WO2002083311A2 - Plateau reservoir - Google Patents

Plateau reservoir Download PDF

Info

Publication number
WO2002083311A2
WO2002083311A2 PCT/EP2002/004172 EP0204172W WO02083311A2 WO 2002083311 A2 WO2002083311 A2 WO 2002083311A2 EP 0204172 W EP0204172 W EP 0204172W WO 02083311 A2 WO02083311 A2 WO 02083311A2
Authority
WO
WIPO (PCT)
Prior art keywords
reservoir
tray
assay kit
component
reservoir tray
Prior art date
Application number
PCT/EP2002/004172
Other languages
English (en)
Other versions
WO2002083311A3 (fr
Inventor
Henric Ekstrand
Original Assignee
Henric Ekstrand
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Henric Ekstrand filed Critical Henric Ekstrand
Priority to AU2002312823A priority Critical patent/AU2002312823A1/en
Publication of WO2002083311A2 publication Critical patent/WO2002083311A2/fr
Publication of WO2002083311A3 publication Critical patent/WO2002083311A3/fr

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D81/00—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents
    • B65D81/02—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents specially adapted to protect contents from mechanical damage
    • B65D81/025—Containers made of sheet-like material and having a shape to accommodate contents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B50/00—Containers, covers, furniture or holders specially adapted for surgical or diagnostic appliances or instruments, e.g. sterile covers
    • A61B50/30—Containers specially adapted for packaging, protecting, dispensing, collecting or disposing of surgical or diagnostic appliances or instruments
    • A61B50/33—Trays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L1/00—Enclosures; Chambers
    • B01L1/52—Transportable laboratories; Field kits
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L9/00—Supporting devices; Holding devices

