WO1994006418A1 - Composition a macher contenant le coenzyme q 10 - Google Patents

Composition a macher contenant le coenzyme q 10 Download PDF

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Publication number
WO1994006418A1
WO1994006418A1 PCT/SE1992/000636 SE9200636W WO9406418A1 WO 1994006418 A1 WO1994006418 A1 WO 1994006418A1 SE 9200636 W SE9200636 W SE 9200636W WO 9406418 A1 WO9406418 A1 WO 9406418A1
Authority
WO
WIPO (PCT)
Prior art keywords
composition
coenzyme
chewable
gum
chewable composition
Prior art date
Application number
PCT/SE1992/000636
Other languages
English (en)
Inventor
Attila Dahlgren
Åke DAHLGREN
Original Assignee
Institut Für Sozial-Medizinische Forschung
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Institut Für Sozial-Medizinische Forschung filed Critical Institut Für Sozial-Medizinische Forschung
Priority to PCT/SE1992/000636 priority Critical patent/WO1994006418A1/fr
Priority to AU28892/92A priority patent/AU2889292A/en
Publication of WO1994006418A1 publication Critical patent/WO1994006418A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A61K9/0058—Chewing gums

Definitions

  • a chewable composition comprising coenzyme 10
  • the present invention relates to a composition for prop ⁇ hylactic and/or therapeutic treatment of impaired gingival conditions such as gingivitis and periodontitis.
  • An object of the invention is to provide a prophylactic and/or therapeutic agent against periodontitis in a form which increases the effect of such agent.
  • a further object is to provide such agent in a convenient and palatable form.
  • Periodontitis the disease of tooth-loosening, is estimated to involve, in one form or another, every second adult person in the occidental world.
  • Gingival diseases affect 9 of 10 americans at least once in life and 25 % will lose all their teeth due to tooth- loosening before reaching the age of 60. Due to the serious nature of the disease, many dentists get in quandary when attempting to cure this often uncontrollable disease. Millions of patients every year are operated on in attempts to clear out inflamed tissue.
  • Tooth loosening is currently considered to be a general disease condition, in which the immunological defence is strongly involved.
  • Coenzyme Q 10 or ubiquinone 50 has advantageous effects on the general health status. It has been employed with systemic and topical administration in treatment of various conditions.
  • JP-A-61286314 published 16 December 1986 discloses oral hygiene compositions containing ubiquinone-10 effective against gingival diseases.
  • the oral hygiene compositions disclosed are dentifrices such as tooth pastes or mouth- washes wherein ubiquinone occurs in admixture with known pharmaceuticals. It has however turned out that ubiquinone in a homogenous aqueous liquid or viscous fluid composition is subject to oxidation and decomposition mediated by usual pharmaceutical additives.
  • the prior art dentifrices provide insufficient contact area and contact time with the tissue affected by periodontitis.
  • the present invention provides a new chewable composition comprising one or more chewable gum bases, and optionally one or more sweeteners and/or further additives, flavouring and aroma, and is characterized in further comprising an amount of coenzyme Q 10 effective in prophylactic or therapeutic treatment of impaired gingival conditions.
  • the chewable composition of the invention has been found to increase the healing ability in inflamed gingiva and to counteract the formation of free radicals and the damage caused by those.
  • the chewable physical form of the composition has been found to increase both the area and the time of contact with the gingiva.
  • An unexpected advantage with the composition of the invention is the attainment of a dual effect of coenzyme Q 10 in that said coenzyme is absorbed both locally by the affected gingival tissue and systemically via saliva swallowed.
  • the chewable composition has been found to provide a massage effect on the tooth supporting tissues, which enhances the valuable effect of the coenzyme Q ' 10.
  • Chewable gum bases are wellknown in the art, and one of ordinary skill in the art can identify am appropriate gum base that will mix well with the active ingredient(s) and which provide an adequate resistance on chewing.
  • the chewable gum bases employed may in particular be selected from chewing gum bases containing natural and/or synthetic elastomers such as styrene-butadiene copolymer, polyisobutadiene and isobutylene-isoprene copolymer.
  • the chewable gum bases may further optionally comprise a plasticizer for the elastomer, a resinous compound, a plasticizer for the resinous compound, ester gums and further optional components.
