WO1999008664A1 - Support pour timbres transdermiques et timbres dotes d'un tel support - Google Patents

Support pour timbres transdermiques et timbres dotes d'un tel support Download PDF

Info

Publication number
WO1999008664A1
WO1999008664A1 PCT/JP1998/003614 JP9803614W WO9908664A1 WO 1999008664 A1 WO1999008664 A1 WO 1999008664A1 JP 9803614 W JP9803614 W JP 9803614W WO 9908664 A1 WO9908664 A1 WO 9908664A1
Authority
WO
WIPO (PCT)
Prior art keywords
patch
base material
support member
support
adhesive
Prior art date
Application number
PCT/JP1998/003614
Other languages
English (en)
Japanese (ja)
Inventor
Shinya Kojima
Original Assignee
Chugai Seiyaku Kabushikikaisha
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chugai Seiyaku Kabushikikaisha filed Critical Chugai Seiyaku Kabushikikaisha
Priority to KR1020007001358A priority Critical patent/KR20010022758A/ko
Priority to AU86487/98A priority patent/AU8648798A/en
Publication of WO1999008664A1 publication Critical patent/WO1999008664A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F13/02—Adhesive bandages or dressings
    • A61F13/023—Adhesive bandages or dressings wound covering film layers without a fluid retention layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F13/02—Adhesive bandages or dressings
    • A61F13/0246—Adhesive bandages or dressings characterised by the skin-adhering layer
    • A61F13/0256—Adhesive bandages or dressings characterised by the skin-adhering layer characterized by the parametric properties of the adhesive
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F13/02—Adhesive bandages or dressings
    • A61F13/0259—Adhesive bandages or dressings characterised by the release liner covering the skin adhering layer

