WO2002063300A1 - Equipement et procede de mesure d'une reaction de stockage - Google Patents

Equipement et procede de mesure d'une reaction de stockage Download PDF

Info

Publication number
WO2002063300A1
WO2002063300A1 PCT/JP2002/001147 JP0201147W WO02063300A1 WO 2002063300 A1 WO2002063300 A1 WO 2002063300A1 JP 0201147 W JP0201147 W JP 0201147W WO 02063300 A1 WO02063300 A1 WO 02063300A1
Authority
WO
WIPO (PCT)
Prior art keywords
equipment
section
measuring
fixing position
storage
Prior art date
Application number
PCT/JP2002/001147
Other languages
English (en)
French (fr)
Inventor
Hideji Tajima
Original Assignee
Bio Strand, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US10/467,361 priority Critical patent/US7473396B2/en
Priority to NZ527456A priority patent/NZ527456A/en
Priority to EP02712302A priority patent/EP1359420B8/en
Priority to DE60235961T priority patent/DE60235961D1/de
Priority to AU2002232159A priority patent/AU2002232159B8/en
Priority to CA002439169A priority patent/CA2439169C/en
Application filed by Bio Strand, Inc. filed Critical Bio Strand, Inc.
Priority to AT02712302T priority patent/ATE464121T1/de
Priority to KR1020037010326A priority patent/KR100858097B1/ko
Priority to JP2002562994A priority patent/JP4076859B2/ja
Publication of WO2002063300A1 publication Critical patent/WO2002063300A1/ja
Priority to NO20033530A priority patent/NO331934B1/no
Priority to US12/326,763 priority patent/US8142737B2/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/0275—Interchangeable or disposable dispensing tips
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00279—Features relating to reactor vessels
    • B01J2219/00281—Individual reactor vessels
    • B01J2219/00286—Reactor vessels with top and bottom openings
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00351—Means for dispensing and evacuation of reagents
    • B01J2219/00353—Pumps
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00497—Features relating to the solid phase supports
    • B01J2219/00513—Essentially linear supports
    • B01J2219/00515—Essentially linear supports in the shape of strings
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00497—Features relating to the solid phase supports
    • B01J2219/00513—Essentially linear supports
    • B01J2219/00518—Essentially linear supports in the shape of tapes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00497—Features relating to the solid phase supports
    • B01J2219/00513—Essentially linear supports
    • B01J2219/0052—Essentially linear supports in the shape of elongated tubes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/0054—Means for coding or tagging the apparatus or the reagents
    • B01J2219/00572—Chemical means
    • B01J2219/00576—Chemical means fluorophore
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00585—Parallel processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00596—Solid-phase processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00657—One-dimensional arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00659—Two-dimensional arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00677—Ex-situ synthesis followed by deposition on the substrate
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068—Means for controlling the apparatus of the process
    • B01J2219/00702—Processes involving means for analysing and characterising the products
    • B01J2219/00707—Processes involving means for analysing and characterising the products separated from the reactor apparatus
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B01J2219/00722—Nucleotides
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B01J2219/00725—Peptides
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B01J2219/00731—Saccharides
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B01J2219/0074—Biological products
    • B01J2219/00743—Cells
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0636—Integrated biosensor, microarrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0812—Bands; Tapes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0832—Geometry, shape and general structure cylindrical, tube shaped
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0478—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure pistons
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/06—Libraries containing nucleotides or polynucleotides, or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/10—Libraries containing peptides or polypeptides, or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/12—Libraries containing saccharides or polysaccharides, or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
    • C40B60/14—Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03—Cuvette constructions
    • G01N2021/0325—Cells for testing reactions, e.g. containing reagents
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/59—Transmissivity
    • G01N21/5907—Densitometers
    • G01N2021/5969—Scanning of a tube, a cuvette, a volume of sample
    • G01N2021/5973—Scanning of a tube, a cuvette, a volume of sample where the cuvette or tube is moved
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N2021/6484—Optical fibres
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N2035/1027—General features of the devices
    • G01N2035/1048—General features of the devices using the transfer device for another function
    • G01N2035/1055—General features of the devices using the transfer device for another function for immobilising reagents, e.g. dried reagents
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N2035/1027—General features of the devices
    • G01N2035/1048—General features of the devices using the transfer device for another function
    • G01N2035/1062—General features of the devices using the transfer device for another function for testing the liquid while it is in the transfer device
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/2575—Volumetric liquid transfer

