WO2001078731A1 - Solutions de perfusion de ciprofloxacine a capacite de stockage amelioree - Google Patents
Solutions de perfusion de ciprofloxacine a capacite de stockage amelioree Download PDFInfo
- Publication number
- WO2001078731A1 WO2001078731A1 PCT/EP2001/004162 EP0104162W WO0178731A1 WO 2001078731 A1 WO2001078731 A1 WO 2001078731A1 EP 0104162 W EP0104162 W EP 0104162W WO 0178731 A1 WO0178731 A1 WO 0178731A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- acid
- active ingredient
- infusion solutions
- infusion
- solutions according
- Prior art date
Links
- 239000003978 infusion fluid Substances 0.000 title claims abstract description 56
- MYSWGUAQZAJSOK-UHFFFAOYSA-N ciprofloxacin Chemical compound C12=CC(N3CCNCC3)=C(F)C=C2C(=O)C(C(=O)O)=CN1C1CC1 MYSWGUAQZAJSOK-UHFFFAOYSA-N 0.000 title claims abstract description 47
- 229960003405 ciprofloxacin Drugs 0.000 title claims abstract description 21
- 238000003860 storage Methods 0.000 title abstract description 14
- 239000000243 solution Substances 0.000 claims abstract description 62
- 239000002253 acid Substances 0.000 claims abstract description 42
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 claims abstract description 34
- 235000011007 phosphoric acid Nutrition 0.000 claims abstract description 17
- 150000005690 diesters Chemical class 0.000 claims abstract description 8
- 239000007864 aqueous solution Substances 0.000 claims abstract description 5
- 239000004480 active ingredient Substances 0.000 claims description 44
- 235000002639 sodium chloride Nutrition 0.000 claims description 29
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 20
- 150000003839 salts Chemical class 0.000 claims description 20
- 239000000203 mixture Substances 0.000 claims description 19
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 19
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 12
- AWUCVROLDVIAJX-UHFFFAOYSA-N glycerol 1-phosphate Chemical compound OCC(O)COP(O)(O)=O AWUCVROLDVIAJX-UHFFFAOYSA-N 0.000 claims description 11
- 238000001802 infusion Methods 0.000 claims description 11
- 238000000034 method Methods 0.000 claims description 11
- 239000011780 sodium chloride Substances 0.000 claims description 11
- DHCLVCXQIBBOPH-UHFFFAOYSA-N Glycerol 2-phosphate Chemical compound OCC(CO)OP(O)(O)=O DHCLVCXQIBBOPH-UHFFFAOYSA-N 0.000 claims description 10
- 238000009472 formulation Methods 0.000 claims description 8
- 229910052784 alkaline earth metal Inorganic materials 0.000 claims description 7
- 239000011521 glass Substances 0.000 claims description 7
- -1 alkaline earth metal salt Chemical class 0.000 claims description 6
- 239000003795 chemical substances by application Substances 0.000 claims description 6
- 239000000126 substance Substances 0.000 claims description 6
- 238000004519 manufacturing process Methods 0.000 claims description 5
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims description 4
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 4
- 229930195725 Mannitol Natural products 0.000 claims description 4
- 229930006000 Sucrose Natural products 0.000 claims description 4
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims description 4
- 150000001450 anions Chemical class 0.000 claims description 4
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims description 4
- 239000008103 glucose Substances 0.000 claims description 4
- 235000010355 mannitol Nutrition 0.000 claims description 4
- 239000000594 mannitol Substances 0.000 claims description 4
- 238000002360 preparation method Methods 0.000 claims description 4
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- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 3
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims description 3
- 239000005715 Fructose Substances 0.000 claims description 3
- 229930091371 Fructose Natural products 0.000 claims description 3
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 claims description 3
- 241001465754 Metazoa Species 0.000 claims description 3
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 claims description 3
- 239000003513 alkali Substances 0.000 claims description 3
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- 239000000600 sorbitol Substances 0.000 claims description 3
- 235000010356 sorbitol Nutrition 0.000 claims description 3
- 239000000811 xylitol Substances 0.000 claims description 3
- 235000010447 xylitol Nutrition 0.000 claims description 3
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 claims description 3
