WO2001068030A1 - Recipient pour substances pateuses ou liquides a doses differentiees et ensembles de recipients a cet effet - Google Patents

Recipient pour substances pateuses ou liquides a doses differentiees et ensembles de recipients a cet effet Download PDF

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Publication number
WO2001068030A1
WO2001068030A1 PCT/EP2001/002590 EP0102590W WO0168030A1 WO 2001068030 A1 WO2001068030 A1 WO 2001068030A1 EP 0102590 W EP0102590 W EP 0102590W WO 0168030 A1 WO0168030 A1 WO 0168030A1
Authority
WO
WIPO (PCT)
Prior art keywords
containers
container
semi
cut line
necks
Prior art date
Application number
PCT/EP2001/002590
Other languages
English (en)
Inventor
Luigi Boltri
Rocco Cassandri
Gaetano Clavenna
Marco Gentile
Francesco Ippoliti
Original Assignee
Dompe' S.P.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dompe' S.P.A. filed Critical Dompe' S.P.A.
Priority to AT01923650T priority Critical patent/ATE266994T1/de
Priority to DE60103377T priority patent/DE60103377T2/de
Priority to SI200130103T priority patent/SI1263389T1/xx
Priority to EP01923650A priority patent/EP1263389B1/fr
Priority to AU2001250370A priority patent/AU2001250370A1/en
Publication of WO2001068030A1 publication Critical patent/WO2001068030A1/fr

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D75/00—Packages comprising articles or materials partially or wholly enclosed in strips, sheets, blanks, tubes, or webs of flexible sheet material, e.g. in folded wrappers
    • B65D75/52—Details
    • B65D75/58—Opening or contents-removing devices added or incorporated during package manufacture
    • B65D75/5805—Opening or contents-removing devices added or incorporated during package manufacture for tearing a side strip parallel and next to the edge, e.g. by means of a line of weakness
    • B65D75/5811—Opening or contents-removing devices added or incorporated during package manufacture for tearing a side strip parallel and next to the edge, e.g. by means of a line of weakness and defining, after tearing, a small dispensing spout, a small orifice or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A61J1/06—Ampoules or carpules
    • A61J1/067—Flexible ampoules, the contents of which are expelled by squeezing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D1/00—Containers having bodies formed in one piece, e.g. by casting metallic material, by moulding plastics, by blowing vitreous material, by throwing ceramic material, by moulding pulped fibrous material, by deep-drawing operations performed on sheet material
    • B65D1/09—Ampoules
    • B65D1/095—Ampoules made of flexible material
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D75/00—Packages comprising articles or materials partially or wholly enclosed in strips, sheets, blanks, tubes, or webs of flexible sheet material, e.g. in folded wrappers
    • B65D75/28—Articles or materials wholly enclosed in composite wrappers, i.e. wrappers formed by associating or interconnecting two or more sheets or blanks
    • B65D75/30—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding
    • B65D75/32—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents
    • B65D75/321—Both sheets being recessed
    • B65D75/323—Both sheets being recessed and forming several compartments
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D75/00—Packages comprising articles or materials partially or wholly enclosed in strips, sheets, blanks, tubes, or webs of flexible sheet material, e.g. in folded wrappers
    • B65D75/28—Articles or materials wholly enclosed in composite wrappers, i.e. wrappers formed by associating or interconnecting two or more sheets or blanks
    • B65D75/30—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding
    • B65D75/32—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents
    • B65D75/325—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents one sheet being recessed, and the other being a flat not- rigid sheet, e.g. puncturable or peelable foil
    • B65D75/327—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents one sheet being recessed, and the other being a flat not- rigid sheet, e.g. puncturable or peelable foil and forming several compartments

