WO2000043057A1 - Dispositif d'injection d'un produit fluide - Google Patents

Dispositif d'injection d'un produit fluide Download PDF

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Publication number
WO2000043057A1
WO2000043057A1 PCT/EP2000/000396 EP0000396W WO0043057A1 WO 2000043057 A1 WO2000043057 A1 WO 2000043057A1 EP 0000396 W EP0000396 W EP 0000396W WO 0043057 A1 WO0043057 A1 WO 0043057A1
Authority
WO
WIPO (PCT)
Prior art keywords
cartridge
injection device
tube
product
plunger
Prior art date
Application number
PCT/EP2000/000396
Other languages
English (en)
Inventor
Giambattista Apolloni
Giancarlo Brun
Original Assignee
Tecnologia S.A.S Di Valentino Brazzale & C.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tecnologia S.A.S Di Valentino Brazzale & C. filed Critical Tecnologia S.A.S Di Valentino Brazzale & C.
Priority to AU24388/00A priority Critical patent/AU2438800A/en
Publication of WO2000043057A1 publication Critical patent/WO2000043057A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/28—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle
    • A61M5/281—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle using emptying means to expel or eject media, e.g. pistons, deformation of the ampoule, or telescoping of the ampoule
    • A61M5/283—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle using emptying means to expel or eject media, e.g. pistons, deformation of the ampoule, or telescoping of the ampoule by telescoping of ampoules or carpules with the syringe body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/28—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle
    • A61M5/284—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle comprising means for injection of two or more media, e.g. by mixing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/28—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle
    • A61M5/285—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle with sealing means to be broken or opened
    • A61M5/286—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle with sealing means to be broken or opened upon internal pressure increase, e.g. pierced or burst
    • A61M2005/287—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle with sealing means to be broken or opened upon internal pressure increase, e.g. pierced or burst by displacing occluding plugs

