WO2002043477A1 - Method of constructing mouse suitable for the take, differentiation and proliferation of heterogenous cells, mouse constructed by this method and use of the mouse - Google Patents

Method of constructing mouse suitable for the take, differentiation and proliferation of heterogenous cells, mouse constructed by this method and use of the mouse Download PDF

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Publication number
WO2002043477A1
WO2002043477A1 PCT/JP2001/009401 JP0109401W WO0243477A1 WO 2002043477 A1 WO2002043477 A1 WO 2002043477A1 JP 0109401 W JP0109401 W JP 0109401W WO 0243477 A1 WO0243477 A1 WO 0243477A1
Authority
WO
WIPO (PCT)
Prior art keywords
mouse
proliferation
differentiation
take
constructing
Prior art date
Application number
PCT/JP2001/009401
Other languages
English (en)
French (fr)
Inventor
Mamoru Ito
Kimio Kobayashi
Tatsutoshi Nakahata
Koichiro Tsuji
Sonoko Habu
Yoshio Koyanagi
Naoki Yamamoto
Kazuo Sugamura
Kiyoshi Ando
Tatsuji Nomura
Original Assignee
Central Institute For Experimental Animals
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=18837744&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO2002043477(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Central Institute For Experimental Animals filed Critical Central Institute For Experimental Animals
Priority to EP01978918A priority Critical patent/EP1338198B1/en
Priority to CA002402459A priority patent/CA2402459A1/en
Priority to JP2002545467A priority patent/JP3753321B2/ja
Priority to DE60131676T priority patent/DE60131676T2/de
Priority to US10/221,549 priority patent/US7145055B2/en
Publication of WO2002043477A1 publication Critical patent/WO2002043477A1/ja
Priority to US11/517,698 priority patent/US20070011753A1/en
Priority to US12/620,469 priority patent/US8541033B2/en
Priority to US14/032,934 priority patent/US20140178408A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New breeds of animals
    • A01K67/027—New breeds of vertebrates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New breeds of animals
    • A01K67/027—New breeds of vertebrates
    • A01K67/0271—Chimeric animals, e.g. comprising exogenous cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/461—Cellular immunotherapy characterised by the cell type used
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
    • A61K39/464838—Viral antigens
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/0331—Animal model for proliferative diseases
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/0337—Animal models for infectious diseases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
    • A61K2239/31—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterized by the route of administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
    • A61K2239/38—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
PCT/JP2001/009401 2000-12-01 2001-10-25 Method of constructing mouse suitable for the take, differentiation and proliferation of heterogenous cells, mouse constructed by this method and use of the mouse WO2002043477A1 (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
EP01978918A EP1338198B1 (en) 2000-12-01 2001-10-25 Method of constructing mouse suitable for the take, differentiation and proliferation of heterogenous cells, mouse constructed by this method and use of the mouse
CA002402459A CA2402459A1 (en) 2000-12-01 2001-10-25 Method of producing a mouse suitable for engraftment, differentiation and proliferation of heterologous cells, mouse produced by this method and use of the mouse
JP2002545467A JP3753321B2 (ja) 2000-12-01 2001-10-25 異種細胞の生着、分化および増殖に適したマウスの作出方法、該方法により作出されたマウスならびにそのマウスの用途
DE60131676T DE60131676T2 (de) 2000-12-01 2001-10-25 Verfahren zur herstellung einer maus, die für die aufnahme, differenzierung und proliferation von heterogenen zellen geeignet ist, die hierdurch hergestellte maus und ihre verwendung
US10/221,549 US7145055B2 (en) 2000-12-01 2001-10-25 Method of producing a mouse suitable for the engraftment, differentiation and proliferation of heterologous cells, mouse produced by this method and use of the mouse
US11/517,698 US20070011753A1 (en) 2000-12-01 2006-09-08 Method of producing a mouse suitable for engraftment, differentiation and proliferation of heterologous cells, mouse produced by this method and use of the mouse
US12/620,469 US8541033B2 (en) 2000-12-01 2009-11-17 Production of human antibodies using NOD/SCID/γcnull mice
US14/032,934 US20140178408A1 (en) 2000-12-01 2013-09-20 Method of producing an antibody