- 229960002675 xylitol Drugs 0.000 claims description 3
- XYZZKVRWGOWVGO-UHFFFAOYSA-N Glycerol-phosphate Chemical compound OP(O)(O)=O.OCC(O)CO XYZZKVRWGOWVGO-UHFFFAOYSA-N 0.000 claims description 2
- 239000003963 antioxidant agent Substances 0.000 claims description 2
- 239000008139 complexing agent Substances 0.000 claims description 2
- 238000004090 dissolution Methods 0.000 claims description 2
- 239000002552 dosage form Substances 0.000 claims description 2
- 239000012530 fluid Substances 0.000 claims description 2
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- 238000010438 heat treatment Methods 0.000 claims description 2
- 150000004677 hydrates Chemical class 0.000 claims description 2
- 230000003472 neutralizing effect Effects 0.000 claims description 2
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- 229910052783 alkali metal Inorganic materials 0.000 claims 1
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- 230000015572 biosynthetic process Effects 0.000 description 5
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- 150000001720 carbohydrates Chemical class 0.000 description 3
- 235000014633 carbohydrates Nutrition 0.000 description 3
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- 238000002347 injection Methods 0.000 description 3
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
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- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 description 2
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- 235000019260 propionic acid Nutrition 0.000 description 2
- IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 description 2
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- 239000012601 sub-visual particle Substances 0.000 description 2
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- NRBJWZSFNGZBFQ-UHFFFAOYSA-N 1-cyclopropyl-6-fluoro-4-oxo-7-piperazin-1-ylquinoline-3-carboxylic acid;2-hydroxypropanoic acid Chemical compound CC(O)C(O)=O.C12=CC(N3CCNCC3)=C(F)C=C2C(=O)C(C(=O)O)=CN1C1CC1 NRBJWZSFNGZBFQ-UHFFFAOYSA-N 0.000 description 1
- RTBFRGCFXZNCOE-UHFFFAOYSA-N 1-methylsulfonylpiperidin-4-one Chemical compound CS(=O)(=O)N1CCC(=O)CC1 RTBFRGCFXZNCOE-UHFFFAOYSA-N 0.000 description 1
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- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Definitions
- the present invention relates to infusion solutions of l-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7- (l-piperazinyl) -quinoline-3-carboxylic acid containing 0.015 to 0.5 g of the active ingredient mentioned per 100 ml aqueous solution and a sufficient amount of one or more physiologically acceptable acid (s) to dissolve the active ingredient and to stabilize the solution. Furthermore, the invention relates to the process of producing and using such infusion solutions.
- the invention describes ready-to-use infusion solutions as well as other dosage forms which are introduced into such infusion solutions before application, the active ingredient being 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7- (1-piperazinyl) -quinoline-3-carboxylic acid is known as ciprofloxacin.
- EP-A-0049 355 protects i.a. Medicines containing 7-amino-l-cyclopropyl-4-oxo-l, 4-dihydronaphtyridine-3-carboxylic acid.
- EP-A-0 078 362 protects 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-piperazino-quinoline-3-carboxylic acids.
- the active ingredients known from the two EPs have high antibacterial effects and are therefore suitable as medicaments for combating bacterial infections in humans and animals.
- the known compounds are not or only very little suitable for producing infusion and / or injection solutions because, for example, the pH value and / or the solubility and / or the shelf life, in particular with regard to excretions, of the ready-to-use infusion and / or injection solutions do not meet the pharmaceutical requirements for such solutions.
- DE 33 33 719 AI discloses solutions of the lactic acid salts of piperazinyl-quinolonic and / or -azaquinolonecarboxylic acids which, in addition to the lactic acid salts mentioned and optionally conventional auxiliaries, additionally contain at least one acid which does not lead to precipitation.
- acids which do not lead to precipitation include lactic acid, methanesulfonic acid, propionic acid or succinic acid, although lactic acid is by far preferred.
- the lactic acid content of the infusion solutions according to DE 33 33 719 AI can carry 0.1 to 90%.
- the lactic acid content of the solution to be applied can be 0.1 to 10%.
