WO2000038661A3 - Die verwendung von hemmern des natrium-wasserstoff-austauschers zur herstellung eines medikaments zur verhinderung von altersbedingten organ-dysfunktionen, altersbedingten erkrankungen und zur lebensverlängerung - Google Patents
Die verwendung von hemmern des natrium-wasserstoff-austauschers zur herstellung eines medikaments zur verhinderung von altersbedingten organ-dysfunktionen, altersbedingten erkrankungen und zur lebensverlängerung Download PDFInfo
- Publication number
- WO2000038661A3 WO2000038661A3 PCT/EP1999/009621 EP9909621W WO0038661A3 WO 2000038661 A3 WO2000038661 A3 WO 2000038661A3 EP 9909621 W EP9909621 W EP 9909621W WO 0038661 A3 WO0038661 A3 WO 0038661A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- inhibitors
- medicament
- producing
- particular age
- sodium hydrogen
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicinal Preparation (AREA)
Abstract
Priority Applications (11)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
HU0104652A HUP0104652A3 (en) | 1998-12-23 | 1999-12-08 | The utilisation of inhibitors of the sodium hydrogen exchanger for producing a medicament for preventing organ dysfunctions and diseases related to a particular age and for prolonging life |
AU16576/00A AU776761B2 (en) | 1998-12-23 | 1999-12-08 | The utilisation of inhibitors of the sodium hydrogen exchanger for producing a medicament for preventing organ dysfunctions and diseases related to a particular age and for prolonging life |
BR9916505-8A BR9916505A (pt) | 1998-12-23 | 1999-12-08 | O emprego de inibidores da troca desódio-hidrogênio para a preparação de ummedicamento para evitar disfunções de órgãoscondicionadas pela idade, doenças condicionadaspela idade e para o prolongamento da vida |
SK904-2001A SK9042001A3 (en) | 1998-12-23 | 1999-12-08 | The utilisation of inhibitors of the sodium hydrogen exchanger for producing a medicament for preventing organ dysfunctions and diseases related to a particular age and for prolonging life |
EP99959387A EP1140056A2 (de) | 1998-12-23 | 1999-12-08 | Die verwendung von hemmern des natrium-wasserstoff-austauschers zur herstellung eines medikaments zur verhinderung von altersbedingten organ-dysfunktionen, altersbedingten erkrankungen und zur lebensverlängerung |
KR1020017008052A KR20010086152A (ko) | 1998-12-23 | 1999-12-08 | 특정의 노화 관련 기관의 기능부전과 질병 예방 및 수명연장용 약제를 제조하기 위한 나트륨 수소 교환체억제제의 용도 |
JP2000590615A JP2002533386A (ja) | 1998-12-23 | 1999-12-08 | 年齢関連器官機能不全および年齢関連疾患予防および寿命延長のための薬剤を製造するためのナトリウム/水素交換物質阻害剤の使用 |
IL14337299A IL143372A0 (en) | 1998-12-23 | 1999-12-08 | The utilisation of inhibitors of the sodium hydrogen exchanger for producing a medicament for preventing organ dysfunctions and diseases related to a particular age and for prolonging life |
CA002357837A CA2357837A1 (en) | 1998-12-23 | 1999-12-08 | The utilisation of inhibitors of the sodium hydrogen exchanger for producing a medicament for preventing organ dysfunctions and diseases related to a particular age and for prolonging life |
HR20010470A HRPK20010470B1 (en) | 1998-12-23 | 2001-06-20 | The utilisation of inhibitors of the sodium hydrogen exchanger for producing a medicament for preventing organ dysfunctions and diseases related to a particular age and for prolonging life |