Definitions

  • the present invention relates to a support used when applying a patch such as an external anti-inflammatory analgesic to an affected part, and a patch provided with the support.
  • a patch such as an external anti-inflammatory analgesic is composed of a base material and a plaster provided on one surface of the base, and the plaster or the like has a transdermally applicable medicinal effect such as an anti-inflammatory analgesic. Contains ingredients.
  • the adhesive surface is coated with a protective film or the like to prevent the adhesive surface provided with the plaster or the like from being stained or dried before use.
  • Such a patch is used by a patient or a third party after peeling off a protective film or the like from the adhesive surface on which the plaster or the like is provided, and then applying it so that the adhesive surface side adheres to the affected part.
  • the mainstream of such patches has been to use a soft and thin base material to reduce the weight of the plaster or the like in order to improve the adhesion to the affected area and to improve the feel after application. I have.
  • a first object of the present invention is to provide a patch having a soft base material, which can prevent sticking of the adhesive surfaces from each other, and can be easily attached to affected parts such as shoulders, back, and waist.
  • An object of the present invention is to provide an agent support.
  • a second object of the present invention is to make use of the above-mentioned advantages as a patch having a soft base material, without sticking the adhesive surfaces together, and allowing the patient to apply the patch to affected areas such as shoulders, back, and waist.
  • An object of the present invention is to provide an easy-to-use patch. Disclosure of the invention
  • the support is used to temporarily make the substrate of the patch have rigidity so as to prevent the adhesive surfaces from sticking to each other. I have to.
  • the support when a patch having a flexible base material is applied to an affected area, the support is used temporarily to support the base material of the patch. And a support member attached to the non-stick side of the substrate, and a belt provided on the support member, wherein the support member is attached to the substrate when attached to the substrate. It is characterized in that it has a size and rigidity capable of maintaining the flatness of the material, and is attached to the non-sticking side of the substrate by an attaching means having an adhesive force lower than the adhesive force of the adhesive surface of the adhesive patch. A patch support is obtained.
  • the support member is formed in a sheet shape having substantially the same size as the base material, and the attaching means is provided on one surface of the sheet-like support member, and is based on the adhesive strength of the adhesive surface of the patch. It can be constituted by another adhesive surface having a low viscosity.
  • the belt portion may be formed of a tubular portion or a bag-shaped portion provided on the other surface of the support member and into which a finger of a hand can be inserted.
  • the other adhesive surface is covered with a release paper for protection.
  • the support member is made of cloth such as cotton cloth, regenerated cellulose cloth, chemical fiber cloth, and non-woven cloth, paper such as Japanese paper and craft paper, hard vinyl chloride, polypropylene, and polyethylene. It can be composed of resin, polyester, polyamide, polycarbonate, and their copolymers, plastic films such as vent fans, metal flakes, or laminates thereof.
  • a patch is prepared by previously bonding a support member including the belt portion to a surface of the substrate opposite to the adhesive surface. After the agent is applied, the support member including the belt portion is peeled off from the base material so that only the base material and the medicinal component are used.
  • a patch comprising: a flexible base material; and a medicinal component contained in the base material, wherein the patch is affixed to an affected area by an adhesive surface provided on the base material. And a support member attached to the non-stick side of the base material, and a belt provided on the support member, wherein the support member can maintain the flatness of the base material. It has a size and rigidity, and is attached to the non-stick side of the substrate by an attaching means having an adhesive force lower than the adhesive force of the adhesive surface of the substrate, and the patch is attached to the affected area. Thereafter, the support member including the belt portion is peeled off from the base material, and a patch is obtained, wherein the base material and the medicinal component are used.
  • the support member is formed in a sheet shape having substantially the same size as the base material, and the attaching means is provided on one surface of the sheet-like support member, and is provided based on the adhesive strength of the adhesive surface of the base material. It may be constituted by another adhesive surface having a low viscosity.
  • the belt portion is provided on the other surface of the support member, and can be constituted by a cylindrical portion or a pocket portion into which a finger can be inserted.
  • the support member is made of a cloth such as a cotton cloth, a regenerated cellulose cloth, a chemical fiber cloth, a nonwoven cloth, a paper such as a Japanese paper and a craft paper, a hard vinyl chloride, a polypropylene, a polyethylene, a polyester, a polyamide, a polycarbonate, or the like. And a copolymer thereof, a plastic film such as cellophane, a metal flake, or a laminate thereof.
