WO2001017541A1 - Composition for extending post meal satiety - Google Patents
Composition for extending post meal satiety Download PDFInfo
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- WO2001017541A1 WO2001017541A1 PCT/US2000/020157 US0020157W WO0117541A1 WO 2001017541 A1 WO2001017541 A1 WO 2001017541A1 US 0020157 W US0020157 W US 0020157W WO 0117541 A1 WO0117541 A1 WO 0117541A1
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- WIPO (PCT)
- Prior art keywords
- composition
- weight
- nutritional composition
- meal
- satiety
- Prior art date
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- UJMBCXLDXJUMFB-UHFFFAOYSA-K trisodium;5-oxo-1-(4-sulfonatophenyl)-4-[(4-sulfonatophenyl)diazenyl]-4h-pyrazole-3-carboxylate Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)C1=NN(C=2C=CC(=CC=2)S([O-])(=O)=O)C(=O)C1N=NC1=CC=C(S([O-])(=O)=O)C=C1 UJMBCXLDXJUMFB-UHFFFAOYSA-K 0.000 claims 1
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- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 description 1
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Classifications
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/534—Mentha (mint)
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/40—Complete food formulations for specific consumer groups or specific purposes, e.g. infant formula
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- A61K36/42—Cucurbitaceae (Cucumber family)
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- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Definitions
- the present invention relates to a nutritional composition for extending satiety following a meal More particularly the nutritional composition includes protein, medium and/or long chain fatty acids and calcium to stimulate the secretion of cholecystokinin a gastric peptide, and a source of proteinase inhibitor extracted from potatoes that prevents the breakdown of cholecystokinin By increasing and sustaining the levels of cholecystokinin, the present invention extends satiety
- a second approach has focused on slowing gastric emptying thereby creating a feeling of fullness
- This approach utilizes insoluble fibers, which slow the movement of food through the gastrointestinal tract
- the disadvantage with the use of fiber is that the quantities needed to produce an effect create an unpalatable diet as well as numerous gastrointestinal effects including bloating, gas and dian iea
- a third approach investigates stimulating the body's satiety mechanism. When food is consumed a peptide is released called Cholecystokinin Releasing Protein (CCK-RP). Cholecystokinin Releasing Protein then stimulates the release of cholecystokinin in the gut. Cholecystokinin has been shown to increase satiety.
- CCK-RP When cholecystokinin is released it also stimulates the release of enzymes which inactivate CCK-RP. When CCK-RP is inactivated, CCK levels drop and the feeling of satiation is diminished. Studies have shown that cholecystokinin is extremely effective in extending satiety following ingestion of a meal. Although CCK has been shown to extend satiety and reduce food intake, a major disadvantage is that it must be given intravenously. When administered orally, CCK is inactivated by gastric enzymes. This has severely limited its use as a potential weight loss agent.
- a number of nutritive agents can stimulate the release of cholecystokinin.
- proteins, fat (particularly medium chain fatty acids), and calcium stimulate the release of CCK.
- United States Patent No. 4,491 ,578 discloses the oral administration of a trypsin inhibitor to stimulate satiety by stimulating the release of cholecystokinin.
- the trypsin inhibitor was postulated to act by inhibiting the negative feedback signal for cholecystokinin secretion. In this fashion, the trypsin inhibitor sustained levels of cholecystokinin thereby extending satiety.
- the present invention provides for nutritional composition in a dry powder form for extending satiety following ingestion of a meal
- the dry nutritional composition includes proteins in the range of 10% to 80%
- the protein can be in the form of soy, whey, casein or a specific amino acid mixture containing essential amino acids or of the amino acid phenylalanine
- the dry nutritional composition also includes the mineral calcium in the range of 2% to 6%
- the calcium can be in the form of a salt including calcium chloride, calcium carbonate, calcium lactate etc
- the dry nutritional composition also includes medium and/or long chain fatty acids (C ⁇ 2 - C 22 ) in the range of 10%-40%
- the dry nutritional composition also includes a source of proteinase inhibitor extracted from potatoes wherein the protease inhibitor is present in the range of 0.02%-5%
