WO2000016737A1 - Composition et procede permettant de blanchir les dents sans endommager le tissu mou - Google Patents

Composition et procede permettant de blanchir les dents sans endommager le tissu mou Download PDF

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Publication number
WO2000016737A1
WO2000016737A1 PCT/US1999/021371 US9921371W WO0016737A1 WO 2000016737 A1 WO2000016737 A1 WO 2000016737A1 US 9921371 W US9921371 W US 9921371W WO 0016737 A1 WO0016737 A1 WO 0016737A1
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Prior art keywords
composition
agent
tooth
sulfate
peroxymonopersulfate
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PCT/US1999/021371
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English (en)
Inventor
Gerald G. Mclaughlin
Original Assignee
Mclaughlin Gerald G
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Application filed by Mclaughlin Gerald G filed Critical Mclaughlin Gerald G
Priority to AU62518/99A priority Critical patent/AU6251899A/en
Publication of WO2000016737A1 publication Critical patent/WO2000016737A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/22—Peroxides; Oxygen; Ozone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/88—Two- or multipart kits

Definitions

  • the present invention relates to the field of dentistry, and specifically to the whitening of the teeth.
  • Teeth generally become more darkly pigmented with age and exposure to materials such as tea and coffee, and it has long been a goal of dentistry to provide a means to safely and effectively reverse this darkening process.
  • the conventional techniques commonly use abrasives, sometimes augmented with solvents. While rapidly effective, these techniques have the disadvantage of only being able to remove external stains, leaving all internal pigmentation unchanged. Thus, the whitening effect is extremely limited.
  • a second technique involves a method of using oxidizing agents to penetrate into the tooth structure and bleach out the undesired pigmentation.
  • the active agents are usually either weak solutions of carbamide peroxide or hydrogen peroxide.
  • the application of the whitening agent utilizes either custom or stock trays that are shaped to hold the bleaching agent against the teeth to be whitened. The trays are filled with gel or liquid peroxide, and worn for long periods of time, sometimes even overnight. After a series of lengthy treatments, the teeth usually begin to show the desired whitening effect. The length of the treatment can be discouraging, and increases the cost.
  • the present invention provides a composition for whitening teeth consisting of a therapeutically effective amount of a bleaching compound which is not of the peroxide class.
  • a composition for whitening a tooth in a dental arch, including at least 30% by weight of potassium hydrogen peroxymonopersulfate sulfate (2KHSO 5 »KHSO 4 *K 2 SO 4 ) in a slurry or in a dry form, wherein the composition does not cause damage visible to the naked eye to a soft tissue during a treatment period.
  • a composition for whitening a tooth including at least 30% by weight of potassium hydrogen peroxymonopersulfate sulfate
  • the composition includes potassium monopersulfate with a pH modifying agent such as, for example, tri-poly phosphate or tri-sodium phosphate.
  • a method for whitening a tooth including contacting the tooth with a composition including at least 30% by weight of potassium hydrogen peroxymonopersulfate sulfate (2KHSO 5 »KHSO 4 »K 2 SO 4 ) in a slurry or in an aqueous solution, wherein the pH of the composition is adjusted to range from about 5.0 to about 8.5, and removing the composition comprising at least 30%) by weight of potassium hydrogen peroxymonopersulfate sulfate (2KHSO 5 «KHSO 4 'K 2 SO 4 ).
  • the method also includes contacting the tooth with a composition including a peroxide bleaching agent, wherein the agent generates hydrogen peroxide as 15% or less by weight of the composition; and removing the composition including a peroxide bleaching agent.
  • a kit for whitening teeth including a carrier means being compartmentalized to receive in close confinement therein one or more containers including a first container containing potassium hydrogen peroxymonopersulfate sulfate (2KHSO 5 «KHSO 4 «K 2 SO 4 ) and an agent to adjust the pH from about 5.0 to about 8.5.
  • a carrier means being compartmentalized to receive in close confinement therein one or more containers including a first container containing potassium hydrogen peroxymonopersulfate sulfate (2KHSO 5 «KHSO 4 «K 2 SO 4 ) and an agent to adjust the pH from about 5.0 to about 8.5.
