WO2004028497A1 - Procede permettant d'ameliorer l'aspect des dents - Google Patents

Procede permettant d'ameliorer l'aspect des dents Download PDF

Info

Publication number
WO2004028497A1
WO2004028497A1 PCT/GB2003/004155 GB0304155W WO2004028497A1 WO 2004028497 A1 WO2004028497 A1 WO 2004028497A1 GB 0304155 W GB0304155 W GB 0304155W WO 2004028497 A1 WO2004028497 A1 WO 2004028497A1
Authority
WO
WIPO (PCT)
Prior art keywords
whitening agent
tooth
teeth
fluorescent whitening
bis
Prior art date
Application number
PCT/GB2003/004155
Other languages
English (en)
Inventor
Yue Hugh Guan
Terence Henry Lilley
Original Assignee
The Boots Company Plc
The University Of Sheffield
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Boots Company Plc, The University Of Sheffield filed Critical The Boots Company Plc
Priority to AU2003269192A priority Critical patent/AU2003269192A1/en
Publication of WO2004028497A1 publication Critical patent/WO2004028497A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
    • A61K8/4946—Imidazoles or their condensed derivatives, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
    • A61K8/4926—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having six membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
    • A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
    • A61K8/8141—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
    • A61K8/8147—Homopolymers or copolymers of acids; Metal or ammonium salts thereof, e.g. crotonic acid, (meth)acrylic acid; Compositions of derivatives of such polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • A61Q11/02—Preparations for deodorising, bleaching or disinfecting dentures
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/42—Colour properties
    • A61K2800/43—Pigments; Dyes
    • A61K2800/434—Luminescent, Fluorescent; Optical brighteners; Photosensitizers

