WO1999032516A2 - Pharmaceutical compositions containing the long pentraxin ptx3 - Google Patents

Pharmaceutical compositions containing the long pentraxin ptx3 Download PDF

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Publication number
WO1999032516A2
WO1999032516A2 PCT/IT1998/000364 IT9800364W WO9932516A2 WO 1999032516 A2 WO1999032516 A2 WO 1999032516A2 IT 9800364 W IT9800364 W IT 9800364W WO 9932516 A2 WO9932516 A2 WO 9932516A2
Authority
WO
WIPO (PCT)
Prior art keywords
ptx3
long pentraxin
cells
treatment
sequence
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IT1998/000364
Other languages
English (en)
French (fr)
Other versions
WO1999032516A3 (en
Inventor
Barbara Bottazzi
Martino Introna
Alberto Mantovani
Annunciata Vecchi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sigma Tau Industrie Farmaceutiche Riunite SpA
Original Assignee
Sigma Tau Industrie Farmaceutiche Riunite SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to JP2000525453A priority Critical patent/JP4173633B2/ja
Priority to DK98962665T priority patent/DK1034185T3/da
Priority to SI9830763T priority patent/SI1034185T1/xx
Priority to CA2315277A priority patent/CA2315277C/en
Priority to EP98962665A priority patent/EP1034185B1/en
Priority to NZ505063A priority patent/NZ505063A/xx
Priority to DE69830251T priority patent/DE69830251T2/de
Priority to KR1020007006739A priority patent/KR100560085B1/ko
Application filed by Sigma Tau Industrie Farmaceutiche Riunite SpA filed Critical Sigma Tau Industrie Farmaceutiche Riunite SpA
Priority to AU17829/99A priority patent/AU756974B2/en
Priority to AT98962665T priority patent/ATE295853T1/de
Publication of WO1999032516A2 publication Critical patent/WO1999032516A2/en
Publication of WO1999032516A3 publication Critical patent/WO1999032516A3/en
Anticipated expiration legal-status Critical
Priority to US11/882,180 priority patent/US8003109B2/en
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Definitions

  • compositions containing the long pentraxin PTX3 are provided.
  • the present invention relates to pharmaceutical compositions
  • PTX3 long pentraxin PTX3
  • the invention relates to the aforesaid
  • compositions. for the therapy of infectious and inflammatory diseases are provided. for the therapy of infectious and inflammatory diseases.
  • the invention also relates to expression vectors containing the
  • the invention relates to gene therapy methods for
  • PTX3 a protein which is expressed in various types of cells
  • IL-lbeta Interleukin lbeta
  • TNF- alpha Tumour Necrosis Factor alpha
  • PTX3 consists of two structural domains, an N-terminal
  • CRP C-reactive protein
  • the PTX3 gene is located on chromosome 3 of the mouse in a
  • mouse PTX3 (mPTX3) (Introna M., Vidal Alles V., Castellano M., Picardi
  • CRP is a marker for immuno-inflammatory and infectious
  • CRP CRP
  • human serum in fact, it is present in concentrations of less than 10
  • tumours tumours and endotoxic shock.
  • SAP serum amyloid P component
  • PTX3 is
  • Plasma/ Atomic Emission Spectroscopy or phosphocholine
  • PTX3 is unable to bind
  • extracellular matrix proteins such as fibronectin or type IV collagen.
  • PTX3 is capable of binding the Clq complement
  • PTX3 or its functional derivatives are useful therapeutic agents
  • long pentraxin PTX3 is any long pentraxin
  • PTX3 i.e. regardless of its natural (human or animal) or synthetic
  • Human long pentraxin PTX3 (see sequence 1 and Fig. 5) is the
  • pentraxin PTX3 or one of its functional derivatives consists in
  • expression vectors e.g. plasmids
  • pentraxin PTX3 are also utilised in gene therapy methods for the
  • a first gene therapy method consists in:
  • an expression vector of viral origin such as an
  • adenovirus or retrovirus containing the complete cDNA
  • tumour cells but rather to mechanisms mediated by the host
  • the protein was purified by chromatography by means of ion exchange
  • Biotinylated protein was used to determine the Clq binding
  • PTX3 was biotinylated according to standard procedures using
  • Leukocyte recruitment the leukocyte recruitment induced by
  • PTX3 was studied in vivo in the subcutaneous pocket system.
  • Anticancer activity a line of murine mastocytoma P815 was
  • pSV2 which endows the transfected cells with neomycin resistance.
  • the clones obtained produced protein levels ranging from 1
  • mice Male DBA/2N CrlBR mice aged 8- 10 weeks were
  • mice were clones or w th clones containing the antisense gene. The mice were
  • mice no such leukocyte recruitment occurs.
  • mice treated with cells of the antisense clones (Fisher test).
  • the binding is assessed as optical density (O.D.) at 405 nm.
  • Panel B shows the saturation curve obtained with the
  • CD 1 mice by inoculation of 5 ml of air.
  • Sequence 1 Amino acid sequence of human PTX3. The underlined
  • hPTX3 consists of 364 amino acids.
  • Sequence 2 Nucleotide sequence of fragment of cDNA of human