Definitions

  • the present invention relates to a device for injecting a fluid product .
  • a cartridge comprises a resilient plunger with a cavity in which an injection tube is housed pivotably.
  • the cavity in turn communicates with the space inside the cartridge which is filled with the product to be injected.
  • the tube can be pivoted selectively between two positions in order to close or open, respectively, a duct which enables the product in the cartridge to flow along the tube towards an output nozzle or needle as a result of the sliding of the plunger inside the cartridge.
  • the present invention proposes to improve the injection device described briefly above and, in general, to provide a cylindrical cartridge which has a series of advantages in comparison with the most common prior art relating to the field of injection cartridges in which the resilient plunger is perforated by a needle. Examples of this prior art are described in prior documents DE-41 20 267, FR-2 741 268, EP-0 206 971, US-2 , 514 , 883 , US-2 , 554 , 451 , US-3 , 980 , 083 , 092/18178 and O-94/19034.
  • Another object of the present invention is to provide an injection device which is easy and inexpensive to manufacture and which can be filled and used easily even when two or more components of the product have to be mixed at the time of administration.
  • the subject of the invention is an injection device of the above-indicated type, having the particular characteristics of the following claims .
  • a first advantage of the present invention consists of the fact that the cylindrical cartridge is easy and inexpensive to produce and may be made, for example, of neutral pharmaceutical glass, preferably - but in non-limiting manner - of borosilicate glass, from an extruded and calibrated clear or, if necessary for light-screening purposes, yellow, tube.
  • Specialized glass-blowing apparatus for producing containers for drugs using pharmaceutical glass tubing on absolutely conventional machines and hence without the need to modify the machines in any way, are able - using exclusively the flame (and hence without performing any emery cutting) - to form a flat base of adequate strength, to form an upper rim with a rounded profile, to print either the name of the product directly or - as is currently required by almost all drug companies - the code in rings of various colours, which enables the product to be recognized and hence permits printing after filling or, alternatively, labelling and coding, possibly after sterilization.
  • the cartridge can be produced inexpensively because it is not necessary to form on the body of the cartridge constrictions and/or shaping of any kind which would lead to a risk of misalignment (particularly of phials) as well as fragility due to the irregular shape of the phial. Similar advantages also exist in comparison with small bottles made from tubing.
  • the glass cartridges or containers can be packed on trays ready for the loading of the loaders of the phial-filling (or washing) machines more easily and more economically than phials.
  • Another advantage of the present invention is that the light- transmission limits provided for by the pharmacopoeias of many industrialized countries (for example USP XXIIl/1995, BP1998, EUP1997) can be ensured along the entire surface of the cartridge.
  • Another advantage of the present invention consists of the ease with which the empty cartridge can be pre-washed by the drug manufacturer.
  • the great majority of drug manufacturers in fact use washing machines in the phial- production cycle. These machines work with needles which enter the body of the phial in order to create a turbulent jet of water which can clean the container. This results in a need - in order to wash phials of known type - for the phials to be loaded in a particularly orderly manner and for a slow production rate. Discharging the washing water completely from the phial also currently constitutes a considerable problem.
  • a further advantage of the invention is represented by the low risks of stress and breakage of the cartridges at the preliminary sterilization stage.
  • the working of the shoulders and of the necks of conventional phials in fact inevitably produces regions in which the material is stressed, with a consequent risk of breakage at the temperatures to which the drying and sterilization ovens are heated (180-200oC) , as well as the risk connected with the dispersal of fragments of glass into other phials at a moment subsequent to the washing operation.
  • this risk does not arise in the present invention, since the cartridge has no stress regions.
  • Yet another advantage consists of the ease with which the cartridges can be loaded, supplied and filled with the use of conventional machines at high speeds which are ensured both by the consistent or uniform diameter of the cartridge body and by the fact that the centre of gravity of the cartridge is lower than that of conventional phials.
  • the cartridge can be filled by lines normally used for the precision filling of small bottles. This leads to the possibility of metering the product into the cartridge with the use of different pumping systems suitable even for particularly high viscosities and/or viscoelasticities .
  • a method of filling an injection device comprises a step for filling the cartridge (2) with a fluid product (3) , a step for the complete assembly of the device, and a subsequent step for sterilization with steam or gamma radiation.
  • a further advantage is that separate product phases, which may be solids (lyophilized or in powered form) or liquids, can be inserted in the same cartridge.
  • the particular shape of the cartridge in fact enables one of the separate phases of the product to be subjected to a lyophilization process without the vapour-outlet diameter being reduced in comparison with the maximum diameter of the cartridge.