Definitions

  • This invention relates to dental methods, and in particular to methods for enhancing or improving the whiteness of teeth.
  • Staining or discolouration of teeth can arise as a result of a number of factors, including
  • Oxidising or bleaching agents such as peroxides are widely used to effect removal of both extrinsic and intrinsic stains. Such agents can be applied either as pastes or gels. However, the treatment may require considerable time to achieve good results. The concentration of oxidising agent may be increased to reduce the time required to achieve effective results, but this may lead to safety concerns.
  • Enzymatic systems comprising proteases such as papain that are claimed to remove stain by dissolution of the pellicle entrapping the stain.
  • Chelating agents have also been used to whiten teeth by interacting either with inorganic components of the tooth and tartar or with stain molecules. Typical examples of such agents are pyrophosphates and polyphosphates.
  • the natural colour of the tooth is very rarely pure white, mainly because the dentin, which contains a substantial amount of collagen, is yellowish and the enamel above it is not completely opaque.
  • the "whitening" approaches 3) and 4) described above are primarily based on interactions with acquired enamel pellicle, plaque and dental calculus. The mechanism employed is to either remove or weaken these tooth surface adsorbents and precipitates. Approach 1) simply polishes the enamel using abrasives and thus removes stains.
  • a shortcoming of all known methods of tooth whitening is that the beneficial effect that is achieved is not as long-lasting as might be desired. With the passage of time, possibly a relatively short length of time, the whitening effect may be lost. This may necessitate repeat treatment, and this is undesirable in terms of the inconvenience and cost, as well as possible harmful effects of the tooth whitening agents when used repeatedly.
  • Such a varnish typically comprises a solution of a polymeric material that forms a polymeric coating on the tooth.
  • Such varnishes are used to deliver therapeutic agents to the tooth surface, eg fluoride, or to seal the tooth, eg to prevent or inhibit pain following the application of temporary repairs to a damaged tooth.
  • a method for treating teeth in particular a method for enhancing or improving the whiteness of the teeth, which overcomes or substantially mitigates the disadvantages associated with conventional tooth- whitening methods.
  • a method for improving or enhancing the appearance of the teeth in particular for whitening of the teeth, which method comprises the steps of: a) applying to the teeth a whitening agent; and b) subsequent to step a), applying to the teeth a tooth varnish.
  • the method according to the invention is advantageous primarily in that the application of the tooth varnish has been found to preserve and prolong the whitening effect of the tooth whitening agent. This results in a lower frequency of whitening treatments being necessary, with concomitant savings in cost and, especially importantly, the avoidance of deleterious effects that might accompany the otherwise-necessary more frequent application of the tooth whitening agent.
  • the tooth whitening agent applied in the first step of the method according to the invention may be any agent conventionally known and used for the purpose of whitening teeth.
  • examples include: a) abrasive agents effective in physically removing stains from the tooth enamel; b) oxidising or bleaching agents such as peroxides; c) enzymatic systems, eg those including proteases such as papain; and d) chelating agents, eg pyrophosphates and polyphosphates.
  • the most preferred of the above conventional tooth whitening agents for use in the present invention are oxidising whitening or bleaching agents.
  • Suitable forms of bleaching agent include compounds containing (or compounds capable, in use, of generating) peroxide or chlorite ions.
  • peroxide or peroxide-generating compounds include hydrogen peroxide, sodium percarbonate, sodium perborate, sodium persilicate, sodium perphosphate, calcium peroxide and sodium peroxide.
  • the presently most preferred peroxide bleaching agents are hydrogen peroxide or adducts such as urea peroxide (carbamide peroxide).
  • Examples of chlorite bleaching agents include alkali metal chlorites such as lithium chlorite, potassium chlorite and, especially, sodium chlorite, and alkaline earth metal chlorites such as calcium chlorite, magnesium chlorite and barium chlorite. Chlorite salts of other metals, and other salts, eg polymeric salts, may also be used. Water-soluble chlorites are generally preferred. Such compounds may generate chlorine dioxide upon contact with acid.
  • Particularly preferred bleaching agents for use in the invention are hydrogen peroxide and urea peroxide (carbamide peroxide).
  • whitening agent Another form of whitening agent that has been found to be particularly beneficial in the method of the invention is a fluorescent whitening agent, as described in our co-pending International patent application [Agents' Ref 1060/600/P/WO] that claims priority from UK patent application no 0222091.1.
  • fluorescent whitening agent a compound that absorbs invisible ultra-violet light and which re-emits the light in the visible spectral range.
  • the compound thus absorbs light of wavelength less than, say, 380nm, and re-emits light in the wavelength range 380nm(violet) to 780nm (red).
  • the re-emitted light should complement the light reflected from the substrate to which the fluorescent whitening agent is applied, so that a more uniform spectral distribution is achieved across the whole visible range. It is particularly preferred, in order to compensate for the yellow cast of discoloured teeth, that the fluorescent whitening agent should emit in the blue region of the visible spectrum, eg in the range 400nm to 450nm.