  • FIG. 1 shows a patch support according to a first embodiment of the present invention, and a release paper thereof is partially peeled. It is a perspective view seen from the adhesive surface side in a separated state,
  • FIG. 2 is a perspective view of the patch support shown in FIG. 1 viewed from a surface opposite to the adhesive surface,
  • FIG. 3 is a perspective view showing a state in which the patch support shown in FIG. 1 is attached to a patch.
  • FIG. 4 is a perspective view showing a state in which the patch, to which the patch support is attached as shown in FIG. 3, is attached to the affected area,
  • FIG. 5 is a perspective view of a patch according to the second embodiment of the present invention. BEST MODE FOR CARRYING OUT THE INVENTION
  • FIG. 1 to FIG. 4 a patch support according to a first embodiment of the present invention will be described.
  • the patch support 1 of the present embodiment is used together with a patch using a soft and thin base material similar to the above-mentioned conventional example.
  • Fig. 1 is a perspective view of the support with the release paper partially peeled from the support, viewed from the adhesive side of the support.
  • Fig. 2 is a perspective view of the support, also viewed from the side opposite to the adhesive. is there.
  • FIG. 3 is a perspective view showing a state in which the support is stuck to a patch
  • FIG. 4 is a perspective view showing a state in which the patch stuck to the support is stuck to an affected part.
  • the patch support 1 includes a support member 2 having an adhesive surface 3 on one surface thereof, and a support member 2 provided on a surface of the support member 2 opposite to the adhesive surface 3. And a release paper 5 attached to the adhesive surface 3 of the support member 2.
  • the supporting member 2 is made of cloth such as cotton cloth, regenerated cellulose cloth, chemical fiber cloth, and non-woven cloth, paper such as Japanese paper and craft paper, hard vinyl chloride, polypropylene, polyethylene, polyester, polyamide, polycarbonate, And a plastic film such as a copolymer thereof or cellophane, etc., and has an appropriate rigidity.
  • the support member 2 may be formed of a laminate of these various materials such as papers, cloths, films, and the like. Furthermore, the support member 2 is made of metal It is also conceivable to get In the present invention, the material, size, and shape of the support member are not particularly limited. That is, the support member may have any shape, but the point is that the support member has a size and rigidity enough to maintain the flatness of the base material when bonded to the base material. Just do it. It is preferable that the base material has substantially the same shape and size as the base material, since the base material is easily supported sufficiently, the manufacturing is easy, and the usability is good.
  • the rigidity of the support member does not prevent the base material from bending in accordance with the shape of the curved portion when the patch is applied to a curved portion such as a shoulder or a waist, for example. That is, the rigidity of the support member is sufficient if the flatness of the base material can be maintained to such an extent that the base material can be prevented from breaking up quickly so that the adhesive surfaces of the base material do not stick.
  • the adhesive surface 3 has a viscosity lower than the viscosity of the adhesive surface of the patch.
  • the support member 2 needs to be separated from the base without sticking the adhesive surface of the patch (substrate) from the affected part after the patch is applied to the affected part.
  • the method of bonding the support member to the substrate is not limited.
  • the method of non-sticking the substrate by an adhesive means having an adhesive force lower than the adhesive force of the adhesive surface of the adhesive agent (substrate) is not limited. It only has to be attached to the side. Therefore, for example, the support member 2 may be bonded to the base material by fixing the adhesive member 3 with a double-sided tape during use without providing the adhesive surface 3.
  • the support member 2 is previously formed with the adhesive surface 3 with an adhesive having a viscosity lower than the viscosity of the adhesive surface of the patch (substrate), and then covered with a release paper 5.
  • the release paper 5 is peeled off so that the adhesive surface 3 and the base material 9 are bonded together. This is preferable because the two adhesive surfaces having different viscosities can be integrally manufactured during the production of the patch, and the support of the base material by the support member is also stable.
  • the belt portion 4 is for attaching the support member 2 to a finger or the like of a user's hand.
  • the material, size and shape of the belt portion are not particularly limited. That is, the belt portion may be of any size and shape, and is not particularly formed separately from the support member, but is appropriately cut so that a finger or the like can be inserted, for example. It is also possible to put it in.
  • the adhesive surface of the support member 2 is used. A belt-like sheet having substantially the same shape and the same size as the support member 2 was attached to the surface on the side opposite to 3, and the belt portion 4 was formed into a tubular shape by bonding both side edges of the belt-like sheet.
