WO2000062781A1 - Arzneimittel enthaltend hemmstoffe der zellvolumenregulierten humanen kinase h-sgk - Google Patents

Arzneimittel enthaltend hemmstoffe der zellvolumenregulierten humanen kinase h-sgk Download PDF

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Publication number
WO2000062781A1
WO2000062781A1 PCT/EP2000/003578 EP0003578W WO0062781A1 WO 2000062781 A1 WO2000062781 A1 WO 2000062781A1 EP 0003578 W EP0003578 W EP 0003578W WO 0062781 A1 WO0062781 A1 WO 0062781A1
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WIPO (PCT)
Prior art keywords
sgk
kinase
expression
human kinase
medicament
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Ceased
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PCT/EP2000/003578
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German (de)
English (en)
French (fr)
Inventor
Florian Lang
Siegfried Waldegger
Carsten Wagner
Stefan Bröer
Karin Klingel
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Priority to BR0009914-7A priority Critical patent/BR0009914A/pt
Priority to AU42972/00A priority patent/AU779941B2/en
Priority to CA002369078A priority patent/CA2369078A1/en
Priority to UA2001117896A priority patent/UA79066C2/uk
Priority to MXPA01010588A priority patent/MXPA01010588A/es
Priority to SK1497-2001A priority patent/SK14972001A3/sk
Priority to EP00922655A priority patent/EP1171131A1/de
Priority to PL352547A priority patent/PL198427B1/pl
Priority to JP2000611917A priority patent/JP2002542196A/ja
Application filed by Individual filed Critical Individual
Publication of WO2000062781A1 publication Critical patent/WO2000062781A1/de
Priority to NO20015054A priority patent/NO20015054L/no
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4741—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having oxygen as a ring hetero atom, e.g. tubocuraran derivatives, noscapine, bicuculline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/005—Enzyme inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Definitions

  • the h-sgk In normal intestinal tissue, the h-sgk is only expressed in the enterocytes. In Crohn's disease, however, the kinase is also found in the connective tissue.
  • Fibrosive pancreatitis In the normal pancreas, the h-sgk is found in acinar cells and also in gang cells. There are isolated h-sgk-expressing mononuclear cells around the pancreatic ducts. The expression of kinase is significantly increased in fibrosing pancreatitis.
  • the stimulation of the ENaC by h-sgk can be reversed by coexpression of the transdominant-inhibitory kinase: Oocytes that express ENaC and h-sgk simultaneously have much larger currents (I) than oocytes that only express ENaC. Co-expression of the transdominant-inhibitory kinase prevents stimulation of the ENaC by the h-sgk.
  • the current through the MDEG (I) increases with the duration of the incubation [day (T) 1 - 4].

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Diabetes (AREA)
  • Neurology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Immunology (AREA)
  • Cardiology (AREA)
  • Pulmonology (AREA)
  • Emergency Medicine (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Obesity (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Dermatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
PCT/EP2000/003578 1999-04-20 2000-04-19 Arzneimittel enthaltend hemmstoffe der zellvolumenregulierten humanen kinase h-sgk Ceased WO2000062781A1 (de)

Priority Applications (10)

Application Number Priority Date Filing Date Title
PL352547A PL198427B1 (pl) 1999-04-20 2000-04-19 Zastosowanie chelerytryny
AU42972/00A AU779941B2 (en) 1999-04-20 2000-04-19 Medicaments containing inhibitors of cell-volume regulated human kinase h-sgk
CA002369078A CA2369078A1 (en) 1999-04-20 2000-04-19 Medicaments containing inhibitors of cell-volume regulated human kinase h-sgk
UA2001117896A UA79066C2 (en) 1999-04-20 2000-04-19 Transdominant inhibitory kinase h-sgk in which lysine is substituted in the 127 position by arginine, and its use for preparation the remedy
MXPA01010588A MXPA01010588A (es) 1999-04-20 2000-04-19 Medicamentos que contienen de la cinasa humana regulada por el volumen celular h-sgk.
BR0009914-7A BR0009914A (pt) 1999-04-20 2000-04-19 Medicamento, e, usos de um inibidor, e de um ativador de quinase h-sgk humana regulada por volume celular
EP00922655A EP1171131A1 (de) 1999-04-20 2000-04-19 Arzneimittel enthaltend hemmstoffe der zellvolumenregulierten humanen kinase h-sgk
SK1497-2001A SK14972001A3 (sk) 1999-04-20 2000-04-19 Liečivá obsahujúce inhibítory bunkovým objemom regulovanej ľudskej kinázy h-sgk
JP2000611917A JP2002542196A (ja) 1999-04-20 2000-04-19 細胞容量調節ヒトキナーゼｈ−ｓｇｋのインヒビター含有医薬
NO20015054A NO20015054L (no) 1999-04-20 2001-10-17 Legemidler omfattende inhibitorer av cellevolumregulert human Kinase H-SGK