- Fig 1 is a graphical representation of the responses of test subjects as to their feeling of satiety taken in fifteen minute intervals over a three and one-half hour period following a meal, showing both subjects who were administered a placebo and subjects who were administered a nutritional supplement according to the present invention
- Fig 2 is a graphical representation of the responses of test subjects as to their feeling of hunger taken in fifteen minute intervals over a three and one-half hour period following a meal, showing both subjects who were administered a placebo and subjects who were administered a nutritional supplement according to the present invention
- the nutritional composition for nutritional intervention for extending satiety includes nutritional agents being protein, medium and/or chain fatty acids, calcium, an extract of potatoes containing proteinase inhibitor, and, in a preferred form, flavoring agents and coloring agents
- the proteinase inhibitor is a heat stable protein present in potatoes and in extracts from potatoes and has a molecular weight of approximately 21 ,000 It is both a trypsin and chymotrypsm inhibitor, with its critical functionality being that it stimulates the release of cholecystokinin
- the protease inhibitor with the desired activity is present m potatoes and m more concentrated form in commercially available extracts or fractions of potatoes, such as coarse potato flour and potato fibei Specifically, coarse potato flour available from Nonpa ⁇ el Company contains approximately 0 49 mg of potato protease inhibitor two per gram, and Paselh PPC potato flour av ailable fiom Avebe Company, The Netherlands, contains about 1 35
- an advantage of the present invention is that it provides for a nutritional intervention composition for extending satiety and reducing hunger following the termination of a meal
- an advantage of the present invention is that it provides continual effectiveness over a 30-day period and by extending satiety results in significant weight loss
- the source of the protease inhibitor may vary depending on the particular application for the satiety extending product of the present invention
- coarse potato flour contains a significant amount of the protease inhibitor, it is difficult to disperse in water
- teachings of the invention set out above can readily accomplish determining an appropriate source of protease inhibitor as well as other components that may be added to the composition to improve characteristics such as mouth feel, taste, and the like
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- Child & Adolescent Psychology (AREA)
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- Proteomics, Peptides & Aminoacids (AREA)
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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Priority Applications (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| BR0006959-0A BR0006959A (pt) | 1999-07-27 | 2000-07-25 | Composição nutricional em uma forma de pó seco |
| CA002348067A CA2348067A1 (en) | 1999-07-27 | 2000-07-25 | Composition for extending post meal satiety |
| EP00950624A EP1115409A4 (en) | 1999-07-27 | 2000-07-25 | COMPOSITION FOR PROLONGING DISASTER AFTER A MEAL |
| MXPA01003054A MXPA01003054A (es) | 1999-07-27 | 2000-07-25 | Composicion para extender la saciedad despues de tomar alimentos. |
| JP2001521331A JP2003508490A (ja) | 1999-07-27 | 2000-07-25 | 食後飽満を延長するための組成物 |
| AU63704/00A AU779377C (en) | 1999-07-27 | 2000-07-25 | Composition for extending post meal satiety |
| KR1020017003896A KR20010075394A (ko) | 1999-07-27 | 2000-07-25 | 식후 포만감을 연장시키기 위한 조성물 |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14589299P | 1999-07-27 | 1999-07-27 | |
| US60/145,892 | 1999-07-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| WO2001017541A1 true WO2001017541A1 (en) | 2001-03-15 |
Family
ID=22515008
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/US2000/020157 WO2001017541A1 (en) | 1999-07-27 | 2000-07-25 | Composition for extending post meal satiety |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP1115409A4 (ko) |
| JP (2) | JP2003508490A (ko) |
| KR (1) | KR20010075394A (ko) |
| AU (1) | AU779377C (ko) |
| BR (1) | BR0006959A (ko) |
| CA (1) | CA2348067A1 (ko) |
| MX (1) | MXPA01003054A (ko) |
| WO (1) | WO2001017541A1 (ko) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6686456B2 (en) | 2001-07-06 | 2004-02-03 | Kemin Foods, L.C. | Method for the elimination of Kunitz and Bowman-Birk trypsin inhibitors and carboxypeptidase inhibitor from potato proteins |
| JP2005015358A (ja) * | 2003-06-25 | 2005-01-20 | Pharma Design Inc | 摂食障害の治療に供される医薬組成物 |
