WO2002053148A1 - Produits de soins dentaires contenant des derives d'ubiquinone - Google Patents
Produits de soins dentaires contenant des derives d'ubiquinone Download PDFInfo
- Publication number
- WO2002053148A1 WO2002053148A1 PCT/EP2001/015172 EP0115172W WO02053148A1 WO 2002053148 A1 WO2002053148 A1 WO 2002053148A1 EP 0115172 W EP0115172 W EP 0115172W WO 02053148 A1 WO02053148 A1 WO 02053148A1
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- WO
- WIPO (PCT)
- Prior art keywords
- dental care
- coenzyme
- product according
- care product
- ubiquinone
- Prior art date
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- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- GPRLSGONYQIRFK-UHFFFAOYSA-N hydron Chemical compound [H+] GPRLSGONYQIRFK-UHFFFAOYSA-N 0.000 description 1
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 239000011256 inorganic filler Substances 0.000 description 1
- 229910003475 inorganic filler Inorganic materials 0.000 description 1
- 229960004903 invert sugar Drugs 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 1
- 230000001527 leucocytic effect Effects 0.000 description 1
- 210000000265 leukocyte Anatomy 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 230000005923 long-lasting effect Effects 0.000 description 1
- 238000011866 long-term treatment Methods 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- GVALZJMUIHGIMD-UHFFFAOYSA-H magnesium phosphate Chemical compound [Mg+2].[Mg+2].[Mg+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O GVALZJMUIHGIMD-UHFFFAOYSA-H 0.000 description 1
- 239000004137 magnesium phosphate Substances 0.000 description 1
- 229910000157 magnesium phosphate Inorganic materials 0.000 description 1
- 229960002261 magnesium phosphate Drugs 0.000 description 1
- 235000010994 magnesium phosphates Nutrition 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 235000012054 meals Nutrition 0.000 description 1
- 235000013372 meat Nutrition 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 239000010445 mica Substances 0.000 description 1
- 229910052618 mica group Inorganic materials 0.000 description 1
- 239000002324 mouth wash Substances 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
- ZVVSSOQAYNYNPP-UHFFFAOYSA-N olaflur Chemical compound F.F.CCCCCCCCCCCCCCCCCCN(CCO)CCCN(CCO)CCO ZVVSSOQAYNYNPP-UHFFFAOYSA-N 0.000 description 1
- 229960001245 olaflur Drugs 0.000 description 1
- TWNQGVIAIRXVLR-UHFFFAOYSA-N oxo(oxoalumanyloxy)alumane Chemical compound O=[Al]O[Al]=O TWNQGVIAIRXVLR-UHFFFAOYSA-N 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 229910001562 pearlite Inorganic materials 0.000 description 1
- 239000004014 plasticizer Substances 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 229920001195 polyisoprene Polymers 0.000 description 1
- 229920001451 polypropylene glycol Polymers 0.000 description 1
- 229920002689 polyvinyl acetate Polymers 0.000 description 1
- 239000011118 polyvinyl acetate Substances 0.000 description 1
- 230000008092 positive effect Effects 0.000 description 1
- 229940088417 precipitated calcium carbonate Drugs 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 239000008262 pumice Substances 0.000 description 1
- 125000004151 quinonyl group Chemical group 0.000 description 1
- 239000003642 reactive oxygen metabolite Substances 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical class OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 235000012239 silicon dioxide Nutrition 0.000 description 1
- 239000010802 sludge Substances 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 229940083542 sodium Drugs 0.000 description 1
- 235000002639 sodium chloride Nutrition 0.000 description 1
- 239000011775 sodium fluoride Substances 0.000 description 1
- 235000013024 sodium fluoride Nutrition 0.000 description 1
- 229940079862 sodium lauryl sarcosinate Drugs 0.000 description 1
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 1
- 229960004711 sodium monofluorophosphate Drugs 0.000 description 1
- ADWNFGORSPBALY-UHFFFAOYSA-M sodium;2-[dodecyl(methyl)amino]acetate Chemical compound [Na+].CCCCCCCCCCCCN(C)CC([O-])=O ADWNFGORSPBALY-UHFFFAOYSA-M 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 235000012424 soybean oil Nutrition 0.000 description 1
- 239000003549 soybean oil Substances 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 239000004575 stone Substances 0.000 description 1
- 239000011115 styrene butadiene Substances 0.000 description 1
- 229920003048 styrene butadiene rubber Polymers 0.000 description 1
- 235000019408 sucralose Nutrition 0.000 description 1
- BAQAVOSOZGMPRM-QBMZZYIRSA-N sucralose Chemical compound O[C@@H]1[C@@H](O)[C@@H](Cl)[C@@H](CO)O[C@@H]1O[C@@]1(CCl)[C@@H](O)[C@H](O)[C@@H](CCl)O1 BAQAVOSOZGMPRM-QBMZZYIRSA-N 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 150000005846 sugar alcohols Chemical class 0.000 description 1
- 230000009469 supplementation Effects 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 229920003051 synthetic elastomer Polymers 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 235000012222 talc Nutrition 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 239000004408 titanium dioxide Substances 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
- 239000001993 wax Substances 0.000 description 1
- 239000010457 zeolite Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G4/00—Chewing gum
- A23G4/06—Chewing gum characterised by the composition containing organic or inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
- A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/35—Ketones, e.g. benzophenone
- A61K8/355—Quinones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Definitions
- the invention relates to a dentifrice containing ubiquinone derivatives for the therapeutic and / or preventive treatment of inflammatory and degenerative diseases of the gums and the tooth-holding apparatus.
