '^^ __ .--- * ----------------- Order --------- Line (Please read the precautions on the back before filling this page) 529931 A7 _B7 _ V. Description of the invention (> 5) Figure 11 shows the measurement with the arteriosclerosis measuring device of Figure 9 Proportion diagram of the degree of increase in blood flow over time. FIG. 12 is a graph showing the average number of numbers shown in FIG. 11. [Explanation of component symbols] 1 loop 2 air pressure control mechanism 3, 24, 32 CPU 4 memory 5 photoelectric pulse wave meter 6 recovery time measurement timer 7 printer 8 display 9, 33 memory card 10 body 11 LAN cable 21 Vasodilation response measurement device 22 Automatic blood blocking device 23 Ring set 25 Start button 26 Timer 27 Ring set Pressure display panel 28 Time display panel 30 Blood level detection device This paper size applies Chinese National Standard (CNS) A4 specifications ( 210 X 297 mm) (Please read the precautions on the back before filling this page) ---- Order --------- Line, 529931 A7 ____B7 V. Description of the invention (xMr) 31 Photoelectric pulse volume Measurement 34 LAN interface This paper size is applicable to China National Standard (CNS) A4 specification (210 X 297 mm) -------------------- Order ----- ---- Line (Please read the notes on the back before filling in this page)