| EP2227966A1 (en) * | 2009-02-25 | 2010-09-15 | Coöperatie Avebe U.A. | Condiment |
| CN111493254A (zh) * | 2020-04-10 | 2020-08-07 | 苏州绿叶日用品有限公司 | 一种含有马铃薯提取物的固体饮料及其制备方法 |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2006235407B2 (en) * | 2005-04-11 | 2011-02-24 | University Of Tennessee Research Foundation | Stable dairy components effective for fat loss |
| JP2010094085A (ja) * | 2008-10-17 | 2010-04-30 | Pola Chem Ind Inc | ダイエット用の食品組成物 |
| JP5691105B2 (ja) * | 2009-01-30 | 2015-04-01 | 株式会社東洋新薬 | ジャガイモ抽出物を含有する食品の呈味改善方法 |
| JP5672588B2 (ja) * | 2009-05-26 | 2015-02-18 | 株式会社東洋新薬 | ダイエット用組成物 |
| WO2011068150A1 (ja) * | 2009-12-04 | 2011-06-09 | 株式会社東洋新薬 | グルカゴン様ペプチド－１分泌促進剤 |
| CN107334875A (zh) * | 2017-08-30 | 2017-11-10 | 南宁学院 | 一种治疗腹泻的药酒及其制备方法 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4491578A (en) * | 1982-06-14 | 1985-01-01 | Peikin Steven R | Method of stimulating satiety in mammals |
| US5221668A (en) * | 1992-02-26 | 1993-06-22 | Abbott Laboratories | Nutritional product for trauma and surgery patients |
| US5340603A (en) * | 1993-08-30 | 1994-08-23 | Abbott Laboratories | Nutritional product for human infants having chronic lung disease |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4833128A (en) * | 1984-12-28 | 1989-05-23 | Neil Solomon | Dietary supplement |
| JPH0699321B2 (ja) * | 1990-01-22 | 1994-12-07 | 不二製油株式会社 | 食欲抑制剤及びこれを含有する食品 |
| US5468727A (en) * | 1990-12-13 | 1995-11-21 | Board Of Regents, The University Of Texas System | Methods of normalizing metabolic parameters in diabetics |
| NZ260933A (en) * | 1993-07-16 | 1996-07-26 | Hercules Inc | Cation-complexed polysaccharides; use in foods and pharmaceuticals |
| DE69530588T2 (de) * | 1994-08-05 | 2004-04-01 | Wisconsin Alumni Research Foundation, Madison | Cck-antikörper zur verbesserung der futterverwertung |
| US5595772A (en) * | 1995-06-07 | 1997-01-21 | Massachusetts Institute Of Technology | Composition and methods for losing weight |
| ES2286339T5 (es) * | 1997-06-23 | 2015-02-26 | Société des Produits Nestlé S.A. | Composición para la nutrición de diabéticos |
| US6475539B1 (en) * | 1998-05-07 | 2002-11-05 | Abbott Laboratories | Nutritionally complete low pH enteral formula |
| US6051236A (en) * | 1998-11-12 | 2000-04-18 | Pacifichealth Laboratories, Inc. | Composition for optimizing muscle performance during exercise |
| US6025363A (en) * | 1998-11-17 | 2000-02-15 | Giles, Jr.; James A. | Composition for suppressing appetite |
-
2000
- 2000-07-25 BR BR0006959-0A patent/BR0006959A/pt not_active IP Right Cessation
- 2000-07-25 WO PCT/US2000/020157 patent/WO2001017541A1/en not_active Application Discontinuation
- 2000-07-25 CA CA002348067A patent/CA2348067A1/en not_active Abandoned
- 2000-07-25 KR KR1020017003896A patent/KR20010075394A/ko not_active Application Discontinuation
- 2000-07-25 MX MXPA01003054A patent/MXPA01003054A/es active IP Right Grant
- 2000-07-25 EP EP00950624A patent/EP1115409A4/en not_active Withdrawn
- 2000-07-25 JP JP2001521331A patent/JP2003508490A/ja active Pending
- 2000-07-25 AU AU63704/00A patent/AU779377C/en not_active Ceased
-
2005
- 2005-08-15 JP JP2005235268A patent/JP2005336208A/ja active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4491578A (en) * | 1982-06-14 | 1985-01-01 | Peikin Steven R | Method of stimulating satiety in mammals |
| US5221668A (en) * | 1992-02-26 | 1993-06-22 | Abbott Laboratories | Nutritional product for trauma and surgery patients |
| US5340603A (en) * | 1993-08-30 | 1994-08-23 | Abbott Laboratories | Nutritional product for human infants having chronic lung disease |
Non-Patent Citations (1)
| Title |
|---|
| See also references of EP1115409A4 * |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6686456B2 (en) | 2001-07-06 | 2004-02-03 | Kemin Foods, L.C. | Method for the elimination of Kunitz and Bowman-Birk trypsin inhibitors and carboxypeptidase inhibitor from potato proteins |
| JP2005015358A (ja) * | 2003-06-25 | 2005-01-20 | Pharma Design Inc | 摂食障害の治療に供される医薬組成物 |
| EP2227966A1 (en) * | 2009-02-25 | 2010-09-15 | Coöperatie Avebe U.A. | Condiment |
| WO2010098663A3 (en) * | 2009-02-25 | 2011-02-24 | Coöperatie Avebe U.A. | Condiment |
| CN111493254A (zh) * | 2020-04-10 | 2020-08-07 | 苏州绿叶日用品有限公司 | 一种含有马铃薯提取物的固体饮料及其制备方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2005336208A (ja) | 2005-12-08 |
| AU6370400A (en) | 2001-04-10 |
| AU779377B2 (en) | 2005-01-20 |
| EP1115409A4 (en) | 2005-04-13 |
| CA2348067A1 (en) | 2001-03-15 |
| JP2003508490A (ja) | 2003-03-04 |
| MXPA01003054A (es) | 2003-07-14 |
| AU779377C (en) | 2005-06-30 |
| EP1115409A1 (en) | 2001-07-18 |
| KR20010075394A (ko) | 2001-08-09 |
| BR0006959A (pt) | 2001-06-26 |
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