  • the chewable composition of the invention is preferably formulated as a chewing gum, which may be in leaf or tablet form and may be uncoated or coated with coating composition soluble in the saliva.
  • the composition may comprise a sweetening agent as known in the art.
  • Sugars or sugar alcohol may be employed. However sucrose and other teeth-damaging sugars are non-preferred.
  • xylitol is used as a sweetener.
  • Other particularly useful sweeteners include e.g. sorbitol and aspartam.
  • coenzyme Q 10 is a lipid soluble compound, an emulsifying agent such as lecithin may be included in the composition.
  • Further additives optionally employed in the composition of this invention include excipients as known in the art such as anti adhesive agents known from SE-B-7604236-5.
  • the composition may optionally comprise further pharmacologically active agents, such as fluorides e.g. sodium fluoride, free radical scavengers such as vitamin E and superoxide dismutase, antiseptics, antibiotics, antiviral agents or enzymes.
  • coenzyme Q 10 is included in the composition in a form providing for release thereof during an extended period of time.
  • coenzyme Q 10 may be microencapsulated or in a form obtained by the method described in EP-B-0 320 552, alone or in admixture with one or more other constituents of the composition.
  • the amount of coenzyme Q 10 in the composition may vary within broad limits depending on whether a prophylactic or therapeutic effect is desired and depending on the recommended number of administrations per day. Thus, the amount may be 0.001 - 75 % by weight of the final composition. In a preferred composition, the amount is 0.1 - 0.5 % by weight of the final composition, and in particular about 0.3 %.
  • the recommended daily dosage of coenzyme Q 10 to an adult human subject is 10 - 100 mg/day, preferably about 30 mg/day.
  • a chewing gum base is made with the following general composition:
  • Elastomer Styrene-butadiene copolymer 0.2-35%
  • Plasticizer for the elastomer Butyl stearate, glyceryl trioleate, oleic acid 0.2-35 %
  • Resinous compound Polyvinyl acetate (mw > 30000) 1-70 % Plasticizer for the resinous compound: Triacetin, acylated monoglyceride 0.5-20 %
  • Optional further compounds Fillers such as CaC0 3 0-55 %, waxes 0-25 %, texturizing and emulsifying agents 0-15 %
  • the ingredients are mixed in a kettle mixer at a temperature of 90 °C by adding to the styrene-butadiene copolymer a first portion of polyvinyl acetate followed by butyl stearate. Then the remaining polyvinyl acetate is added together with glyceryl trioleate and acetylated monoglyceride.
  • a chewing gum base is made with the following general composition:
  • Elastomer Chicle gum 0.2-35%
  • Plasticizer for the elastomer jojoba oil, petrolatum, squalane, squalene, peanut oil 0.2-35 %
  • Resinous compound Gum arabic 1-70 %
  • Plasticizer for the resinous compound Triacetin, acylated monoglyceride 0.5-20 %
  • Optional further compounds Fillers such as CaC0 3 0-55 %, waxes 0-25 %, texturizing and emulsifying agents 0-15 %
  • a chewing gum base was made with the following composition:
  • the gum base thereby formed was found to be smooth, semi ⁇ fluid and flowed easily at the mixing temperature. On cooling no phase separation was observed;
  • a chewing gum base was made with the following composition:
  • a chewing gum composition was prepared with the following formula:
  • Chewing-gum base (Example 1) 250.00 g
  • the ingredients xylitol, gum base, sorbitol and gum arabic were mixed together with glycerol in a kettle mixer at a temperature of 90 °C.
  • lecithin was mixed with coenzyme Q 10 and citric acid at a temperature of 50 °C.
  • the lecithin mixture was added to the first mixture at a temperature of 50 °C and stirred for 1 hour.
  • the flavouring agent was then added to the final product.
  • a chewing gum composition was prepared according to the procedure of Example 5 with the following formula: Xylitol 400.00 g Chewing-gum base (Example 3) 200.00 g
  • a chewing gum composition was prepared according to the procedure of Example 3 with the following formula:
  • a chewing gum composition was prepared with the following formula:
  • sucrose, gum base, sorbitol and glycerol were mixed in a kettle mixer at a temperature of 100 °C to form a homogenous first mixture.
  • lecithin and coenzyme Q 10 were mixed and added to the first mixture.
  • Citric acid was added and the mixture was stirred at 50 °C for one hour.
  • the flavouring agent was added to the product.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Zoology (AREA)
  • Medicinal Preparation (AREA)
  • Confectionery (AREA)