- ubiquinone derivatives encompasses those compounds which have a p-benzoquinone structural element, preferably those of the general formula (!),
- n is an integer from 1 to 13, in particular 5 to 11.
- mixtures of various ubiquinone derivatives can also be used.
- the hydroquinone and quinone content of the substance can merge with one another by oxidation or reduction.
- the loss of 2 ⁇ electrons in the oxidation removes the aromatic character, with the two remaining double bonds being fixed.
- Quinone forms a redox system together with the hydroquinone, the potential of the hydrogen ion concentration and the ratio of the concentrations of the two components.
- Coenzyme Q 10 is a yellow-orange crystalline substance with a melting point of 49 ⁇ 1 OC. It can hardly be found in water and
- Coenzyme Q-io Dissolve methanol, but is somewhat soluble in ethanol, moderately soluble in fats such as corn oil and soybean oil, and very soluble in acetone, ether, chloroform, hexane and benzene.
- Coenzyme Q-io is stable at room temperature for at least 3 years, but is not particularly durable in direct sunlight.
- Coenzyme Q-io is similar to a lipid and can be regarded as a fat-soluble substance with a vitamin character.
- Coenzyme Q 10 Due to its redox potential, Coenzyme Q 10 has antioxidative properties. It counteracts reactive oxygen species and free oxygen radicals, which occur primarily in the tissues of the body with ischemic and inflammatory changes. In this way, coenzyme Q 10 can have an anti-inflammatory effect, especially when applied locally, and protect the tissue against inflammatory and ischemic influences.
- Enzyme activities are subject to change.
- the invention specified in claim 1 is based on the problem of providing a means by means of which it is possible to sustainably suppress paradontal diseases in the population.
- the invention thus relates to a dentifrice containing a carrier which is acceptable in dental care, optionally one or more auxiliaries and at least one ubiquinone derivative for the therapeutic and / or preventive treatment of inflammatory and degenerative diseases of the gums and the tooth-holding apparatus.
- Another object of the invention is the use of ubichirion derivatives for the preparation of a dentifrice for therapeutic and / or preventive treatment of inflammatory and degenerative diseases of the gums and the tooth structure.
- the invention furthermore relates to a method for the preventive treatment of inflammatory and degenerative diseases of the gums and the tooth-holding apparatus, a dental care composition containing an effective amount of an ubiquinone derivative being regularly applied to the teeth and gums of the persons concerned.
- the ubiquinone derivative preferably a compound of the formula I, in particular coenzyme Q10, can be added in any form to the dentifrice according to the invention, for example
- aqueous preparations e.g. in colloidal form, optionally in the presence of surfactants and / or stabilizers such as e.g. US 5,785,976, the disclosure of which is incorporated herein by reference; or
- doctor as used above and below to designate the agent according to the invention includes pasteuse, gel or rubber-like agents which can be applied to the teeth and gums with the aid of brushes or by long-lasting chewing or sucking, it thus comprises toothpastes, toothpastes, tooth gels, sweets with sugar substitutes or substitutes and dental care chewing gum, toothpastes and dental care chewing gum being particularly preferred alcoholic-aqueous tooth washes are used. These include all types of mouthwashes and mouth sprays.