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Devices For Conveying Motion By Means Of Endless Flexible Members (AREA)
  • Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
PCT/JP2002/001147 2001-02-09 2002-02-12 Equipement et procede de mesure d'une reaction de stockage WO2002063300A1 (fr)

Priority Applications (11)

Application Number Priority Date Filing Date Title
NZ527456A NZ527456A (en) 2001-02-09 2002-02-12 Equipment and method for measuring storage reaction
EP02712302A EP1359420B8 (en) 2001-02-09 2002-02-12 Equipment and method for measuring storage reaction
DE60235961T DE60235961D1 (de) 2001-02-09 2002-02-12 Aktion
AU2002232159A AU2002232159B8 (en) 2001-02-09 2002-02-12 Device for containing, reacting and measuring, and method of containing, reacting and measuring
CA002439169A CA2439169C (en) 2001-02-09 2002-02-12 Device for containing, reacting and measuring, and method of containing, reacting and measuring
US10/467,361 US7473396B2 (en) 2001-02-09 2002-02-12 Device for containing, reacting and measuring, and method of containing, reacting and measuring
AT02712302T ATE464121T1 (de) 2001-02-09 2002-02-12 Geräte und verfahren zum messen der speicherungsreaktion
KR1020037010326A KR100858097B1 (ko) 2001-02-09 2002-02-12 수용반응 측정 장치 및 수용반응 측정 방법
JP2002562994A JP4076859B2 (ja) 2001-02-09 2002-02-12 収容反応測定装置および収容反応測定方法
NO20033530A NO331934B1 (no) 2001-02-09 2003-08-08 Integrert baerer, anordning som inkorporerer denne og fremgangsmate for oppbevaring, reaksjon og maling.
US12/326,763 US8142737B2 (en) 2001-02-09 2008-12-02 Device for containing, reacting and measuring, and method of containing, reacting and measuring

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2001-034556 2001-02-09
JP2001034556 2001-02-09

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US10467361 A-371-Of-International 2002-02-12
US12/326,763 Division US8142737B2 (en) 2001-02-09 2008-12-02 Device for containing, reacting and measuring, and method of containing, reacting and measuring

Publications (1)

Publication Number Publication Date
WO2002063300A1 true WO2002063300A1 (fr) 2002-08-15

Family

ID=18898141

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2002/001147 WO2002063300A1 (fr) 2001-02-09 2002-02-12 Equipement et procede de mesure d'une reaction de stockage

Country Status (11)

Country Link
US (5) US7157047B2 (ja)
EP (1) EP1359420B8 (ja)
JP (1) JP4076859B2 (ja)
KR (1) KR100858097B1 (ja)
CN (1) CN100400671C (ja)
AT (1) ATE464121T1 (ja)
CA (1) CA2439169C (ja)
DE (1) DE60235961D1 (ja)
NO (1) NO331934B1 (ja)
NZ (1) NZ527456A (ja)
WO (1) WO2002063300A1 (ja)

Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004144633A (ja) * 2002-10-25 2004-05-20 Sysmex Corp 試料分析装置およびその装置に使用されるピペット洗浄用希釈液
WO2004088291A1 (en) * 2003-04-03 2004-10-14 Bioneer Corporation Real-time monitoring apparatus for biochemical reaction
WO2004092710A1 (ja) * 2003-04-15 2004-10-28 Universal Bio Research Co., Ltd. 分注用シリンダ、大容量分注装置および大容量分注装置の使用方法
WO2004113918A1 (ja) * 2003-06-20 2004-12-29 Universal Bio Research Co., Ltd. 試料配列・集積化装置、その方法、および試料集積体使用装置
WO2005056145A2 (ja) * 2003-12-12 2005-06-23 Mollennium Lab 生物学的チップおよびその利用
WO2005064334A1 (ja) * 2003-12-30 2005-07-14 Universal Bio Research Co., Ltd. 粒子三次元配列体を利用した反応容器及び反応装置
WO2005103724A1 (ja) * 2004-04-20 2005-11-03 Universal Bio Research Co., Ltd. 試料集積用カセット、スポッティング装置および試料集積化装置
EP1664296A1 (en) * 2003-08-28 2006-06-07 Canon Kabushiki Kaisha Probe carrier and method for quantifying target substance using the probe carrier
JP2007302592A (ja) * 2006-05-10 2007-11-22 Sumitomo Heavy Ind Ltd Ｒｉ化合物合成装置及びｒｉ化合物合成方法
JP2011517773A (ja) * 2008-03-28 2011-06-16 バイオティクス， インコーポレイテッド サンプル調製デバイスおよび分析物の処理方法
US7999929B2 (en) 2004-08-02 2011-08-16 The Furukawa Electric Co., Ltd. Specimen optical information recognizing device and its recognizing method
EP2615160A1 (en) 2004-10-06 2013-07-17 Universal Bio Research Co., Ltd. Reaction vessel and reaction controller
US8980093B2 (en) 2003-09-30 2015-03-17 Yuri P. Belov Multicapillary device for sample preparation
WO2015141828A1 (ja) * 2014-03-20 2015-09-24 ユニバーサル・バイオ・リサーチ株式会社 導光集積検査装置およびその検査方法

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7157047B2 (en) 2001-02-09 2007-01-02 Pss Bio Instruments, Inc. Device for containing, reacting and measuring, and method of containing, reacting and measuring
KR100989710B1 (ko) * 2002-01-17 2010-10-26 프레시죤 시스템 사이언스 가부시키가이샤 담체수용처리장치 및 담체수용처리방법
US7197195B2 (en) * 2003-08-14 2007-03-27 Baker Hughes Incorporated Fiber optics head utilizing randomized fibers per sensor
US20050282182A1 (en) * 2003-12-30 2005-12-22 Universal Bio Research Co., Ltd. Reaction vessel and reaction apparatus comprising three-dimensional particle array