Definitions

  • the present invention relates to a reservoir ray. More particularly it relates to a reservoir tray, which also serves as a piece of protective packaging for one or more components of an assay kit packaged in a container. It also relates to an assay kit comprising the reservoir tray and at least one other component of the kit.
  • kit components include, but are not limited to: Consumables, such as, for example chemical reagents, buffers, antibodies, enzymes, reagent bottles and vials of glass and plastics etc; and equipment, such as, for example, micro titre plates, micro pipettes, plate washers, strip washers, plate readers etc
  • Micro titre plates are commonly used in many scientific disciplines. When using micro titre plate based assays, such as, for example, Enzyme Linked Immune Sorbe ⁇ t Assays (ELISAs) it is common practice to prepare the reagents ⁇ n a reservoir tray and transfer them across to the micro titre plate.
  • ELISAs Enzyme Linked Immune Sorbe ⁇ t Assays
  • kits The commercial value of kits is based on a combination of refined and often patented components and / or procedures. The value is a reflection of 1) the saving of an end users time and effort in preparing and pre-formathng fluids and other components; 2) the ease by which the end user can carry out high tech applications, assisted by standardised procedures and protocols; and 3) the greater accuracy often attained as a result of the consistent nature of the kit and its components.
  • Kits often contain assay plates, and may occasionally even contain plate and / or fluid-handling devices such as single or mult ⁇ channel pipettes,, and even plate and / or strip-washers, readers etc
  • kits Since the kits are often posted the box must be quite sturdy, unless a protective outer box is employed. Additionally, to protect and immobilise kit components during transport the kit box must contain internal protective features. Protective supports for bottles include foam or card box inserts with holes punched in them for the receipt of bottles. Due to frequent imperfect design and layout, and due to the nature of many internal protective features, kits can tend to be unnecessarily bulky. A problem with the kits presently available is hence that the volume of the kit-box often is vastly greater than the sum of the contained components.
  • the reservoir tray is able to house one or more other components in. a manner that protects them in transit.
  • the manner in which they are housed also enables the other components to be positioned in a set manner so that they can be viewed clearly for the purpose of identification by the end user.
  • each housing enables the component being housed to be firmly immobilised during handling.
  • the means for housing at least one component of an assay kit, particularly reagent bottles comprises a locking means, such as a clip or one or more resilient members which can exert a locking or retaining force against the component so that it is held firmly in position during transit
  • a locking means such as a clip or one or more resilient members which can exert a locking or retaining force against the component so that it is held firmly in position during transit
  • a locking means such as a clip or one or more resilient members which can exert a locking or retaining force against the component so that it is held firmly in position during transit
  • other mechanical means will be apparent to the skilled man.
  • Alternative, and more complex arrangements include the use of magnetic or other non-mechanical retaining means or chemical means such as adhesives.
  • the means for housing the at least one component of the assay kit not only enables the component to be protected and immobilised but also enables it to be positioned precisely and placed in a manner logical to the order in which the component would be used, and additionally, allowing the component to be clearly viewed for the purpose of identification.
  • a reservoir tray for preparing and transferring reagents to, for example, a micro titre plate, comprising a support having at least one reservoir chamber characterised in that the reservoir tray further comprises means for housing at least one component of an assay kit such that flie at least one component of the assay kit housed therein is afforded protection by the reservoir tray during handling or transportation.
  • the arrangement reduces waste packaging, reduces assay kit bulk thereby increasing free storage space and allows components to be checked by simply opening the container in which they are stored for transport and storage.
  • the provision of the reservoir tray greatly improves the ease of use of the kit, and adds to the user-friendly value of the kit due to the refined and pre-formatted features and multiple functions.
  • a reservoir tray in the assay kit also improves assay reproducibihty since it provides a kit specific standard for the mixing and transfer of reagents and additionally reduces contamination risks from the buffer reservoirs that may be independently available to the end user, and over which the kit supplier has no control.
  • the at least one reservoir chamber is shaped to snugly house the at least one component of the assay kit. Such an arrangement reduces the size and hence cost of the packaging.
  • the at least one reservoir chamber is provided with a means for securing the art least one component in place in the reservoir chamber.
  • a means for securing the art least one component in place in the reservoir chamber prevents the component coming loose in transit thereby avoiding the risk of breakage.
  • the means for securing the at least one component in place in the reservoir chamber is a pair of resilient members which are integral with the reservoir chamber and extend from an uppermost surface partially or completely extending across the reservoir chamber.
  • a means provides a cheap and effective means for securing, particularly bottles.
  • the at least one reservoir chamber is of a size that will accommodate at least a four, more preferably an eight and most preferably a twelve channel micropipette.
  • the at least one reservoir chamber tapers towards its base.
  • the reservoir tray has a planar base and is substantially square or rectangular. These shapes are most suited to the shapes of the boxes most frequently used to transport the assay kits.
  • the reservoir tray comprises a plurality, usually two reservoir chambers.
  • a plurality of reservoir chambers is often needed to house all the components of a kit, and will often be needed to avoid washing a reservoir chamber between steps in an assay and thus reduces the risk of contamination in a given assay.
  • the at least one reservoir chamber houses a plurality of kit components.
  • an assay kit comprising a container and a reservoir tray of the invention.
  • At least one component of the assay is housed in the reservoir tray.
  • the at least one component of the assay housed in the reservoir tray is a reagent bottle.
  • the at least one reagent bottle is housed on its side. This allows easy reading of the bottle without removal.
  • Fig 1 a is a perspective view from one side and above of a reservoir tray according to one aspect ⁇ f the invention
  • Fig lb is a perspective view from the other side and below of the reservoir tray illustrated in Fig 1 a,
  • Fig 2 is a plan view from above of the reservoir tray illustrated in Fig 1 ;
  • Figs 3 a and 3b are side elevations of the reservoir tray illustrated in Fig 1;
  • Figs 4a and 4b are end elevations of the reservoir tray illustrated in Fig 1;
  • Fig 5 is as per Fig 2 with reagent bottles in place in the chambers;
  • Fig 6a and 6b are as per Fig 3 a and 3b with reagent bottles in place in the chambers;
  • Fig 7a and 7b are as per Fig 4a and 4b with reagent bottles in place in the chambers;
  • Fig 8a is a perspective view from one side and above of a further embodiment with a single reservoir chamber;
  • Fig 8b is a perspective view from the other side and below of the reservoir tray illustrated in Fig 8a.
  • Figs 1 to 7 illustrate a plastic reservoir tray (6) formed from, for example, polyvinyl or polypropylene. It comprises a support (8), which supports two reservoir chambers (24; 26).
  • the support comprises a base (10), that is generally rectangular and flat about its outermost perimeter edge (12) (when viewed in plan - see Fig 2) such that it will sit snugly inside a container, such as, for example a box, and in set from the outermost perimeter edge (12) of the base (10), walls (14; 16; 18; and 20) which extend at an inclined angle to an uppermost surface (22) which is recessed to house four containers (100; 102; 104 and 106).
  • the walls (14; 16; 18; and 20) In setting and inclining the walls (14; 16; 18; and 20) from the outer most perimeter edge (12) of the base facilitates easier removal of the reservoir tray from its container (not shown).
  • the recessed housings also function as reservoir chambers (24 and 26).
  • the uppermost surface (22) comprises two reservoir chambers (24 and 26), which are substantially "V" shaped in cross section (Fig 4a and 4b). By tapering towards their bottom (27) the reservoirs are most able to facilitate -the uptake of small volumes of liquids by a fluid-handling device such as a single or multi-channel pipette. Each reservoir is also elongate (Fig 2) such that they will accept up to a 12-channel micropipette. Each reservoir has two sidewalls (28 and 30), which are slightly curved to facilitate a good fit with the containers (100; 102; 104; 106) that they house (Fig 7a and 7b) and also provide a degree of resilience, which assists in locking the containers in place. Two end walls (32 and 34) ensure the reservoir chambers can retain a liquid that is introduced thereto whilst the reagents are mixed and added to the wells of an assay plate.
  • component retaining elements On the uppermost surface (22), and projecting slightly across each reservoir chamber (24 and 26), are two pairs of component retaining elements (36a, 36b; 38a, 38b; and 36b, 36c; 38b, 38 c).
  • These component retaining elements take the form of grippers which project partly across the reservoir chambers and have faces (40) that grip the components (100; 102; 104; 106), for example the bottles illustrated, holding them firmly and securely in place wholly or partly within one of the reservoir chambers.
  • other component retaining means such as, for example, a shaped lid that locks onto the reservoir tray or straps might be used. ..
  • Figs 1 to 7 there are two pairs of grippers ' er reservoir chamber with the central gripper (36b; 38b) having two engaging faces (40) one facing across each of the two adjacent chambers (24; 26).
  • the two reservoir chambers (24; 26) are of different dimensions to receive different sized bottles (100, 102; 104, 106).
  • the grippers (36a; 36b) of the left reservoir chamber (24) are of different dimensions to, and protrude shghtly more than, the grippers (38a; 38b) of the same reservoir chamber (24) to allow the reception of different sized bottles (100; 102) also in the same reservoir chamber (24).
  • kits component or reagent container is preferably housed in a reservoir chamber.
  • components or reagents could be housed in the underside (50), for example in the void (52) between the two reservoir chambers.
  • An assay kit comprises the reservoir tray as described and at least one further component, for example the reagent bottles shown packaged in a container (not illustrated), typically a box. It may further comprise a manual and other consumables and / or equipment as previously described-
  • Figs 8a and 8b illustrates an embodiment in which there is just a single reservoir chamber. Like numbers are used to illustrate like parts and to avoid unnecessary repetition no further details are given below .