Definitions

  • the object of this invention is a differentiated dosage container , particularly for liquid or pasty substances but also usable for powdered substances, suspensions, liposomial preparations for pharmaceuticals, diagnostics, cosmetics and the like.
  • the invention also concerns sets of these containers.
  • US patent 3221939 dated 1962 describes such a container for small volumes and illustrates an attempt to make a set or strip of these containers. It also illustrates the possibility of providing the containers with closures able to dispense the contents in several doses.
  • Patent US-4512475 dated 1983 describes a set of containers pressed in one piece with a closure plug, which, once removed from the container can be used to close it again.
  • the plug has a cylindrical cap, which inserts into the neck of the container and a tubular shell, which fits around the neck.
  • EP-0326529 dated 1989 describes a series of details and improvements aimed et facilitating the separation of the containers from the sets and to improve the rigidity and the machinability of the sets.
  • WO 98/01348 describes a set of containers provided with plugs for re-closing, so as to allow a fractionated consumption of the product.
  • the various containers of the set are joined between themselves by means of easily separated elements, opportunely inclined, so as to increase the rigidity of the set and thus reduce problems on the production line.
  • the problem of being able to use the contents of a single container in more than one part has been resolved by means of a plug which is removed at the moment of opening the container and can then be used to close it again and conserve any second dose of product.
  • antimicrobial activity e.g. benzyl alcohol, paraben, sodium benzoate, benzalkonium chloride
  • anti-oxidant activity e.g. butyl- hydroxytoluene, butyl-hydroxyanisole, propyl gallate, sulphites
  • the object of the invention is that of resolving the above mentioned problem, by providing a single dose container that is able to dispense even fractions of its content guaranteeing the microbiological quality of the product. This object is achieved, according to the invention, by the features of the enclosed independent claim 1.
  • the container according to the invention has two separate half doses disposed in two respective semi-containers, with the necks close together and parallel.
  • the top of the container presents two different pre-cut lines, one horizontal involving the necks of both semi-containers and one oblique involving the neck of a sole semi- container.
  • the opening along the horizontal pre-cut the entire dose is dispensed, that is the contents of the two semi-containers, whereas in making the opening along the oblique pre-cut, the contents of a sole semi-container can be dispensed.
  • the remaining half dose does not come into contact with the operator or with the surroundings, remaining sealed in its respective housing and in consequence maintaining the integrity and microbiological quality of the product, even in the absence of preservatives.
  • the container still presents two separate half doses disposed in semi-containers, with the necks close together and parallel.
  • a vertical pre-cut is made between the two semi- containers, which allows their separation, but also their "book-like” folding without separation.
  • There is a horizontal pre-cut at the top of the container that allows: the dispensing of the entire dose in opening the container after having made a "book-like” fold, the dispensing of a half dose in opening the single semi-container after having separated it from the other half using the vertical pre-cut.
  • the remaining half dose does not come into contact with the operator or with the surroundings and in consequence it maintains the integrity and microbiological quality of the product, even in the absence of preservatives.
  • This second method as distinct from the first, allows the reduction, at the moment of use, of the encumbrance of the top part (neck), both in the case of complete opening and in the case of a half dose, this facilitates the transfer of the "phialoid " contents in restricted spaces, as in the case of ampoules for aerosol therapy.
  • the containers according to the invention can be made in sets with thermoforming techniques, injection moulding, extrusion and blow moulding, from which sets and single containers or semi-containers are detached from time to time. More precisely, the containers of the invention are prepared by a process comprising the following steps: thermoforming of the cavity, leaving a channel open for filling; filling of the cavity with the desired quantity of product; welding and closing of the filling channel; - cutting and removal of the flash according to the design of the container; cutting loose of individual containers or cutting off strips of the number of containers required;
  • containers or sets of containers can be suitably packed in aluminium or aluminium/plastic envelopes to protect them from external contamination and to prevent the possible evaporation of solvents.
  • Figure 1 is a plan view of a container according to a first embodiment of the invention
  • Figure 2 is a lateral profile view of the container in Figure 1 ;
  • Figure 3 is a plan view of the set of containers in Figure 1 ;
  • Figure 4 is a plan view of a container according to a second embodiment of the invention;
  • Figure 5 is a lateral profile view, taken from the right-hand side of Figure
  • Figure 6 is a plan view showing the two semi-containers of Figure 4 with a "book-like" fold, the plan view of a sole semi-container being substantially the same;
  • Figure 7 is a lateral profile view of two semi-containers with "book-like” fold, taken from the right-hand side of Figure 6;
  • Figure 8 is a plan view of a set of containers according to figure 4.
  • a container or single dose "phialoid” has been indicated in its whole by reference number 1 and consists of two semi-containers or “semi- phial oids” each containing a half dose and with their necks 3, close together and parallel.
  • the bodies 4 of the semi-containers 2 have a conveniently rounded form with respect to a media plan, as can be seen from Figure 2.
  • the semi-containers 2 that are contained in a sheet of plastic material, such as polyethylene, polypropylene, polystyrene, PVC, PVDC or similar, from which they are obtained by thermoforming or other known moulding and pressing techniques.
  • the sheet 6 is in practice a substantially rectangular plate that contains the bodies 4 of the semi- containers 2, presenting a narrowing 7 in the upper part, in correspondence with the necks 3 of the semi-containers, and an upper fin 8 that contains the tops of the said necks 3.
  • the container 1 there are two different pre-cut lines, one horizontal 9, disposed immediately beneath the said upper fin 8 of the plate 6, which concerns the necks 3 of both semi-containers 2, and one oblique 10 disposed on the said fin 8 and concerning the top of the neck 3 of a sole semi-container 2.
  • both of the semi-containers 2 are opened and the entire dose can be dispensed from the container.
  • a half of the fin 8 is removed causing the opening of the neck 3 of a sole semi-container 2 and then a sole half dose from container 1 can be used.
  • the containers 1 can be produced in sets 20, as shown in Figure 3, comprising a plurality of these containers 1, joined together by their breakable joints 21 which only allow separation at the moment of use.
  • each container 1 can vary from 1 ml to 30 ml, for which the volume of each semi-container 2 will vary from 0.5 ml to 15 ml.
  • the second embodiment of the invention will now be described, using the same reference numbers as for the first embodiment, sometimes increased by 100, to distinguish parts that are equal or corresponding. Substantially, according to this embodiment, a vertical pre-cut line
  • each semi-container 2 has a rounded form which is developed on one side only of the plate 6, while the other side of the plate remains substantially flat (see Figure 5 in particular), so that there are no obstacles to the above mentioned "book-like" folding.
  • the form of the semi- containers 2 does not differ from that of the first embodiment, and a horizontal pre-cut line 109, is provided, which concerns the top of the necks 3 of the semi-containers 2, which in the attached Figure, has been drawn in a slightly higher position than the corresponding pre-cut line 9 of the first embodiment but it is evident that the pre-cut line 109 can be positioned at the same height as the corresponding pre-cut line 9.
  • Figure 8 shows a set 20 of containers according to the Figures from 4 to 7.

