WO2001029040A2 - PROCESS FOR THE PREPARATION OF PYRIMIDO[5,4-g]PTERIDINE DERIVATIVES - Google Patents

PROCESS FOR THE PREPARATION OF PYRIMIDO[5,4-g]PTERIDINE DERIVATIVES Download PDF

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Publication number
WO2001029040A2
WO2001029040A2 PCT/EP2000/010044 EP0010044W WO0129040A2 WO 2001029040 A2 WO2001029040 A2 WO 2001029040A2 EP 0010044 W EP0010044 W EP 0010044W WO 0129040 A2 WO0129040 A2 WO 0129040A2
Authority
WO
WIPO (PCT)
Prior art keywords
acid
formula
pyrimido
pteridine
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2000/010044
Other languages
English (en)
French (fr)
Other versions
WO2001029040A3 (en
Inventor
Thomas Eichenberger
Max HÜGIN
Karl-Heinz Müller
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BASF Schweiz AG
Original Assignee
Ciba Spezialitaetenchemie Holding AG
Ciba SC Holding AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Spezialitaetenchemie Holding AG, Ciba SC Holding AG filed Critical Ciba Spezialitaetenchemie Holding AG
Priority to AT00992437T priority Critical patent/ATE282618T1/de
Priority to KR1020027005089A priority patent/KR20020039377A/ko
Priority to CA002385672A priority patent/CA2385672A1/en
Priority to JP2001531838A priority patent/JP4808884B2/ja
Priority to BR0014913-6A priority patent/BR0014913A/pt
Priority to AU28344/01A priority patent/AU2834401A/en
Priority to EP00992437A priority patent/EP1222189B1/en
Priority to MXPA02003924A priority patent/MXPA02003924A/es
Priority to DE60016008T priority patent/DE60016008T2/de
Publication of WO2001029040A2 publication Critical patent/WO2001029040A2/en
Publication of WO2001029040A3 publication Critical patent/WO2001029040A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B17/00—Azine dyes
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B57/00—Other synthetic dyes of known constitution

Definitions

  • the chosen reaction pressure in process steps a) and b) is preferably atmospheric pressure, but the reaction may alternatively be carried out at higher or lower pressures, for example in the range of from 50 kPa to 5 MPa.
  • the reaction time of both process steps a) and b) is usually dependent on the chosen reaction temperature and the reactivity of the starting materials. In general, a time in the range of from 1 to 50 hours, preferably from 3 to 24 hours, is chosen.
  • acids generally inorganic acids, such as hydrochloric acid, hydro- bromic acid, hydriodic acid, iodic acid, phosphoric acid, arylphosphoric acids, such as phenylphosphoric acid, alkylphosphoric acids, such as methylphosphoric acid, ethylphos- phoric acid and n-propylphosphoric acid, hypophosphoric acid, polyphosphoric acid, boric acid, arylboric acids, such as phenylboric acid, alkylboric acids, such as methylboric acid, or sulfamic acids, such as sulfamic acid or methyl-, ethyl-, n-propyl-, isopropyl-, n-butyl-, sec- butyl-, isobutyl- or tert-butyl-sulfamic acids, sulfurous acid and sulfuric acid, or organic acids, such as C ⁇ -C alkane acids, such as methane
  • reaction mixture is then heated to a temperature in the range of from 90 to 95°C and stirred at that temperature for 23 hours.
  • the reaction mixture is then filtered over a glass fibre/laminated paper filter while still hot, washed with hot water until the washing water is neutral (pH paper) and dried in vacuo at 110°C. There are obtained 5.60 g (57 % of the theoretical yield) of a yellow powder having the following elemental composition:

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
PCT/EP2000/010044 1999-10-21 2000-10-12 PROCESS FOR THE PREPARATION OF PYRIMIDO[5,4-g]PTERIDINE DERIVATIVES Ceased WO2001029040A2 (en)

Priority Applications (9)

Application Number Priority Date Filing Date Title
AT00992437T ATE282618T1 (de) 1999-10-21 2000-10-12 Prozess zur herstellung von pyrimido(5,4- g)pteridin-derivativen
KR1020027005089A KR20020039377A (ko) 1999-10-21 2000-10-12 피리미도〔５，４­ｇ〕프테리딘 유도체의 제조방법
CA002385672A CA2385672A1 (en) 1999-10-21 2000-10-12 Process for the preparation of pyrimido[5,4-g]pteridine derivatives
JP2001531838A JP4808884B2 (ja) 1999-10-21 2000-10-12 ピリミド〔５，４−ｇ〕プテリジン誘導体の製造方法
BR0014913-6A BR0014913A (pt) 1999-10-21 2000-10-12 Processo para a preparação de derivados de pirimido[5,4-g] pteridina
AU28344/01A AU2834401A (en) 1999-10-21 2000-10-12 Process for the preparation of pyrimido(5,4-g)pteridine derivatives
EP00992437A EP1222189B1 (en) 1999-10-21 2000-10-12 PROCESS FOR THE PREPARATION OF PYRIMIDO[5,4-g]PTERIDINE DERIVATIVES
MXPA02003924A MXPA02003924A (es) 1999-10-21 2000-10-12 Proceso para la preparacion de derivados de pirimidos(5, 4-g)pteridina.
DE60016008T DE60016008T2 (de) 1999-10-21 2000-10-12 PROZESS ZUR HERSTELLUNG VON PYRIMIDO[5,4-g]PTERIDIN-DERIVATIVEN