  • a further advantage of the invention consists of the ease and practicality with which the elastomeric closure, that is, the resilient plunger of the cartridge, can be inserted automatically, particularly when compared with the - very complex - insertion performed with the prefilled syringes of the prior art.
  • the absolutely uniform shape of the elastomeric closure to be fitted after the filling of the cartridge enables the pieces to be supplied by vibration directly on a filling machine; positioning in the mouth of the cartridge and thus along the top portion of the body until it touches the liquid can be effected by simple automated systems which certainly do not limit the speed of the filling lines.
  • the elastomeric closure or resilient plunger has a through-hole for subsequently housing the tube, particularly the glass tube which supplies the needle, there are no problems of elimination and/or compression of the gaseous atmosphere trapped under the closure.
  • the closure plunger in prefilled syringes currently in use, it is essential to perform an operation under vacuum, preceded by a particularly difficult multiple positioning of the plungers relative to their input opening on the cylinder.
  • a particularly important advantage of the present invention consists of the fact that the drug manufacturer can guarantee, up to the time of administration of a product to a patient, that the liquid or product contained in the cartridge satisfies the rigid requirements of certain pharmacopoeias (e.g. JP XI edition) relating to the quantity of insoluble particles present in the product.
  • certain pharmacopoeias e.g. JP XI edition
  • the current Japanese pharmacopoeia provides that, for each ml of product, there shall be no more than twenty particles with diameters greater than 10 microns and no more than two particles with diameters equal to or greater than 25 microns.
  • An important additional advantage consists of the possibility of eliminating or at least drastically reducing the gaseous atmosphere above the surface of the liquid contained in the cartridge.
  • the air disposed above the fluid product contained therein can be completely eliminated.
  • An advantage of primary importance is constituted by the fact that the elastomeric closure, that is, the resilient plunger, is not perforated by a needle as is common practice in the prior art . Even though the pharmacopoeias of many countries provide for checking of the breaking-off of particles from the elastomeric closure material after perforation with a needle, the risk of detachment of particles of dimensions not perceptible to the naked eye cannot be excluded. Moreover, even if the elastomeric material is torn by well sharpened needles, it behaves, with regard to the breaking-off of particles, quite differently from the surface formed by moulding of the plunger in the present invention.
  • Another advantage of the invention consists of the very small amount of handling by operators at the time of administration and, in particular, of the fact that infection and contamination of operators by bacterial, fungal, viral, chemical and chemico-physical agents is impossible. This is due to the leaktight nature of the individual components in contact with the liquid. This is an exceptional advantage in comparison with administration from normal phials or small bottles by means of conventional syringes; in the case of products with several components (for example, lyophilized or powdered components to be dissolved in solvent beforehand) it is increased. In the light of recently-emerged scientific evidence, the problems of bacterial, mycotic and particularly viral contamination currently represent unacceptable risks at the medical and ethical levels.
  • BSE bovine spongiform encephalitis
  • slow viruses which are capable of bringing about (presumably only by the entry of viral proteins into the organism) dramatic alterations in an individual's genetic make-up with the occurrence of extremely serious pathological conditions even many years after the penetration of the viral agent.
  • "opportunistic viruses” such as, for example, the AIDS virus, which for the necessary replication, can actually make use of the defensive phenomena which the organism sets in operation in order to stop the infection and which hitherto had reassured health workers with regard to the possibility of infection and spread being brought about with low levels of infective agent.
  • the present invention also enables multiple packages to be produced, containing several injection cartridges and a single operating device, that is, a single holder for the cartridges.
  • the absolutely basic nature and the consequent inexpensiveness of the invention enable packages containing several injection cartridges to be produced.
  • the cost of the injection cartridges according to the present invention is comparable with that of currently-used phials, with the possibility of using a single operating device for several injection cartridges.
  • the aforementioned advantage is of considerable importance both for packages intended for the public and for packages for use in a hospital environment.
  • a further advantage is that materials which have been known per se and considered to be acceptable by the pharmacopoeias of all countries for some time can be used in contact with the liquid product.
  • Eco-compatible plastics materials high-density polyethylene or polypropylene
  • Eco-compatible plastics materials may be used in very small quantities purely for the construction of the operating device which in no way and at no stage comes into contact with the product.
  • a further advantage of the invention consists of a substantial reduction in the total quantity of materials to be eliminated and disposed of after use.
  • the predominant material used in the manufacture of the cartridge according to the present invention can be glass which can consequently be disposed of easily and cheaply. This advantage is also particularly important in the light of the ever stricter regulations which are now in force in almost all countries with advanced economies with regard to waste disposal.
