CN107334875A - 一种治疗腹泻的药酒及其制备方法 - Google Patents

一种治疗腹泻的药酒及其制备方法 Download PDF

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CN107334875A
CN107334875A CN201710763092.2A CN201710763092A CN107334875A CN 107334875 A CN107334875 A CN 107334875A CN 201710763092 A CN201710763092 A CN 201710763092A CN 107334875 A CN107334875 A CN 107334875A
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medicinal liquor
diarrhoea
pepper
snake
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尹选平
唐锋
黄译锋
黄雄
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/482Cassia, e.g. golden shower tree
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • AHUMAN NECESSITIES
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    • A61K36/67Piperaceae (Pepper family), e.g. Jamaican pepper or kava
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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    • A61K9/0095Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
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    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH

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Abstract

本发明提供了一种治疗腹泻的药酒及其制备方法,该药酒由蛇灭门、路边草、马鞭草、胡椒、玉米酒制成,该药酒配方简单,用于治疗腹泻效果非常显著,且无任何毒副作用。

Description

一种治疗腹泻的药酒及其制备方法
技术领域
本发明属于中药技术领域,具体涉及一种治疗腹泻的药酒及其制备方法。
背景技术
饮食不洁或水土不服引起的腹泻、腹痛是由于人的机体对新的气候、地势、水质、食物等条件的一种失调反应。腹泻是一组由多病原、多因素引起的大便次数增多和大便性状改变为特点,可分为感染性和非感染性两种。起病可缓可急,轻症仅有胃肠道症状,食欲不振,偶有呕吐,大便次数增多及性状改变;重者大便次数要达一天十余次,甚至几十次,大便可呈水样、糊状、粘液状,有的可解脓血便,同时可出现较明显的脱水和电解质紊乱和全身中毒症状如高热、烦躁、精神萎靡等。频繁腹泻会使体内的水分和营养素迅速丢失,造成急性脱水。一般是服用口服补液后症状没有好转,出现精神萎靡、发烧、频繁呕吐、水样大便,甚至便中带有脓血,应立即去医院就诊,但在途中仍应不断补充口服液体。
饮食不洁或水土不服引起的腹泻常临床常用药物为藿香正气丸/水及抗感染及助消化药如黄连素,但是藿香正气丸/水及黄连素具有强烈的刺激性气味,不易为患者特别接受。
发明内容:
针对上述步骤,本发明提供了一种治疗腹泻的药酒及其制备方法,该药酒由蛇灭门、路边草、马鞭草、胡椒、玉米酒制成,该药酒配方简单,用于治疗腹泻效果非常显著,且无任何毒副作用。
具体地,本发明提供了一种治疗腹泻的药酒,由蛇灭门10-20g、路边草10-20g、马鞭草10-20g、胡椒10-20g、玉米酒2000ml制成。
优选地,本发明提供了一种治疗腹泻的药酒,由蛇灭门13-17g、路边草13-17g、马鞭草13-17g、胡椒13-17g、玉米酒2000ml制成。
更优选地:本发明提供了一种治疗腹泻的药酒,由蛇灭门15g、路边草15g、马鞭草15g、胡椒15g、玉米酒2000ml制成。
本发明提供了一种治疗腹泻药酒的制备方法,包括以下步骤:取配方量蛇灭门、路边草、马鞭草、胡椒洗净,用水蒸气蒸煮3-7min,放入药玉米酒中浸泡。密封,浸泡10-15天,即得到治疗腹泻的药酒。
上述所述的治疗腹泻药酒的制备方法,包括以下步骤:取配方量蛇灭门、路边草、马鞭草、胡椒洗净,用水蒸气蒸煮5min,放入药玉米酒中浸泡。密封,浸泡12天,即得到治疗腹泻的药酒。
上述所述的玉米酒酒精度优选为30-50%VOL,更优选为42%VOL。
为了使本领域普通技术人员更好的理解本发明,本申请人进行了一系列实验研究,以证明本发明的效果:
1、急性毒性试验:取健康小鼠进行预试验后另取40只小白鼠进行正式试验,试验前将动物禁食16小时,不限制饮水,给药本发明药酒剂量为,20ml/kg,观察7天,正常饮食,饮水,观察指标为动物死亡数。结果,该浓度一次给药(小鼠)观察7天,无一小鼠死亡。
3.2连续给药毒性试验:取健康小鼠80只,随机分成4组,试验药小剂量组每天给药1次;中剂量组每天给药3次;大剂量(成人剂量的100倍)组每天给药6次;空白对照组给等量的N.S;根据急性口服毒性试验,试验药小、中、大剂量组给药量均为10ml/kg,连续给药14天,正常饮食饮水,连续观察,对照组同。观察指标为动物体重增长情况、活动情况、饮食情况、粪便情况和死亡情况。结果,各组小鼠均无中毒情况,活动、饮食饮水、粪便情况均正常,无一死亡,体重情况以空白对照组进行统计学处理,p值均大于0.05,无显著性差异。试验结果见表3。
表3连续给药毒性试验结果
试验总结:试验表明本发明所述制剂无毒,安全性好。
2、本发明药酒的临床试验:
本发明在2016年南宁市门诊,随着筛选30名确诊为腹泻的病人,服用本发明制得的药酒治疗,每日早中晚三次,每次饮用10-20ml,连续服用7天。结果:治愈率80%,显效率90%,说明本发明药酒组方合理,协同增效,共奏药效。
具体实施方式:
实施例1:治疗腹泻的药酒的制备:
配方:蛇灭门10g、路边草10g、马鞭草10g、胡椒10g、玉米酒2000ml;
制备方法:取配方量蛇灭门、路边草、马鞭草、胡椒洗净,用水蒸气蒸煮3min,放入玉米酒中浸泡,密封,浸泡10天,即得到治疗腹泻的药酒。
实施例2:治疗腹泻的药酒的制备:
配方:蛇灭门13g、路边草13g、马鞭草13g、胡椒13g、玉米酒2000ml;
制备方法:取配方量蛇灭门、路边草、马鞭草、胡椒洗净,用水蒸气蒸煮5min,放入玉米酒中浸泡,密封,浸泡12天,即得到治疗腹泻的药酒。
实施例3治疗腹泻的药酒的制备:
配方:蛇灭门15g、路边草15g、马鞭草15g、胡椒15g、玉米酒2000ml;
制备方法:取配方量蛇灭门、路边草、马鞭草、胡椒洗净,用水蒸气蒸煮5min,放入玉米酒中浸泡,密封,浸泡12天,即得到治疗腹泻的药酒。
实施例4:治疗腹泻的药酒的制备:
配方:蛇灭门17g、路边草17g、马鞭草17g、胡椒17g、玉米酒2000ml;
制备方法:取配方量蛇灭门、路边草、马鞭草、胡椒洗净,用水蒸气蒸煮5min,放入玉米酒中浸泡,密封,浸泡12天,即得到治疗腹泻的药酒。
实施例5:治疗腹泻的药酒的制备:
配方:蛇灭门20g、路边草20g、马鞭草20g、胡椒20g、玉米酒2000ml;制备方法:取配方量蛇灭门、路边草、马鞭草、胡椒洗净,用水蒸气蒸煮7min,放入玉米酒中浸泡,密封,浸泡15天,即得到治疗腹泻的药酒。