  • FIG. 1 is a graph of the change in brightness of a stained artificial tooth after treatment with a 3.7 g Potassium hydrogen peroxymonopersulfate sulfate mixed with 1 ml of water yielding a pH of 3.1 including different amounts of peroxide. The results show a decreased brightness using compositions including 10% or more peroxide. DESCRIPTION OF THE PREFERRED EMBODIMENTS
  • the invention provides a composition for whitening teeth consisting of a therapeutically effective amount of a bleaching compound which is not of the peroxide class.
  • a “bleaching compound” is any compound which has the ability of whitening teeth.
  • the peroxide class refers to any compound whose main bleaching action is derived from the breakdown of peroxide ions such as hydrogen peroxide, carbamide peroxide, urea peroxide, sodium percarbonate, and perhydrol urea.
  • bleaching compounds not of the peroxide class are potassium monopersulfate and ozone.
  • therapeutically effective amount is meant the quantity of bleaching agent, when placed in contact with the teeth of a subject according to the invention, necessary to whiten the teeth of the subject.
  • the bleaching agent employed is placed in a composition such that it will produce a strength in solution of at least 2% and can range up to a saturated solution.
  • One particularly useful active agent utilized in such compositions is formed from the combination of water and a potassium monopersulfate compound.
  • a useful potassium monopersulfate compound is produced by Dupont under the trade name "Oxone" and consists of a combination of materials as shown below:
  • Such a mixture in concentrated form will usually cause a burn to the soft tissues within ten to twenty minutes of exposure. This is primarily caused because of the highly acidic nature of the mixture.
  • By regulating the acidity of the mixture it is possible to create mixtures which do not cause visible irritation of the soft tissue within the therapeutic time periods needed for effective tooth whitening.
  • One great difficulty encountered in creating these acidity-regulated mixtures comes from the fact that many of the active agents used such as the monopersulfate ion are more stable in highly acidic mixtures. If the pH of the stable monopersulfate mixture is raised too high, above 5.0 for example, the monopersulfate ion becomes "blown off and no longer is available for bleaching.
  • a composition for whitening a tooth in a dental arch, including at least 30% by weight of potassium hydrogen peroxymonopersulfate sulfate (2KHSO 5 »KHSO 4 »K 2 SO 4 ) in a slurry or in a dry form, wherein the composition does not cause damage visible to the naked eye to a soft tissue during a treatment period.
  • the composition can be used to whiten one tooth, or an entire dental arch.
  • a "dental arch” includes a tooth and the surrounding gingiva of a subject.
  • a subject is any mammal, preferably human.
  • Potassium hydrogen peroxymonopersulfate sulfate has the chemical formula 2KHSO 5 »KHSO 4 «K 2 SO 4 , and is also known as "oxone.” Potassium hydrogen peroxymonopersulfate sulfate is used in a wide variety of products and process, including pool and spa disinfectants, paper recycling process aids, microetchants for printed circuits, laundry bleaches, and denture cleansers. The physical properties of potassium hydrogen peroxymonopersulfate sulfate are known in the art. The pH of a 1 -3% solution is 2.0-2.3, and is stable. Potassium hydrogen peroxymonopersulfate sulfate is very soluble and is stable at a low pH.
  • Stability is affected by pH, so that at a pH of greater than 7.0 potassium hydrogen peroxymonopersulfate sulfate is less stable and can decompose.
  • Potassium hydrogen peroxymonopersulfate sulfate is soluble as 256 g/liter at 20 °C. At concentrations above saturation potassium sulfate precipitates, but additional potassium monopersulfate can remain in solution, so that the attainable %> active oxygen in solution can be increased. At 20°C the active oxygen in solution is 0.92 weight percent (wt%), and at 71°C the active oxygen in solution is 1.13 (wt%).
  • One of skill in the art can readily determine the solubility of potassium hydrogen peroxymonopersulfate sulfate at different temperatures and the resulting weight percent of active oxygen.
  • Potassium hydrogen peroxymonopersulfate sulfate has a low order of toxicity, such that the approximate lethal dose for rats is 2250 mg/kg. It should be noted that even though potassium hydrogen peroxymonopersulfate sulfate has been documented to have a low order of toxicity, manufacture's do not recommend taking potassium hydrogen peroxymonopersulfate sulfate internally.