  • Figure 1 shows a first embodiment of an injection device of the type with a cartridge, formed in accordance with the invention
  • Figure 2 shows a second embodiment of the injection device
  • Figure 3 shows an example of a device for injecting products with two components to be mixed at the time of use
  • Figure 4 shows an embodiment of a device for injecting products with three components to be mixed at the time of use
  • Figure 5 shows another embodiment of a device for injecting products with three components
  • Figure 6 shows a third embodiment of an injection device for a single-component product
  • Figure 7 shows a further embodiment of an injection device
  • FIG. 8 and Figure 9 show two consecutive stages of the use of another embodiment of the injection device.
  • an injection device 1 comprises a cylindrical cartridge 2, preferably but not exclusively made of glass.
  • the cartridge 2 is filled with an injectable product 3 and is closed at the top by a plunger or plug 4 slidable in a leaktight manner in the cartridge 2.
  • the cavity 5 comprises a hemispherical base 7 and a wider portion 8 in the vicinity of the mouth 6.
  • a transverse duct 9 extends from the central region of the cavity 5 and communicates with a longitudinal duct 10 opening inside the cartridge 2.
  • the cavity 5 houses a ball 11, preferably made of glass, which shuts off communication between the cavity 5 and the transverse duct 9 and is restrained in this position by virtue of the resilience of the plunger 4.
  • the ball 11 can selectively be urged towards the base 7, reaching the position indicated by the reference numeral 11 ' in Figure 1, so as to open communication between the cavity 5 and the transverse duct 9, by virtue of the force which can be exerted thereon by means of the end 12 of a tube 13 which is fitted in the mouth 6.
  • An annular projection 14 formed on the body of the tube 13 in the vicinity of the end 12 can be fitted in the wider portion 8 of the cavity 5 in use.
  • a chamber 15 communicating with a delivery duct 16 which communicates at its other end with the injection needle (not shown) opens in the end 12, which is preferably flat.
  • the tube 13 is engaged, preferably on an operating device, that is, on a holder of the type described, for example in Italian patent application No. BO98A000012.
  • the plunger 4 of the cartridge 2 is thus pushed against the end 12 of the tube 13 until the annular projection 14 is fitted in the wider portion 8 of the cavity 5.
  • the end 12 urges the ball 11 towards the base 7 of the cavity 5, to the position indicated by the numeral 11' so that, as a result of the resilient deformation of the plunger 4, communication is opened between the interior of the cartridge 2 and the delivery duct 16.
  • a further push on the cartridge 2 causes the plunger 4 to slide and the product 3 to be delivered through the delivery duct 16 towards the needle (not shown) .
  • Figure 2 shows another embodiment of the present invention in which the plunger 4 has a substantially cylindrical, longitudinal through-hole 17 with two dished, wider regions 18, 19 at the ends and a wider portion 20 in a central position for housing a spherical end portion 21 of a tube 22.
  • the spherical end portion 21 has a transverse duct 23 communicating with the delivery duct 16 which also communicates, as described with reference to the embodiment of Figure 1, with an end needle (not shown) .
  • An annular bearing projection 24 is formed on the body of the tube 22 in the vicinity of the spherical end portion 21.
  • the tube 22 is mounted on an operating device of known type.
  • a first pressure on the base of the cartridge 2 causes the tube 22 to penetrate further into the resilient plunger 44, resulting in resilient deformation thereof until the annular projection 24 bears on the dished widened region 18.
  • the spherical end portion 21 leaves the wider portion 20 and emerges into the other dished, wider region 19 so that the product 3 is free to enter the duct 23 and to be sent towards the delivery duct 16 as a result of a further pressure on the cartridge 2 which causes the resilient plunger to slide in a leaktight manner 4 therein.
  • a hole 25 formed in the plunger 4 of elastomeric material has an inner annular lip 26 beneath which a ball 27 is housed and restrained in position in the configuration shown in the drawing by a resilient undercut 28. Above the lip 26, the hole 25 has a spherical wider portion 29 and, on the outer face of the plunger 4, the hole 25 is widened to form a dished housing 30.
  • the tube 22 has a shape substantially corresponding to that of Figure 2 with the spherical end portion 21 and the annular projection 24.
  • the delivery duct 16 is continuous and straight as far as the lower end of the spherical end portion 21 and, in the position shown in Figure 4, opens in the region of the lip 26 so as to be blocked by the ball 27.
  • Figure 6 also shows how the delivery duct 16 opens, at its other end, into an injection needle 31 covered, preferably but in non-limiting manner, by a cap 32 which has no sealing function but merely protects the needle.
  • the members 33 for the engagement of the tube 22 and hence of the cartridge 4 connected thereto on an operating device or holder of known type are also visible in Figure 6.
  • FIG. 7 A further variant of a device for injecting a fluid product is shown in Figure 7, in which the end 55 of the tube 13 has a cylindrical skirt 56 having a diameter substantially corresponding to the inside diameter of the cartridge 2.
  • Two tangential, preferably diametrally-opposed fins 54 extend from the end 55.
  • the number of fins is not limited merely to two, the device being able to comprise one or more fins as required by the designer.
  • Each tangential fin 54 is spaced slightly from the cylindrical skirt 56 radially so that a space 57 is formed between the two elements .