Landscapes

  • Health & Medical Sciences (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Mechanical Engineering (AREA)
  • Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Details Of Rigid Or Semi-Rigid Containers (AREA)
  • Packages (AREA)

Abstract

L'invention concerne un plateau réservoir (6) destiné à la préparation et au transfert de réactifs vers, par exemple, une plaque de microtitration, comprenant un support (8) présentant au moins une chambre réservoir (24; 26), caractérisé en ce que ledit plateau réservoir contient également des moyens (24; 26/36; 38) permettant de loger au moins un constituant (100; 102; 104; 106) d'un kit de dosage de telle sorte que ledit constituant dudit kit de dosage logé dans celui-ci bénéficie d'une protection procurée par le plateau réservoir pendant la manipulation ou le transport. L'invention concerne également un kit de dosage, emballé dans une boîte, comprenant un récipient et un plateau réservoir.
PCT/EP2002/004172 2001-04-12 2002-04-12 Plateau reservoir WO2002083311A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002312823A AU2002312823A1 (en) 2001-04-12 2002-04-12 Reservoir tray

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0109164.4 2001-04-12
GB0109164A GB2374413A (en) 2001-04-12 2001-04-12 Reservoir tray

Publications (2)

Publication Number Publication Date
WO2002083311A2 true WO2002083311A2 (fr) 2002-10-24
WO2002083311A3 WO2002083311A3 (fr) 2003-05-08

Family

ID=9912739

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2002/004172 WO2002083311A2 (fr) 2001-04-12 2002-04-12 Plateau reservoir

Country Status (3)

Country Link
AU (1) AU2002312823A1 (fr)
GB (1) GB2374413A (fr)
WO (1) WO2002083311A2 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100119417A1 (en) * 2008-11-10 2010-05-13 Biotix, Inc. Degradable fluid handling devices
CN107042932A (zh) * 2016-02-05 2017-08-15 B·布莱恩·阿维图姆股份公司 医疗无菌包装单元

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2119642A1 (fr) * 2008-05-02 2009-11-18 Rowa Automatisierungssysteme GmbH Procédé de stockage d'une multitude de récipients cylindriques dans un rayonnage automatisé et support de récipient utilisé à cet effet
ES2569220T3 (es) * 2010-06-22 2016-05-09 F. Hoffmann-La Roche Ag Envase de suspensión para partículas de unión para el aislamiento de material biológico
US20130071946A1 (en) 2011-09-21 2013-03-21 Roche Molecular Systems, Inc. Suspension Container For Binding Particles For The Isolation Of Biological Material