  • the fluorescent whitening agent may be any compound that exhibits appropriate spectroscopic properties, and which is acceptable for administration in the manner contemplated by this invention, eg from the point of view of its toxicological properties.
  • Fluorescent whitening agents of potential utility in the present invention include the following classes of compound:
  • naphthalimide derivatives having the following chromophore system:
  • R represents a conjugated group, eg an ethylene group or a stilbene moiety (see above);
  • Preferred bis-styrylbiphenyl compounds of utility in the invention may be represented by the general formula:
  • bis-styrylbiphenyl compounds examples include 4,4'-bis(2- sulfostyryl)biphenyl (sold under the name of Tinopal CBS) and disodium 4,4'-bis(3- sulfo-4-chlorostyryl)biphenyl, both of which are supplied by Ciba Speciality Chemicals pic.
  • bistriazineamino derivatives of stilbene are disodium 4,4'-bis[(4- anilino-6-morpholino-1 ,3,5-triazin-2-yl)amino]stilbene-2,2'-disulfonate (sold under the trade name Tinopal DMS), disodium 4,4'-bis ⁇ [4-anilino-6-(N-methyl-N-2- hydroxyethyl)amino ⁇ 1 ,3,5-triazin-2-yl] amino ⁇ stilbene-2,2'-disulfonate, and disodium 4,4'-bis[(4-anilino-6-methylamino-1 ,3,5-triazin-2-yl)aminolstilbene-2,2'- disulfonate (all of which are supplied by Ciba Specialty Chemicals pic).
  • coumarin fluorescent whitening agent is Coumarin 102, the structure of which is:
  • naphthalimide fluorescent whitening agent 1 ,8-naphthalimide, the structure of which is:
  • a particularly preferred fluorescent whitening agent is 4,4'-bis(2- sulfostyryl)biphenyl or a salt or other soluble derivative thereof, eg the disodium salt, one such compound being sold under the trade name Tinopal CBS-X by Ciba Speciality Chemicals.
  • the teeth are treated both with a first form of tooth whitening agent, which is preferably an oxidising tooth whitening agent, especially a peroxide, and with a fluorescent whitening agent, most preferably 4,4'-bis(2-sulfostyryl)biphenyl or a salt thereof.
  • a first form of tooth whitening agent which is preferably an oxidising tooth whitening agent, especially a peroxide, and with a fluorescent whitening agent, most preferably 4,4'-bis(2-sulfostyryl)biphenyl or a salt thereof.
  • the effects of the first form of tooth whitening agent and the fluorescent whitening agent may be more than simply cumulative. It is believed that, at least in some instances, treatment of the teeth with the first form of tooth whitening agent may enhance the binding to the teeth of the fluorescent whitening agent, and thereby lead to a greater-than-additive overall effect of the two agents.
  • the tooth varnish that is used may be a conventional tooth varnish.
  • Such products commonly comprise a polymer or pre-polymer in solution.
  • pre- polymer is meant a polymerisable monomer or oligomer that, in use, undergoes polymerisation.
  • the solution is applied to the teeth, commonly by brushing.
  • a polymer coating is formed on the surface of the teeth and this coating may persist for a period of several weeks or months.
  • the varnish may be a known and commercially available tooth varnish. Examples of formulations that are commercially available are those known by the trade names Chem Varnish (supplied by Dentsply), Espe Varnish (supplied by 3M) and Copalite (supplied by Cooley & Cooley).
  • the varnish formulation may be formulated specifically for use in the invention.
  • a formulation will contain a natural resin or suitable synthetic polymer in a solvent such as chloroform, ether or, most preferably, ethanol.
  • Suitable natural resins and polymers include such copolymers such as polyvinylpyrrolidone/vinyl acetate, eg Plasdone S-630 from ISP, shellac and methacrylic polymers such as those sold under the trade name Eudragit supplied by Rohm Pharma.
  • tooth varnish would normally be carried by, or under the direct supervision of a professional dental surgeon. It is therefore generally the case that the method of the invention would be performed by a dental surgeon, rather than patients carrying out the treatment themselves, eg at home. Nonetheless, it is possible that the certain variants of the method may be suitable for being carried out by the patient, or at least that certain stages of the method may be so suitable.
  • the patient may apply repeat treatments between clinical applications of a bleaching agent, or may apply maintenance treatments following the completion of a course of clinical treatment.
  • compositions used in the invention to the teeth may involve simply bringing the composition into contact with the teeth, eg by introducing the composition into the buccal cavity and allowing it to disperse within that cavity. Toothguards or the like may be used to constrain the composition to the vicinity of the teeth.
  • the composition may be applied to the teeth for a period of from several minutes, say from 1 minute to 5 minutes, up to one hour or so. Afterwards, the composition is preferably removed from the buccal cavity by rinsing. Treatment by a dental surgeon will normally begin with a conventional scale-and- polish treatment. This may be followed by one or more applications of a bleaching agent, eg at daily or weekly intervals, in a conventional manner. The fluorescent whitening agent may then be applied after the last bleaching treatment, and finally application of the tooth varnish. The tooth varnish will normally be applied by being brushed or painted onto the teeth.