  • the release paper 5 covers the adhesive surface 3 of the support member 2 until use, and prevents the adhesive surface 3 from being stained and dried.
  • Reference numeral 6 denotes a patch using a soft and thin substrate, and 7 denotes a protective film for covering the adhesive surface of the patch 6.
  • the viscosity of the adhesive surface 3 needs to be smaller than the viscosity of the adhesive surface of the patch 6, but there is no particular limitation on this viscosity value. May be appropriately selected from commonly used materials.
  • Acrylic, vinyl acetate, polyvinyl alcohol, vinyl chloride, polyamide, polyethylene, cell-based adhesives, gelatin, etc. are used as the adhesive for forming the adhesive surface. It is possible.
  • the release papers 5, 5 are peeled from the patch support 1 to expose the adhesive surface 3. It is preferable that the release papers 5 and 5 be completely peeled off from the adhesive patch support 1 to expose the entire surface of the adhesive surface 3. As will be described later, the release papers 5 may be discarded after being peeled off, unless the patch support 1 is used again.
  • the adhesive surface 3 of the adhesive support 1 is attached to the surface of the adhesive 6 opposite to the adhesive surface. Thereby, as shown in FIG. 3, a patch 6 integrated with the patch support 1 is obtained.
  • a finger of a hand is inserted between the support member 2 and the belt portion 4, and in this state, that is, the patch 6 is applied to the hand of the user via the patch support 1. Peel off the protective film 7 of the patch 6 shown in Fig. 3 while supporting the patch After exposing the adhesive surface of 6, the patch 6 is applied to the desired affected area.
  • the patch support 1 is slowly peeled off the patch 6 attached to the affected area.
  • the patch support 1 peeled off from the patch 6 is stored by pasting the release papers 5 and 5 again on the adhesive surface 3, and is used again when pasting another patch 6. Although it is possible to do so, since it is intended for drugs, it is desirable to dispose it for sanitation.
  • the patch support 1 formed to be approximately the same size as the patch 6 was used as it is.For example, when the patch 6 is cut into small pieces depending on the affected area and used. In addition, the patch support 1 may be cut and used accordingly.
  • an example of a method for manufacturing the patch support according to the present example will be described.
  • an adhesive having a viscosity smaller than the viscosity of the adhesive surface of the adhesive 6 is applied to the support member, and at the same time, a film for forming a release paper is attached.
  • the supporting member to which the film is attached is passed through a drying oven.
  • a film for forming a belt portion is placed thereon, and both ends thereof are heat-sealed.
  • a slit for separating the release paper into two pieces from the center and a cut to the belt portion may be added as necessary.
  • the patch 8 according to the present embodiment is previously provided on the surface opposite to the adhesive surface (not shown) of the base material 9 with the support in the above-described support of the first embodiment. It has a support member and a belt portion having substantially the same configuration. Note that the patch 8 of the present embodiment does not have the equivalent to the release papers 5, 5 in the support of the first embodiment described above.
  • the patch 8 of the present embodiment is composed of a soft and thin base material 9 and a plaster applied to the base material 9 (shown in FIG. And the plaster contains a medicinal ingredient such as anti-inflammatory and analgesic. Further, in order to prevent the adhesive surface coated with the plaster from being stained or dried before use, a protective film 10 for covering the adhesive surface is provided.
  • the patch 8 of the present example was further provided on a support member 12 mounted on the surface of the base material 9 opposite to the adhesive surface, and on a surface of the support member 12 opposite to the bonding surface. It has a belt portion 13.
  • the support member 12 is made of the same material as the support member 2 in the first embodiment described above, and has an appropriate rigidity.
  • the support member 12 is formed to have substantially the same size as the base material 9 and is mounted on the surface of the base material 9 opposite to the adhesive surface.
  • the support member 12 needs to be separated from the base material 9 without sticking the adhesive surface of the base material 9 from the affected part after the patch 8 is applied to the affected part.
  • the method of bonding the support member to the substrate is not limited. In short, the method of bonding the support member to the non-adhering side of the substrate by an adhesive means having an adhesive force lower than the adhesive force of the adhesive surface of the adhesive agent (substrate) It should just be stuck to.
  • the support member may be bonded to the base material by simply fixing a plurality of places with clips or the like without using an adhesive.
  • the support member 12 is bonded to the substrate 9 with an adhesive having a viscosity lower than that of the adhesive surface of the substrate 9, that is, the adhesive surface of the adhesive. ing. In this way, two adhesive surfaces having different viscosities can be integrally manufactured during the production of the patch, and the support of the base material by the support member is also stable, which would be preferable.