NO20013145A NO20013145L (no) | 1998-12-23 | 2001-06-22 | Anvendelse av inhibitorer av natriumhydrogenutbytteren for fremstilling av et medikament for prevensjon av organdysfunksjonerog -sykdommer relatert en spesiell alder og for a forlengelevetiden |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19859727A DE19859727A1 (de) | 1998-12-23 | 1998-12-23 | Die Verwendung von Hemmern des Natrium-Wasserstoff-Austauschers zur Herstellung eines Medikaments zur Verhinderung von altersbedingten Organ-Dysfunktionen, altersbedingten Erkrankungen zur Lebensverlängerung |
DE19859727.4 | 1998-12-23 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2000038661A2 WO2000038661A2 (de) | 2000-07-06 |
WO2000038661A3 true WO2000038661A3 (de) | 2000-11-09 |
Family
ID=7892436
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP1999/009621 WO2000038661A2 (de) | 1998-12-23 | 1999-12-08 | Die verwendung von hemmern des natrium-wasserstoff-austauschers zur herstellung eines medikaments zur verhinderung von altersbedingten organ-dysfunktionen, altersbedingten erkrankungen und zur lebensverlängerung |
Country Status (20)
Country | Link |
---|---|
US (1) | US6420430B1 (de) |
EP (1) | EP1140056A2 (de) |
JP (1) | JP2002533386A (de) |
KR (1) | KR20010086152A (de) |
CN (1) | CN1367689A (de) |
AR (1) | AR021965A1 (de) |
AU (1) | AU776761B2 (de) |
BR (1) | BR9916505A (de) |
CA (1) | CA2357837A1 (de) |
CZ (1) | CZ20012309A3 (de) |
DE (1) | DE19859727A1 (de) |
HR (1) | HRPK20010470B1 (de) |
HU (1) | HUP0104652A3 (de) |
IL (1) | IL143372A0 (de) |
NO (1) | NO20013145L (de) |
RU (1) | RU2238721C2 (de) |
SK (1) | SK9042001A3 (de) |
TR (1) | TR200101803T2 (de) |
WO (1) | WO2000038661A2 (de) |
ZA (1) | ZA200104301B (de) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6844361B2 (en) * | 2002-02-04 | 2005-01-18 | Aventis Pharma Deutschland Gmbh | Pharmaceutical composition comprising a sodium hydrogen exchange inhibitor and an angiotensin converting enzyme inhibitor |
MXPA04007569A (es) * | 2002-02-04 | 2004-11-01 | Aventis Pharma Gmbh | Preparacion de la combinacion del inhibidor del intercambio sodio-hidrogeno cariporida con inhibidores ace para evitar la insuficiencia cardiaca y otras disfunciones de los organos relacionadas con la edad, padecimientos relacionados con la edad y pa |
US7375138B2 (en) | 2002-05-18 | 2008-05-20 | Sanofi-Aventis Deutschland Gmbh | Pentafluorosulfanylbenzoylguanidines, processes for their preparation, their use as medicaments or diagnostic aids, and medicaments comprising them |
FR2840302B1 (fr) * | 2002-06-03 | 2004-07-16 | Aventis Pharma Sa | Derives d'isoindolones, procede de preparation et intermediaire de ce procede a titre de medicaments et compositions pharmaceutiques les renfermant |
US6878748B2 (en) | 2002-06-13 | 2005-04-12 | Aventis Pharma Deutschland Gmbh | Fluorinated cycloalkyl-derivatized benzoylguanidines, process for their preparation, their uses as medicament, and medicament containing them |
KR101153254B1 (ko) * | 2003-06-26 | 2012-07-02 | 바이오트론 리미티드 | 항바이러스 화합물 및 방법 |
US8017863B2 (en) * | 2005-11-02 | 2011-09-13 | The Regents Of The University Of Michigan | Polymer wrapped carbon nanotube near-infrared photoactive devices |
US7947897B2 (en) * | 2005-11-02 | 2011-05-24 | The Trustees Of Princeton University | Organic photovoltaic cells utilizing ultrathin sensitizing layer |
US8013240B2 (en) * | 2005-11-02 | 2011-09-06 | The Trustees Of Princeton University | Organic photovoltaic cells utilizing ultrathin sensitizing layer |
KR101042078B1 (ko) * | 2009-01-13 | 2011-06-16 | 한국항공우주산업 주식회사 | 치공구 제작용 수평 측면 가공 치구 |
CN104103253B (zh) | 2014-07-04 | 2016-08-17 | 京东方科技集团股份有限公司 | 发射电极扫描电路、阵列基板和显示装置 |
Citations (14)