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19917990.5 1999-04-20
DE19917990A DE19917990A1 (de) 1999-04-20 1999-04-20 Arzneimittel enthaltend Hemmstoffe der zellvolumenregulierten humanen Kinase h-sgk

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US10/984,945 Division US20050064501A1 (en) 1999-04-20 2004-11-10 Medicaments comprising inhibitors of the cell volume-regulated human kinase h-sgk

Publications (1)

Publication Number Publication Date
WO2000062781A1 true WO2000062781A1 (de) 2000-10-26

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PCT/EP2000/003578 Ceased WO2000062781A1 (de) 1999-04-20 2000-04-19 Arzneimittel enthaltend hemmstoffe der zellvolumenregulierten humanen kinase h-sgk

Country Status (18)

Country Link
EP (1) EP1171131A1 (https=)
JP (1) JP2002542196A (https=)
KR (1) KR100718900B1 (https=)
CN (1) CN1351496A (https=)
AU (1) AU779941B2 (https=)
BR (1) BR0009914A (https=)
CA (1) CA2369078A1 (https=)
CZ (1) CZ20013778A3 (https=)
DE (1) DE19917990A1 (https=)
HU (1) HUP0200819A3 (https=)
MX (1) MXPA01010588A (https=)
NO (1) NO20015054L (https=)
PL (1) PL198427B1 (https=)
RU (1) RU2288718C9 (https=)
SK (1) SK14972001A3 (https=)
UA (1) UA79066C2 (https=)
WO (1) WO2000062781A1 (https=)
ZA (1) ZA200108610B (https=)

Cited By (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002074987A3 (de) * 2001-03-21 2003-12-04 Florian Lang Quantitative diagnostische analyse der hypertonie
WO2004084889A1 (en) * 2003-03-28 2004-10-07 Pfizer Inc. Use of protein kinase c inhibitor for suppressing sustained slow postsynaptic excitation (sspe) of enteric neurons
WO2003102206A3 (de) * 2002-06-04 2005-02-24 Florian Lang Sgk und nedd als diagnostische und therapeutische targets
WO2005037773A1 (de) * 2003-10-09 2005-04-28 Merck Patent Gmbh Acylhydrazonderivate und ihre verwendung bei der hemmung, regulierung und/oder modulation des signaltransduktion von kinasen
WO2005094829A1 (en) * 2004-03-11 2005-10-13 Merck Patent Gmbh Methods for modulating glutamate receptors for treating neuropsychiatric disorders comprising the use of modulators of serum and glucocorticoid inducible kinases
WO2005106491A3 (en) * 2004-04-30 2005-12-15 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with serum/glucocorticoid regulated kinase 1 (sgk1)
WO2006000293A1 (de) * 2004-06-26 2006-01-05 Merck Patent Gmbh Ortho-substituierte (3-hydroxyphenyl)-essigsäure benzyliden-hydrazide
WO2006072354A1 (de) * 2005-01-07 2006-07-13 Merck Patent Gmbh Quadratsäurederivate
WO2006105850A1 (de) * 2005-04-04 2006-10-12 Merck Patent Gmbh Acylhyclrazide als kinase inhibitoren insbesondere für sgk
EP1389941A4 (en) * 2001-04-27 2006-11-15 Cold Spring Harbor Lab RELIEF OF MEMORY DISORDERS AND MEMORY COMPONENTS OF PSYCHIATRIC DYSFUNCTIONS BY MODIFICATION OF ATYPIC PKM ACTIVITY
WO2005094796A3 (en) * 2004-03-11 2006-12-28 Merck Patent Gmbh Methods for interfering with fibrosis
WO2007014608A1 (de) * 2005-07-29 2007-02-08 Merck Patent Gmbh Quadratsäurederivate ii
WO2007022858A1 (de) * 2005-08-22 2007-03-01 Merck Patent Gmbh 3-oxo-indazol-quadratsäurederivate
WO2008086854A1 (de) 2007-01-18 2008-07-24 Merck Patent Gmbh 5-([1,3,4] 0xadiaz0l-2-yl)-1h-indazol und 5-([1,3,4] thiadiaz0l-2-yl)-1h-indazol derivate als sgk-inhibitoren zur behandlung von diabetes
DE102007022565A1 (de) 2007-05-14 2008-11-20 Merck Patent Gmbh Heterocyclische Indazolderivate
DE102008038222A1 (de) 2008-08-18 2010-02-25 Merck Patent Gmbh Indazol-5-carbonsäurehydrazid-derivate
WO2010020305A1 (de) 2008-08-18 2010-02-25 Merck Patent Gmbh Oxadiazolderivate für die behandlung von diabetes
DE102008038221A1 (de) 2008-08-18 2010-02-25 Merck Patent Gmbh 7-Azaindolderivate
DE102008059133A1 (de) 2008-11-26 2010-05-27 Merck Patent Gmbh Difluorphenyl-diacylhydrazid-derivate
WO2012064981A3 (en) * 2010-11-10 2012-08-16 National Jewish Health Methods to test allergic conditions