  • the belt portion 13 has the same function as the belt portion 4 in the first embodiment.
  • the belt portion 13 is supported on the surface of the support member 12 opposite to the surface bonded to the base material 9.
  • a band-like sheet having substantially the same shape and the same size as the holding member 12 is attached, and the three sides of the band-like sheet are adhered to each other to form a bag.
  • the patch 8 of this example is obtained by peeling the protective film 10 from the adhesive surface of the base material 9 and then inserting a finger or the like of the hand into the bag-like belt portion 13 from the opening side. However, it is sufficient to position the patch 8 at the desired affected area and then paste it. It is to be noted that, after the attachment, the support member 12 is loosely peeled off and separated from the substrate 9 in the same manner as in the first embodiment described above.
  • a support used when a patch as an external anti-inflammatory analgesic is applied to an affected part and a patch containing the support are described.
  • the present invention provides, in addition to antiphlogistic analgesics, antipyretic antiphlogistic analgesics, steroid anti-inflammatory agents, vasodilators, hypertension / arrhythmic agents, antihypertensive agents, antitussives / expectorants, antitumor agents, local anesthesia Agents, hormones, asthma, nasal allergy treatment, antihistamine, anticoagulant, antispasmodic, cerebral circulation, metabolic improver, antidepressant, anxiolytic, vitamin D preparation, hypoglycemic, antiulcer, sleep , Antibiotics, adrenergic bronchodilators, narcotic analgesics, diuretics, sedatives, antifungals, bactericides, calcium antagonists, antiparkinson, anticholinergic, shoulder stiffness, muscle pain remedies Percutaneously absorbable medicinal ingredients such as low back pain remedy, antidepressants, decubitus ulcers, skin ulcer treatments, cold-sensitive skin irritants, warm
  • a patch for medical use or medical rescue which is directly attached to the skin for the purpose of a patch test, blood stoppage, disinfection, protection, etc., and a topical or circulatory system Dermal patch attached to the skin for the purpose of drug administration to the skin, and a skin care sheet containing an extract of animal tissue or plant or crude drug as a moisturizing component, etc. for back, shoulder, etc. It is widely applied to hair removal tapes, hair dressing materials, surgical tapes, etc. to which hair removal adhesive has been applied when used to remove stains and breakouts, pimples, fish eyes, and octopuses.
  • the present invention relates to an adhesive (adhesion) in which a flexible substrate and a therapeutic agent are mixed. It is widely applicable as long as it has a drug layer and is applied to the skin or the like, regardless of the use of the patch.
  • the present invention can be applied to a pressure-sensitive tape or the like containing a ditroglycerin solution as a therapeutic agent for angina pectoris and congestive heart failure in the adhesive portion of the tape.
  • an S-blocker is contained in a polymer matrix, and the matrix itself has no skin adhesiveness, and can be applied to a patch or the like which tightly administers a / 8-blocker in the matrix to the skin with an adhesive tape. In these cases, the tape itself corresponds to a flexible substrate.
  • an adhesive layer carried on a flexible base material contains a lidocaine hydrochloride solution as a local anesthetic.
  • the present invention is applied not only to a transdermal absorption plaster sheet, but also to a so-called dressing sheet, such as a waterproofing film, a breathable sheet for covering a wound, and the like. Further, in the first and second embodiments described above, a relatively large patch is described, in which several fingers are inserted between the support member and the belt portion, and are attached.
  • the present invention provides a therapeutic adhesive tape or sheet provided with a thin layer of a pressure-sensitive adhesive layer mixed with an antifungal agent or the like for the purpose of treating athlete's foot. It is needless to say that the present invention is also applied to smaller patches, such as sticking to a finger or the like.
  • the present invention as long as it is provided with a flexible base material and is attached to an affected area, for example, burns, trauma, skin wounds using chitin, etc. It can be applied not only to tapes for treatment or protection of wounds such as but also to adhesive tapes or sheets such as adhesive tapes or sheets for protecting the affected area where a simple gauze containing no drug is attached to the base material. is there. In addition, it is needless to say that the present invention is also applied to a poultice for reducing stiff shoulders or the like in which a magnet (magnetic material) is attached to a base material.
  • antipyretic and anti-inflammatory drugs include indomethacin, diclofenac sodium, methyl salicylate , Monoglycol salicylate, aspirin, acetaminophen, ibuprofen, sulindac, naproxen, ketoprofen, flufenamic acid, ibufenac, fempfen, al Non-steroid anti-inflammatory drugs such as clofenac, phenylbutazone, mefenamic acid, bendazac, piroxicam, flurbiprofen, pentazocine, buprenorphine hydrochloride, and butorphanol tartrate.
  • steroid anti-inflammatory agents include hydrocortisone, prednisolone, fluocinolone acetate, fludoxycortide, methylprednisolone, hydrocortisone acetate, triamcinolone acetate, dexamethasone, betamethasone acetate, Examples include diflucortron valerate, clobesol propionate, and fluocinonide.