Abstract

On décrit une composition à mâcher contenant une ou plusieurs gommes-bases et éventuellement un ou plusieurs édulcorants et/ou d'autres additifs, des agents de sapidité et des agents aromatisants. La composition contient en outre une certaine quantité de coenzyme Q 10 qui est efficace pour le traitement préventif et curatif d'affections des gencives.
PCT/SE1992/000636 1992-09-16 1992-09-16 Composition a macher contenant le coenzyme q 10 WO1994006418A1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
PCT/SE1992/000636 WO1994006418A1 (fr) 1992-09-16 1992-09-16 Composition a macher contenant le coenzyme q 10
AU28892/92A AU2889292A (en) 1992-09-16 1992-09-16 A chewable composition comprising coenzyme q 10

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/SE1992/000636 WO1994006418A1 (fr) 1992-09-16 1992-09-16 Composition a macher contenant le coenzyme q 10

Publications (1)

Publication Number Publication Date
WO1994006418A1 true WO1994006418A1 (fr) 1994-03-31

Family

ID=20385489

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/SE1992/000636 WO1994006418A1 (fr) 1992-09-16 1992-09-16 Composition a macher contenant le coenzyme q 10

Country Status (2)

Country Link
AU (1) AU2889292A (fr)
WO (1) WO1994006418A1 (fr)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994015595A1 (fr) * 1993-01-06 1994-07-21 Jemo-Pharm A/S Preparation comprenant une substance active pharmacologique/biologique
EP1135100A1 (fr) * 1998-12-11 2001-09-26 Q-Pharma, Inc. Compositions pour soins buccaux comprenant une coenzyme q 10?
WO2002053148A1 (fr) * 2000-12-31 2002-07-11 Hans Michael Brecht Produits de soins dentaires contenant des derives d'ubiquinone
US6503483B2 (en) * 1997-06-12 2003-01-07 C.S. Bioscience, Inc. Dental formulation

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4514382A (en) * 1982-11-17 1985-04-30 Colgate-Palmolive Company Oral product for controlling gingivitis
JPS61286314A (ja) * 1985-06-11 1986-12-16 Shiseido Co Ltd 口腔用組成物

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4514382A (en) * 1982-11-17 1985-04-30 Colgate-Palmolive Company Oral product for controlling gingivitis
JPS61286314A (ja) * 1985-06-11 1986-12-16 Shiseido Co Ltd 口腔用組成物

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
PATENT ABSTRACTS OF JAPAN, Vol. 11, No. 150, C-422; & JP,A,61 286 314 (SHISEIDO CO LTD), 16 December 1986. *

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994015595A1 (fr) * 1993-01-06 1994-07-21 Jemo-Pharm A/S Preparation comprenant une substance active pharmacologique/biologique
US6503483B2 (en) * 1997-06-12 2003-01-07 C.S. Bioscience, Inc. Dental formulation
EP1135100A1 (fr) * 1998-12-11 2001-09-26 Q-Pharma, Inc. Compositions pour soins buccaux comprenant une coenzyme q 10?
EP1135100A4 (fr) * 1998-12-11 2002-07-17 Pharma Inc Q Compositions pour soins buccaux comprenant une coenzyme q 10?
WO2002053148A1 (fr) * 2000-12-31 2002-07-11 Hans Michael Brecht Produits de soins dentaires contenant des derives d'ubiquinone

Also Published As

Publication number Publication date
AU2889292A (en) 1994-04-12

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