WO1998036755A1 - Sulfonylurea-glitazone synergistic combinations for diabetes - Google Patents

Sulfonylurea-glitazone synergistic combinations for diabetes Download PDF

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Publication number
WO1998036755A1
WO1998036755A1 PCT/US1997/021996 US9721996W WO9836755A1 WO 1998036755 A1 WO1998036755 A1 WO 1998036755A1 US 9721996 W US9721996 W US 9721996W WO 9836755 A1 WO9836755 A1 WO 9836755A1
Authority
WO
WIPO (PCT)
Prior art keywords
baseline
troglitazone
glyburide
patients
mean
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US1997/021996
Other languages
English (en)
French (fr)
Inventor
Randall W. Whitcomb
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Warner Lambert Co LLC
Original Assignee
Warner Lambert Co LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to IL13002797A priority Critical patent/IL130027A/xx
Priority to CA002272478A priority patent/CA2272478A1/en
Priority to SK1118-99A priority patent/SK111899A3/sk
Priority to JP53661198A priority patent/JP2001512478A/ja
Priority to NZ336002A priority patent/NZ336002A/en
Priority to EA199900725A priority patent/EA199900725A1/ru
Priority to EP97952250A priority patent/EP0957923A1/en
Priority to EEP199900345A priority patent/EE9900345A/xx
Priority to BR9714505A priority patent/BR9714505A/pt
Application filed by Warner Lambert Co LLC filed Critical Warner Lambert Co LLC
Priority to HU0001528A priority patent/HUP0001528A3/hu
Priority to AU55908/98A priority patent/AU741215B2/en
Priority to PL97335166A priority patent/PL335166A1/xx
Publication of WO1998036755A1 publication Critical patent/WO1998036755A1/en
Priority to IS5058A priority patent/IS5058A/is
Priority to NO993982A priority patent/NO993982D0/no
Priority to BG103671A priority patent/BG103671A/xx
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/64—Sulfonylureas, e.g. glibenclamide, tolbutamide, chlorpropamide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Definitions

  • glitazones include:
  • Troglitazone was supplied in the form of 200-mg tablets (Table 2) . Matching glyburide tablets were also supplied to maintain blinding.
  • beta blockers which block the acute adrenergic symptoms (the early warnings) of hypoglycemia .
  • Previous oral antidiabetic medications were discontinued upon completion of screening and start of the baseline phase.
  • Lipid Indicator 2 included Apo Al, Apo B, and Lp(a) .
  • Characteristics of Total Patient Sample Characteristics of all patients randomized to treatment are summarized in Table 4; overall, 40% of the patients were women and 26% were ⁇ 65 years of age (mean age 58 years) . Patients were evenly distributed across treatment groups with respect to sex and race. Mean age, duration of diabetes, and body mass index (BMI) were also similar across treatments. The mean BMI of 32 mg/kg indicates that, in general, the patients were obese. Overall, the mean duration of diabetes was greater than 8 years; mean FSG was 224 mg/dL and mean HbA- j _ c was 9.6%, indicating that these patients were generally in poor glycemic control at baseline.
  • BMI Body Mass Index

Landscapes

  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Obesity (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
PCT/US1997/021996 1997-02-19 1997-12-01 Sulfonylurea-glitazone synergistic combinations for diabetes Ceased WO1998036755A1 (en)

Priority Applications (15)

Application Number Priority Date Filing Date Title
BR9714505A BR9714505A (pt) 1997-02-19 1997-12-01 para o diabetes.
SK1118-99A SK111899A3 (en) 1997-02-19 1997-12-01 Sulfonylurea-glitazone synergistic combinations for diabetes
HU0001528A HUP0001528A3 (en) 1997-02-19 1997-12-01 Sulfonylurea-glitazone synergic combinations for diabetes
NZ336002A NZ336002A (en) 1997-02-19 1997-12-01 Sulfonylurea and glitazone synergistic combinations for treatment of non-insulin dependent diabetes mellitus
EA199900725A EA199900725A1 (ru) 1997-02-19 1997-12-01 Синергетические комбинации сульфонилмочевины и глитазона при лечении диабета
EP97952250A EP0957923A1 (en) 1997-02-19 1997-12-01 Sulfonylurea-glitazone synergistic combinations for diabetes
EEP199900345A EE9900345A (et) 1997-02-19 1997-12-01 Sulfonüülkarbamiidi ja glitasooni sünergistilised kombinatsioonid diabeedi raviks
IL13002797A IL130027A (en) 1997-02-19 1997-12-01 Rosiglitazone - glyburide synergistic combinations for treatment of diabetes
JP53661198A JP2001512478A (ja) 1997-02-19 1997-12-01 糖尿病のためのスルホニル尿素−グリタゾン相乗的組み合わせ物
CA002272478A CA2272478A1 (en) 1997-02-19 1997-12-01 Sulfonylurea-glitazone synergistic combinations for diabetes
AU55908/98A AU741215B2 (en) 1997-02-19 1997-12-01 Sulfonylurea-glitazone synergistic combinations for diabetes
PL97335166A PL335166A1 (en) 1997-02-19 1997-12-01 Synergic combination of sulphonylurea and glytazone
IS5058A IS5058A (is) 1997-02-19 1999-05-27 Samverkandi súlfónýlþvagefnis-glitasónsblöndur við sykursýki
NO993982A NO993982D0 (no) 1997-02-19 1999-08-18 Synergistiske sulfonylurea-glitazone-kombinasjoner for diabetes
BG103671A BG103671A (en) 1997-02-19 1999-08-19 Combinations of sulphonylcarbamide-glytazone having synergetic effect for the treatment of diabetes

