WO2001085950A3 - Gene des 1-desoxy-d-xylulose-biosynthesewegs - Google Patents

Gene des 1-desoxy-d-xylulose-biosynthesewegs Download PDF

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Publication number
WO2001085950A3
WO2001085950A3 PCT/EP2001/004537 EP0104537W WO0185950A3 WO 2001085950 A3 WO2001085950 A3 WO 2001085950A3 EP 0104537 W EP0104537 W EP 0104537W WO 0185950 A3 WO0185950 A3 WO 0185950A3
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WO
WIPO (PCT)
Prior art keywords
genes
desoxy
xylulose
antiparasitic
prokaryotes
Prior art date
Application number
PCT/EP2001/004537
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English (en)
French (fr)
Other versions
WO2001085950A2 (de
Inventor
Hassan Jomaa
Original Assignee
Jomaa Pharmaka Gmbh
Hassan Jomaa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Jomaa Pharmaka Gmbh, Hassan Jomaa filed Critical Jomaa Pharmaka Gmbh
Priority to CA002407955A priority Critical patent/CA2407955A1/en
Priority to JP2001582539A priority patent/JP2003532422A/ja
Priority to EP01923731A priority patent/EP1337646A2/de
Priority to AU2001250428A priority patent/AU2001250428A1/en
Publication of WO2001085950A2 publication Critical patent/WO2001085950A2/de
Publication of WO2001085950A3 publication Critical patent/WO2001085950A3/de

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/44—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from protozoa
    • C07K14/445—Plasmodium
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

Die vorliegende Erfindung betrifft DNA-Sequenzen aus Plasmodium falciparum, nämlich die Gene lytB und yfgB, die bei Integration in das Genom von Viren, Eukaryonten und Prokaryonten die Isoprenoid-Biosynthese verändern sowie gentechnologische Verfahren zur Herstellung dieser transgenen Viren, Eukaryonten und Prokaryonten. Ausserdem betrifft sie Verfahren zur Identifizierung von Stoffen mit herbizider, antimikrobieller, antiparasitärer, antiviraler, fungizider, bakterizider Wirkung bei Pflanzen und antimikrobieller, antiparasitärer, antimykotischer, antibakterieller und antiviraler Wirkung bei Mensch und Tier.
PCT/EP2001/004537 2000-05-05 2001-04-21 Gene des 1-desoxy-d-xylulose-biosynthesewegs WO2001085950A2 (de)

Priority Applications (4)

Application Number Priority Date Filing Date Title
CA002407955A CA2407955A1 (en) 2000-05-05 2001-04-21 Genes of the 1-desoxy-d-xylulose biosynthesis path
JP2001582539A JP2003532422A (ja) 2000-05-05 2001-04-21 １−デオキシ−ｄ−キシルロース生合成経路の遺伝子
EP01923731A EP1337646A2 (de) 2000-05-05 2001-04-21 Gene des 1-desoxy-d-xylulose-biosynthesewegs
AU2001250428A AU2001250428A1 (en) 2000-05-05 2001-04-21 Genes of the 1-desoxy-d-xylulose biosynthesis path

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10021688A DE10021688A1 (de) 2000-05-05 2000-05-05 Gene des 1-Desoxy-D-xylulose-Biosynthesewegs
DE10021688.9 2000-05-05

Publications (2)

Publication Number Publication Date
WO2001085950A2 WO2001085950A2 (de) 2001-11-15
WO2001085950A3 true WO2001085950A3 (de) 2002-06-20

Family

ID=7640743

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2001/004537 WO2001085950A2 (de) 2000-05-05 2001-04-21 Gene des 1-desoxy-d-xylulose-biosynthesewegs

Country Status (7)