  • vasodilators examples include diltiazem, verapamil, pentaerythritol tetranitrate, dipyridamole, isosorbide dinitrate, difludipine, nitroglycerin and the like.
  • agents for hypertension and arrhythmia include bupranolol, propanolol, athenolol, pindolol, quinidine sulfate, adimarin, alprenolol hydrochloride, metprolol tartrate, nadolol, timolol maleate, disopyramide and the like.
  • antihypertensive agents examples include clonidine hydrochloride, captopril, prazosin hydrochloride, pentolol sulfate, guanavenz acetate, guanfacine hydrochloride, bunazosin hydrochloride, elanapril maleate, arotinolol hydrochloride, and bunitrolol hydrochloride.
  • antitussive expectorants examples include propoterol hydrochloride, terbutaline sulfate, phenoterol hydrobromide, rlobbuterol hydrochloride, amproxol hydrochloride, pyrbuterol hydrochloride, mabuterol hydrochloride, clenbuterol hydrochloride, trimethokinol hydrochloride, and formoterol fumarate. No.
  • antitumor agent examples include 5-fluorouracil, 1- (2-tetrahydrofurfuryl) -15-fluorouracil, mitomycin C and the like.
  • Examples of the local anesthetic include benzocaine, procarin, lidocaine, and tetracaine.
  • hormonal agents include steroid hormones such as estrogen, estradiol, testosterone, and progesterone, peptide hormones such as insulin, and prostaglandins.
  • Examples of the therapeutic agent for asthma and nasal allergy include ketotifan fumarate, azelastine hydrochloride, sodium cromoglycate and the like.
  • antihistamine examples include cycloheptadine hydrochloride, diphenhydramine hydrochloride, fenbenzamine, mequitazine and the like.
  • anticoagulants examples include heparin.
  • antispasmodics examples include scopolamine and clofluverol.
  • cerebral circulation and metabolism improving agents examples include vinpocetine, flunarizine hydrochloride, dicardipine hydrochloride, provincamine fumarate, dihydroergotoxine mesylate, ifenprodil tartrate, isoxsuprine hydrochloride and the like.
  • antidepressants / anxiolytics examples include maprotiline hydrochloride, etizolam, diazebam, promazepam, amitributyline hydrochloride, mianserin hydrochloride and the like.
  • Examples of vitamin D preparations include alfacalcidol and ergocalciferol.
  • hypoglycemic agents examples include glibenclamide, gliclazide and the like.
  • anti-ulcer agents examples include crepopride malate, famotidine, glycopyrronium bromide and the like.
  • hypnotics examples include phenobarbital, amobarbital, etc.o
  • antibiotics examples include tetracycline, chloramphenicol, etc.o
  • bactericide examples include chlorhexidine diglyconate, acrynol and the like.
  • coronary vasodilators include nitroglycerin, isosorbitol dinatrate, glycol dinitrate, triethanolamine trinitrate, pentaerythritol tetranitrate, propachinitritol, nicorandil and the like.
  • the tranquilizer include flupanazine, thioridasin, and diazepam.
  • suitable contained substances include perapamil, galopamil, anipamil, piperidene, haloperidol, and the like.
  • antitussives and antidepressants include morphine hydrochloride and morphine sulfate.
  • a pressure ulcer medicine containing a mixture of sucrose, povidone and glycerin, and a patch for treating skin ulcer.
  • Cool-sensitive skin irritants include 1-menthol, d1-camphor, thymol, d-borneol and the like.
  • warm skin irritants examples include red pepper, vanillyl nonylate, capsaicin, ginger extract, cantharis tincture, and cantharidin.
  • a cosmetic pack containing a beauty active substance such as hyaluronic acid, amino acid, protein, hormone, natural substance such as placental extract substance, surfactant, skin lightening substance, vitamin and the like may be used.
  • a hair removal tape or a poultice containing a hair removal agent may be used.
  • miso sheet as a patch for the treatment of fever
  • a material containing oxycellulose, oxidized collagen, sodium cellulose, calcium alginate and the like may be used.
  • the support of the present invention has the above-described configuration, even when a conventional patch made of a soft base material is used, the base material can be temporarily made rigid at the time of application. Therefore, even when the protective film or the like is peeled off from the patch or when the patch is applied to a desired affected area after the protective film or the like is peeled off, it is possible to effectively prevent the sticking of the adhesive surfaces from each other. it can.
  • the belt portion into a tubular shape or a bag shape through which a finger can be inserted, for example, over the entire width of the support member, when the patch is stuck to a desired affected part, Since several fingers can be inserted between the belt and the belt, the patch can be applied smoothly, and when the support is released after the patch is applied. This can be done smoothly.
  • the belt portion is formed in a tubular shape or a bag shape through which a finger of a hand can be inserted, for example, over the entire width of the support member. Since a plurality of fingers can be inserted in a state in which the fingers are arranged in between, the patch can be smoothly applied and the support member can be smoothly separated when the support member is separated from the base material.
  • a patch having a soft base material provides a patch that does not stick to the adhesive surfaces and is easy for patients to apply to affected areas such as shoulders, back, and waist. This makes it easier for children, the physically handicapped, and the elderly with poor vision to stick to the affected area and has great medical value.