  • the varnish may incorporate a fluorescent whitening agent, the varnish then serving to entrap the fluorescent whitening agent and thereby augmenting the effects of fluorescent whitening agent that is bound to the tooth surface prior to application of the varnish.
  • the method of the invention involves the use of at least one tooth whitening agent and a tooth varnish.
  • two tooth whitening agents are used sequentially, prior to application of the varnish.
  • compositions required to carry out the invention may be packaged together in a kit, which forms a further aspect of the invention, and which comprises a) a whitening composition including a tooth whitening agent; and b) a varnish composition comprising a tooth varnish.
  • the whitening composition may include both the first tooth whitening agent and the fluorescent whitening agent, or the kit further comprises a second whitening composition that comprises a fluorescent whitening agent.
  • the first tooth whitening agent is most preferably hydrogen peroxide or a compound capable of generating, in use, hydrogen peroxide
  • the fluorescent whitening agent is most preferably 4,4'-bis(2-sulfostyryl)biphenyl or a salt thereof, especially the disodium salt.
  • the concentration of first tooth whitening agent in the whitening composition will depend on factors such as the nature of that agent and the magnitude of the desired bleaching effect.
  • the bleaching agent will typically be present in the composition at a level sufficient to generate a concentration of peroxide of up to 50% by weight in the case of a composition for clinical use, more typically up to 30%, and usually between 1% and 15%, typically from 5% to 15%.
  • the concentration of bleaching agent will generally be much lower, usually less than 10%, and often less than 1 %, eg 0.1 %.
  • the concentration of fluorescent whitening agent in the whitening composition (or the second whitening composition if the fluorescent whitening agent is formulated separately from the first whitening agent) will depend on factors such as the nature of the fluorescent whitening agent and the effect desired. Again, a distinction may be drawn between compositions intended for clinical use by a dental surgeon, and those for self-administration (eg at home) by the patient. In the former case, the concentration of fluorescent whitening agent may be up to lOOOppm, but is more commonly 500ppm or less, say between
  • the concentration of fluorescent whitening agent will generally be much lower, say up to 100ppm, and more usually up to 50ppm, eg between 5ppm and 50ppm.
  • the fluorescent whitening agent and the first whitening agent may be simultaneous, in which case the fluorescent whitening agent and the bleaching agent may both be formulated in the same whitening composition.
  • the fluorescent whitening agent and the first whitening agent may be applied sequentially, in which case they will be formulated in separate compositions.
  • the first whitening agent is preferably applied first, followed by the fluorescent whitening agent.
  • Example 1 is an example of a dental gel comprising carbamide peroxide as bleaching agent
  • Example 2 is an example of a gel formulation containing Tinopal CBS-X as fluorescent whitening agent (FWA); and
  • Example 3 is an example of a tooth varnish formulation.
  • the formulations can generally be prepared by simple admixture of the various ingredients, in a manner that will be evident to, or readily determined by, those skilled in the art.
  • each tooth was glued onto a numbered glass microscope slide.
  • a pellicle was formed on the teeth by soaking in sterilised Artificial saliva with the composition set out in Table 1. After the 24 hr period of pellicle formation, the teeth were then brushed with an Oral B Plaque remover electric toothbrush for 2 mins, with a standard fluoride toothpaste, the composition of which is set out in Table 2.
  • teeth were bleached by immersion in a 15% hydrogen peroxide solution (prepared from 45g Urea Hydrogen Peroxide in 55g deionised water) for 1 hr. Teeth were returned to a fresh aliquot of artificial saliva and a Post-bleach measurement taken.
  • a 15% hydrogen peroxide solution prepared from 45g Urea Hydrogen Peroxide in 55g deionised water
  • FWA was applied to the teeth by immersion in a 500 ppm FWA solution (50 mg FWA in 100 ml deionised water stirred for 30 minutes) for a 1 hr.
  • the teeth were returned to a fresh aliquot of artificial saliva and a post-FWA measurement taken.
  • each tooth was removed from the saliva and coated with a varnish using a small round disposable brush and left to dry to a film (30 mins). Each tooth was placed back into artificial saliva. The teeth were analysed after 2 hrs, 24 hours and 7 days. Teeth were replaced in a fresh aliquot of artificial saliva between each measurement.
  • Each tooth was imaged using a Kodak DCS 410 camera, which was mounted 10cm above and perpendicular to the specimen, using aperture F11 and a shutter speed of 1/10 second.
  • the standardised lighting source comprised two UV tubes and two 6500K 'daylight' tubes.
  • Each image was transferred to Adobe PhotoShop software.
  • For each image, an 8mm 2 area was analysed and an average Adobe L,a,b reading obtained using the software. All L,a,b values were converted to CIE L*,a*,b* and then to the CIE whiteness index W, using the equation :
  • Y is the Y-tristimulus value of the specimen
  • x and y are the chromaticity coordinates for the specimen and for the perfect diffuser for the CIE 1931 2° Standard Observer, respectively.
  • Table 3 shows the average percentage increase in whiteness index W for the eighteen teeth studied, at various times after application of tooth varnish. It can be seen that there is no appreciable reduction in whiteness over a period of 7 days.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Cosmetics (AREA)