- EP-A-0 219 784 The problems occurring according to DE 33 33 719 AI (corresponds to EP-A 0 138 018) are tried to be avoided by EP-A-0 219 784 by providing infusion solutions of ciprofloxacin which contain 0.015 to 0.5 g of the active ingredient per 100 ml of aqueous solution and, depending on the active substance concentration, 0.9 to 5.0 mol, based on 1 mol of active substance, of one or more physiologically tolerated acids.
- the infusion solutions according to EP-A 0 219 784 contain, in addition to the active ingredient, water and other customary formulation auxiliaries, an amount of one or more acids from the group consisting of hydrochloric acid, methanesulfonic acid, propionic acid, succinic acid, glutaric acid, sufficient to dissolve the active ingredient and stabilize the solution.
- hydrochloric acid methanesulfonic acid, propionic acid, succinic acid, glutaric acid
- Citric acid fumaric acid, maleic acid, tartaric acid, glutamic acid, gluconic acid, glucuronic acid, galacturonic acid, ascorbic acid, phosphoric acid, adipic acid, hydroxyacetic acid, sulfuric acid, nitric acid, Acetic acid, malic acid, L-aspartic acid and lactic acid.
- EP-A-0 287 926 relates to parenterally administrable solutions of quinolonecarboxylic acids, i.a. Ciprofloxacin, where it is proposed to use particularly pure main active ingredient components to improve storage stability.
- EP-A-0 287 926 relates to those solutions which can be administered parenterally and in which no more than 1 to 10 ppm, based on the main active ingredient (ciprofloxacin) of the solution, are present on secondary components (“impurities” of the active ingredient)
- impurities of the active ingredient
- the publication DE 197 03 023 A discloses that the number of detectable particles is reduced by using glass bottles which have a silicone coating on the inner surface. This can further improve the shelf life of high-purity infusion solutions. It can therefore be assumed that the formation of precipitates is due to the number of particles that are inherently present. The more particles there are, the more particles are formed. This accelerates the formation of particles over time.
- the mono- or diesters of orthophosphoric acid are compounds in which the alcohol component is glycerol or another higher-value physiologically compatible sugar such as glucose, sucrose, fructose or a higher-value physiologically compatible sugar alcohol such as sorbitol, mannitol or xylitol.
- the alcohol component is glycerol or another higher-value physiologically compatible sugar such as glucose, sucrose, fructose or a higher-value physiologically compatible sugar alcohol such as sorbitol, mannitol or xylitol.
- the acid to be used for stabilizing the infusion solutions of ciprofloxacin is particularly preferably glycerol esters of orthophosphoric acid. Are particularly preferred
- Monoglycerinorthophosphorklareester Of very great interest are infusion solutions in which the acid (s) is glycerol 1 phosphate, glycerol 2 phosphate or a mixture of the glycerol phosphoric acid monoesters.
- Diphosphates are also particularly suitable acids. These include in particular glucose diphosphate and fructose-1,6-diphosphate. The acids mentioned are about as strong as phosphoric acid.
- additions of glycerol-1-phosphate, glycerol-2-phosphate, glucose diphosphate and / or fructose-1,6-diphosphate significantly outperform phosphoric acid in terms of improving storage stability.
- the total amount of acid (s) can be significantly reduced.
- An advantageous variant of the infusion solutions according to the invention is that the total content of the amount of acid (s) is below 1.04 moles based on 1 mole of active ingredient.
- the total amount of acid can be reduced even further.
- a further preferred embodiment according to the invention is characterized in that the infusion solution has a total acid content of less than 0.96 mol per 1 mol of active ingredient.
- the minimum amount of acid required per mole of active ingredient to dissolve naturally also depends on the active ingredient concentration and the acid (s) used and is therefore not constant. It should also be noted that the information in the amounts of acid relates only to the amounts that are not converted into the corresponding salt (s) by adding bases according to generally known basic chemical rules. Dissociation of the acids was not taken into account in the quantities, so that they relate to the dissociated and undissociated amount of acid.
- the infusion solutions according to the invention can also contain further formulation agents such as complexing agents, antioxidants, isotonizing agents and / or agents for adjusting the pH.