JP2005283304A (ja) * 2004-03-29 2005-10-13 Lintec Corp プローブアレイ
JP2006030156A (ja) * 2004-06-15 2006-02-02 Olympus Corp 反応容器及びその反応容器を用いた反応装置並びに検出装置
EP1821106B1 (en) * 2004-12-10 2018-02-14 Universal Bio Research Co., Ltd. Biomaterial immobilization carrier enclosing tip and method of treating therefor
TWI416107B (zh) 2004-12-10 2013-11-21 Universal Bio Research Co Ltd 封入生物材料固定用區域之滴尖、生物材料固定用區域處理裝置及其方法
JP4436261B2 (ja) * 2005-02-01 2010-03-24 ユニバーサル・バイオ・リサーチ株式会社 解析処理方法及び装置
CN101268371B (zh) * 2005-09-05 2013-06-12 环球生物研究株式会社 各种物质保持体、各种物质保持体处理装置及其处理方法
CA2548931A1 (en) * 2006-05-11 2007-11-11 The Fluid Life Corporation Method and apparatus for improving accuracy of optic sensors used in capillary tube instruments
JP2011247859A (ja) * 2010-05-31 2011-12-08 Universal Bio Research Co Ltd バイオチップ
AU2013202793B2 (en) 2012-07-31 2014-09-18 Gen-Probe Incorporated System, method and apparatus for automated incubation
WO2014034928A1 (ja) 2012-08-31 2014-03-06 ユニバーサル・バイオ・リサーチ株式会社 変形要素内蔵分注チップ、変形要素内蔵分注装置および変形要素内蔵分注処理方法
AU2013202805B2 (en) 2013-03-14 2015-07-16 Gen-Probe Incorporated System and method for extending the capabilities of a diagnostic analyzer
WO2014153308A2 (en) * 2013-03-20 2014-09-25 Siemens Healthcare Diagnostics Inc. Pipette components useful for medical diagnostics
KR102593185B1 (ko) * 2015-03-19 2023-10-24 베크만 컬터, 인코포레이티드 분석기용 분배기
JP6851079B2 (ja) 2015-05-01 2021-03-31 ユニバーサル・バイオ・リサーチ株式会社 多重反応並行測定装置およびその方法
EP3290114B1 (en) * 2016-09-02 2020-02-12 Bio-Rad Europe GmbH Pipette tip container
AU2018362024B2 (en) 2017-11-02 2022-08-18 Memed Diagnostics Ltd. Cartridge and system for analyzing body liquid
CN109925979A (zh) * 2019-04-24 2019-06-25 四川轻化工大学 管式气液界面反应器、管式化学发光检测装置及检测方法
FI130934B1 (fi) * 2021-01-29 2024-06-07 Marginum Oy Laite fluoresenssin havaitsemiseksi
CN112760199B (zh) * 2021-02-22 2023-06-20 辽东学院 一种化妆品微生物检测用防富集装置
WO2022232550A1 (en) 2021-04-29 2022-11-03 Abbott Laboratories Systems and methods for pooling samples for high-throughput analysis