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2000367296 2000-12-01
JP2000-367296 2000-12-01

Related Child Applications (3)

Application Number Title Priority Date Filing Date
US10221549 A-371-Of-International 2001-10-25
US10/221,549 A-371-Of-International US7145055B2 (en) 2000-12-01 2001-10-25 Method of producing a mouse suitable for the engraftment, differentiation and proliferation of heterologous cells, mouse produced by this method and use of the mouse
US11/517,698 Division US20070011753A1 (en) 2000-12-01 2006-09-08 Method of producing a mouse suitable for engraftment, differentiation and proliferation of heterologous cells, mouse produced by this method and use of the mouse

Publications (1)

Publication Number Publication Date
WO2002043477A1 true WO2002043477A1 (en) 2002-06-06

Family

ID=18837744

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2001/009401 WO2002043477A1 (en) 2000-12-01 2001-10-25 Method of constructing mouse suitable for the take, differentiation and proliferation of heterogenous cells, mouse constructed by this method and use of the mouse

Country Status (7)

Country Link
US (4) US7145055B2 (ja)
EP (1) EP1338198B1 (ja)
JP (1) JP3753321B2 (ja)
CA (1) CA2402459A1 (ja)
DE (1) DE60131676T2 (ja)
ES (1) ES2295218T3 (ja)
WO (1) WO2002043477A1 (ja)

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WO2004040970A1 (ja) * 2002-11-06 2004-05-21 Central Institute For Experimental Animals ヒト造血器腫瘍の動物モデル
WO2005013682A3 (en) * 2003-07-10 2005-07-28 Central Inst Exper Animals Animal model for the analysis of tumor metastasis
EP1645183A1 (en) * 2003-06-16 2006-04-12 Kyushu Tlo Company, Limited Process for producing human-origin immunocompetent cell
JP2006271376A (ja) * 2005-03-04 2006-10-12 Jitsuken Doubutsu Chuo Kenkyusho ヒト血小板数調節薬のスクリーニング方法
JP2007105037A (ja) * 2005-09-16 2007-04-26 Univ Of Tokyo キメリズムを利用した幹細胞移植のための検査
WO2007088857A1 (ja) * 2006-01-31 2007-08-09 Takeda Pharmaceutical Company Limited 遺伝子改変動物およびその用途
JP2010110254A (ja) * 2008-11-05 2010-05-20 Primetech Kk 共通サイトカイン受容体γ鎖遺伝子ノックアウトブタ
WO2010082385A1 (ja) * 2009-01-16 2010-07-22 財団法人実験動物中央研究所 ヒト肝細胞が移植されたマウス
WO2012046797A1 (ja) 2010-10-06 2012-04-12 ファーマロジカルズ・リサーチ プライベート リミテッド 癌幹細胞集団及びその作製方法
US8343761B2 (en) 2004-04-27 2013-01-01 Chugai Seiyaku Kabushiki Kaisha Methods of generating and using antibody-producing cells
WO2013035824A1 (ja) 2011-09-07 2013-03-14 ファーマロジカルズ・リサーチ プライベート リミテッド 癌幹細胞の分離
WO2013062083A1 (ja) 2011-10-28 2013-05-02 ファーマロジカルズ・リサーチ プライベート リミテッド 癌幹細胞特異的分子
WO2014051009A1 (ja) * 2012-09-26 2014-04-03 独立行政法人理化学研究所 尋常性乾癬モデルマウス及びその製造方法
WO2014152321A1 (en) 2013-03-15 2014-09-25 The Jackson Laboratory Isolation of non-embryonic stem cells and uses thereof
WO2017110931A1 (ja) * 2015-12-22 2017-06-29 公立大学法人横浜市立大学 ウイルス感染モデル、その作製方法及びその利用
WO2019133810A1 (en) 2017-12-28 2019-07-04 Tract Pharmaceuticals, Inc. Stem cell culture systems for columnar epithelial stem cells, and uses related thereto
WO2020122178A1 (ja) 2018-12-14 2020-06-18 公益財団法人実験動物中央研究所 ヒト肝細胞が移植された非ヒト脊椎動物及びその製造方法
WO2020196742A1 (ja) 2019-03-28 2020-10-01 公益財団法人実験動物中央研究所 免疫不全げっ歯類