Abstract

L'invention concerne un procédé permettant d'améliorer l'aspect des dents, en particulier pour le blanchiment des dents, qui consiste: a) à appliquer un agent de blanchiment sur les dents; et b) après l'étape a), à appliquer un vernis dentaire sur les dents. L'agent de blanchiment peut être du peroxyde d'hydrogène ou un agent de blanchiment fluorescent, de type 4,4'-bis(2-sulfostyryl) biphényle ou un sel de celui-ci. Le vernis dentaire comprend de préférence un polymère, par exemple un copolymère de méthacrylate, dans une solution, par exemple une solution éthanolique.
PCT/GB2003/004155 2002-09-24 2003-09-23 Procede permettant d'ameliorer l'aspect des dents WO2004028497A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003269192A AU2003269192A1 (en) 2002-09-24 2003-09-23 Method for improving or enhancing the appearance of teeth

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0222090.3 2002-09-24
GB0222090A GB0222090D0 (en) 2002-09-24 2002-09-24 Dental methods

Publications (1)

Publication Number Publication Date
WO2004028497A1 true WO2004028497A1 (fr) 2004-04-08

Family

ID=9944626

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2003/004155 WO2004028497A1 (fr) 2002-09-24 2003-09-23 Procede permettant d'ameliorer l'aspect des dents

Country Status (3)

Country Link
AU (1) AU2003269192A1 (fr)
GB (1) GB0222090D0 (fr)
WO (1) WO2004028497A1 (fr)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014056212A1 (fr) * 2012-10-13 2014-04-17 Zhang Bin Dentifrice multi-actions
WO2014097053A1 (fr) * 2012-12-18 2014-06-26 Koninklijke Philips N.V. Procédé amélioré de blanchiment des dents contenant un vernis à libération prolongée et activé par la lumière
US20140314691A1 (en) * 2013-03-14 2014-10-23 C3 Jian, Inc. Compositions for improving the appearance and/or health of teeth
WO2015033262A3 (fr) * 2013-09-04 2015-07-02 Koninklijke Philips N.V. Cartouche contenant une composition de blanchiment des dents combinée à une brosse applicatrice
US20150245984A1 (en) * 2012-10-23 2015-09-03 Oraceutical Llc Method of simultaneously cleaning and whitening teeth
US10912717B2 (en) 2010-04-21 2021-02-09 Oraceutical Llc Compositions and methods for whitening teeth
US11179299B2 (en) 2013-11-14 2021-11-23 Koninklijke Philips N.V. System and method for applying oral care agents

Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0717822A (ja) * 1993-06-29 1995-01-20 Hanix:Kk 歯牙の被覆用組成物およびその製造方法
US5395241A (en) * 1992-02-21 1995-03-07 Kandelman; Daniel Solution of stannous and amino fluorides and method of use dental treatment
US5438076A (en) * 1988-05-03 1995-08-01 Perio Products, Ltd. Liquid polymer composition, and method of use
US5814304A (en) * 1996-08-02 1998-09-29 Colgate Palmolive Company Stable aqueous abrasive peroxide tooth whitening dentifrice
US6083421A (en) * 1996-01-19 2000-07-04 Huang; Lizi Film coating composition for whitening teeth
WO2001001939A1 (fr) * 1999-07-02 2001-01-11 The Procter & Gamble Company Compositions comprenant des resines organosiloxanes, pour la liberation de substances d'hygiene buccale
WO2001064175A1 (fr) * 2000-03-01 2001-09-07 Lucas Huybrechts Produits de blanchiment des dents et procedures associees
US20020004190A1 (en) * 2000-05-26 2002-01-10 Adam Diasti Method for whitening teeth
WO2002062303A1 (fr) * 2001-02-07 2002-08-15 Despina Kostomiri Methode de blanchiment des dents avec de la resine synthetique incorporee dans un liquide blanc du type vernis a ongles
WO2002098374A1 (fr) * 2001-06-01 2002-12-12 Lipo Chemicals, Inc. Procede d'utilisation de particules a effets optiques dans des preparations cosmetiques

Patent Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5438076A (en) * 1988-05-03 1995-08-01 Perio Products, Ltd. Liquid polymer composition, and method of use
US5395241A (en) * 1992-02-21 1995-03-07 Kandelman; Daniel Solution of stannous and amino fluorides and method of use dental treatment
JPH0717822A (ja) * 1993-06-29 1995-01-20 Hanix:Kk 歯牙の被覆用組成物およびその製造方法
US6083421A (en) * 1996-01-19 2000-07-04 Huang; Lizi Film coating composition for whitening teeth
US5814304A (en) * 1996-08-02 1998-09-29 Colgate Palmolive Company Stable aqueous abrasive peroxide tooth whitening dentifrice
WO2001001939A1 (fr) * 1999-07-02 2001-01-11 The Procter & Gamble Company Compositions comprenant des resines organosiloxanes, pour la liberation de substances d'hygiene buccale
WO2001064175A1 (fr) * 2000-03-01 2001-09-07 Lucas Huybrechts Produits de blanchiment des dents et procedures associees
US20020004190A1 (en) * 2000-05-26 2002-01-10 Adam Diasti Method for whitening teeth
WO2002062303A1 (fr) * 2001-02-07 2002-08-15 Despina Kostomiri Methode de blanchiment des dents avec de la resine synthetique incorporee dans un liquide blanc du type vernis a ongles
WO2002098374A1 (fr) * 2001-06-01 2002-12-12 Lipo Chemicals, Inc. Procede d'utilisation de particules a effets optiques dans des preparations cosmetiques

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
PATENT ABSTRACTS OF JAPAN vol. 1995, no. 04 31 May 1995 (1995-05-31) *