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57171266A (en) * 1981-04-14 1982-10-21 Sunstar Kinzoku Kk Apparatus for examining mixed reagent
JPH10150975A (ja) * 1996-09-26 1998-06-09 Becton Dickinson & Co サンプル液に対する生物学的又は化学的プロセスを行う装置、同方法、及び核酸アッセイを行うための装置セット
JPH11125637A (ja) * 1997-10-22 1999-05-11 Olympus Optical Co Ltd 自動分析装置
JPH11326339A (ja) * 1998-05-08 1999-11-26 Wako Pure Chem Ind Ltd 診断用自動分析装置用試験具
JP2001083158A (ja) * 1999-09-17 2001-03-30 Fuji Photo Film Co Ltd マクロアレイと支持具を用いた分析方法とその為の用具

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4031399A (en) * 1975-02-24 1977-06-21 Beckman Instruments, Inc. Fluorometer
US4447546A (en) * 1982-08-23 1984-05-08 Myron J. Block Fluorescent immunoassay employing optical fiber in capillary tube
US4499052A (en) * 1982-08-30 1985-02-12 Becton, Dickinson And Company Apparatus for distinguishing multiple subpopulations of cells
US4551435A (en) * 1983-08-24 1985-11-05 Immunicon, Inc. Selective removal of immunospecifically recognizable substances from solution
US4844869A (en) * 1985-09-09 1989-07-04 Ord, Inc. Immunoassay apparatus
EP0286119B1 (en) * 1987-04-09 1993-12-08 Kabushiki Kaisha Meidensha Instrument for quantitative analysis
US5077078A (en) * 1990-03-14 1991-12-31 University Of Pittsburgh Of The Commonwealth System Of Higher Education Surface modification of plastic optical fibers
US5082630A (en) * 1990-04-30 1992-01-21 The United States Of America As Represented By The United States Department Of Energy Fiber optic detector for immuno-testing
EP0514927A1 (en) 1991-05-24 1992-11-25 Walter Gilbert Method and apparatus for rapid nucleic acid sequencing
CA2069537A1 (en) * 1991-06-07 1992-12-08 Thomas A. Cook Multiple output referencing system for evanescent wave sensor
JPH0510951A (ja) * 1991-07-05 1993-01-19 Konica Corp 免疫学的測定装置
US20020022261A1 (en) * 1995-06-29 2002-02-21 Anderson Rolfe C. Miniaturized genetic analysis systems and methods
US6794127B1 (en) * 1997-06-16 2004-09-21 Diversa Corporation Capillary array-based sample screening
DE19610538A1 (de) * 1996-03-18 1997-09-25 Deutsches Krebsforsch Strahlungsermittlungsvorrichtung
US6057100A (en) * 1996-06-07 2000-05-02 Eos Biotechnology, Inc. Oligonucleotide arrays
EP0812920A1 (en) * 1996-06-14 1997-12-17 Packard Instrument B.V. Use of porphyrins in instrumental detection methods
GB9620934D0 (en) * 1996-10-08 1996-11-27 Molecular Drives Limited Multi-well containers
US5804384A (en) * 1996-12-06 1998-09-08 Vysis, Inc. Devices and methods for detecting multiple analytes in samples
US6406845B1 (en) * 1997-05-05 2002-06-18 Trustees Of Tuft College Fiber optic biosensor for selectively detecting oligonucleotide species in a mixed fluid sample
US6251688B1 (en) * 1998-03-20 2001-06-26 Ia, Inc. Method and apparatus for measurement of binding between a protein and a nucleotide
US5996128A (en) * 1998-12-31 1999-12-07 Korea Ogk Co., Ltd. Air flow adjusting rear member of the helmet
WO2000040334A1 (en) * 1999-01-08 2000-07-13 Pe Corporation (Ny) Fiber array for contacting chemical species and methods for using and making same
US7157047B2 (en) * 2001-02-09 2007-01-02 Pss Bio Instruments, Inc. Device for containing, reacting and measuring, and method of containing, reacting and measuring
US7861155B2 (en) * 2001-03-05 2010-12-28 International Business Machines Corporation Method and system for providing message publishing on a dynamic page builder on the internet

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57171266A (en) * 1981-04-14 1982-10-21 Sunstar Kinzoku Kk Apparatus for examining mixed reagent
JPH10150975A (ja) * 1996-09-26 1998-06-09 Becton Dickinson & Co サンプル液に対する生物学的又は化学的プロセスを行う装置、同方法、及び核酸アッセイを行うための装置セット
JPH11125637A (ja) * 1997-10-22 1999-05-11 Olympus Optical Co Ltd 自動分析装置
JPH11326339A (ja) * 1998-05-08 1999-11-26 Wako Pure Chem Ind Ltd 診断用自動分析装置用試験具
JP2001083158A (ja) * 1999-09-17 2001-03-30 Fuji Photo Film Co Ltd マクロアレイと支持具を用いた分析方法とその為の用具

