WO1999052877A1 - Ligands de recepteur - Google Patents

Ligands de recepteur Download PDF

Info

Publication number
WO1999052877A1
WO1999052877A1 PCT/US1998/007389 US9807389W WO9952877A1 WO 1999052877 A1 WO1999052877 A1 WO 1999052877A1 US 9807389 W US9807389 W US 9807389W WO 9952877 A1 WO9952877 A1 WO 9952877A1
Authority
WO
WIPO (PCT)
Prior art keywords
receptor
trans
cis
multimeric
γçö
Prior art date
Application number
PCT/US1998/007389
Other languages
English (en)
Inventor
Martin Rosenberg
Katherine Louisa Widdowson
Original Assignee
Smithkline Beecham Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corporation filed Critical Smithkline Beecham Corporation
Priority to EP98918154A priority Critical patent/EP1071667A4/fr
Priority to JP2000543439A priority patent/JP2002511569A/ja
Priority to CA002328252A priority patent/CA2328252A1/fr
Priority to PCT/US1998/007389 priority patent/WO1999052877A1/fr
Publication of WO1999052877A1 publication Critical patent/WO1999052877A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
    • C07D223/22—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C61/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C61/12—Saturated polycyclic compounds
    • C07C61/125—Saturated polycyclic compounds having a carboxyl group bound to a condensed ring system
    • C07C61/13—Saturated polycyclic compounds having a carboxyl group bound to a condensed ring system having two rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

L'invention concerne des ligands de récepteur multimères, non anticorps, leurs procédés de fabrication et d'identification et leur utilisation comme récepteurs multimères antagonistes ou agonistes.
PCT/US1998/007389 1998-04-14 1998-04-14 Ligands de recepteur WO1999052877A1 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP98918154A EP1071667A4 (fr) 1998-04-14 1998-04-14 Ligands de recepteur
JP2000543439A JP2002511569A (ja) 1998-04-14 1998-04-14 受容体リガンド
CA002328252A CA2328252A1 (fr) 1998-04-14 1998-04-14 Ligands de recepteur
PCT/US1998/007389 WO1999052877A1 (fr) 1998-04-14 1998-04-14 Ligands de recepteur

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US1998/007389 WO1999052877A1 (fr) 1998-04-14 1998-04-14 Ligands de recepteur

Publications (1)

Publication Number Publication Date
WO1999052877A1 true WO1999052877A1 (fr) 1999-10-21

Family

ID=22266829

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1998/007389 WO1999052877A1 (fr) 1998-04-14 1998-04-14 Ligands de recepteur

Country Status (4)

Country Link
EP (1) EP1071667A4 (fr)
JP (1) JP2002511569A (fr)
CA (1) CA2328252A1 (fr)
WO (1) WO1999052877A1 (fr)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001025277A1 (fr) * 1999-10-07 2001-04-12 Maxygen Aps Polypeptides antagonistes a chaine unique
WO2003062276A2 (fr) * 2002-01-25 2003-07-31 Asterion Limited Variantes de polypeptides
WO2003102207A2 (fr) * 2002-05-30 2003-12-11 Centre National De La Recherche Scientifique Nouvelles molecules multimeriques, leur procede de preparation, et leur utilisation pour la preparation de medicaments
WO2006018429A1 (fr) * 2004-08-16 2006-02-23 Novo Nordisk A/S Mutlimeres de peptides
FR2879202A1 (fr) * 2004-12-15 2006-06-16 Centre Nat Rech Scient Nouveaux ligands multimeriques de cd40, leur procede de preparation et leur utilisation pour la preparation de medicaments
US7998481B2 (en) 2004-04-05 2011-08-16 The Regents Of The University Of California Modulation of NKG2D for treating or preventing solid organ allograft rejection

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3271365A (en) * 1962-11-05 1966-09-06 Du Pont Polyesters of decahydronaphthalenedicarboxylic acid and dihydric phenols
US3361716A (en) * 1962-02-01 1968-01-02 Du Pont Polyesters of decahydro-bis-(hydroxy-methyl)-naphthalene

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1961760A3 (fr) * 1995-06-07 2008-09-03 Glaxo Group Limited Peptides et composés se liant à un récepteur de la thrombopoïétine
WO1997044033A1 (fr) * 1996-05-22 1997-11-27 Smithkline Beecham Corporation Minetique du g-csf non peptidique
WO1999022734A1 (fr) * 1997-10-31 1999-05-14 Smithkline Beecham Corporation Nouveaux complexes metalliques

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3361716A (en) * 1962-02-01 1968-01-02 Du Pont Polyesters of decahydro-bis-(hydroxy-methyl)-naphthalene
US3271365A (en) * 1962-11-05 1966-09-06 Du Pont Polyesters of decahydronaphthalenedicarboxylic acid and dihydric phenols