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10042137A1 (de) * 2000-08-28 2002-03-14 Florian Lang sgk2 und sgk3 als diagnostische und therapeutische Targets
DE10149393A1 (de) * 2001-09-28 2003-04-24 Florian Lang sgk1 als diagnostisches und therapeutisches target
DE10305212A1 (de) * 2003-02-07 2004-08-19 Florian Prof. Dr.med. Lang Verwendung der sgk-Genfamilie zur Diagnose und zur Therapie von Katarakt und Glaukom
AU2003215623B2 (en) * 2003-03-03 2009-10-22 Florian Lang Sgk1 as diagnostic and therapeutic target
WO2005084702A1 (ja) * 2004-03-02 2005-09-15 Hokkaido Technology Licensing Office Co., Ltd. 臓器線維症予防・治療剤
WO2005118832A2 (en) * 2004-06-01 2005-12-15 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with serum/glucocorticoid regulated kinase-like protein (sgkl)
MX2007001155A (es) * 2004-07-29 2007-08-14 Creabilis Therapeutics Spa Uso de inhibidores de k-252a y de quinasa para la prevencion o el tratamiento de patologias asociadas con hmgb1.
EP2014651A1 (en) * 2007-07-12 2009-01-14 Exonhit Therapeutics SA Compounds and methods for modulating Rho GTPases
DE102008010362A1 (de) 2008-02-18 2009-08-20 Florian Prof. Dr. Lang Sgk1 als therapeutisches und diagnostisches Target für virale Erkrankungen
DE102008010361A1 (de) 2008-02-18 2009-08-20 Merck Patent Gmbh sgk1-Inhibitoren zur Prophylaxe und/oder Therapie von viralen Erkrankungen und/oder Karzinomen
DE102008010363A1 (de) 2008-02-18 2009-08-20 Lang, Florian, Prof. Dr.med. Sgk1 als therapeutisches und diagnostisches Target für karzinomatöse Erkrankungen
DE102008029072A1 (de) * 2008-06-10 2009-12-17 Lang, Florian, Prof. Dr.med. Sgk3 als therapeutisches und diagnostisches Target für Alterserkrankungen
CN107875153A (zh) * 2017-11-16 2018-04-06 上海壹志医药科技有限公司 去甲白屈菜红碱的药物用途

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Cited By (32)

* Cited by examiner, † Cited by third party
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WO2002074987A3 (de) * 2001-03-21 2003-12-04 Florian Lang Quantitative diagnostische analyse der hypertonie
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PL352547A1 (en) 2003-08-25
KR100718900B1 (ko) 2007-05-17
PL198427B1 (pl) 2008-06-30
NO20015054D0 (no) 2001-10-17
CN1351496A (zh) 2002-05-29
NO20015054L (no) 2001-12-14
MXPA01010588A (es) 2004-09-06
DE19917990A1 (de) 2000-11-02
CA2369078A1 (en) 2000-10-26
JP2002542196A (ja) 2002-12-10
AU4297200A (en) 2000-11-02
AU779941B2 (en) 2005-02-17
HUP0200819A2 (hu) 2002-07-29
HUP0200819A3 (en) 2009-08-28
RU2288718C9 (ru) 2008-04-27
SK14972001A3 (sk) 2002-06-04
CZ20013778A3 (cs) 2002-06-12
BR0009914A (pt) 2002-01-08
RU2288718C2 (ru) 2006-12-10
ZA200108610B (en) 2002-01-02
KR20020012172A (ko) 2002-02-15
UA79066C2 (en) 2007-05-25

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