- the osmolality of the infusion solutions is 0.20 to 0.70 Osm / kg, preferably 0.26 to 0.39 Osm / kg and is adjusted by isotonic agents such as NaCl, mannitol, glucose, sucrose and glycerol or mixtures of such substances. If necessary, substances can also be used that are contained in common, commercially available infusion carrier solutions.
- the usual infusion carrier solutions include infusion solutions with an electrolyte supply without carbohydrates such as saline, Ringer's lactate solution and others, and those with carbohydrates and solutions for the supply of amino acids, each with and without carbohydrate content.
- infusion carrier solutions are in Rote Liste 1998, list of finished medicinal products of the members of the Federal Association of the Pharmaceutical Industry eV, Editio Cantor, Aulendorf / Württ. listed.
- the infusion solutions according to the invention have a pH of 3.0 to 5.2. pH values of 3.6 to 4.7 and 3.9 to 4.5 are preferred. PH values in the range from 4.1 to 4.3 are very particularly preferred.
- the infusion solutions according to the invention can be present in dosage units suitable for infusion with removable contents of 40 to 600 ml, preferably 50 to 120 ml.
- the present invention also relates to a process for the preparation of infusion solutions according to the independent claim relating to the infusion solutions, which is characterized in that a suitable amount of the active ingredient, optionally in the form of a salt such as alkali or alkaline earth metal salt or addition salt, a hydrate or a hydrate of the salt or in the form of mixtures of these salts or hydrates, with an amount of a physiologically tolerable monoester or diester of orthophosphoric acid or a mixture of several physiologically tolerable monoester or diester derivatives of orthophosphoric acid, which is preferably less than 1.04 mol per mol of active ingredient , if necessary, adding formulation auxiliaries and making up with water or a conventional infusion carrier solution in such a way that a concentration range of 0.015 to 0.5 g for the active ingredient, whereby when using an alkali or alkaline earth metal salt of the active ingredient, the amounts required for dissolution are additionally contained in the amounts necessary for neutralizing the active ingredient anion and, when using
- the solutions correspond to the properties already listed with regard to pH, amounts of acid and osmolality. If the active ingredient is used in salt form, it is expedient to use an acid whose anion corresponds to the anion of the active ingredient salt or of the salt hydrate.
- the pH of the infusion solutions according to the invention can be adjusted to the above-mentioned values with (physiologically) compatible acids and / or bases, i.e. Set 3.0 to 5.2, especially 3.6 to 4.7.
- the solutions or only a part thereof can be heated slightly, preferably to temperatures between 20 ° C and 80 ° C.
- the solutions according to the invention can be produced particularly economically via concentrated solutions.
- the amounts of active ingredient required for a batch with the main amount of acid required for the batch e.g. 95% based on molar basis
- This concentrate is then diluted.
- any other auxiliary substances - such as Table salt for isotonization - added, as well as the possibly still missing amount of acid.
- the solutions according to the invention show a high storage stability, which is not limited by the number of particles.
- the effort as described in documents EP 0 287 926 and DE-A-197 30 23 to make the solutions durable can be dispensed with.
- the solution thus obtained was filtered, placed in a glass bottle for medical purposes and then sterilized at 121 ° C.
- the sterile solution thus obtained was stored at room temperature for 6 months and regularly checked visually. No changes were visually observed after this period.
- the subvisual particles determined by the usual method of light blocking, were low and also remained unchanged. They met the special requirements of the pharmacopoeia for such solutions.
- Example 1 was essentially repeated. However, the solution obtained was not filled into a glass bottle but into a polyolefin-based bag, which is also suitable for medical purposes. No changes were visually observed after storage for 6 months.
- the solution thus obtained was filtered like Example 1, filled into a glass bottle for medical purposes and then sterilized at 121 ° C.
- the sterile solution thus obtained was stored at room temperature for 2 months and regularly checked visually. After two months there was a visually detectable crystal formation. The attempt was then stopped.