Cited By (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004144633A (ja) * 2002-10-25 2004-05-20 Sysmex Corp 試料分析装置およびその装置に使用されるピペット洗浄用希釈液
WO2004088291A1 (en) * 2003-04-03 2004-10-14 Bioneer Corporation Real-time monitoring apparatus for biochemical reaction
US8139210B2 (en) 2003-04-03 2012-03-20 Bioneer Corporation Real-time monitoring apparatus for biochemical reaction
WO2004092710A1 (ja) * 2003-04-15 2004-10-28 Universal Bio Research Co., Ltd. 分注用シリンダ、大容量分注装置および大容量分注装置の使用方法
US7947512B2 (en) 2003-04-15 2011-05-24 Universal Bio Research Co., Ltd. Dispensing cylinder, large capacity dispensing device, and method of using large capacity dispensing device
JP4526481B2 (ja) * 2003-06-20 2010-08-18 ユニバーサル・バイオ・リサーチ株式会社 試料配列・集積化装置、その方法、および試料集積体使用装置
US8034303B2 (en) 2003-06-20 2011-10-11 Universal Bio Research Co., Ltd. Sample arraying/assembling device, its method, and apparatus using sample assembly
JPWO2004113918A1 (ja) * 2003-06-20 2006-09-28 ユニバーサル・バイオ・リサーチ株式会社 試料配列・集積化装置、その方法、および試料集積体使用装置
US8506904B2 (en) 2003-06-20 2013-08-13 Universal Bio Research Co., Ltd. Sample arraying/assembling device, its method, and apparatus using sample assembly
WO2004113918A1 (ja) * 2003-06-20 2004-12-29 Universal Bio Research Co., Ltd. 試料配列・集積化装置、その方法、および試料集積体使用装置
EP1664296A1 (en) * 2003-08-28 2006-06-07 Canon Kabushiki Kaisha Probe carrier and method for quantifying target substance using the probe carrier
EP1664296A4 (en) * 2003-08-28 2009-05-06 Canon Kk PROBE SUPPORT AND METHOD OF QUANTIFYING TARGET SUBSTANCES USING THE PROBE CARRIER
US8980093B2 (en) 2003-09-30 2015-03-17 Yuri P. Belov Multicapillary device for sample preparation
WO2005056145A2 (ja) * 2003-12-12 2005-06-23 Mollennium Lab 生物学的チップおよびその利用
WO2005056145A3 (ja) * 2003-12-12 2005-08-18 Mollennium Lab 生物学的チップおよびその利用
WO2005064334A1 (ja) * 2003-12-30 2005-07-14 Universal Bio Research Co., Ltd. 粒子三次元配列体を利用した反応容器及び反応装置
JP4699993B2 (ja) * 2004-04-20 2011-06-15 ユニバーサル・バイオ・リサーチ株式会社 試料集積用カセット、スポッティング装置および試料集積化装置
US8168142B2 (en) 2004-04-20 2012-05-01 Universal Bio Research Co., Ltd. Cassette for stacking specimen, spotting device, and specimen stacking device
WO2005103724A1 (ja) * 2004-04-20 2005-11-03 Universal Bio Research Co., Ltd. 試料集積用カセット、スポッティング装置および試料集積化装置
US7999929B2 (en) 2004-08-02 2011-08-16 The Furukawa Electric Co., Ltd. Specimen optical information recognizing device and its recognizing method
EP2615160A1 (en) 2004-10-06 2013-07-17 Universal Bio Research Co., Ltd. Reaction vessel and reaction controller
JP2007302592A (ja) * 2006-05-10 2007-11-22 Sumitomo Heavy Ind Ltd Ｒｉ化合物合成装置及びｒｉ化合物合成方法
JP2011517773A (ja) * 2008-03-28 2011-06-16 バイオティクス， インコーポレイテッド サンプル調製デバイスおよび分析物の処理方法
WO2015141828A1 (ja) * 2014-03-20 2015-09-24 ユニバーサル・バイオ・リサーチ株式会社 導光集積検査装置およびその検査方法
JPWO2015141828A1 (ja) * 2014-03-20 2017-04-13 ユニバーサル・バイオ・リサーチ株式会社 導光集積検査装置およびその検査方法

Also Published As

Publication number Publication date
AU2002232159B2 (en) 2007-08-16
KR100858097B1 (ko) 2008-09-10
NZ527456A (en) 2005-05-27
US7473396B2 (en) 2009-01-06
NO20033530D0 (no) 2003-08-08
CN1502041A (zh) 2004-06-02
US20020110817A1 (en) 2002-08-15
ATE464121T1 (de) 2010-04-15
CA2439169A1 (en) 2002-08-15
EP1359420A4 (en) 2004-03-31
EP1359420A1 (en) 2003-11-05
US20090149351A1 (en) 2009-06-11
JP4076859B2 (ja) 2008-04-16
NO331934B1 (no) 2012-05-07
US7157047B2 (en) 2007-01-02
US20040114890A1 (en) 2004-06-17
US20090124021A1 (en) 2009-05-14
DE60235961D1 (de) 2010-05-27
NO20033530L (no) 2003-10-08
JPWO2002063300A1 (ja) 2004-12-16
EP1359420B1 (en) 2010-04-14
KR20030086257A (ko) 2003-11-07
US20050142655A1 (en) 2005-06-30
CA2439169C (en) 2009-06-30
CN100400671C (zh) 2008-07-09
EP1359420B8 (en) 2010-09-15
US8142737B2 (en) 2012-03-27