  • the end 55 of the tube 13 can be inserted in the cartridge 2 so that the cylindrical skirt 56 slides in a leaktight manner on the internal wall of the cartridge 2.
  • the tangential fins 54 laterally compress and resiliently deform the resilient plunger 4 so that the fluid product 3 contained in the cartridge 2 can flow through the spaces 57 and reach the tube 13.
  • the positioning of the tangential fins 54 on the sides of the plunger 4 is favoured by the conical front wall 58 thereof.
  • a pressure on the cartridge 2 causes the plunger 4 to slide and the product 3 consequently to be supplied into the delivery duct 16 and hence towards the needle 31.
  • Figures 8 and 9 show a variant of the above-described device for injecting a fluid product, in which a resilient plunger 4a is substantially spherical and the end of the tube 13 comprises a cylindrical skirt 59, the outside diameter of which is substantially equal to the inside diameter of the cartridge 2.
  • One or more radial fins 60 are provided on the internal wall of the end of the tube 13.
  • the end of the tube 13 can be inserted in the cartridge 2 so that the cylindrical skirt 59 slides in a leaktight manner on the internal wall of the cartridge 2.
  • the radial fins 60 radially compress and resiliently deform the resilient plunger 4a so that the fluid product 3 contained in the cartridge 2 can flow through the spaces between one fin and another and thus reach the tube 13.
  • a pressure on the cartridge 2 causes the plunger 4a to slide and the product 3 consequently to be supplied into the delivery duct 16 of the tube 13.
  • tangential or radial fins is not dependent on the shape of the resilient plunger which may be cylindrical, conical or spherical.
  • FIG. 3 shows such an embodiment of the device in which two plungers 4, 40 of elastomeric material are fitted for sliding in a leaktight manner inside the same cartridge.
  • the upper plunger 4 acts as a closure for the cartridge 2 and as a delivery member, in use, and has an axial hole 42 through which the body of a tube 22 is inserted for sliding in a leaktight manner.
  • the axial hole 42 comprises a wider portion 43 the diameter of which is equal to or greater than the diameter of a bearing plate 44 integral with the body of the tube 22 and disposed in the vicinity of the spherical end portion 21 inside which the transverse duct 23 which communicates with the delivery duct 16 is formed.
  • the inner resilient plunger 40 separates the two components 3, 3' of the product which are to be mixed immediately before injection.
  • the inner plunger 40 has an axial hole 45 with a seat 46 for the spherical end portion 21. The side walls of the seat 46 block the transverse duct 23 and restrain the spherical end portion 21 resiliently in the configuration of Figure 3.
  • the device comprising the cartridge 2 and the tube 22 is mounted on the operating device so that an abutment portion 47 thereof bears on the outer face 48 of the plunger 4.
  • the operating device is shaped in a manner such that the tube 22 is movable axially. It is therefore possible, by pulling on the tube 22, to release the spherical end portion 21 from the seat 46 in the inner plunger 40 which deforms resiliently and opens communication 'between the two components 3, 3' which can thus be mixed.
  • the tube 22 can be pulled out until the bearing plate 44 enters the wider portion 43 in the plunger 4.
  • a subsequent pressure on the base of the cartridge 2 enables the product resulting from the mixing of the components 3, 3' to pass along the transverse duct 23 and the delivery duct 16 for injection.
  • Figure 4 shows a variant of the injection device described above, in which it is possible to provide for three different components 3, 3', 3" to be mixed together at the time of administration.
  • an intermediate plunger 50 is also inserted in the cartridge 2 and has a cylindrical hole 49 through which the body of the tube 22 extends in a leaktight manner, the tube 22 terminating in the cylindrical end portion 21 which, as in the previous embodiment, is housed in the seat 46.
  • the tube 22 is pulled so that the end portion 21 is removed from the seat 46 and the components 3', 3" of the product can thus be mixed together.
  • the tube 22 By exerting an further pull on the tube 22 it is possible to cause the end portion 21 to pass through the hole 49 in the intermediate plunger 50, by virtue of the resilience thereof, so as to add the component 3 to the mixture of the other two.
  • the end portion 21 reaches the wider portion 43 in the plunger 4, the final product contained in the cartridge 2 can be supplied through the transverse duct 23 and the delivery duct 16 simply by pushing the base of the cartridge 2 in opposition to the abutment portion 47 of the operating device.
  • FIG. 5 A further variant of the device for injecting a product constituted by three or more components to be mixed at the time of injection is shown in Figure 5.
  • the tube 22 has no end portion and the delivery duct opens directly beneath the intermediate plunger 50 into the chamber containing the component 3 ' .
  • the tube 22 houses a small separating tube 51 which extends beyond the base of the tube 22 in order to extend in a leaktight manner through a cylindrical hole 52 formed in the lower plunger 40 and opening in the lower chamber containing the component 3 " .
  • the upper portion of the tube 22 is closed by a plug 53, preferably a T-shaped plug made of elastomeric material.
  • the small separating tube 51 can be removed completely from the tube 22 so as to free the hole 52 in the lower plunger 40 and to enable the components 3' and 3" to be mixed.
  • the tube 22 can be pulled out until the plate 44 reaches the housing 43 in the upper plunger 44. This also frees the hole 49 in the intermediate plunger 50 enabling all three components 3, 3' and 3" to be mixed.
  • the mixed product can be supplied, as in the previous embodiment, by pushing the base of the cartridge 2, previously disposed in an operating device .