Country Link
US (1) US20030115634A1 (de)
EP (1) EP1337646A2 (de)
JP (1) JP2003532422A (de)
AU (1) AU2001250428A1 (de)
CA (1) CA2407955A1 (de)
DE (1) DE10021688A1 (de)
WO (1) WO2001085950A2 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE373715T1 (de) 1999-08-04 2007-10-15 Adelbert Bacher Isoprenoid biosynthese
DE10027821A1 (de) 2000-06-05 2001-12-06 Adelbert Bacher Der Mevalonat-unabhängige Isoprenoidbiosyntheseweg
US6660507B2 (en) 2000-09-01 2003-12-09 E. I. Du Pont De Nemours And Company Genes involved in isoprenoid compound production
DE10201458A1 (de) * 2001-04-11 2002-10-17 Adelbert Bacher Intermediate und Enzyme des Mevalonat-unabhängigen Isoprenoidbiosyntheseweg
DE10247478A1 (de) * 2002-10-11 2004-06-24 Bioagency Ag Verfahren zur Bestimmung der enzymatischen Aktivität von Proteinen
KR101408488B1 (ko) * 2006-12-01 2014-06-17 닛토덴코 가부시키가이샤 도네페질 함유 접착 제제의 경시적인 변색을 억제하는 방법
EP2098232B1 (de) * 2006-12-01 2013-06-05 Nitto Denko Corporation Zubereitung mit perkutaner absorption
CA2724502A1 (en) * 2008-05-30 2009-12-03 Nitto Denko Corporation Adhesive preparation containing donepezil, and package of the same
CN102046171B (zh) * 2008-05-30 2013-06-19 日东电工株式会社 经皮吸收制剂
CN104593406A (zh) * 2015-01-08 2015-05-06 山西医科大学 pIRES/TgDHFR-TS真核表达重组质粒及其构建和应用
CA3084263A1 (en) 2017-12-07 2019-06-13 Zymergen Inc. Engineered biosynthetic pathways for production of (6e)-8-hydroxygeraniol by fermentation
EP3728212A1 (de) 2017-12-21 2020-10-28 Zymergen Inc. Nepetalactol-oxidoreduktasen, nepetalactol-synthasen und nebalacton produzierende mikroben

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000072022A1 (de) * 1999-05-21 2000-11-30 Jomaa Pharmaka Gmbh Verwendung von genen des desoxy-d-xylulose-phosphatbiosynthesewegs zur veränderung der isoprenoidkonzentration

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999052938A2 (de) * 1998-04-14 1999-10-21 Jomaa Hassan Identifizierung chemischer wirkstoffe zur hemmung des 1-desoxy-d-xylulose-5-phosphat-biosynthesewegs in parasiten
IL141888A0 (en) * 1998-09-22 2002-03-10 Jomaa Pharmaka Gmbh Genes of the 1-deoxy-d-xylulose biosynthetic pathway

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000072022A1 (de) * 1999-05-21 2000-11-30 Jomaa Pharmaka Gmbh Verwendung von genen des desoxy-d-xylulose-phosphatbiosynthesewegs zur veränderung der isoprenoidkonzentration

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
DATABASE EMBL [online] 11 January 1999 (1999-01-11), ALTINCICEK B. ET AL.: "dxr as a potential target for antimalarial drugs", XP002178780, Database accession no. AF111813 *
DATABASE EMBL [online] 24 September 1998 (1998-09-24), BOWMAN S. ET AL.: "Plasmodium falciparum DNA", XP002178779, Database accession no. AL031744 *
GUSTAFSON CORINNE E ET AL: "Identification of the Escherichia coli lytB gene, which is involved in penicillin tolerance and control of the stringent response.", JOURNAL OF BACTERIOLOGY, vol. 175, no. 4, 1993, pages 1203 - 1205, XP001024635, ISSN: 0021-9193 *
REDDY G ROMAN ET AL: "Gene sequence tags from Plasmodium falciparum genomic DNA fragments prepared by the "genease" activity of mung bean nuclease.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES, vol. 90, no. 21, 1993, 1993, pages 9867 - 9871, XP002184271, ISSN: 0027-8424 *
ROHMER M ET AL: "ISOPRENOID BIOSYNTHESIS IN BACTERIA: A NOVEL PATHWAY FOR THE EARLY STEPS LEADING TO ISOPENTENYL DIPHOSPHATE", BIOCHEMICAL JOURNAL, PORTLAND PRESS, LONDON, GB, vol. 295, no. PART 2, 15 October 1993 (1993-10-15), pages 517 - 524, XP000944875, ISSN: 0264-6021 *
TAKAHASHI SHUNJI ET AL: "A 1-deoxy-D-xylulose 5-phosphate reductoisomerase catalyzing the formation of 2-C-methyl-D-erythritol 4-phosphate in an alternative nonmevalonate pathway for terpenoid biosynthesis.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES, vol. 95, no. 17, 18 August 1998 (1998-08-18), Aug. 18, 1998, pages 9879 - 9884, XP002178778, ISSN: 0027-8424 *

Also Published As

Publication number Publication date
EP1337646A2 (de) 2003-08-27
WO2001085950A2 (de) 2001-11-15
DE10021688A1 (de) 2001-11-15
US20030115634A1 (en) 2003-06-19
CA2407955A1 (en) 2001-11-15
AU2001250428A1 (en) 2001-11-20
JP2003532422A (ja) 2003-11-05

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