Similar Documents

Publication Publication Date Title
WO2002063300A1 (fr) Equipement et procede de mesure d'une reaction de stockage
ATE430621T1 (de) Biologische vorrichtung
WO2004031399A3 (en) Parallel loading of arrays
EP1906186A3 (en) Assay system
WO2001049346A3 (en) Stacked microneedle systems
AU2003304525A8 (en) Sers diagnostic platforms, methods and systems including microarrays, biosensors and biochips
WO2004067162A3 (en) Apparatus for microfluidic processing and reading of biochip arrays
ATE503587T1 (de) Apparat zum ausbringen von fluessigkeiten, hierzu geeignete behaelterpatrone, und system aus dem apparat zum ausbringen von fluessigkeiten und der behaelterpatrone
IL175275A0 (en) Chemical and biological agent sensor array detectors
WO2002087762A8 (en) Reagent delivery system
EP1354186A4 (en) LATERAL FLOW TESTER WITH CHEMICAL RESOURCE ONBOARD
DK1594559T3 (da) Flertrins fluidumudleveringsapparat
WO2004075713A3 (en) Multiple marker assay for detection of ovarian cancer
SG117495A1 (en) High purity chemical container with diptube and level sensor terminating in lowest most point of concave floor
AU2002364120A1 (en) Sensor for the use in testing biological chemical or environmental samples
WO2002088650A3 (en) System for sensing temperature at multiple points within a vessel
GB2399517B (en) A Device for the simultaneous dialysis of a number of fluid samples
CA2434437A1 (en) Test device for analysing a biological sample liquid
GB2390157B (en) Wound fluid collecting and indicating device
GB2403535A8 (en) Method for characterizing a highly parallelized liquid handling technique using microplates and test kit for carrying out the method
AU2003250277A1 (en) Device for handling liquids contained in a plurality of channels
WO2006003657A3 (en) Indicator strip and a device for automatic testing of liquids
GB0224826D0 (en) A robust,compact spectrophotometer for measuring the analyte concentration in biological or other fluids
GB0125475D0 (en) A robust compact spectrophotometer for measuring the analyte concentration in biological or other fluids
AU2003298969A1 (en) Device for forming database for detecting biological agents and chemical substances

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A1

Designated state(s): AU CA CN JP KR NO NZ US

AL Designated countries for regional patents

Kind code of ref document: A1

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
WWE Wipo information: entry into national phase

Ref document number: 1020037010326

Country of ref document: KR

WWE Wipo information: entry into national phase

Ref document number: 527456

Country of ref document: NZ

WWE Wipo information: entry into national phase

Ref document number: 2002712302

Country of ref document: EP

Ref document number: 2002562994

Country of ref document: JP

Ref document number: 2439169

Country of ref document: CA

WWE Wipo information: entry into national phase

Ref document number: 2002232159

Country of ref document: AU

WWE Wipo information: entry into national phase

Ref document number: 028079795

Country of ref document: CN

WWP Wipo information: published in national office

Ref document number: 2002712302

Country of ref document: EP

WWP Wipo information: published in national office

Ref document number: 1020037010326

Country of ref document: KR

WWE Wipo information: entry into national phase

Ref document number: 10467361

Country of ref document: US

WWP Wipo information: published in national office

Ref document number: 527456

Country of ref document: NZ

WWG Wipo information: grant in national office

Ref document number: 527456

Country of ref document: NZ