  • a composition including potassium hydrogen peroxymonopersulfate sulfate can be prepared as a dry granular or powdered form.
  • a composition can be prepared as a slurry or as an aqueous solution.
  • slurry generally means a watery mixture of insoluble materials or soluble materials wherein the soluble material is in such a high concentration that some of the material remains undissolved.
  • a slurry or a dry form of the composition of the invention includes at least 30% by weight of potassium hydrogen peroxymonopersulfate sulfate (2KHSO 5 «KHSO 4 »K 2 SO 4 ) . Potassium hydrogen peroxymonopersulfate sulfate is soluble in water, and thus a solution for the treatment of the dental arches can be prepared from the composition as an aqueous solution.
  • the composition including at least 30%) by weight of potassium hydrogen peroxymonopersulfate sulfate is applied to a dental arch.
  • the compositions can be applied as a slurry or an aqueous solution, however, it has been discovered that better control can be achieved by first thickening up the liquid into the form of a gel, paste, foam, or the like. A liquid tends to run off the tooth and would have to be held in place using something like a sponge or cotton.
  • the composition of the invention includes at least 30%> by weight of potassium hydrogen peroxymonopersulfate sulfate, and does not cause damage visible to the naked eye to a soft tissue during a treatment period.
  • soft tissue means any component of the mouth, throat or dental arches that is not composed of bone and teeth.
  • damage includes any visible destruction of the soft tissues. Examples of soft tissue damage include, but are not limited to burning, necrosis, laceration, tissue sluff and bleeding.
  • visible means anything visible to the naked eye under ample indoor illumination over the treatment period.
  • the “treatment period” is the time that the composition is applied to the dental arch. In one embodiment, the treatment period is from about 5 to about 10 minutes. The treatment period can be repeated, so that the composition of the invention is applied for more than one treatment period, wherein each treatment period lasts from about 5 to about 10 minutes.
  • four or five treatment periods are utilized, so that the total amount of time that the dental arches are exposed to the composition of the invention can be from about forty to about fifty minutes.
  • Longer, single treatments are also applicable depending upon the mode and composition of application, thus it is envisioned that a single treatment can be about 5 to 10 minutes or about 10 to 40 minutes.
  • the composition of the invention can also include a pH adjusting agent sufficient to change the pH of the slurry or an aqueous solution prepared from said dry form of potassium hydrogen peroxymonopersulfate sulfate.
  • a pH adjusting agent is an acid, base, or buffer which can be used to change the concentration of hydrogen ions (the pH) in a formulation.
  • the agent to adjust the pH is sodium phosphate tripoly (Na 5 P 3 O 10 ).
  • Other agents are known in the art and include, but are not limited to, tri-sodium phosphate, sodium tri-polyphosphate, and perborates, such as sodium perborate.
  • the composition of the invention does not include a peroxide bleaching agent.
  • a "peroxide bleaching agent” is a bleaching agent that generates hydrogen peroxide.
  • the composition of the invention includes a peroxide bleaching agent.
  • Peroxide bleaching agents include, but are not limited to, hydrogen peroxide, carbamide peroxide, urea peroxide, sodium percarbonate, sodium perborate, calcium hydroxide, potassium chlorate, magnesium carbonate and perhydrol urea. In one embodiment, the peroxide bleaching agent is 15% or less by weight in the composition of the invention.
  • a surfactant can also be included in the composition of the invention.
  • a "surfactant” is a substance which changes the nature of a surface, including water surface tension. In general, a surfactant lowers the surface tension of a liquid.
  • Surfactants include, but are not limited to detergents, emulsifiers, penetrants, and wetting agents.
  • Surfactants of use with in the composition of the invention include, but are not limited to sodium lauryl sulfate, Pluronic 127 ® (poloxymer 407 or block co-polyol of ethyleneoxide and propylene oxide), Tween 20 ® (polyoxyethlyne (2) sorbitan monolaurate), Surfynal 485W ® (ethoxylated 2,4,7,9-tetramethyl 5 decyn-4,7- diol), Pemulan ® (acrylates 10-30 alkyla acrylate crosspolymer), and sodium dodcylbenensulfanate.