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Cell Biology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Rheumatology (AREA)
  • Virology (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
PCT/IT1998/000364 1997-12-19 1998-12-16 Pharmaceutical compositions containing the long pentraxin ptx3 Ceased WO1999032516A2 (en)

Priority Applications (11)

Application Number Priority Date Filing Date Title
DE69830251T DE69830251T2 (de) 1997-12-19 1998-12-16 Langes pentraxin ptx3 enthaltende pharmazeutische zusammensetzungen
SI9830763T SI1034185T1 (https=) 1997-12-19 1998-12-16
CA2315277A CA2315277C (en) 1997-12-19 1998-12-16 Pharmaceutical compositions containing the long pentraxin ptx3
EP98962665A EP1034185B1 (en) 1997-12-19 1998-12-16 Pharmaceutical compositions containing the long pentraxin ptx3
NZ505063A NZ505063A (en) 1997-12-19 1998-12-16 Pharmaceutical use of long pentraxin PTX3 in treating tumour conditions
KR1020007006739A KR100560085B1 (ko) 1997-12-19 1998-12-16 긴 펜트락신 ｐｔｘ3를 포함하는 약제학적 조성물
AU17829/99A AU756974B2 (en) 1997-12-19 1998-12-16 Pharmaceutical compositions containing the long pentraxin PTX3
JP2000525453A JP4173633B2 (ja) 1997-12-19 1998-12-16 長いペントラキシンｐｔｘ３を含む医薬組成物
DK98962665T DK1034185T3 (da) 1997-12-19 1998-12-16 Farmaceutisk sammensætning indeholdende den lange pentraxin PTX3
AT98962665T ATE295853T1 (de) 1997-12-19 1998-12-16 Langes pentraxin ptx3 enthaltende pharmazeutische zusammensetzungen
US11/882,180 US8003109B2 (en) 1997-12-19 2007-07-31 Pharmaceutical compositions containing the long pentraxin PTX3

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT97RM000796A IT1298487B1 (it) 1997-12-19 1997-12-19 Composizioni farmaceutiche comprendenti pentraxina lunga ptx3 per la terapia di patologie di tipo infettivo, infiammatorio o tumorale,
ITRM97A000796 1997-12-19

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US11/882,180 Division US8003109B2 (en) 1997-12-19 2007-07-31 Pharmaceutical compositions containing the long pentraxin PTX3

Publications (2)

Publication Number Publication Date
WO1999032516A2 true WO1999032516A2 (en) 1999-07-01
WO1999032516A3 WO1999032516A3 (en) 1999-10-28

Family

ID=11405409

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IT1998/000364 Ceased WO1999032516A2 (en) 1997-12-19 1998-12-16 Pharmaceutical compositions containing the long pentraxin ptx3

Country Status (13)

Country Link
US (1) US8003109B2 (https=)
EP (1) EP1034185B1 (https=)
JP (1) JP4173633B2 (https=)
KR (1) KR100560085B1 (https=)
AT (1) ATE295853T1 (https=)
AU (1) AU756974B2 (https=)
CA (1) CA2315277C (https=)
DE (1) DE69830251T2 (https=)
ES (1) ES2242309T3 (https=)
IT (1) IT1298487B1 (https=)
NZ (1) NZ505063A (https=)
PT (1) PT1034185E (https=)
WO (1) WO1999032516A2 (https=)

