WO2000055129A1 - Derives de dithiocarbonimidate - Google Patents

Derives de dithiocarbonimidate Download PDF

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Publication number
WO2000055129A1
WO2000055129A1 PCT/JP2000/001616 JP0001616W WO0055129A1 WO 2000055129 A1 WO2000055129 A1 WO 2000055129A1 JP 0001616 W JP0001616 W JP 0001616W WO 0055129 A1 WO0055129 A1 WO 0055129A1
Authority
WO
WIPO (PCT)
Prior art keywords
optionally substituted
methyl
substituted
derivative
pharmaceutically acceptable
Prior art date
Application number
PCT/JP2000/001616
Other languages
English (en)
Japanese (ja)
Inventor
Hiroshi Yamaga
Tsutomu Nakagawa
Mutsuo Taiji
Teruhisa Tokunaga
W. Ewan Hume
Ryu Nagata
Original Assignee
Sumitomo Pharmaceuticals Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sumitomo Pharmaceuticals Co., Ltd. filed Critical Sumitomo Pharmaceuticals Co., Ltd.
Priority to AU31929/00A priority Critical patent/AU3192900A/en
Publication of WO2000055129A1 publication Critical patent/WO2000055129A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/192—Radicals derived from carboxylic acids from aromatic carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C333/00—Derivatives of thiocarbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C333/14—Dithiocarbamic acids; Derivatives thereof
    • C07C333/18—Esters of dithiocarbamic acids
    • C07C333/24—Esters of dithiocarbamic acids having nitrogen atoms of dithiocarbamate groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pulmonology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne des dérivés de dithiocarbonimidate représentés par la formule (1), des promédicaments, ou des sels desdites substances acceptables d'un point de vue pharmaceutique, utiles en tant qu'inhibiteurs de la fibroplasie d'organes ou de tissus, et d'autres médicaments. Dans ladite formule R1 désigne alkyle, alcényle, alcynyle ou cycloalkyle; E désigne C¿1?-C5 alkylène, C3-C5 alcénylène, ou C3-C5 alcynylène; A désigne hétéroaryle azoté ou un groupe représenté par la formule (2) (dans laquelle R?2¿ désigne hydrogène ou un substituant ; et R3 désigne hydroxy, alcoxy, alcényloxy, alcynyloxy, ou NR4R5); et Ar désigne aryle ou hétéroaryle.
PCT/JP2000/001616 1999-03-18 2000-03-16 Derives de dithiocarbonimidate WO2000055129A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU31929/00A AU3192900A (en) 1999-03-18 2000-03-16 Dithiocarbonimidate derivatives

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP7288099 1999-03-18
JP11/72880 1999-03-18

Publications (1)

Publication Number Publication Date
WO2000055129A1 true WO2000055129A1 (fr) 2000-09-21

Family

ID=13502103

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2000/001616 WO2000055129A1 (fr) 1999-03-18 2000-03-16 Derives de dithiocarbonimidate

Country Status (2)

Country Link
AU (1) AU3192900A (fr)
WO (1) WO2000055129A1 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004063365A1 (fr) * 2003-01-15 2004-07-29 Toudai Tlo, Ltd. Nouvelle utilisation d'un compose ayant une activite inhibitrice du tgf$g(b)
EP1589960A4 (fr) * 2002-12-19 2008-09-10 Scios Inc Traitement de l'obesite et de manifestations connexes au moyen d'inhibiteurs tgf-beta

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3892761A (en) * 1973-10-28 1975-07-01 American Cyanamid Co Certain imidodithiocarbonates
EP0228113A2 (fr) * 1985-12-03 1987-07-08 Nederlandse Organisatie Voor Toegepast-Natuurwetenschappelijk Onderzoek Tno Utilisation des inhibiteurs de la biosynthèse des stérols pour combattre certaines bactéries gram-négatives
EP0656351A1 (fr) * 1993-12-03 1995-06-07 Sumitomo Chemical Company, Limited Dérivés de dithiocarbonimide comme fongicides, insecticides et acaricides
JPH08333249A (ja) * 1995-06-07 1996-12-17 Ono Pharmaceut Co Ltd ＴＧＦ−β放出、活性化および合成抑制剤
EP0811612A1 (fr) * 1996-05-28 1997-12-10 Sumitomo Chemical Company Limited Procédé pour la préparation de dérivés de dithiocarbonimide

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3892761A (en) * 1973-10-28 1975-07-01 American Cyanamid Co Certain imidodithiocarbonates
EP0228113A2 (fr) * 1985-12-03 1987-07-08 Nederlandse Organisatie Voor Toegepast-Natuurwetenschappelijk Onderzoek Tno Utilisation des inhibiteurs de la biosynthèse des stérols pour combattre certaines bactéries gram-négatives
EP0656351A1 (fr) * 1993-12-03 1995-06-07 Sumitomo Chemical Company, Limited Dérivés de dithiocarbonimide comme fongicides, insecticides et acaricides
JPH08333249A (ja) * 1995-06-07 1996-12-17 Ono Pharmaceut Co Ltd ＴＧＦ−β放出、活性化および合成抑制剤
EP0811612A1 (fr) * 1996-05-28 1997-12-10 Sumitomo Chemical Company Limited Procédé pour la préparation de dérivés de dithiocarbonimide

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1589960A4 (fr) * 2002-12-19 2008-09-10 Scios Inc Traitement de l'obesite et de manifestations connexes au moyen d'inhibiteurs tgf-beta
WO2004063365A1 (fr) * 2003-01-15 2004-07-29 Toudai Tlo, Ltd. Nouvelle utilisation d'un compose ayant une activite inhibitrice du tgf$g(b)

Also Published As

Publication number Publication date
AU3192900A (en) 2000-10-04

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