  • Pluronic 127 ® polymer 407 or block co-polyol of ethyleneoxide and propylene oxide
  • Tween 20 ® polyoxyethlyne (2) sorbitan monolaurate
  • Surfynal 485W ® ethoxylated 2,4,7,9-tetramethyl 5 decyn-4,7- diol
  • composition of the invention can also include a whitening enhancer.
  • a "whitening enhancer” is a material that is not capable of creating significant whitening effect on the teeth within a reasonable time frame on their own but which can augment the effect of other, more effective whitening agents.
  • Specific, non- limiting examples of whitening enhancers include, but are not limited to ammonium persulfate, sodium persulfate, and potassium persulfate.
  • composition of the invention can also include an agent for decreasing tooth sensitivity.
  • agent for decreasing tooth sensitivity is an agent that lowers the susceptibility of a tooth to a stimulation such as temperature or pressure.
  • Ingredients to decrease tooth sensitivity include, but are not limited to potassium nitrate, citric acid, citric acid salts, sodium fluoride, and strontium chloride.
  • the composition of the invention can also include an optical brightener.
  • An "optical brightener is a material such as a dye or pigment that absorbs electromagnetic energy of one portion of the spectrum and re-emits the energy as visible light in the blue portion of the spectrum. The absorbed electromagnetic energy is often in the ultra-violet range. The material can be incorporated into the structure of the tooth and the optical properties of the tooth are thus enhanced. When energy is emitted in the blue portion of the spectrum the blue light given off by the tooth is perceived as having a whitening effect.
  • An additional benefit of optical brighteners is that they absorb energy, such as ultra-violet energy. Thus, these materials can protect the tissues from effects of exposure to the energy, such as protecting the soft tissues from the effects of ultra-violet light.
  • Optical brighteners include, but are not limited to, Tinopal PT ® (CAS No. 16470-24-9), Eastobright ® (2,2'-(l,2-ethenediyl)bis(4,l-phenylene)bisbenzoxazole), and Uvitex-OB ® (CAS No. 7128-64-5).
  • the composition of the invention can also include a texturing agent, such as a gelling agent.
  • a "texturing agent” is an agent which provides a texture that is detectable by a subject.
  • “Texturing agents” include, but are not limited to Carbopol, carboxymethyl cellulose, hydroxyethyl cellulose, gum arabic, sodium polyacrylate, potassium polyacrylate, silicon dioxide, fumed silicon dioxide, sodium polyacrylamide, aluminum silica, and fumed alumina silica.
  • the composition can include a gelling agent.
  • a "gelling agent” is a agent which forms a semisolid suspension of small inorganic or large organic molecules upon addition of an aqueous solution. The aqueous solution interpenetrates the inorganic or large organic molecules in order to form the gel.
  • a gelling agent examples include an alpha starch, an agar, hydroxyethyl cellulose, mangrot seed, hydroxymethyl cellulose, sodium polyacrylate, sodium polyacrylamide, poly-N-vinylpyrrolidone, poly-vinyltoluenesulfonate, poly-sulfoethyl acrylate, poly-2-hydroxyethyl acrylate, poly-vinylmethyloxazolidinone, hydrolyzed polyacrylamide, polyacrylic acid, copolymers of acrylamide and acrylic acid and alkali metal salts of such of the polymers that contain sulfonate or carboxylate groups.
  • composition of the invention can further include a humectant.
  • a "humectant” is a substance that absorbs and promotes the retention of moisture from the air. Suitable humectants include, but are not limited to glycerine and propylene glycol.
  • a material to enhance the conversion of energy from one form to another can also be included in the composition of the invention.
  • the material converts light to heat.
  • a material that converts light energy in the visible spectrum of between 400 and 700 nm to heat is of use in the composition of the invention.
  • the optical energy can accelerate the production of free radical production of hydrogen peroxide.
  • the material converts ultraviolet light to heat.
  • the material converts visible light to heat. Examples of materials which can convert light of specific wavelengths to heat include, but are not limited to beta carotene, phenothalein, guinea green, red aluminum lake, benzoil peroxide and titanium dioxide.