Cited By (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002038169A1 (en) * 2000-11-08 2002-05-16 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Use of the long pentraxin ptx3 for the treatment of diseases caused by an altered activation of the growth factor fgf-2
WO2003011326A1 (en) * 2001-08-03 2003-02-13 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Use of long pentraxin ptx3 for treating female infertility
WO2003084561A1 (en) * 2002-04-08 2003-10-16 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Use of long pentraxin ptx3 for the treatment of fgf-8 mediated tumour diseases
WO2002036151A3 (en) * 2000-11-03 2003-10-16 Sigma Tau Ind Farmaceuti Use of the long pentraxin ptx3 for the preparation of medicament for the prevention and cure of autoimmune pathologies
WO2003072603A3 (en) * 2002-02-28 2004-03-18 Sigma Tau Ind Farmaceuti Long pentraxin ptx3 functional derivatives for preparing an autologous vaccine for the treatment of tumours
WO2005060997A3 (en) * 2003-12-23 2005-09-09 Defiante Farmaceutica Lda Medicament comprising inhibitors of long pentraxin ptx3
WO2005107791A1 (en) * 2004-05-07 2005-11-17 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Medicament for the treatment of fungal infections, particularly aspergillosis
WO2006037744A1 (en) 2004-10-08 2006-04-13 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Deglycosylated and desialidated long pentraxin ptx3
US7041648B2 (en) 2001-08-03 2006-05-09 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Compositions and methods for treating female fertility
EP1832295A1 (en) * 2006-03-10 2007-09-12 Tecnogen S.P.A. Use of PTX3 for the treatment of viral diseases
WO2007128647A1 (en) 2006-05-02 2007-11-15 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. USE OF THYMOSIN α1, ALONE OR IN COMBINATION WITH PTX3 OR GANCICLOVIR, FOR THE TREATMENT OF CYTOMEGALOVIRUS INFECTION
WO2009095403A1 (en) * 2008-01-29 2009-08-06 Tecnogen S.P.A. Expression system and uses thereof for the production of human long pentraxin 3
WO2011012496A1 (en) 2009-07-29 2011-02-03 Tecnogen S.P.A. Improved human long pentraxin 3 expression system and uses thereof
US8003109B2 (en) 1997-12-19 2011-08-23 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Pharmaceutical compositions containing the long pentraxin PTX3
AU2007209581B2 (en) * 2006-01-24 2013-03-28 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. FGF2-binding peptides and uses thereof
CN105132459A (zh) * 2015-09-14 2015-12-09 武汉市星熠艾克生物医药有限责任公司 人类ptx3重组蛋白的制备方法及应用
US9610325B2 (en) 2013-06-07 2017-04-04 National Cheng Kung University Method for inhibiting euPTX3 to treat nasopharyngeal carcinoma by amino acid sequence

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KR101305515B1 (ko) 2011-06-10 2013-09-06 경북대학교 산학협력단 펜트락신 3 단백질의 파킨슨 질환 진단 용도
WO2013191280A1 (ja) * 2012-06-22 2013-12-27 国立大学法人 東京大学 全身性炎症反応症候群の治療又は予防剤
TWI531375B (zh) 2015-05-29 2016-05-01 國立成功大學 抑制癌細胞活性之短肽治療劑及含此之醫藥組成物
EP4103592A4 (en) * 2020-02-12 2024-01-10 BioTissue Holdings Inc. METHODS OF DESTRUCTING OR INHIBITING THE GROWTH OF CANCER CELLS
US20230227511A1 (en) * 2020-05-14 2023-07-20 Nippon Medical School Foundation Therapeutic or preventive agent for infectious disease

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IT1298487B1 (it) 1997-12-19 2000-01-10 Sigma Tau Ind Farmaceuti Composizioni farmaceutiche comprendenti pentraxina lunga ptx3 per la terapia di patologie di tipo infettivo, infiammatorio o tumorale,
IT1317927B1 (it) * 2000-11-03 2003-07-15 Sigma Tau Ind Farmaceuti Uso della pentraxina lunga ptx3 per la preparazione di un medicamentoper il trattamento di patologie autoimmuni.
IT1317930B1 (it) * 2000-11-08 2003-07-15 Sigma Tau Ind Farmaceuti Uso della pentraxina lunga ptx3 per la preparazione di un medicamentoper il trattamento di patalogie associate ad una alterata attivazione
US6872541B2 (en) * 2001-07-25 2005-03-29 Coulter International Corp. Method and compositions for analysis of pentraxin receptors as indicators of disease
US7041648B2 (en) * 2001-08-03 2006-05-09 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Compositions and methods for treating female fertility
US20040198655A1 (en) * 2001-08-03 2004-10-07 Alberto Mantovani Use of long pentraxin ptx3 for treating female infertility
US20040137544A1 (en) * 2002-10-31 2004-07-15 Roberto Latini PTX3 as an early prognostic indicator of cardiovascular and cerebrovascular pathologies
WO2004094991A2 (en) 2003-04-23 2004-11-04 Sciclone Pharmaceuticals, Inc. Treatment or prevention of respiratory viral infections with alpha thymosin peptides
ITRM20030596A1 (it) * 2003-12-23 2005-06-24 Sigma Tau Ind Farmaceuti Uso di inibitori della pentraxina lunga ptx3, per la preparazione di un medicamento per la prevenzione e cura di patologie che rispondono all'inibizione dell'attivita' biologica di detta ptx3.
ITRM20040489A1 (it) * 2004-10-08 2005-01-08 Sigma Tau Ind Farmaceuti Pentraxina lunga ptx3 deglicosilata o desialidata.
EP1832295A1 (en) * 2006-03-10 2007-09-12 Tecnogen S.P.A. Use of PTX3 for the treatment of viral diseases
PT2012816E (pt) * 2006-05-02 2012-08-17 Sigma Tau Ind Farmaceuti Uso de timosina 1, isolada ou em combinação com ptx3 ou ganciclovir, para o tratamento da infeção por citomegalovírus