Citations (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB767661A (en) * 1954-03-26 1957-02-06 Nat Res Dev Improved liquid dispensing apparatus
US3272371A (en) * 1965-03-12 1966-09-13 Chase Instr Corp Tube tray
US3653839A (en) * 1970-07-06 1972-04-04 Henry Valve Co Field test kit reagent transferring system and method for using same
US3707227A (en) * 1970-07-06 1972-12-26 Owens Illinois Inc Tray package for tubes
US4153160A (en) * 1978-01-30 1979-05-08 Johannah Medical Services, Inc. Disposable slide-step percutaneous transhepatic cholangiography procedure tray
US4248349A (en) * 1978-12-07 1981-02-03 Dougherty Brothers Company Tray for ampoules or the like
FR2538549A1 (fr) * 1982-12-24 1984-06-29 Manni Maria Cuvette a fond retreci particulierement pour liquides a prelever au moyen de pipettes multiples
US4554839A (en) * 1983-10-14 1985-11-26 Cetus Corporation Multiple trough vessel for automated liquid handling apparatus
US4767008A (en) * 1987-11-02 1988-08-30 Warnecke Armand E Injection monitor appliance
US5449071A (en) * 1993-10-28 1995-09-12 Levy; Abner Tray for medical specimen collection kit
FR2771930A1 (fr) * 1997-12-05 1999-06-11 Draeger Sicherheitstech Gmbh Cartouche parfumee
WO2000034720A1 (fr) * 1998-12-10 2000-06-15 Annita Brugnera Plateau pour cubes de glace a couverture detachable
US6119876A (en) * 1998-10-21 2000-09-19 Lacourse; Jean-Francois Support structure for germination jars

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1240553A (en) * 1968-03-20 1971-07-28 Smith & Nephew Res Hospital packs
US4523679A (en) * 1984-03-05 1985-06-18 Sterling Drug Inc. Pre-sterilized medical procedure kit packages
US6010462A (en) * 1998-05-28 2000-01-04 Becton Dickinson And Company Blister style culture transport device and method for using the same

Patent Citations (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB767661A (en) * 1954-03-26 1957-02-06 Nat Res Dev Improved liquid dispensing apparatus
US3272371A (en) * 1965-03-12 1966-09-13 Chase Instr Corp Tube tray
US3653839A (en) * 1970-07-06 1972-04-04 Henry Valve Co Field test kit reagent transferring system and method for using same
US3707227A (en) * 1970-07-06 1972-12-26 Owens Illinois Inc Tray package for tubes
US4153160A (en) * 1978-01-30 1979-05-08 Johannah Medical Services, Inc. Disposable slide-step percutaneous transhepatic cholangiography procedure tray
US4248349A (en) * 1978-12-07 1981-02-03 Dougherty Brothers Company Tray for ampoules or the like
FR2538549A1 (fr) * 1982-12-24 1984-06-29 Manni Maria Cuvette a fond retreci particulierement pour liquides a prelever au moyen de pipettes multiples
US4554839A (en) * 1983-10-14 1985-11-26 Cetus Corporation Multiple trough vessel for automated liquid handling apparatus
US4767008A (en) * 1987-11-02 1988-08-30 Warnecke Armand E Injection monitor appliance
US5449071A (en) * 1993-10-28 1995-09-12 Levy; Abner Tray for medical specimen collection kit
FR2771930A1 (fr) * 1997-12-05 1999-06-11 Draeger Sicherheitstech Gmbh Cartouche parfumee
US6119876A (en) * 1998-10-21 2000-09-19 Lacourse; Jean-Francois Support structure for germination jars
WO2000034720A1 (fr) * 1998-12-10 2000-06-15 Annita Brugnera Plateau pour cubes de glace a couverture detachable

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100119417A1 (en) * 2008-11-10 2010-05-13 Biotix, Inc. Degradable fluid handling devices
WO2010054337A2 (fr) * 2008-11-10 2010-05-14 Biotix, Inc. Dispositifs de manipulation de liquides dégradables
WO2010054337A3 (fr) * 2008-11-10 2010-08-26 Biotix, Inc. Dispositifs de manipulation de liquides dégradables
CN107042932A (zh) * 2016-02-05 2017-08-15 B·布莱恩·阿维图姆股份公司 医疗无菌包装单元
US10383696B2 (en) 2016-02-05 2019-08-20 B. Braun Avitum Ag Medical sterile packaging unit

Also Published As

Publication number Publication date
GB0109164D0 (en) 2001-05-30
AU2002312823A1 (en) 2002-10-28
WO2002083311A3 (fr) 2003-05-08
GB2374413A (en) 2002-10-16

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