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10912717B2 (en) 2010-04-21 2021-02-09 Oraceutical Llc Compositions and methods for whitening teeth
WO2014056212A1 (fr) * 2012-10-13 2014-04-17 Zhang Bin Dentifrice multi-actions
US20150245984A1 (en) * 2012-10-23 2015-09-03 Oraceutical Llc Method of simultaneously cleaning and whitening teeth
US9662284B2 (en) * 2012-10-23 2017-05-30 Oraceutical Llc Methods for whitening teeth
US9775790B2 (en) 2012-10-23 2017-10-03 Oraceutical Llc Method and compositions for whitening teeth
WO2014097053A1 (fr) * 2012-12-18 2014-06-26 Koninklijke Philips N.V. Procédé amélioré de blanchiment des dents contenant un vernis à libération prolongée et activé par la lumière
US20140314691A1 (en) * 2013-03-14 2014-10-23 C3 Jian, Inc. Compositions for improving the appearance and/or health of teeth
WO2015033262A3 (fr) * 2013-09-04 2015-07-02 Koninklijke Philips N.V. Cartouche contenant une composition de blanchiment des dents combinée à une brosse applicatrice
US11179299B2 (en) 2013-11-14 2021-11-23 Koninklijke Philips N.V. System and method for applying oral care agents

Also Published As

Publication number Publication date
GB0222090D0 (en) 2002-10-30
AU2003269192A1 (en) 2004-04-19
AU2003269192A8 (en) 2004-04-19

Similar Documents

Publication Publication Date Title
Alqahtani Tooth-bleaching procedures and their controversial effects: A literature review
JP6730248B2 (ja) 光励起性酸素放出組成物および歯のホワイトニング方法
EP1542648A1 (fr) Composition pour les dents et procedes
RU2106136C1 (ru) Пленкообразующая жидкая полимерная композиция, способ внешнего и внутреннего отбеливания зубов, способ лечения гингивита и зубного камня
RU2567791C2 (ru) Композиции для ухода за полостью рта
CA2632187C (fr) Procedes et compositions pour le blanchiment des dents
KR100239675B1 (ko) 수성 연마성 치마제 조성물
RU2673236C2 (ru) Отбеливающие композиции для ухода за полостью рта
RU2391964C2 (ru) Композиции и способы для отбеливания зубов с уменьшенной концентрацией пероксида
JPH05194169A (ja) 歯を白くする効果のすぐれた口腔用組成物
NZ506250A (en) Light-activated tooth whitening composition containing a whitening compound and a carrier
BR112020017909A2 (pt) Composições para tratamento bucal para promover a saúde das gengivas
RU2608441C1 (ru) Способы отбеливания зубов
WO2000009079A1 (fr) Procedes et compositions permettant de blanchir les dents
WO2000016737A1 (fr) Composition et procede permettant de blanchir les dents sans endommager le tissu mou
WO2004028497A1 (fr) Procede permettant d'ameliorer l'aspect des dents
EP4084766A1 (fr) Composition de soin buccal durcissable contenant de l'argent et du fluorure
EP3774944B1 (fr) Nouveau polymère, composition, procédé et kit de blanchiment des dents
EP3634366B1 (fr) Composition, procédé et kit de blanchiment des dents
CA2519548A1 (fr) Procede et appareil de blanchiment des dents, en particulierbain de bouche de pretraitement et lumiere utilisateur portative a formule de blanchiment des dents a application directe contenant une substance photoactive
CA3018963A1 (fr) Colles dentaires polyelectrolytiques pour le blanchiment des dents et de composants dentaires
WO2017109889A1 (fr) Composition de blanchiment de dents et procédé de blanchiment de dents
WO2022118254A1 (fr) Compositions comprenant un iodure ou un thiocyanate, et procédés de traitement des dents
RU2597386C1 (ru) Способ изменения цвета эмали зубов
Zaghloul et al. Impact of Laser Tooth Bleaching Activation Techniques on the Enamel Ultra-Micromorphology, Surface Roughness, and Microtensile Bond Strength: A literature review

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A1

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE EG ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NI NO NZ OM PG PH PL PT RO RU SC SD SE SG SK SL SY TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A1

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LU MC NL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
122 Ep: pct application non-entry in european phase
NENP Non-entry into the national phase

Ref country code: JP

WWW Wipo information: withdrawn in national office

Country of ref document: JP