Cited By (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8003109B2 (en) 1997-12-19 2011-08-23 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Pharmaceutical compositions containing the long pentraxin PTX3
CZ297242B6 (cs) * 2000-11-03 2006-10-11 Sigma-Tau Industrie Farmaceutiche Riunite S. P. A. Pouzití pentraxinu s dlouhým retezcem PTX3 k príprave léciva pro prevenci a lécbu autoimunních patologických projevu
KR100812805B1 (ko) * 2000-11-03 2008-03-12 시그마타우 인두스트리에 파르마슈티케 리우니테 에스.피.에이. 자가면역 질환의 예방 및 치료용 약제의 제조를 위한 긴펜트락신 ｐｔｘ3의 용도
WO2002036151A3 (en) * 2000-11-03 2003-10-16 Sigma Tau Ind Farmaceuti Use of the long pentraxin ptx3 for the preparation of medicament for the prevention and cure of autoimmune pathologies
KR100822357B1 (ko) * 2000-11-08 2008-04-16 시그마타우 인두스트리에 파르마슈티케 리우니테 에스.피.에이. 성장 인자 ｆｇｆ-2의 변경된 활성화에 의해 야기된질병의 치료를 위한 긴 펜트락신 ｐｔｘ3의 용도
WO2002038169A1 (en) * 2000-11-08 2002-05-16 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Use of the long pentraxin ptx3 for the treatment of diseases caused by an altered activation of the growth factor fgf-2
US7858577B2 (en) 2000-11-08 2010-12-28 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Use of the long pentraxin PTX3 for the treatment of diseases caused by an altered activation of the growth factor FGF-2
AU2002222513B2 (en) * 2000-11-08 2006-10-26 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Use of the long pentraxin PTX3 for the treatment of diseases caused by an altered activation of the growth factor FGF-2
AU2002222513B8 (en) * 2000-11-08 2006-11-23 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Use of the long pentraxin PTX3 for the treatment of diseases caused by an altered activation of the growth factor FGF-2
CN1304047C (zh) * 2000-11-08 2007-03-14 希格马托制药工业公司 长五亚基环蛋白ptx3在由生长因子fgf－2激活改变所致疾病的治疗中的用途
CZ299673B6 (cs) * 2000-11-08 2008-10-15 Sigma-Tau Industrie Farmaceutiche Riunite S. P. A. Použití pentraxinu s dlouhým retezcem k príprave léciva pro lécbu onemocnení zpusobených pozmenenouaktivací rustového faktoru FGF-2
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JP4173633B2 (ja) 2008-10-29
JP2002503642A (ja) 2002-02-05
EP1034185B1 (en) 2005-05-18
PT1034185E (pt) 2005-07-29
US20080015153A1 (en) 2008-01-17
KR20010033297A (ko) 2001-04-25
US8003109B2 (en) 2011-08-23
WO1999032516A3 (en) 1999-10-28
CA2315277C (en) 2010-02-23
AU1782999A (en) 1999-07-12
DE69830251D1 (de) 2005-06-23
KR100560085B1 (ko) 2006-03-13
ITRM970796A1 (it) 1999-06-19
IT1298487B1 (it) 2000-01-10
CA2315277A1 (en) 1999-07-01
NZ505063A (en) 2002-12-20
AU756974B2 (en) 2003-01-30
ES2242309T3 (es) 2005-11-01
EP1034185A2 (en) 2000-09-13
DE69830251T2 (de) 2005-10-27

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