  • composition of the invention can also include a palliative ingredient for periodontal tissues.
  • examples of such ingredients include, but are not limited to aloe, eugenol, corticosteroid and vitamin E.
  • Agents that protect the soft tissues can also be included in the composition of the invention. These agents include, but are not limited to ascorbic acid, para amino benzoic acid, melatonin, and aloe vera. Pigments, sweeteners, colors, and flavors may also be incorporated into the composition.
  • the composition can also include an agent for administering fluoride, such as a fluorine providing salt, which can prevent cavities.
  • an agent for administering fluoride such as a fluorine providing salt, which can prevent cavities.
  • fluoride such as a fluorine providing salt
  • Such materials are characterized by their ability to release fluoride ions in water.
  • Agents for administering fluoride include, but are not limited to, inorganic metal salts such as sodium fluoride, potassium fluoride, and tin fluoride such as stannous fluoride or stannous chlorofluoride, sodium fluorosilicate, ammonium fluorosilicate and sodium monofluorophosphate.
  • the contact of the composition including at least 30%) by weight of potassium hydrogen peroxymonopersulfate sulfate (2KHSO 5 »KHSO 4 «K 2 SO 4 ) does not cause damage visible to the naked eye to a soft tissue of the of a soft tissue of the mouth or a dental arch during the treatment period.
  • compositions of the invention are then removed from the dental arch. Removal can be by any means known to one of skill in the art.
  • the composition can be removed by rinsing with water or another aqueous solution such as a mouthwash.
  • the composition can be removed by contacting the dental arch with an absorbent material such as cotton gauze or a soft cloth, suitable to absorb or wipe away the composition.
  • Another method for removing the composition can be through the use of a suction or vacuum which is used to aspirate or remove the composition from the dental arch.
  • composition including at least 30%> by weight of potassium hydrogen peroxymonopersulfate sulfate
  • the treatment period is from about 5 to about 10 minutes.
  • the treatment period can be repeated, so that the composition of the invention is applied for more than one treatment period, wherein each treatment period lasts from about 5 to about 10 minutes.
  • the composition of the invention can be removed between treatment periods, reapplied or left in place. In one embodiment, four or five treatment periods are utilized, so that the total amount of time that the dental arches are exposed to the composition of the invention is from about twenty to about fifty minutes.
  • the composition includes at least 30%> by weight of potassium hydrogen peroxymonopersulfate sulfate (2KHSO 5 «KHSO 4 «K 2 SO 4 ) and includes a material to enhance the conversion of energy from one form to another is treated with an energy source.
  • the material that enhances the conversion of energy from one form to another is a material that converts light energy to heat.
  • the light can be light in the visible spectrum of between 400 and 700 nm as well as light from the non-visible spectrum (e.g., the infrared spectrum).
  • Light energy is applied to the composition including a material that converts light to heat in order to produce heat.
  • the application of light energy to the composition can be maintained for an entire treatment period, or may be applied prior to the treatment period.
  • the composition includes a material that converts light to heat. The composition is therefore treated with light prior to the treatment, or intermittently or continuously during the treatment of a dental arch.
  • a method for whitening a tooth including contacting the tooth with a composition comprising at least 30%) by weight of potassium hydrogen peroxymonopersulfate sulfate (2KHSO 5 »KHSO 4 »K 2 SO 4 ) in a slurry or in an aqueous solution, wherein the pH of said composition is adjusted to range from about 5.0 to about 8.5, and subsequently removing the composition comprising at least 30%> by weight of potassium hydrogen peroxymonopersulfate sulfate (2KHSO 5 «KHSO 4 «K 2 SO 4 ).
  • the tooth is also contacted with a composition comprising a peroxide bleaching agent which generates hydrogen peroxide as 15%> or less by weight of said composition, and removing said composition comprising said peroxide bleaching agent.
  • the tooth can be contacted with the peroxide bleaching composition prior to, subsequent to, or simultaneously with the contact of the tooth with the composition including at least 30%> by weight of potassium hydrogen peroxymonopersulfate sulfate (2KHSO 5 »KHSO 4 «K 2 SO 4 ) .