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  • Health & Medical Sciences (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

Ce dispositif d'injection d'un produit fluide comprend une cartouche cylindrique (2) contenant un produit fluide (3) à injecter, un piston élastique (4), lequel est monté pour coulisser de manière étanche à l'intérieur de la cartouche (2) et est mobile le long de l'axe de celle-ci, ainsi qu'un tube (13, 22) comprenant un conduit de distribution (16) doté d'une ouverture de sortie. Ce dispositif comprend en outre des moyens destinés à déformer de manière élastique le piston élastique (4). Lors de l'utilisation du dispositif, un déplacement axial du tube (13, 22) par rapport à la cartouche (2) provoque l'interaction entre les moyens de déformations élastiques et le piston élastique (4), et l'ouverture d'au moins une voie de communication (5, 10, 17, 25), de manière à permettre au fluide provenant de la cartouche (2) de pénétrer dans le conduit de distribution (16).
PCT/EP2000/000396 1999-01-21 2000-01-17 Dispositif d'injection d'un produit fluide WO2000043057A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU24388/00A AU2438800A (en) 1999-01-21 2000-01-17 A device for injecting a fluid product

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP99100979.6 1999-01-21
EP99100979 1999-01-21

Publications (1)

Publication Number Publication Date
WO2000043057A1 true WO2000043057A1 (fr) 2000-07-27

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PCT/EP2000/000396 WO2000043057A1 (fr) 1999-01-21 2000-01-17 Dispositif d'injection d'un produit fluide

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AU (1) AU2438800A (fr)
WO (1) WO2000043057A1 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2426293A (en) * 2005-05-19 2006-11-22 Bosch Gmbh Robert Dispensing device
CN110141719A (zh) * 2013-12-19 2019-08-20 美敦力迷你迈德公司 贴身注射器及其使用方法