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US3822497P 1997-02-19 1997-02-19
US60/038,224 1997-02-19

Publications (1)

Publication Number Publication Date
WO1998036755A1 true WO1998036755A1 (en) 1998-08-27

Family

ID=21898725

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1997/021996 Ceased WO1998036755A1 (en) 1997-02-19 1997-12-01 Sulfonylurea-glitazone synergistic combinations for diabetes

Country Status (29)

Country Link
US (2) US5859037A (https=)
EP (1) EP0957923A1 (https=)
JP (1) JP2001512478A (https=)
KR (1) KR20000071179A (https=)
CN (1) CN1244801A (https=)
AR (1) AR011829A1 (https=)
AU (1) AU741215B2 (https=)
BG (1) BG103671A (https=)
BR (1) BR9714505A (https=)
CA (1) CA2272478A1 (https=)
CZ (1) CZ289299A3 (https=)
EA (1) EA199900725A1 (https=)
EE (1) EE9900345A (https=)
GT (1) GT199800037A (https=)
HN (1) HN1997000167A (https=)
HU (1) HUP0001528A3 (https=)
IL (1) IL130027A (https=)
IS (1) IS5058A (https=)
NO (1) NO993982D0 (https=)
NZ (1) NZ336002A (https=)
PA (1) PA8447401A1 (https=)
PE (1) PE74399A1 (https=)
PL (1) PL335166A1 (https=)
SK (1) SK111899A3 (https=)
SV (1) SV1998000010A (https=)
TR (1) TR199902033T2 (https=)
UY (1) UY24893A1 (https=)
WO (1) WO1998036755A1 (https=)
ZA (1) ZA981343B (https=)

Cited By (10)

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WO1998057649A1 (en) * 1997-06-18 1998-12-23 Smithkline Beecham Plc Treatment of diabetes with thiazolidinedione and sulphonylurea
WO1999003476A1 (en) * 1997-07-18 1999-01-28 Smithkline Beecham Plc Treatment of diabetes with thiazolidinedione and sulphonylurea
EP1145717A3 (en) * 2000-04-13 2002-08-14 Pfizer Products Inc. Synergistic effect of a sulfonylurea and/or non-sulfonylurea K plus ATP channel blocker, and a phosphodiesterase 3 type inhibitor
JP2003515523A (ja) * 1998-12-24 2003-05-07 メタベイシス・セラピューティクス・インコーポレーテッド 糖尿病治療のためのｆｂｐアーゼ阻害物質とインスリンセンシタイザの組み合わせ
WO2005041962A1 (en) 2003-10-31 2005-05-12 Takeda Pharmaceutical Company Limited Solid preparation comprising an insulin sensitizer, an insulin secretagogue and a polyoxyethylene sorbitan fatty acid ester
WO2006033568A1 (es) * 2004-09-23 2006-03-30 Jorge Luis Rosado Loria Composicion sinergistica para el tratamiento de diabetes y sus comorbilidades
US7045519B2 (en) 1998-06-19 2006-05-16 Chiron Corporation Inhibitors of glycogen synthase kinase 3
WO2007072992A2 (en) 2005-12-22 2007-06-28 Takeda Pharmaceutical Company Limited Solid preparation containing an insulin sensitizer
EP2036554A1 (en) * 2000-06-19 2009-03-18 SmithKline Beecham plc Combinations of dipeptidyl peptidase iv inhibitors and other antidiabetic agents for the treatment for diabetes mellitus
US10117834B2 (en) 2007-12-04 2018-11-06 Biogen Chesapeake Llc Formulations and methods for lyophilization and lyophilates provided thereby