  • the tooth is contacted with a composition including at least 30%> by weight of potassium hydrogen peroxymonopersulfate sulfate (2KHSO 5 »KHSO 4 »K 2 SO 4 ) in a slurry or in an aqueous solution, wherein the pH of said composition is adjusted to range from about 5.0 to about 8.5, and/or the tooth is contacted with a peroxide bleaching agent which generates hydrogen peroxide as 15%> or less by weight of said composition.
  • a composition including at least 30%> by weight of potassium hydrogen peroxymonopersulfate sulfate (2KHSO 5 »KHSO 4 «K 2 SO 4 ) an additional whitening effect is achieved.
  • kits may comprise a carrier means containing one or more container means such as vials, tubes, and the like, each of the container means including one of the separate elements to be used in the method.
  • the kit includes a carrier means being compartmentalized to receive in close confinement therein one or more containers.
  • a first container is included in the kit which contains potassium hydrogen peroxymonopersulfate sulfate
  • a first container is included in the kit which contains potassium hydrogen peroxymonopersulfate sulfate (2KHSO 5 «KHSO 4 »K 2 SO 4 ) and a second container is included in the kit which contains an agent to adjust the pH of a solution or slurry prepared from potassium hydrogen peroxymonopersulfate sulfate (2KHSO 5 »KHSO 4 «K 2 SO 4 ) from about 5.0 to about 8.5 (e.g., sodium phosphate tripoly (Na 5 P 3 O 10 )).
  • the kit can also include a container which contains a peroxide bleaching agent.
  • compositions of the invention are high. Accordingly, although the examples below present exemplary compositions, these compositions can include any number of additional compounds such as flavoring agents, gelling agents, combinations of peroxides, and other combinations recognized by those of skill in the art.
  • EXAMPLE 1 A custom fabricated outer layer of a dental tray was produced by vacuuforming a sheet of 0.20 inch plastic to a plastic model of a subjects teeth. The tray was trimmed to cover the teeth and very little of the surrounding tissue. A dry composition was prepared including:
  • Pemulen 0.5 gm of Pemulen (Union Carbide) (Note: Pemulen is acrylates/C 10-30 Alkyl
  • Acrylate cross polymer a high molecular weight co polymer of acrylic acid and a long chain alkyl methacrylate cross-linked with polyalkenyl ethers of polyalcohols) flavoring (sufficient for a pleasant taste)
  • a toothbrush was dipped into the powder to coat the brush. Upon making contact with the moisture in the toothbrush and with the subject's saliva the whitening agent became active. A subject brushed their teeth using the composition; the procedure was repeated three times in three minutes. At the end of fifteen sessions a visible difference was evident in the brightness of the teeth.
  • EXAMPLE 3 A mixture of 3 parts potassium monopersulfate compound such as produced by DuPont under the trade name Oxone was mixed with 2 parts tri-sodium phosphate into a slurry with a solution that was composed of 10 parts water to 4 parts glycerin and placed on a human tooth for a period of 30 minutes. No protection of the soft tissue was used. At the end of 20 minutes the mixture was removed from the teeth and the teeth were rinsed with fresh water. The amount of whitening exhibited was approximately equal to that expected from a two-week regimen of wearing custom trays with peroxide gels fro two weeks.
  • EXAMPLE 4 A slurry was made as in Example 1 except that tin place of plain water, a solution of water and ozone in a concentration of 3-4% was mixed and applied to the tooth. As the mixture began to dry it was stirred on the tooth with a small sable paintbrush that had been dipped into the ozone solution. The results of this treatment were even more dramatic than that of Example 3.