Citations (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2514883A (en) 1946-10-24 1950-07-11 Marshall L Lockhart Hypodermic syringe
US2554451A (en) 1946-09-16 1951-05-22 Aaron W Barry Hypodermic syringe
GB743789A (en) * 1953-02-22 1956-01-25 Hubert Percival Schofield Improvements in or relating to cartridges and the like tubular containers for use in dispensing liquids
DE1441390A1 (de) * 1962-04-21 1968-11-14 Rota App Und Maschb Dr Hennig Spritzampulle mit Kolben
US3766917A (en) * 1968-01-26 1973-10-23 West Co Two compartment ampul syringe
US3980083A (en) 1975-02-13 1976-09-14 Illinois Tool Works Inc. Medicament infusor unit
WO1984001510A1 (fr) * 1982-10-12 1984-04-26 Tulcea Sa Seringue pre-remplie
WO1984004252A1 (fr) * 1983-05-04 1984-11-08 Meditec Sa Seringue preremplie a dose unitaire
EP0206971A1 (fr) 1985-05-29 1986-12-30 VECTA GLASS COMPANY Ltd. Seringue pour prompt emploi
WO1992018178A1 (fr) 1991-04-18 1992-10-29 Tecnomedica Ricerche S.R.L. Dispositif pour l'administration de medicaments
DE4120267A1 (de) 1991-06-19 1992-12-24 Bader & Partner Medizintechnik Verfahren zum betrieb einer vorrichtung zur abgabe eines fluessigen medizinischen behandlungsstoffes an einen zu behandelnden koerper und vorrichtung zur durchfuehrung des verfahrens
WO1994019034A1 (fr) 1993-02-19 1994-09-01 Medicorp Holding S.A. Seringue preremplie de stockage et de transfert d'une substance medicamenteuse liquide et sterile
EP0652019A1 (fr) * 1993-11-08 1995-05-10 Ferring Arzneimittel GmbH Seringue pour le mélange et l'administration de produits injectables
FR2741268A1 (fr) 1995-11-21 1997-05-23 Turtaut Patrick Seringue preremplie avec aiguille a longueur variable et auto-protegee

Patent Citations (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2554451A (en) 1946-09-16 1951-05-22 Aaron W Barry Hypodermic syringe
US2514883A (en) 1946-10-24 1950-07-11 Marshall L Lockhart Hypodermic syringe
GB743789A (en) * 1953-02-22 1956-01-25 Hubert Percival Schofield Improvements in or relating to cartridges and the like tubular containers for use in dispensing liquids
DE1441390A1 (de) * 1962-04-21 1968-11-14 Rota App Und Maschb Dr Hennig Spritzampulle mit Kolben
US3766917A (en) * 1968-01-26 1973-10-23 West Co Two compartment ampul syringe
US3980083A (en) 1975-02-13 1976-09-14 Illinois Tool Works Inc. Medicament infusor unit
WO1984001510A1 (fr) * 1982-10-12 1984-04-26 Tulcea Sa Seringue pre-remplie
WO1984004252A1 (fr) * 1983-05-04 1984-11-08 Meditec Sa Seringue preremplie a dose unitaire
EP0206971A1 (fr) 1985-05-29 1986-12-30 VECTA GLASS COMPANY Ltd. Seringue pour prompt emploi
WO1992018178A1 (fr) 1991-04-18 1992-10-29 Tecnomedica Ricerche S.R.L. Dispositif pour l'administration de medicaments
DE4120267A1 (de) 1991-06-19 1992-12-24 Bader & Partner Medizintechnik Verfahren zum betrieb einer vorrichtung zur abgabe eines fluessigen medizinischen behandlungsstoffes an einen zu behandelnden koerper und vorrichtung zur durchfuehrung des verfahrens
WO1994019034A1 (fr) 1993-02-19 1994-09-01 Medicorp Holding S.A. Seringue preremplie de stockage et de transfert d'une substance medicamenteuse liquide et sterile
EP0652019A1 (fr) * 1993-11-08 1995-05-10 Ferring Arzneimittel GmbH Seringue pour le mélange et l'administration de produits injectables
FR2741268A1 (fr) 1995-11-21 1997-05-23 Turtaut Patrick Seringue preremplie avec aiguille a longueur variable et auto-protegee

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2426293A (en) * 2005-05-19 2006-11-22 Bosch Gmbh Robert Dispensing device
GB2426293B (en) * 2005-05-19 2008-12-24 Bosch Gmbh Robert Dispensing device and method of operation thereof
US8235953B2 (en) 2005-05-19 2012-08-07 Robert Bosch Gmbh Metering device and method for operating same
US8728986B2 (en) 2005-05-19 2014-05-20 Robert Bosch Gmbh Metering device and method for operating same
CN110141719A (zh) * 2013-12-19 2019-08-20 美敦力迷你迈德公司 贴身注射器及其使用方法
CN114832183A (zh) * 2013-12-19 2022-08-02 美敦力迷你迈德公司 贴身注射器及其使用方法
CN114832183B (zh) * 2013-12-19 2024-05-24 美敦力迷你迈德公司 贴身注射器及其使用方法

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