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EP0589336A1 (de) * | 1992-09-22 | 1994-03-30 | Hoechst Aktiengesellschaft | Benzoylguanidine, Verfahren zu ihrer Herstellung, sowie ihre Verwendung als Antiarrythmika |
EP0640587A1 (de) * | 1993-08-24 | 1995-03-01 | Hoechst Aktiengesellschaft | Diacylsubstituierte Guanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
EP0699666A1 (de) * | 1994-08-31 | 1996-03-06 | MERCK PATENT GmbH | Heterocyclyl-benzoylguanidine |
EP0723963A1 (de) * | 1995-01-28 | 1996-07-31 | MERCK PATENT GmbH | 4-Amino-benzoylguanidin-Derivate |
DE19502895A1 (de) * | 1995-01-31 | 1996-08-01 | Merck Patent Gmbh | 4-Mercapto-benzoylguanidin-Derivate |
EP0738712A1 (de) * | 1995-04-18 | 1996-10-23 | Hoechst Aktiengesellschaft | Substituierte Indenoylguanidines mit antiarrhythmischer und cardioprotektiver Wirkung |
EP0765867A1 (de) * | 1995-09-27 | 1997-04-02 | Hoechst Aktiengesellschaft | Substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Antiarrhytmika oder Diagnostikum sowie sie enthaltendes Medikament |
EP0774459A1 (de) * | 1995-11-14 | 1997-05-21 | Hoechst Aktiengesellschaft | Sulfonylamino-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
EP0810207A1 (de) * | 1996-05-28 | 1997-12-03 | Hoechst Aktiengesellschaft | Bis-ortho-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
WO1997046226A2 (de) * | 1996-06-03 | 1997-12-11 | Hoechst Aktiengesellschaft | VERWENDUNG VON INHIBITOREN DES ZELLULÄREN Na+/H+-EXCHANGERS (NHE) ZUR HERSTELLUNG EINES MEDIKAMENTS ZUR NORMALISIERUNG DER SERUMLIPIDE |
DE19734693A1 (de) * | 1997-08-11 | 1998-01-22 | Hoechst Marion Roussel De Gmbh | Verwendung von Cariporide als Inhibitor des zellulären NA+/H+-Exchangers (NHE) zur Herstellung eines Medikaments zur Behandlung von cardialen und nichtcardialen Krankheiten |
WO1998055475A1 (en) * | 1997-06-02 | 1998-12-10 | Fujisawa Pharmaceutical Co., Ltd. | Guanidine deriviatives as inhibitors of na+/h+ exchange in cells |
WO1999033460A1 (en) * | 1997-12-24 | 1999-07-08 | Bristol-Myers Squibb Company | Acyl guanidine sodium/proton exchange inhibitors and method |
EP0937459A2 (de) * | 1998-01-29 | 1999-08-25 | Sumitomo Pharmaceuticals Company, Limited | Pharmazeutische Zubereitung zur behandlung der ischämischen Gehirnkrankheit |
Family Cites Families (3)
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DK0590455T3 (da) * | 1992-09-28 | 2001-01-22 | Hoechst Ag | Antiarrytmiske og cardioprotektive substiuerede 1(2H)-isoquinoliner, fremgangsmåde til deres fremstilling, lægemiddel indeh |
SE508028C2 (sv) * | 1993-05-12 | 1998-08-10 | Moelnlycke Ab | Midjebälte för absorberande plagg |
DE69501219T2 (de) | 1994-02-25 | 1998-04-16 | Whitehead Alenia Sistemi Subacquei Spa | Elektrolyt-aktivierte Batterie |
-
1998
- 1998-12-23 DE DE19859727A patent/DE19859727A1/de not_active Withdrawn
-
1999
- 1999-12-08 EP EP99959387A patent/EP1140056A2/de not_active Ceased
- 1999-12-08 IL IL14337299A patent/IL143372A0/xx unknown
- 1999-12-08 BR BR9916505-8A patent/BR9916505A/pt not_active IP Right Cessation
- 1999-12-08 CA CA002357837A patent/CA2357837A1/en not_active Abandoned
- 1999-12-08 RU RU2001120358A patent/RU2238721C2/ru not_active IP Right Cessation
- 1999-12-08 CN CN99815044A patent/CN1367689A/zh active Pending
- 1999-12-08 WO PCT/EP1999/009621 patent/WO2000038661A2/de not_active Application Discontinuation
- 1999-12-08 KR KR1020017008052A patent/KR20010086152A/ko not_active Application Discontinuation
- 1999-12-08 CZ CZ20012309A patent/CZ20012309A3/cs unknown
- 1999-12-08 SK SK904-2001A patent/SK9042001A3/sk unknown