- doctor as used above and below to designate the agent according to the invention also means periodontal therapeutic agents, gum bandages and denture adhesive creams.
- composition of the dentifrice according to the invention is not critical per se with regard to the carrier materials and auxiliary substances.
- it contains cleaning cleaning agents which are dispersed in an aqueous phase, various additives such as pigments, surfactants, thickeners, preservatives, caries-inhibiting fluorine compounds, flavoring and flavoring agents including sweeteners and salts, optionally colorants and other active ingredients.
- Fine-particle, solid substances which have no sharp edges but instead have flat surfaces in powder form are preferably used as cleaning bodies, in particular calcium carbonate, precipitated lime, sludge chalk, pumice stone, calcium and magnesium phosphate, barium carbonate, glass powder, zeolites, mica, pearlite, coral lime, Talc, kaolin, bone substance, diatomaceous earth, aluminum oxide, silicon dioxide, silica gel, titanium dioxide, potassium hydroxide.
- surfactants are sodium lauryl sulfate, sodium lauryl sarcosinate or sodium thaw.
- toothpaste can contain fluorine compounds for caries prophylaxis, the ones to be used
- Fluorine compounds are known to the person skilled in the art, preference is given to olaflur (N'-octadecyltrimethyldiamine-N, N, N , -tris (2-ethanol) dihydrofluoride), decaflur (9-octacecenylamine hydrofluoride), sodium fluoride and sodium monofluorophosphate. Vitamin A can also be added to increase periodontal prophylaxis.
- glycerol for example disaccharides and / or sugar alcohols, and also polyethylene glycol, polypropylene glycol, PEG-40, castor oil, genuine, natural or synthetic sweeteners such as saccharin or sweetening peptides; Binders and thickeners, for example cellulose esters and ethers such as carboxymethyl celluloses or
- hydroxyethylcelluloses Preservatives such as hydroxybenzoates, ascorbic acid or citric acid, dyes, flavorings such as peppermint oil or meat flavoring for use in pets, especially in dogs and cats, pigments.
- Advantageous embodiments of the agent according to the invention are dental care agents with a content of 0.1 to 10.0% by weight, preferably 0.3 to 3.0% by weight, in particular approximately 0.5 to 2.5% by weight. on at least one ubiquinone derivative of the formula (I), in particular coenzyme Q 10 .
- the dentifrice according to the invention in the form of a toothpaste has the following composition: Component part
- the dental care chewing gum according to the invention is also regarding the
- Carrier materials and auxiliary materials are not critical per se. As a rule, it contains a water-insoluble "gumbase” and a water-soluble portion, which contains flavorings. The water-soluble portion dissolves during chewing and the "gumbase” remains in the mouth during the chewing process.
- the “gumbase” can contain elastomers, resins, fats, oils, plasticizers, waxes and inorganic fillers.
- the elastomers can contain synthetic elastomers such as polyisobutylene, isobutylene-isoprene copolymers, styrene-butadiene
- the chewing gum contains 5 to 95% by weight, preferably 10 to 50% by weight, in particular 20 to 35% by weight, of "gumbase”.
- the water-soluble portion includes sweeteners, flavors, emulsifiers, colorings, acidulants, fillers, antioxidants and other components that give chewing gum the desired attributes.
- the sweeteners include sugar and sugar-free components. Suitable sugars are sucrose, dextrose, maltose, dextrin, invert sugar, fructose, levulose, galactose. Sorbitol is preferably used as a sugar-free sweetener; In addition, mannitol, xylitol and other hydrogenated starch hydrolysates can also be used.
- the chewing gum according to the invention generally contains 5 to 95% by weight, preferably 20 to 80% by weight, in particular 30 to 60% by weight, of one or more of these sweeteners.
- artificial sweeteners such as sucralose, aspartame, salts of acesulfame, alitame, saccharin, cyclamate and gycyrrhizin and the like can be added.
- the chewing gum according to the invention generally contains 0.02 to 8% by weight of one or more of these sweeteners.
- peppermint oil For example, peppermint oil, spearmint oil, mint oil, anise oil and cinnamon come into consideration as flavorings.
- the dental care product according to the invention in the form of a dental care chewing gum has the following composition: Component part
- Sweetener especially sorbitol, mannitol, xylitol and aspartame 50 to 70 organic thickeners 0 to 3
- Flavor especially peppermint or 0.1 to 2.0
- the dentifrice according to the invention is usually administered regularly, preferably two to four times a day, in particular in the morning and in the evening and after meals with the aid of a toothbrush or directly, for example by chewing a dentifrice gum according to the invention or sucking a sugar-free candy on the teeth and / or the gums applied and massaged if necessary.