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Biomedical Technology (AREA)
  • Dermatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
  • Medicinal Preparation (AREA)
  • Materials For Medical Uses (AREA)

Abstract

L'invention concerne un support pour timbres transdermiques, destiné à donner une rigidité temporaire à un substrat, en étant collé sur une surface opposée à une surface à coller du substrat du timbre. Ce support comprend une surface collante (3), laquelle possède une viscosité inférieure à celle d'un timbre et est appliquée sur une des surfaces d'un élément (2) présentant une rigidité appropriée et fabriqué dans un tissu, du papier, un textile non tissé, un film plastique, etc., ainsi qu'une portion ceinturante cylindrique ou de type poche (4) permettant l'insertion de doigts dans celle-ci, et placée sur la surface opposée à la surface collante (3). L'invention concerne également des timbres transdermiques sur lesquels on a collé à l'avance le support.
PCT/JP1998/003614 1997-08-13 1998-08-13 Support pour timbres transdermiques et timbres dotes d'un tel support WO1999008664A1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
KR1020007001358A KR20010022758A (ko) 1997-08-13 1998-08-13 패치용 지지구 및 이 지지구를 구비한 패치
AU86487/98A AU8648798A (en) 1997-08-13 1998-08-13 Support for patches and patches provided with the support

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP9/231714 1997-08-13
JP23171497 1997-08-13

Publications (1)

Publication Number Publication Date
WO1999008664A1 true WO1999008664A1 (fr) 1999-02-25

Family

ID=16927872

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP1998/003614 WO1999008664A1 (fr) 1997-08-13 1998-08-13 Support pour timbres transdermiques et timbres dotes d'un tel support

Country Status (3)

Country Link
KR (1) KR20010022758A (fr)
AU (1) AU8648798A (fr)
WO (1) WO1999008664A1 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6963809B2 (en) 2000-06-14 2005-11-08 Abb Research Ltd. Gas meter
US9850480B2 (en) 2009-04-03 2017-12-26 Sequenom, Inc. Nucleic acid preparation compositions and methods