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CA2402459A1 (en) 2000-12-01 2002-06-06 Central Institute For Experimental Animals Method of producing a mouse suitable for engraftment, differentiation and proliferation of heterologous cells, mouse produced by this method and use of the mouse
US20070092881A1 (en) * 2003-07-10 2007-04-26 Central Institute For Experimental Animals Gene markers of tumor metastasis
US20050249666A1 (en) * 2003-07-10 2005-11-10 Central Institute For Experimental Animals Establishment of human cancer cell lines with metastatic potential using NOD/SCID
CA2572193A1 (en) 2004-06-24 2006-01-05 Biogen Idec Ma Inc. Treatment of conditions involving oligodendrocytes with sp35 based agents
US20060177926A1 (en) * 2004-09-07 2006-08-10 Erika Sasaki Common marmoset embryonic stem cell lines
JP2008514205A (ja) * 2004-09-29 2008-05-08 財団法人実験動物中央研究所 Ｎｏｇマウスを用いた高転移性細胞株の樹立
CA3065947C (en) 2005-10-18 2023-03-07 National Jewish Health Conditionally immortalized long-term stem cells and methods of making and using such cells
CA2680613A1 (en) * 2007-03-13 2008-09-18 National Jewish Medical And Research Center Methods for generation of antibodies
US9125384B2 (en) * 2007-10-18 2015-09-08 Riken Mouse having human leukemic stem cell and leukemic non-stem cell amplified therein, and method for production thereof
US8986702B2 (en) 2008-05-16 2015-03-24 Taiga Biotechnologies, Inc. Antibodies and processes for preparing the same
EP2746387A1 (en) * 2008-07-21 2014-06-25 Taiga Biotechnologies, Inc. Differentiated anucleated cells and method for preparing the same
ES2681478T3 (es) 2008-08-28 2018-09-13 Taiga Biotechnologies, Inc. Moduladores de MYC, métodos de uso de los mismos y métodos para identificar agentes que modulan MYC
KR20100118091A (ko) * 2009-04-27 2010-11-04 사회복지법인 삼성생명공익재단 인간화된 ｎｓｇ 마우스 및 그 제조 및 이용 방법
US20110091427A1 (en) * 2009-10-02 2011-04-21 Baxter International Inc. Methods for treating a kidney injury
CA2720567C (en) * 2009-11-09 2016-06-21 The Jackson Laboratory Transgenic non-human animal and methods for stem cell engraftment
EP4190149A1 (en) * 2009-12-25 2023-06-07 Chugai Seiyaku Kabushiki Kaisha Method for searching and screening for target of anti-cancer agent using non-human animal model having nog established cancer cell line transplanted therein
JPWO2011125948A1 (ja) 2010-04-02 2013-07-11 独立行政法人理化学研究所 Ｅｓ細胞の製造方法
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WO2012051572A1 (en) * 2010-10-15 2012-04-19 Massachusetts Institute Of Technology A humanized non-human mammal model of malaria and uses thereof
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JP6654001B2 (ja) 2015-05-27 2020-02-26 公益財団法人実験動物中央研究所 ヒトｉｌ−１５分泌免疫不全マウス
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JP6935383B2 (ja) 2018-09-27 2021-09-15 公益財団法人実験動物中央研究所 免疫不全マウス
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Cited By (27)