- 1999-12-08 JP JP2000590615A patent/JP2002533386A/ja not_active Withdrawn
- 1999-12-08 TR TR2001/01803T patent/TR200101803T2/xx unknown
- 1999-12-08 HU HU0104652A patent/HUP0104652A3/hu unknown
- 1999-12-08 AU AU16576/00A patent/AU776761B2/en not_active Ceased
- 1999-12-21 AR ARP990106639A patent/AR021965A1/es unknown
- 1999-12-22 US US09/469,299 patent/US6420430B1/en not_active Expired - Fee Related
-
2001
- 2001-05-25 ZA ZA200104301A patent/ZA200104301B/xx unknown
- 2001-06-20 HR HR20010470A patent/HRPK20010470B1/xx not_active IP Right Cessation
- 2001-06-22 NO NO20013145A patent/NO20013145L/no not_active Application Discontinuation
Patent Citations (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0589336A1 (de) * | 1992-09-22 | 1994-03-30 | Hoechst Aktiengesellschaft | Benzoylguanidine, Verfahren zu ihrer Herstellung, sowie ihre Verwendung als Antiarrythmika |
EP0640587A1 (de) * | 1993-08-24 | 1995-03-01 | Hoechst Aktiengesellschaft | Diacylsubstituierte Guanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
EP0699666A1 (de) * | 1994-08-31 | 1996-03-06 | MERCK PATENT GmbH | Heterocyclyl-benzoylguanidine |
EP0723963A1 (de) * | 1995-01-28 | 1996-07-31 | MERCK PATENT GmbH | 4-Amino-benzoylguanidin-Derivate |
DE19502895A1 (de) * | 1995-01-31 | 1996-08-01 | Merck Patent Gmbh | 4-Mercapto-benzoylguanidin-Derivate |
EP0738712A1 (de) * | 1995-04-18 | 1996-10-23 | Hoechst Aktiengesellschaft | Substituierte Indenoylguanidines mit antiarrhythmischer und cardioprotektiver Wirkung |
EP0765867A1 (de) * | 1995-09-27 | 1997-04-02 | Hoechst Aktiengesellschaft | Substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Antiarrhytmika oder Diagnostikum sowie sie enthaltendes Medikament |
EP0774459A1 (de) * | 1995-11-14 | 1997-05-21 | Hoechst Aktiengesellschaft | Sulfonylamino-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
EP0810207A1 (de) * | 1996-05-28 | 1997-12-03 | Hoechst Aktiengesellschaft | Bis-ortho-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
WO1997046226A2 (de) * | 1996-06-03 | 1997-12-11 | Hoechst Aktiengesellschaft | VERWENDUNG VON INHIBITOREN DES ZELLULÄREN Na+/H+-EXCHANGERS (NHE) ZUR HERSTELLUNG EINES MEDIKAMENTS ZUR NORMALISIERUNG DER SERUMLIPIDE |
WO1998055475A1 (en) * | 1997-06-02 | 1998-12-10 | Fujisawa Pharmaceutical Co., Ltd. | Guanidine deriviatives as inhibitors of na+/h+ exchange in cells |
DE19734693A1 (de) * | 1997-08-11 | 1998-01-22 | Hoechst Marion Roussel De Gmbh | Verwendung von Cariporide als Inhibitor des zellulären NA+/H+-Exchangers (NHE) zur Herstellung eines Medikaments zur Behandlung von cardialen und nichtcardialen Krankheiten |
WO1999033460A1 (en) * | 1997-12-24 | 1999-07-08 | Bristol-Myers Squibb Company | Acyl guanidine sodium/proton exchange inhibitors and method |
EP0937459A2 (de) * | 1998-01-29 | 1999-08-25 | Sumitomo Pharmaceuticals Company, Limited | Pharmazeutische Zubereitung zur behandlung der ischämischen Gehirnkrankheit |
Non-Patent Citations (15)
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BAUMGARTH, MANFRED ET AL: "[2-Methyl-5-(methylsulfonyl)benzoyl]guanidine Na+/H+ Antiporter Inhibitors", J. MED. CHEM. (1997), 40(13), 2017-2034, XP000914594 * |
BAUMGARTH, MANFRED ET AL: "Bicyclic acylguanidine Na+/H+ antiporter inhibitors", J. MED. CHEM. (1998), 41(19), 3736-3747, XP000914595 * |
BEERS M.H.; BERKOW R. (EDS.).: "MERCK MANUAL OF DIAGNOSIS AND THERAPY.", 1999, MERCK & CO., INC., RAHWAY, N.J., XP002141065, 23624 * |