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20010083439A (ko) * 2000-02-14 2001-09-01 원인호 활성자석파스 및 이의 제조방법

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1984001285A1 (fr) * 1982-09-28 1984-04-12 American Hospital Supply Corp Systeme et procede de bandage d'un patient
JPS6277314A (ja) * 1985-09-30 1987-04-09 Nitto Electric Ind Co Ltd 医薬製剤
JPH01107761A (ja) * 1987-09-15 1989-04-25 Smith & Nephew Plc 接着剤塗布ドレッシングとそのアプリケーター

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1984001285A1 (fr) * 1982-09-28 1984-04-12 American Hospital Supply Corp Systeme et procede de bandage d'un patient
JPS6277314A (ja) * 1985-09-30 1987-04-09 Nitto Electric Ind Co Ltd 医薬製剤
JPH01107761A (ja) * 1987-09-15 1989-04-25 Smith & Nephew Plc 接着剤塗布ドレッシングとそのアプリケーター

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6963809B2 (en) 2000-06-14 2005-11-08 Abb Research Ltd. Gas meter
US9850480B2 (en) 2009-04-03 2017-12-26 Sequenom, Inc. Nucleic acid preparation compositions and methods

Also Published As

Publication number Publication date
KR20010022758A (ko) 2001-03-26
AU8648798A (en) 1999-03-08

Similar Documents

Publication Publication Date Title
US11918097B2 (en) Device for delivery of skin care composition
US7063859B1 (en) Barrier film lined backing layer composition and method for topical administration of active agents
US5662925A (en) Transdermal delivery system with adhesive overlay and peel seal disc
ES2651020T3 (es) Un producto de vendaje
RU2542091C2 (ru) Медицинский приклеиваемый при надавливании лейкопластырь
RU2442610C2 (ru) Расслаиваемый материал кожного пластыря
JPH01107761A (ja) 接着剤塗布ドレッシングとそのアプリケーター
KR100740056B1 (ko) 신축성 첩부제
JP2004512356A (ja) 改善された水分吸収能および接着性を有する経皮投与剤
JPH03139348A (ja) 自制造瘻患者用包帯
CA2634376A1 (fr) Timbre adhesif
US20130304002A1 (en) Sheet and liquid combination systems for dermal drug delivery
KR20050044656A (ko) 장기간 수송 편의성이 향상된 경피 치료 시스템
JP4799783B2 (ja) 伸縮性外用貼付剤
JP3002772B2 (ja) 貼付剤及びその製造法
WO1999008664A1 (fr) Support pour timbres transdermiques et timbres dotes d'un tel support
JP2837337B2 (ja) 貼付剤
JPH1067652A (ja) 貼付剤用支持体及びそれを用いた貼付剤
JPH06145050A (ja) 貼付剤の製造方法
JP3188587B2 (ja) 温熱性貼付剤
WO2009084611A1 (fr) Feuille antiprurigineuse
PT1732487E (pt) Emplastro medicinal para a aplicação sobre a pele
JP2000175960A (ja) 貼付剤
JP3197035B2 (ja) 口腔粘膜適用製剤
JP2000175961A (ja) 貼付剤

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A1

Designated state(s): AL AM AT AU AZ BA BB BG BR BY CA CH CN CU CZ DE DK EE ES FI GB GE GH HR HU ID IL IS JP KE KG KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT UA UG US UZ VN YU ZW

AL Designated countries for regional patents

Kind code of ref document: A1

Designated state(s): GH GM KE LS MW SD SZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
121 Ep: the epo has been informed by wipo that ep was designated in this application
WWE Wipo information: entry into national phase

Ref document number: 1020007001358

Country of ref document: KR

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

122 Ep: pct application non-entry in european phase
NENP Non-entry into the national phase

Ref country code: CA

WWP Wipo information: published in national office

Ref document number: 1020007001358

Country of ref document: KR

WWW Wipo information: withdrawn in national office

Ref document number: 1020007001358

Country of ref document: KR