Claims (7)

1.一种治疗腹泻的药酒,其特征在于:由蛇灭门10-20g、路边草10-20g、马鞭草10-20g、胡椒10-20g、玉米酒2000ml制成。
2.根据权利要求1所述的治疗腹泻的药酒,其特征在于:由蛇灭门13-17g、路边草13-17g、马鞭草13-17g、胡椒13-17g、玉米酒2000ml制成。
3.根据权利要求1或2所述的治疗腹泻的药酒,其特征在于:由蛇灭门15g、路边草15g、马鞭草15g、胡椒15g、玉米酒2000ml制成。
4.一种治疗腹泻药酒的制备方法,其特征在于:包括以下步骤:取配方量蛇灭门、路边草、马鞭草、胡椒洗净,用水蒸气蒸煮3-7min,放入药玉米酒中浸泡。密封,浸泡10-15天,即得到治疗腹泻的药酒。
5.根据权利要求4所述的治疗腹泻药酒的制备方法,其特征在于:包括以下步骤:取配方量蛇灭门、路边草、马鞭草、胡椒洗净,用水蒸气蒸煮5min,放入药玉米酒中浸泡。密封,浸泡12天,即得到治疗腹泻的药酒。
6.根据权利要求1-3任一所述的治疗腹泻的药酒,其特征在于:所述的玉米酒酒精度优选为30-50%VOL。
7.根据权利要求1-3任一所述的治疗腹泻的药酒,其特征在于:所述的玉米酒酒精度优选为42%VOL。
CN201710763092.2A 2017-08-30 2017-08-30 一种治疗腹泻的药酒及其制备方法 Pending CN107334875A (zh)

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Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0415941A1 (en) * 1988-03-09 1991-03-13 Kabivitrum Ab NUTRITIVE COMPOSITION AND PROCESS FOR PREPARING THE SAME.
US5498408A (en) * 1992-09-21 1996-03-12 Sandoz Nutrition Ltd. Oral rehydration composition
EP1115409A4 (en) * 1999-07-27 2005-04-13 Kemin Consumer Care L C COMPOSITION FOR PROLONGING DISASTER AFTER A MEAL
CN106924581A (zh) * 2017-03-30 2017-07-07 南宁学院 一种治疗腹痛的药酒及其制备方法

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0415941A1 (en) * 1988-03-09 1991-03-13 Kabivitrum Ab NUTRITIVE COMPOSITION AND PROCESS FOR PREPARING THE SAME.
US5498408A (en) * 1992-09-21 1996-03-12 Sandoz Nutrition Ltd. Oral rehydration composition
EP1115409A4 (en) * 1999-07-27 2005-04-13 Kemin Consumer Care L C COMPOSITION FOR PROLONGING DISASTER AFTER A MEAL
CN106924581A (zh) * 2017-03-30 2017-07-07 南宁学院 一种治疗腹痛的药酒及其制备方法

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Application publication date: 20171110