BEIER, N. ET AL: "EMD 96785: A potent cardioprotective Na+/H+-exchange (NHE) inhibitor.", JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, (JUNE, 1998) VOL. 30, NO. 6, PP. A144. MEETING INFO.: XVI WORLD CONGRESS OF THE INTERNATIONAL SOCIETY FOR HEART RESEARCH: CARDIOVASCULAR BIOLOGY AND MEDICINE INTO THE 21ST CENTURY, XP000920869 * |
BERKOW R.; FLETCHER A. (EDS.).: "MERCK MANUAL OF DIAGNOSIS AND THERAPY.", 1987, MERCK & CO., INC., RAHWAY, N.J., XP002141064, 14658 * |
GRAUL, A. ET AL: "Cariporide Mesilate. Cardioprotectant Na+/H+-exchange inhibitor", DRUGS FUTURE (1997), 22(11), 1197-1200, XP000920592 * |
GUMINA, RICHARD J. ET AL: "A new sodium/hydrogen exchange inhibitor, EMD 85131, limits infarct size in dogs when administered before or after coronary artery occlusion", J. PHARMACOL. EXP. THER. (1998), 286(1), 175-183, XP000920539 * |
HILDEBRANDT H. (ED.).: "PSCHYREMBEL KLINISCHES WOERTERBUCH", 1998, WALTER DE GRUYTER, BERLIN NEW YORK, XP002141063, 240171 * |
HOQUE, A.N. EHSANUL ET AL: "Effect of sodium-hydrogen exchange inhibition on functional and metabolic impairment produced by oxidative stress in the isolated rat heart", CAN. J. PHYSIOL. PHARMACOL. (1997), 75(4), 326-334, XP000920595 * |
LEVITSKY, JOSH ET AL: "Sodium ion/hydrogen ion exchange inhibition: a new pharmacologic approach to myocardial ischemia and reperfusion injury", J. CLIN. PHARMACOL. (1998), 38(10), 887-897, XP000920868 * |
LINZ, W. ET AL: "Dose-dependent reduction of myocardial infarct mass in rabbits by the NHE-1 inhibitor cariporide ( HOE 642 )", CLIN. EXP. HYPERTENS. (1998), 20(7), 733-749, XP000920536 * |
MIURA, TETSUJI ET AL: "Infarct size limitation by a new Na+-H+ exchange inhibitor, Hoe 642: difference from preconditioning in the role of protein kinase C", J. AM. COLL. CARDIOL. (1997), 29(3), 693-701, XP000920593 * |
MYERS, MARY LEE ET AL: "Hydrogen peroxide-induced impairment of post-ischemic ventricular function is prevented by the sodium-hydrogen exchange inhibitor HOE 642 ( cariporide )", CARDIOVASC. RES. (1998), 40(2), 290-296, XP000920530 * |
PFEFFER M A; FINN P V; GANNON J B; PFEFFER J M: "Cariporide, a Na+/H+ ion exchange inhibitor, prolongs survival in rats with experimental myocardial infarction.", JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, vol. 31, 1998, pages 268a, XP002141068 * |
SCHOLZ W ET AL: "PROTECTIVE EFFECTS OF HOE642, A SELECTIVE SODIUM-HYDROGEN EXCHANGE SUBTYPE 1 INHIBITOR, ON CARDIAC ISCHAEMIA AND REPERFUSION", CARDIOVASCULAR RESEARCH,XX,XX, vol. 29, no. 2, 1 January 1995 (1995-01-01), pages 260 - 268, XP000602918, ISSN: 0008-6363 * |
Also Published As
Publication number | Publication date |
---|---|
WO2000038661A2 (de) | 2000-07-06 |
TR200101803T2 (tr) | 2001-10-22 |
AU1657600A (en) | 2000-07-31 |
CA2357837A1 (en) | 2000-07-06 |
EP1140056A2 (de) | 2001-10-10 |
RU2001120358A (ru) | 2005-12-10 |
SK9042001A3 (en) | 2001-12-03 |
AR021965A1 (es) | 2002-09-04 |
IL143372A0 (en) | 2002-04-21 |
CZ20012309A3 (cs) | 2001-09-12 |
CN1367689A (zh) | 2002-09-04 |
ZA200104301B (en) | 2003-02-20 |
HRP20010470A2 (en) | 2002-06-30 |
AU776761B2 (en) | 2004-09-23 |
HUP0104652A3 (en) | 2002-09-30 |
BR9916505A (pt) | 2001-11-20 |
HRPK20010470B1 (en) | 2003-10-31 |
RU2238721C2 (ru) | 2004-10-27 |
US6420430B1 (en) | 2002-07-16 |
KR20010086152A (ko) | 2001-09-08 |
NO20013145L (no) | 2001-08-22 |
JP2002533386A (ja) | 2002-10-08 |
HUP0104652A2 (hu) | 2002-03-28 |
NO20013145D0 (no) | 2001-06-22 |
DE19859727A1 (de) | 2000-06-29 |
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