  • EXAMPLE 5 Various mixtures of agents listed above were placed on stained bovine teeth and the brightness of the teeth were measured both before and after a five minute exposure to the agents. The table below list some of the combinations tested and the results. A higher delta number indicates a greater amount of change in brightness of the substrate as a result of the exposure:

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Abstract

Composition destinée à blanchir les dents dans une arcade dentaire, comprenant au moins 30 % en poids de sulfate péroxymonopersulfate acide de potassium (2KHSO5.KHSO4.K2SO4) en coulis ou sec. La composition ne provoque aucune lésion visible à l'oeil nu au tissu mou pendant la durée de traitement. L'invention concerne également une composition permettant de blanchir les dents comprenant au moins 30 % en poids de sulfate péroxymonopersulfate acide de potassium (2KHSO5.KHSO4.K2SO4) en coulis ou sec, la composition ne comportant pas d'agent de blanchiment peroxydé. Dans un autre mode de réalisation, un procédé permettant de blanchir les dents dans une arcade dentaire consiste: (1) à mettre en contact l'arcade dentaire avec une composition contenant au moins 30 % en poids de sulfate péroxymonopersulfate acide de potassium (2KHSO5.KHSO4.K2SO4) en coulis ou en solution aqueuse, le pH de ladite composition étant réglé de pH=5,0 à pH=8,5 environ, la mise en contact ne provoquant aucune lésion visible à l'oeil nu au tissu mou de l'arcade dentaire durant la période de traitement; et (2) à enlever la composition de l'arcade dentaire. Dans un autre mode de réalisation, un procédé permettant de blanchir les dents, consiste à mettre en contact les dents avec une composition comprenant au moins 30 % en poids de sulfate péroxymonopersulfate acide de potassium (2KHSO5.KHSO4.K2SO4) en coulis ou en solution aqueuse, le pH de ladite composition étant réglé de 5,0 à 8,5 environ, et à enlever la composition comprenant au moins 30 % en poids de sulfate péroxymonopersulfate acide de potassium (2KHSO5.KHSO4.K2SO4). Le procédé consiste également à mettre en contact les dents avec une composition contenant un agent de blanchiment peroxydé, l'agent générant le peroxyde d'hydrogène représentant 15 % au maximum du poids de la composition, et à enlever la composition contenant un agent de blanchiment peroxydé. L'invention concerne en outre une trousse pour blanchir les dents comportant un support compartimenté destiné à recevoir en milieu bien fermé un ou plusieurs récipients, un premier récipient contenant du sulfate péroxymonopersulfate acide de potassium (2KHSO5.KHSO4.K2SO4) et un agent permettant de régler le pH de 5,0 à 8,5 environ.
PCT/US1999/021371 1998-09-18 1999-09-17 Composition et procede permettant de blanchir les dents sans endommager le tissu mou WO2000016737A1 (fr)

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US60/100,779 1998-09-18

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Cited By (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6391283B1 (en) * 1997-01-10 2002-05-21 Ultradent Products, Inc. Methods and apparatus for activating dental compositions
WO2003009824A1 (fr) * 2001-07-26 2003-02-06 Unilever N.V. Composition orale comprenant des derives de peroxyamidophtalamide
WO2004028498A1 (fr) * 2002-09-24 2004-04-08 The Boots Company Plc Composition pour les dents et procedes
US6986883B2 (en) 1999-09-09 2006-01-17 Discus Dental, Inc. Increased peroxide content tooth bleaching gel
US7060256B2 (en) 1999-09-09 2006-06-13 Discus Dental, Inc. Increased peroxide content tooth bleaching gel
US7086862B2 (en) 2002-11-15 2006-08-08 Discus Dental, Inc. Tooth bleaching process
JP2007217323A (ja) * 2006-02-15 2007-08-30 Sun Medical Co Ltd 歯牙漂白剤組成物
WO2009139906A1 (fr) * 2008-05-15 2009-11-19 Shenberg James E Utilisation de liquides ozonés et de peroxydes pour le blanchiment des dents