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH192499 1999-10-21
CH1924/99 1999-10-21

Publications (2)

Publication Number Publication Date
WO2001029040A2 true WO2001029040A2 (en) 2001-04-26
WO2001029040A3 WO2001029040A3 (en) 2001-12-06

Family

ID=4221784

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2000/010044 Ceased WO2001029040A2 (en) 1999-10-21 2000-10-12 PROCESS FOR THE PREPARATION OF PYRIMIDO[5,4-g]PTERIDINE DERIVATIVES

Country Status (12)

Country Link
US (1) US6600042B1 (enExample)
EP (1) EP1222189B1 (enExample)
JP (1) JP4808884B2 (enExample)
KR (1) KR20020039377A (enExample)
CN (1) CN1162431C (enExample)
AT (1) ATE282618T1 (enExample)
AU (1) AU2834401A (enExample)
BR (1) BR0014913A (enExample)
CA (1) CA2385672A1 (enExample)
DE (1) DE60016008T2 (enExample)
MX (1) MXPA02003924A (enExample)
WO (1) WO2001029040A2 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006037728A1 (en) * 2004-10-01 2006-04-13 Ciba Specialty Chemicals Holding Inc. Use of pyrimido[5,4-g]pteridines as shading component in color filter colorant compositions
US7794707B2 (en) 2002-06-19 2010-09-14 University Health Network ACE2 activation for treatment of heart, lung and kidney disease and hypertension

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0512724A (pt) * 2004-06-30 2008-04-01 Ciba Sc Holding Ag preparação de pigmentos de pteridina
JP7579849B2 (ja) 2019-10-10 2024-11-08 メディビーコン，インク． ５－アミノウラシルの陽極酸化
CN111925373B (zh) * 2020-09-02 2025-11-25 北京斯利安药业有限公司 一种叶酸ep杂质f的制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2581889A (en) * 1948-07-07 1952-01-08 Burroughs Wellcome Co Method of preparing pyrimidopyrazines
JPH07278456A (ja) * 1994-04-12 1995-10-24 Nippon Soda Co Ltd 蛍光着色剤
DE4415656A1 (de) * 1994-05-04 1995-11-09 Bayer Ag Neue Pigmentsalze und deren Verwendung zum Färben und Pigmentieren
AU5050798A (en) 1996-10-25 1998-05-22 Ciba Specialty Chemicals Holding Inc. Process for colouring high molecular weight organic material and polycyclic pigments
JP2002513046A (ja) * 1998-04-24 2002-05-08 チバ スペシャルティ ケミカルズ ホールディング インコーポレーテッド 少なくとも９８の色相角度を有する黄色プテリジン
WO2000031079A1 (de) * 1998-11-25 2000-06-02 Ciba Specialty Chemicals Holding Inc. Verfahren zur herstellung von pyrimidopteridinen

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7794707B2 (en) 2002-06-19 2010-09-14 University Health Network ACE2 activation for treatment of heart, lung and kidney disease and hypertension
US8211426B2 (en) 2002-06-19 2012-07-03 Apeiron Biologics Ag ACE2 activation for treatment of heart, lung and kidney disease and hypertension
US8802084B2 (en) 2002-06-19 2014-08-12 Apeiron Biologics Ag ACE2 activation for treatment of heart, lung and kidney disease and hypertension
WO2006037728A1 (en) * 2004-10-01 2006-04-13 Ciba Specialty Chemicals Holding Inc. Use of pyrimido[5,4-g]pteridines as shading component in color filter colorant compositions
KR101204288B1 (ko) * 2004-10-01 2012-11-27 시바 홀딩 인크 컬러 필터 착색제 조성물의 음영 성분으로서의 피리미도［5,4-ｇ］프테리딘의 용도

Also Published As

Publication number Publication date
ATE282618T1 (de) 2004-12-15
JP2003512376A (ja) 2003-04-02
CN1379778A (zh) 2002-11-13
WO2001029040A3 (en) 2001-12-06
KR20020039377A (ko) 2002-05-25
AU2834401A (en) 2001-04-30
EP1222189B1 (en) 2004-11-17
BR0014913A (pt) 2002-06-11
CA2385672A1 (en) 2001-04-26
EP1222189A2 (en) 2002-07-17
JP4808884B2 (ja) 2011-11-02
US6600042B1 (en) 2003-07-29
CN1162431C (zh) 2004-08-18
MXPA02003924A (es) 2002-10-23
DE60016008D1 (de) 2004-12-23
DE60016008T2 (de) 2005-04-07

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