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US20030153607A1 (en) * 1998-11-12 2003-08-14 Smithkline Beecham P.L.C. Novel composition and use
US20040102486A1 (en) * 1998-11-12 2004-05-27 Smithkline Beecham Corporation Novel method of treatment
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EP2266576A1 (en) * 1997-06-18 2010-12-29 SmithKline Beecham Limited Treatment of diabetes with thiazolidinedione and sulphonylurea
CZ299310B6 (cs) * 1997-06-18 2008-06-18 Smithkline Beecham Plc Lécivo pro lécbu diabetes mellitus a stavu spojených s diabetes mellitus
EP1671637A3 (en) * 1997-06-18 2007-12-19 SmithKline Beecham P.L.C. Treatment of diabetes with thiazolidinedione and sulphonylurea
WO1998057649A1 (en) * 1997-06-18 1998-12-23 Smithkline Beecham Plc Treatment of diabetes with thiazolidinedione and sulphonylurea
AP1318A (en) * 1997-07-18 2004-10-22 Smithkline Beecham Plc Treatment of diabetes with thiazolidinedione and sulphonylurea.
CZ302668B6 (cs) * 1997-07-18 2011-08-24 Smithkline Beecham Plc Farmaceutický prostredek obsahující 5-[4-[2-(N-methyl-N-(2-pyridyl)amino)ethoxy]benzyl]thiazolidin-2,4-dion a jeho použití
EA003303B1 (ru) * 1997-07-18 2003-04-24 Смитклайн Бичам Плс Способ лечения диабета тиазолидиндионом и сульфонилмочевиной
WO1999003476A1 (en) * 1997-07-18 1999-01-28 Smithkline Beecham Plc Treatment of diabetes with thiazolidinedione and sulphonylurea
US7045519B2 (en) 1998-06-19 2006-05-16 Chiron Corporation Inhibitors of glycogen synthase kinase 3
US7425557B2 (en) 1998-06-19 2008-09-16 Novartis Vaccines And Diagnostics, Inc. Inhibitors of glycogen synthase kinase 3
JP2003515523A (ja) * 1998-12-24 2003-05-07 メタベイシス・セラピューティクス・インコーポレーテッド 糖尿病治療のためのｆｂｐアーゼ阻害物質とインスリンセンシタイザの組み合わせ
US6610746B2 (en) 2000-04-13 2003-08-26 Pfizer Inc. Synergistic effect of a sulfonylurea and/or non-sulfonylurea K+ATP channel blocker, and a phosphodiesterase 3 type inhibitor
EP1145717A3 (en) * 2000-04-13 2002-08-14 Pfizer Products Inc. Synergistic effect of a sulfonylurea and/or non-sulfonylurea K plus ATP channel blocker, and a phosphodiesterase 3 type inhibitor
EP2036554A1 (en) * 2000-06-19 2009-03-18 SmithKline Beecham plc Combinations of dipeptidyl peptidase iv inhibitors and other antidiabetic agents for the treatment for diabetes mellitus
US7700128B2 (en) 2003-10-31 2010-04-20 Takeda Pharmaceutical Company Limited Solid preparation comprising an insulin sensitizer, an insulin secretagogue and a polyoxyethylene sorbitan fatty acid ester
WO2005041962A1 (en) 2003-10-31 2005-05-12 Takeda Pharmaceutical Company Limited Solid preparation comprising an insulin sensitizer, an insulin secretagogue and a polyoxyethylene sorbitan fatty acid ester
WO2006033568A1 (es) * 2004-09-23 2006-03-30 Jorge Luis Rosado Loria Composicion sinergistica para el tratamiento de diabetes y sus comorbilidades
WO2007072992A2 (en) 2005-12-22 2007-06-28 Takeda Pharmaceutical Company Limited Solid preparation containing an insulin sensitizer
US8071130B2 (en) 2005-12-22 2011-12-06 Takeda Pharmaceutical Company Limited Solid preparation
US10117834B2 (en) 2007-12-04 2018-11-06 Biogen Chesapeake Llc Formulations and methods for lyophilization and lyophilates provided thereby
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PE74399A1 (es) 1999-08-20
EA199900725A1 (ru) 2000-04-24
SK111899A3 (en) 2000-09-12
AR011829A1 (es) 2000-09-13
AU5590898A (en) 1998-09-09
HN1997000167A (es) 1999-02-09
GT199800037A (es) 1999-08-12
HUP0001528A2 (hu) 2000-11-28
EE9900345A (et) 2000-02-15
IS5058A (is) 1999-05-27
TR199902033T2 (xx) 2000-02-21
CZ289299A3 (cs) 1999-11-17
ZA981343B (en) 1998-11-16
CA2272478A1 (en) 1998-08-27
US5972973A (en) 1999-10-26
IL130027A0 (en) 2000-02-29
BR9714505A (pt) 2000-03-21
UY24893A1 (es) 1998-07-10
HUP0001528A3 (en) 2000-12-28
AU741215B2 (en) 2001-11-29
PA8447401A1 (es) 2001-12-14
JP2001512478A (ja) 2001-08-21
NZ336002A (en) 2002-03-28
PL335166A1 (en) 2000-04-10
SV1998000010A (es) 1999-02-02
NO993982L (no) 1999-08-18
IL130027A (en) 2005-09-25
EP0957923A1 (en) 1999-11-24
US5859037A (en) 1999-01-12
KR20000071179A (ko) 2000-11-25
NO993982D0 (no) 1999-08-18
BG103671A (en) 2000-04-28
CN1244801A (zh) 2000-02-16

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