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP1071667A4 *

Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001025277A1 (fr) * 1999-10-07 2001-04-12 Maxygen Aps Polypeptides antagonistes a chaine unique
WO2003062276A2 (fr) * 2002-01-25 2003-07-31 Asterion Limited Variantes de polypeptides
WO2003062276A3 (fr) * 2002-01-25 2003-10-16 Asterion Ltd Variantes de polypeptides
US7741280B2 (en) 2002-05-30 2010-06-22 Centre National De La Recherche Scientifique Multimeric molecules, the preparation method thereof and use of same for the preparation of medicaments
WO2003102207A3 (fr) * 2002-05-30 2004-04-08 Centre Nat Rech Scient Nouvelles molecules multimeriques, leur procede de preparation, et leur utilisation pour la preparation de medicaments
WO2003102207A2 (fr) * 2002-05-30 2003-12-11 Centre National De La Recherche Scientifique Nouvelles molecules multimeriques, leur procede de preparation, et leur utilisation pour la preparation de medicaments
US7998481B2 (en) 2004-04-05 2011-08-16 The Regents Of The University Of California Modulation of NKG2D for treating or preventing solid organ allograft rejection
US8637011B2 (en) 2004-04-05 2014-01-28 The Regents Of The University Of California Modulation of NKG2D
US9211328B2 (en) 2004-04-05 2015-12-15 The Regents Of The University Of California Modulation of NKG2D for prolonging survival of a hematopoietic graft
WO2006018429A1 (fr) * 2004-08-16 2006-02-23 Novo Nordisk A/S Mutlimeres de peptides
FR2879202A1 (fr) * 2004-12-15 2006-06-16 Centre Nat Rech Scient Nouveaux ligands multimeriques de cd40, leur procede de preparation et leur utilisation pour la preparation de medicaments
WO2006064133A2 (fr) 2004-12-15 2006-06-22 Centre National De La Recherche Scientifique Nouveaux ligands multimeriques de cd40, leur procede de preparation et leur utilisation pour la preparation de medicaments
WO2006064133A3 (fr) * 2004-12-15 2006-08-31 Centre Nat Rech Scient Nouveaux ligands multimeriques de cd40, leur procede de preparation et leur utilisation pour la preparation de medicaments
US8357654B2 (en) 2004-12-15 2013-01-22 Centre National De La Recherche Scientifique Multimeric CD40 ligands, method for preparing same and use thereof for preparing drugs

Also Published As

Publication number Publication date
EP1071667A4 (fr) 2004-10-20
EP1071667A1 (fr) 2001-01-31
CA2328252A1 (fr) 1999-10-21
JP2002511569A (ja) 2002-04-16

Similar Documents

Publication Publication Date Title
CN106748748B (zh) 一种布瓦西坦的制备方法及其中间体
Gou et al. PdII‐Catalyzed Intermolecular Amination of Unactivated C (sp3) H Bonds
JP5422229B2 (ja) オレフィンの製造法
EP1071667A1 (fr) Ligands de recepteur
US20010016569A1 (en) Receptor ligands
US5371293A (en) Process for producing bisaminomethylcyclohexane
CN110156660A (zh) 一种异吲哚啉类衍生物及其制备方法
CN108658717B (zh) 一种脱羧反应制备三取代烯烃的合成方法
DeCosta et al. Synthesis and absolute configuration of optically pure enantiomers of a ϰ‐opioid receptor selective agonist
CN1420861A (zh) 将腈官能团氢化为胺官能团的方法
CN1160334C (zh) 多氯吡啶的制备方法
TWI644893B (zh) 多元醇-醚化合物及其製造方法
Young et al. Preparation of a tricyclopropylamino acid derivative via Simmons–Smith cyclopropanation with downstream intramolecular aminoacetoxylation for impurity control
JP2008280300A (ja) 環状アルキレンイミンの製造方法
Siddiquee et al. Synthesis of cyclopropanes via organoiron methodology: preparation of rac-dysibetaine CPa
JP2713615B2 (ja) ビス（アミノメチル）ノルカンファン類の製造方法
CN110256349B (zh) 多取代吡唑及其制备方法
CN114645288B (zh) 一种反式烯烃类化合物的制备方法
JP2713623B2 (ja) ビス（アミノメチル）ノルカンファン類の製造方法
CN114539090B (zh) 一种无机铵盐和烯烃多相催化制伯酰胺的方法
KR102008622B1 (ko) 생체물질 도입을 위한 링커 및 상기 링커가 결합된 자성 나노입자
CN1116620A (zh) 一种β-拟肾上腺素兴奋剂型饲料添加剂的合成方法
JPH10513447A (ja) ニトリルの還元的加水分解法の改良法
JP2001512441A (ja) コンビナトリアルライブラリーの収束的合成
JPH04117348A (ja) 脂肪族第一級アミンの製造方法

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A1

Designated state(s): CA JP US

AL Designated countries for regional patents

Kind code of ref document: A1

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
ENP Entry into the national phase

Ref document number: 2328252

Country of ref document: CA

Ref country code: CA

Ref document number: 2328252

Kind code of ref document: A

Format of ref document f/p: F

WWE Wipo information: entry into national phase

Ref document number: 1998918154

Country of ref document: EP

WWW Wipo information: withdrawn in national office

Ref document number: 1998918154

Country of ref document: EP

WWP Wipo information: published in national office

Ref document number: 1998918154

Country of ref document: EP