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Abstract
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP01933818A EP1282422A1 (fr) | 2000-04-15 | 2001-04-11 | Solutions de perfusion de ciprofloxacine a capacite de stockage amelioree |
AU2001260198A AU2001260198A1 (en) | 2000-04-15 | 2001-04-11 | Ciprofloxacin infusion solutions with improved storage life |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10018781A DE10018781A1 (de) | 2000-04-15 | 2000-04-15 | Infusionslösungen des Ciprofloxacins mit verbesserter Lagerfähigkeit |
DE10018781.1 | 2000-04-15 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2001078731A1 true WO2001078731A1 (fr) | 2001-10-25 |
Family
ID=7638902
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2001/004162 WO2001078731A1 (fr) | 2000-04-15 | 2001-04-11 | Solutions de perfusion de ciprofloxacine a capacite de stockage amelioree |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP1282422A1 (fr) |
AU (1) | AU2001260198A1 (fr) |
DE (1) | DE10018781A1 (fr) |
WO (1) | WO2001078731A1 (fr) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002026233A1 (fr) * | 2000-09-29 | 2002-04-04 | Fresenius Kabi Deutschland Gmbh | Solution pour perfusion de ciprofloxacine stable au stockage et a teneur reduite en acide |
DE102004005186B3 (de) * | 2004-02-02 | 2005-10-13 | Krka Tovarna Zdravil, D.D. | Verfahren zur Herstellung von gereinigtem Ciprofloxacin |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0101185A2 (fr) * | 1982-07-20 | 1984-02-22 | SHIMIZU SEIYAKU KABUSHIKI KAISHA also known as Shimizu Pharmaceutical Co., Ltd. | Composition de transfusion pour infusion par voie intraveineuse |
US5334589A (en) * | 1989-12-29 | 1994-08-02 | Abbott Laboratories | Quinolone carboxylic acid--metal ion--acid complexes |
US5843930A (en) * | 1995-06-06 | 1998-12-01 | Bayer Corporation | Method of treating otitis with ciprofloxacin-hydrocortisone suspension |
DE19730023A1 (de) * | 1997-07-11 | 1999-01-14 | Bayer Ag | Hochreine Ciprofloxacin-Infusion |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS60261252A (ja) * | 1984-06-08 | 1985-12-24 | Dainippon Screen Mfg Co Ltd | 画像信号の密度変換方法 |
-
2000
- 2000-04-15 DE DE10018781A patent/DE10018781A1/de not_active Withdrawn
-
2001
- 2001-04-11 WO PCT/EP2001/004162 patent/WO2001078731A1/fr not_active Application Discontinuation
- 2001-04-11 EP EP01933818A patent/EP1282422A1/fr not_active Withdrawn
- 2001-04-11 AU AU2001260198A patent/AU2001260198A1/en not_active Abandoned
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0101185A2 (fr) * | 1982-07-20 | 1984-02-22 | SHIMIZU SEIYAKU KABUSHIKI KAISHA also known as Shimizu Pharmaceutical Co., Ltd. | Composition de transfusion pour infusion par voie intraveineuse |
US5334589A (en) * | 1989-12-29 | 1994-08-02 | Abbott Laboratories | Quinolone carboxylic acid--metal ion--acid complexes |
US5843930A (en) * | 1995-06-06 | 1998-12-01 | Bayer Corporation | Method of treating otitis with ciprofloxacin-hydrocortisone suspension |
DE19730023A1 (de) * | 1997-07-11 | 1999-01-14 | Bayer Ag | Hochreine Ciprofloxacin-Infusion |
Non-Patent Citations (1)
Title |
---|
FAOUZI, M. A. ET AL: "Stability and compatibility studies of pefloxacin, ofloxacin and ciprofloxacin with PVC infusion bags", INT. J. PHARM. (1993), 89(2), 125-31, XP001008191 * |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002026233A1 (fr) * | 2000-09-29 | 2002-04-04 | Fresenius Kabi Deutschland Gmbh | Solution pour perfusion de ciprofloxacine stable au stockage et a teneur reduite en acide |
DE102004005186B3 (de) * | 2004-02-02 | 2005-10-13 | Krka Tovarna Zdravil, D.D. | Verfahren zur Herstellung von gereinigtem Ciprofloxacin |
Also Published As
Publication number | Publication date |
---|---|
EP1282422A1 (fr) | 2003-02-12 |
DE10018781A1 (de) | 2001-10-25 |
AU2001260198A1 (en) | 2001-10-30 |
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