WO2001037869A9 - Compositions vaccinales - Google Patents

Compositions vaccinales

Info

Publication number
WO2001037869A9
WO2001037869A9 PCT/AU2000/001410 AU0001410W WO0137869A9 WO 2001037869 A9 WO2001037869 A9 WO 2001037869A9 AU 0001410 W AU0001410 W AU 0001410W WO 0137869 A9 WO0137869 A9 WO 0137869A9
Authority
WO
WIPO (PCT)
Prior art keywords
hcv
charged
polyprotein
antigen
fragment
Prior art date
Application number
PCT/AU2000/001410
Other languages
English (en)
Other versions
WO2001037869A1 (fr
Inventor
Debbie Drane
John Cox
Michael Houghton
Xavier Paliard
Original Assignee
Csl Ltd
Chiron Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Csl Ltd, Chiron Corp filed Critical Csl Ltd
Priority to AU13730/01A priority Critical patent/AU772617B2/en
Priority to CA2391843A priority patent/CA2391843C/fr
Priority to NZ518999A priority patent/NZ518999A/xx
Priority to JP2001539483A priority patent/JP2003514872A/ja
Priority to DE60039715T priority patent/DE60039715D1/de
Priority to KR1020027006431A priority patent/KR100875483B1/ko
Priority to EP00975681A priority patent/EP1239876B1/fr
Publication of WO2001037869A1 publication Critical patent/WO2001037869A1/fr
Publication of WO2001037869A9 publication Critical patent/WO2001037869A9/fr
Priority to HK03100096.0A priority patent/HK1047892B/zh

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/385—Haptens or antigens, bound to carriers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/29—Hepatitis virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55544—Bacterial toxins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55572—Lipopolysaccharides; Lipid A; Monophosphoryl lipid A
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55577—Saponins; Quil A; QS21; ISCOMS
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/24011—Flaviviridae
    • C12N2770/24211—Hepacivirus, e.g. hepatitis C virus, hepatitis G virus
    • C12N2770/24234—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

L'invention concerne généralement un complexe immunogénique comprenant un véhicule organique chargé et un antigène chargé et, notamment un véhicule organique à charge négative et un antigène à charge positive, l'antigène chargé étant une polyprotéine du virus de l'Hépatite C (VHC), particulièrement la protéine noyau de VHC ou un fragment de celui-ci, ou une protéine de fusion comprenant ladite polyprotéine ou un fragment de celle-ci. Les complexes de l'invention sont utiles, entre autres, dans des compositions vaccinales, en tant qu'agents thérapeutiques et/ou prophylactiques, pour faciliter l'induction de réponses immunitaires, et notamment une réponse des cellules T cytotoxiques, dans le traitement d'un état pathologique résultant d'une infection à VHC.
PCT/AU2000/001410 1999-11-19 2000-11-17 Compositions vaccinales WO2001037869A1 (fr)

Priority Applications (8)

Application Number Priority Date Filing Date Title
AU13730/01A AU772617B2 (en) 1999-11-19 2000-11-17 Vaccine compositions
CA2391843A CA2391843C (fr) 1999-11-19 2000-11-17 Compositions vaccinales contre le vhc
NZ518999A NZ518999A (en) 1999-11-19 2000-11-17 Vaccine compositions
JP2001539483A JP2003514872A (ja) 1999-11-19 2000-11-17 ワクチン組成物
DE60039715T DE60039715D1 (de) 1999-11-19 2000-11-17 Hcv-impfstoff zusammensetzungen
KR1020027006431A KR100875483B1 (ko) 1999-11-19 2000-11-17 백신 조성물
EP00975681A EP1239876B1 (fr) 1999-11-19 2000-11-17 Compositions vaccinales hcv
HK03100096.0A HK1047892B (zh) 1999-11-19 2003-01-03 Hcv疫苗成份

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US16665299P 1999-11-19 1999-11-19
US60/166,652 1999-11-19
US22436200P 2000-08-11 2000-08-11
US60/224,362 2000-08-11

Publications (2)

Publication Number Publication Date
WO2001037869A1 WO2001037869A1 (fr) 2001-05-31
WO2001037869A9 true WO2001037869A9 (fr) 2002-07-18

Family

ID=26862451

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/AU2000/001410 WO2001037869A1 (fr) 1999-11-19 2000-11-17 Compositions vaccinales

Country Status (12)

Country Link
US (2) US20040191270A1 (fr)
EP (1) EP1239876B1 (fr)
JP (1) JP2003514872A (fr)
KR (1) KR100875483B1 (fr)
AT (1) ATE402715T1 (fr)
AU (1) AU772617B2 (fr)
CA (1) CA2391843C (fr)
DE (1) DE60039715D1 (fr)
ES (1) ES2311478T3 (fr)
HK (1) HK1047892B (fr)
NZ (2) NZ520976A (fr)
WO (1) WO2001037869A1 (fr)

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CN1636015A (zh) * 2001-06-29 2005-07-06 希龙公司 Hcv e1e2疫苗组合物
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ATE458496T1 (de) * 2002-01-14 2010-03-15 Novartis Vaccines & Diagnostic Hiv-vakzine und anwendungsverfahren
EP2263687B1 (fr) * 2002-12-27 2015-03-25 Novartis Vaccines and Diagnostics, Inc. Compositions immunogènes contenant des phospholipides
WO2004089978A2 (fr) * 2003-04-11 2004-10-21 The Provost, Fellows And Scholars Of The College Of The Holy And Undivided Trinity Of Queen Elizabeth Near Dublin Utilisation de proteines du vhc
EP2484374A1 (fr) * 2004-07-18 2012-08-08 CSL Limited Formulations à base de complexes immunostimulants et d'oligonucléotides permettant d'induire des réponses d'Interféron-Gamma ameliorées
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EP2563389B1 (fr) 2010-04-30 2015-07-08 Temasek Life Sciences Laboratory Limited Vaccin universel contre les lignées h5n1
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CU24112B1 (es) * 2012-11-05 2015-08-27 Ct De Ingeniería Genética Y Biotecnología Antígenos vacunales quiméricos contra el virus de la hepatitis c
JP5931113B2 (ja) * 2014-04-08 2016-06-08 ザ ユニバーシティー オブ メルボルン 免疫原性組成物およびその使用
CN106749672B (zh) * 2016-11-18 2020-06-30 江西农业大学 一种丙型肝炎病毒融合抗原蛋白及其应用

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Also Published As

Publication number Publication date
DE60039715D1 (de) 2008-09-11
EP1239876A1 (fr) 2002-09-18
KR100875483B1 (ko) 2008-12-22
NZ520976A (en) 2005-01-28
EP1239876A4 (fr) 2003-05-02
CA2391843A1 (fr) 2001-05-31
NZ518999A (en) 2002-12-20
ATE402715T1 (de) 2008-08-15
KR20020073338A (ko) 2002-09-23
JP2003514872A (ja) 2003-04-22
WO2001037869A1 (fr) 2001-05-31
EP1239876B1 (fr) 2008-07-30
US20100047271A1 (en) 2010-02-25
HK1047892B (zh) 2009-01-09
AU1373001A (en) 2001-06-04
CA2391843C (fr) 2011-10-18
HK1047892A1 (en) 2003-03-14
AU772617B2 (en) 2004-05-06
US20040191270A1 (en) 2004-09-30
ES2311478T3 (es) 2009-02-16

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