US8801763B2 (en) 2009-12-23 2014-08-12 Koninklijke Philips N.V. System for protection of soft tissues against a teeth whitening substance
JP2015063490A (ja) * 2013-09-25 2015-04-09 クラレノリタケデンタル株式会社 有機蛍光色素に好適な化合物及びそれを含む硬化性組成物
WO2017105457A1 (fr) * 2015-12-17 2017-06-22 Colgate-Palmolive Company Système de blanchiment à plusieurs composants
WO2017112672A1 (fr) * 2015-12-23 2017-06-29 Colgate-Palmolive Company Composition solide stable en stockage de peroxymosulfate
WO2018236864A1 (fr) * 2017-06-19 2018-12-27 Colgate-Palmolive Company Produits de soin buccodentaire et compositions de blanchiment de ceux-ci
US10716741B1 (en) * 2018-12-26 2020-07-21 Colgate-Palmolive Company Oral care compositions and methods for the same
CN112156028A (zh) * 2020-10-28 2021-01-01 上海交通大学医学院附属第九人民医院 一种新型牙齿美白凝胶及其制备方法和应用

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US6391283B1 (en) * 1997-01-10 2002-05-21 Ultradent Products, Inc. Methods and apparatus for activating dental compositions
US6986883B2 (en) 1999-09-09 2006-01-17 Discus Dental, Inc. Increased peroxide content tooth bleaching gel
US7060256B2 (en) 1999-09-09 2006-06-13 Discus Dental, Inc. Increased peroxide content tooth bleaching gel
WO2003009824A1 (fr) * 2001-07-26 2003-02-06 Unilever N.V. Composition orale comprenant des derives de peroxyamidophtalamide
WO2004028498A1 (fr) * 2002-09-24 2004-04-08 The Boots Company Plc Composition pour les dents et procedes
US7086862B2 (en) 2002-11-15 2006-08-08 Discus Dental, Inc. Tooth bleaching process
US7581864B2 (en) 2002-11-15 2009-09-01 Discus Dental, Llc Tooth bleaching process
JP2007217323A (ja) * 2006-02-15 2007-08-30 Sun Medical Co Ltd 歯牙漂白剤組成物
WO2009139906A1 (fr) * 2008-05-15 2009-11-19 Shenberg James E Utilisation de liquides ozonés et de peroxydes pour le blanchiment des dents
US8801763B2 (en) 2009-12-23 2014-08-12 Koninklijke Philips N.V. System for protection of soft tissues against a teeth whitening substance
US9468393B2 (en) 2009-12-23 2016-10-18 Koninklijke Philips N.V. System for protection of soft tissues against a teeth whitening substance
JP2015063490A (ja) * 2013-09-25 2015-04-09 クラレノリタケデンタル株式会社 有機蛍光色素に好適な化合物及びそれを含む硬化性組成物
WO2017105457A1 (fr) * 2015-12-17 2017-06-22 Colgate-Palmolive Company Système de blanchiment à plusieurs composants
CN108366946A (zh) * 2015-12-17 2018-08-03 高露洁-棕榄公司 多组分漂白系统
US10729626B2 (en) 2015-12-23 2020-08-04 Colgate-Palmolive Company Storage-stable solid peroxymonosulfate composition
CN108601957A (zh) * 2015-12-23 2018-09-28 高露洁-棕榄公司 储存稳定的固体过一硫酸盐组合物
US11229588B2 (en) 2015-12-23 2022-01-25 Colgate-Palmolive Company Storage-stable solid peroxymonosulfate composition
AU2016378548B2 (en) * 2015-12-23 2019-04-04 Colgate-Palmolive Company Storage-stable solid peroxymonosulfate composition
AU2016378548C1 (en) * 2015-12-23 2019-07-25 Colgate-Palmolive Company Storage-stable solid peroxymonosulfate composition
WO2017112672A1 (fr) * 2015-12-23 2017-06-29 Colgate-Palmolive Company Composition solide stable en stockage de peroxymosulfate
CN108601957B (zh) * 2015-12-23 2021-12-10 高露洁-棕榄公司 储存稳定的固体过一硫酸盐组合物
CN110799248A (zh) * 2017-06-19 2020-02-14 高露洁-棕榄公司 口腔护理产品及其美白组合物
US10744075B2 (en) 2017-06-19 2020-08-18 Colgate-Palmolive Company Oral care products and whitening compositions thereof
AU2018289422B2 (en) * 2017-06-19 2021-01-21 Colgate-Palmolive Company Oral care products and whitening compositions thereof
WO2018236864A1 (fr) * 2017-06-19 2018-12-27 Colgate-Palmolive Company Produits de soin buccodentaire et compositions de blanchiment de ceux-ci
US10716741B1 (en) * 2018-12-26 2020-07-21 Colgate-Palmolive Company Oral care compositions and methods for the same
CN112156028A (zh) * 2020-10-28 2021-01-01 上海交通大学医学院附属第九人民医院 一种新型牙齿美白凝胶及其制备方法和应用

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