Landscapes

  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Composite Materials (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Ceramic Engineering (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hematology (AREA)
  • Packages (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Cosmetics (AREA)
  • Closures For Containers (AREA)
  • Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)

Abstract

Récipient pour substances ou poudres liquides ou pâteuses, pour des suspensions ou des préparations de liposomes, à usage pharmaceutique, diagnostique, cosmétique ou similaire; il est constitué d'une plaque (6) d'une matière plastique, qui comprend deux moitiés de récipient (2) avec des corps (4) et des goulots (3), rapprochés et parallèles. Plusieurs lignes de cassure ( (9-10); (109-110) ont été réalisées; parmi elles, au moins quelques-unes sont faites sur la partie supérieure des goulots (3), de manière à ce que la séparation le long des lignes de cassure provoque l'ouverture sélective d'une moitié de récipient (2) ou des deux de ces moitiés, ce qui permet la distribution d'une moitié de la dose globale du produit dans le récipient (1). L'invention concerne aussi un ensemble (20) de récipients (1), qui comprend plusieurs récipients (1) reliés entre eux le long des lignes de cassure (21), ce qui permet de les séparer pendant l'utilisation.
PCT/EP2001/002590 2000-03-14 2001-03-08 Recipient pour substances pateuses ou liquides a doses differentiees et ensembles de recipients a cet effet WO2001068030A1 (fr)

Priority Applications (5)

Application Number Priority Date Filing Date Title
AT01923650T ATE266994T1 (de) 2000-03-14 2001-03-08 Behälter für flüssige oder pastöse substanzen und behälterset aus solchen behältern
DE60103377T DE60103377T2 (de) 2000-03-14 2001-03-08 Behälter für flüssige oder pastöse substanzen und behälterset aus solchen behältern
SI200130103T SI1263389T1 (en) 2000-03-14 2001-03-08 Container for liquid or pasty substances and container sets thereof
EP01923650A EP1263389B1 (fr) 2000-03-14 2001-03-08 Recipient pour substances pateuses ou liquides et ensembles de tels recipients
AU2001250370A AU2001250370A1 (en) 2000-03-14 2001-03-08 Container for liquid or pasty substances at differentiated doses and container sets thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP00830190.5 2000-03-14
EP00830190A EP1133969A1 (fr) 2000-03-14 2000-03-14 Ampoule pour substances liquides ou pâteuses en doses différenciées et ensembles de ce type d'ampoules

Publications (1)

Publication Number Publication Date
WO2001068030A1 true WO2001068030A1 (fr) 2001-09-20

Family

ID=8175236

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2001/002590 WO2001068030A1 (fr) 2000-03-14 2001-03-08 Recipient pour substances pateuses ou liquides a doses differentiees et ensembles de recipients a cet effet

Country Status (9)

Country Link
EP (2) EP1133969A1 (fr)
AT (1) ATE266994T1 (fr)
AU (1) AU2001250370A1 (fr)
DE (1) DE60103377T2 (fr)
DK (1) DK1263389T3 (fr)
ES (1) ES2220761T3 (fr)
PT (1) PT1263389E (fr)
SI (1) SI1263389T1 (fr)
WO (1) WO2001068030A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109573324A (zh) * 2019-01-16 2019-04-05 叶卫东 一次性补充液包装瓶