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US7259290B1 (en) 2002-11-06 2007-08-21 Central Institute For Experimental Animals Animal model of human hematopoietic tumor
WO2004040970A1 (ja) * 2002-11-06 2004-05-21 Central Institute For Experimental Animals ヒト造血器腫瘍の動物モデル
US7960175B2 (en) 2003-06-16 2011-06-14 Kyushu University, National University Corporation Process for producing human-origin immunocompetent cell
EP1645183A1 (en) * 2003-06-16 2006-04-12 Kyushu Tlo Company, Limited Process for producing human-origin immunocompetent cell
EP1645183A4 (en) * 2003-06-16 2009-01-14 Univ Kyushu Nat Univ Corp PROCESS FOR THE MANUFACTURE OF IMMUNOMETER CELLS OF HUMAN ORIGIN
JP4663634B2 (ja) * 2003-07-10 2011-04-06 財団法人実験動物中央研究所 腫瘍転移の分析のための動物モデル
WO2005013682A3 (en) * 2003-07-10 2005-07-28 Central Inst Exper Animals Animal model for the analysis of tumor metastasis
JP2007527216A (ja) * 2003-07-10 2007-09-27 財団法人実験動物中央研究所 腫瘍転移の分析のための動物モデル
US8343761B2 (en) 2004-04-27 2013-01-01 Chugai Seiyaku Kabushiki Kaisha Methods of generating and using antibody-producing cells
JP5314242B2 (ja) * 2004-04-27 2013-10-16 中外製薬株式会社 プラズマ細胞の増殖方法
JP2006271376A (ja) * 2005-03-04 2006-10-12 Jitsuken Doubutsu Chuo Kenkyusho ヒト血小板数調節薬のスクリーニング方法
JP2007105037A (ja) * 2005-09-16 2007-04-26 Univ Of Tokyo キメリズムを利用した幹細胞移植のための検査
WO2007088857A1 (ja) * 2006-01-31 2007-08-09 Takeda Pharmaceutical Company Limited 遺伝子改変動物およびその用途
JP2010110254A (ja) * 2008-11-05 2010-05-20 Primetech Kk 共通サイトカイン受容体γ鎖遺伝子ノックアウトブタ
WO2010082385A1 (ja) * 2009-01-16 2010-07-22 財団法人実験動物中央研究所 ヒト肝細胞が移植されたマウス
WO2012046797A1 (ja) 2010-10-06 2012-04-12 ファーマロジカルズ・リサーチ プライベート リミテッド 癌幹細胞集団及びその作製方法
WO2013035824A1 (ja) 2011-09-07 2013-03-14 ファーマロジカルズ・リサーチ プライベート リミテッド 癌幹細胞の分離
WO2013062083A1 (ja) 2011-10-28 2013-05-02 ファーマロジカルズ・リサーチ プライベート リミテッド 癌幹細胞特異的分子
EP3603671A2 (en) 2011-10-28 2020-02-05 Chugai Seiyaku Kabushiki Kaisha Cancer stem cell-specific molecule
WO2014051009A1 (ja) * 2012-09-26 2014-04-03 独立行政法人理化学研究所 尋常性乾癬モデルマウス及びその製造方法
JPWO2014051009A1 (ja) * 2012-09-26 2016-08-22 国立研究開発法人理化学研究所 尋常性乾癬モデルマウス及びその製造方法
WO2014152321A1 (en) 2013-03-15 2014-09-25 The Jackson Laboratory Isolation of non-embryonic stem cells and uses thereof
WO2017110931A1 (ja) * 2015-12-22 2017-06-29 公立大学法人横浜市立大学 ウイルス感染モデル、その作製方法及びその利用
JPWO2017110931A1 (ja) * 2015-12-22 2018-10-11 公立大学法人横浜市立大学 ウイルス感染モデル、その作製方法及びその利用
WO2019133810A1 (en) 2017-12-28 2019-07-04 Tract Pharmaceuticals, Inc. Stem cell culture systems for columnar epithelial stem cells, and uses related thereto
WO2020122178A1 (ja) 2018-12-14 2020-06-18 公益財団法人実験動物中央研究所 ヒト肝細胞が移植された非ヒト脊椎動物及びその製造方法
WO2020196742A1 (ja) 2019-03-28 2020-10-01 公益財団法人実験動物中央研究所 免疫不全げっ歯類

Also Published As

Publication number Publication date
DE60131676D1 (de) 2008-01-10
EP1338198A4 (en) 2005-01-19
US20070011753A1 (en) 2007-01-11
EP1338198B1 (en) 2007-11-28
DE60131676T2 (de) 2008-10-30
US7145055B2 (en) 2006-12-05
US20110010781A1 (en) 2011-01-13
ES2295218T3 (es) 2008-04-16
CA2402459A1 (en) 2002-06-06
JP3753321B2 (ja) 2006-03-08
US20140178408A1 (en) 2014-06-26
JPWO2002043477A1 (ja) 2004-04-02
US20030182671A1 (en) 2003-09-25
EP1338198A1 (en) 2003-08-27
US8541033B2 (en) 2013-09-24

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