- 1 to 100 mg, preferably 3 to 40 mg, of ubiquinone derivative is applied to each application.
- the dentifrice according to the invention can be further modified and perfected within the scope of the following claims.
- a certain synergistic effect can occur between coenzyme Q10 and vitamin A in certain patient groups.
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Food Science & Technology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Polymers & Plastics (AREA)
- Engineering & Computer Science (AREA)
- Emergency Medicine (AREA)
- Birds (AREA)
- Inorganic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Cosmetics (AREA)
Abstract
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10065413.4 | 2000-12-31 | ||
DE2000165413 DE10065413A1 (de) | 2000-12-31 | 2000-12-31 | Zahnpflegemittel |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2002053148A1 true WO2002053148A1 (fr) | 2002-07-11 |
Family
ID=7669256
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2001/015172 WO2002053148A1 (fr) | 2000-12-31 | 2001-12-20 | Produits de soins dentaires contenant des derives d'ubiquinone |
Country Status (2)
Country | Link |
---|---|
DE (1) | DE10065413A1 (fr) |
WO (1) | WO2002053148A1 (fr) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2003037284A1 (fr) * | 2001-10-31 | 2003-05-08 | Smithkline Beecham P.L.C. | Composition pour hygiene buccale |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10312173A1 (de) * | 2003-03-19 | 2004-09-30 | Ingo Hornung | Kaugummi mit beigemengten Mitteln |
DE202009007704U1 (de) | 2009-06-02 | 2009-08-20 | Hurtig, Sven | Zahnreinigungsmittel |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS61286314A (ja) * | 1985-06-11 | 1986-12-16 | Shiseido Co Ltd | 口腔用組成物 |
WO1994006418A1 (fr) * | 1992-09-16 | 1994-03-31 | Institut Für Sozial-Medizinische Forschung | Composition a macher contenant le coenzyme q 10 |
WO1998056336A1 (fr) * | 1997-06-12 | 1998-12-17 | C.S. Bioscience Inc. | Formulation dentaire |
US5908613A (en) * | 1997-09-08 | 1999-06-01 | Bozzacco; Craig | Composition for the treatment and prevention of periodontal disease |
DE19802050A1 (de) * | 1998-01-21 | 1999-07-22 | Labtec Gmbh | Zubereitung zur Freisetzung von Coenzym Q 10 in die Mundhöhle |
WO2000033802A1 (fr) * | 1998-12-11 | 2000-06-15 | Q-Pharma, Inc. | Compositions pour soins buccaux comprenant une coenzyme q¿10? |
-
2000
- 2000-12-31 DE DE2000165413 patent/DE10065413A1/de not_active Withdrawn
-
2001
- 2001-12-20 WO PCT/EP2001/015172 patent/WO2002053148A1/fr not_active Application Discontinuation
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS61286314A (ja) * | 1985-06-11 | 1986-12-16 | Shiseido Co Ltd | 口腔用組成物 |
WO1994006418A1 (fr) * | 1992-09-16 | 1994-03-31 | Institut Für Sozial-Medizinische Forschung | Composition a macher contenant le coenzyme q 10 |
WO1998056336A1 (fr) * | 1997-06-12 | 1998-12-17 | C.S. Bioscience Inc. | Formulation dentaire |
US5908613A (en) * | 1997-09-08 | 1999-06-01 | Bozzacco; Craig | Composition for the treatment and prevention of periodontal disease |
DE19802050A1 (de) * | 1998-01-21 | 1999-07-22 | Labtec Gmbh | Zubereitung zur Freisetzung von Coenzym Q 10 in die Mundhöhle |
WO2000033802A1 (fr) * | 1998-12-11 | 2000-06-15 | Q-Pharma, Inc. | Compositions pour soins buccaux comprenant une coenzyme q¿10? |
Non-Patent Citations (1)
Title |
---|
PATENT ABSTRACTS OF JAPAN vol. 011, no. 150 (C - 422) 15 May 1987 (1987-05-15) * |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2003037284A1 (fr) * | 2001-10-31 | 2003-05-08 | Smithkline Beecham P.L.C. | Composition pour hygiene buccale |
Also Published As
Publication number | Publication date |
---|---|
DE10065413A1 (de) | 2002-12-12 |
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