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6457612B1 (en) * 2001-10-12 2002-10-01 Amphastar Pharmaceuticals Inc. Sealable and manipulable pre-filled disposable pipette
GB2407312A (en) * 2003-10-23 2005-04-27 Maureen Linda Blogg Divided or separable container for liquid medicines
GB0513581D0 (en) 2005-07-01 2005-08-10 Norton Healthcare Ltd Container
FR2894942A1 (fr) * 2005-12-15 2007-06-22 Ronith Stemmer Dispositif de conditionnement et de distribution de produits dentaires
US20090114677A1 (en) * 2007-11-05 2009-05-07 Geoffrey Catherwood Stuart Dual Receptacle Symmetrical Package for Liquids
FR2945797B1 (fr) 2009-05-20 2015-11-06 Virbac Sa Conditionnement alimentaire,pharmaceutique ou veterinaire de securite et son procede de fabrication
DE102010031734A1 (de) 2010-07-21 2012-01-26 Multivac Sepp Haggenmüller Gmbh & Co. Kg Verpackung für ein flüssiges, pulvriges oder pastöses Produkt
WO2020180202A1 (fr) * 2019-03-01 2020-09-10 Николай Валерьевич ХОХЛОВ Composition à base de nanoparticules de dioxyde de cérium et de polysaccharides d'algues brunes pour traiter les blessures
WO2020212757A1 (fr) * 2019-04-15 2020-10-22 Contract Pharmaceuticals Limited Emballages à dose unique à ouverture par rupture
WO2024068523A1 (fr) 2022-09-30 2024-04-04 Boehringer Ingelheim Vetmedica Gmbh Emballage d'administration, appareil de production et procédé de production

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3221939A (en) 1962-01-08 1965-12-07 Barnes Hind International Inc Disposable dispensers
FR2016456A1 (fr) * 1968-08-27 1970-05-08 Smith & Nephew
US3913734A (en) * 1972-08-03 1975-10-21 Pharmacare Inc Package assembly
US4512475A (en) 1983-11-04 1985-04-23 Alberto Federighi Single or multiple dose container-closure assemblies
EP0361028A1 (fr) * 1988-09-29 1990-04-04 Bernd Hansen Récipient à double compartiment
EP0326529B1 (fr) 1988-01-28 1992-12-30 Lameplast S.R.L. Chapelet de fioles pour produits pharmaceutiques, cosmétiques et autres
WO1995011176A1 (fr) * 1993-10-21 1995-04-27 Cambridge Consultants Limited Recipient a goulot comprenant une paille
WO1998001348A1 (fr) 1996-07-05 1998-01-15 Chiesi Farmaceutici S.P.A. Bande de contenants pour liquides ou pates
DE19627243A1 (de) * 1996-07-08 1998-01-15 Hassia Verpackung Ag Verpackung

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3221939A (en) 1962-01-08 1965-12-07 Barnes Hind International Inc Disposable dispensers
FR2016456A1 (fr) * 1968-08-27 1970-05-08 Smith & Nephew
US3913734A (en) * 1972-08-03 1975-10-21 Pharmacare Inc Package assembly
US4512475A (en) 1983-11-04 1985-04-23 Alberto Federighi Single or multiple dose container-closure assemblies
EP0326529B1 (fr) 1988-01-28 1992-12-30 Lameplast S.R.L. Chapelet de fioles pour produits pharmaceutiques, cosmétiques et autres
EP0361028A1 (fr) * 1988-09-29 1990-04-04 Bernd Hansen Récipient à double compartiment
WO1995011176A1 (fr) * 1993-10-21 1995-04-27 Cambridge Consultants Limited Recipient a goulot comprenant une paille
WO1998001348A1 (fr) 1996-07-05 1998-01-15 Chiesi Farmaceutici S.P.A. Bande de contenants pour liquides ou pates
DE19627243A1 (de) * 1996-07-08 1998-01-15 Hassia Verpackung Ag Verpackung

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109573324A (zh) * 2019-01-16 2019-04-05 叶卫东 一次性补充液包装瓶

Also Published As

Publication number Publication date
EP1263389A1 (fr) 2002-12-11
EP1133969A1 (fr) 2001-09-19
PT1263389E (pt) 2004-09-30
EP1263389B1 (fr) 2004-05-19
SI1263389T1 (en) 2004-08-31
AU2001250370A1 (en) 2001-09-24
ES2220761T3 (es) 2004-12-16
DE60103377D1 (de) 2004-06-24
ATE266994T1 (de) 2004-06-15
DE60103377T2 (de) 2004-09-16
DK1263389T3 (da) 2004-09-27

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