WO1998034630A1 - Use of gastrointestinal lipase inhibitors - Google Patents
Use of gastrointestinal lipase inhibitors Download PDFInfo
- Publication number
- WO1998034630A1 WO1998034630A1 PCT/EP1998/000468 EP9800468W WO9834630A1 WO 1998034630 A1 WO1998034630 A1 WO 1998034630A1 EP 9800468 W EP9800468 W EP 9800468W WO 9834630 A1 WO9834630 A1 WO 9834630A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- tetrahydrolipstatin
- gastrointestinal lipase
- diabetes mellitus
- lipase inhibitor
- oral
- Prior art date
Links
- 230000002496 gastric effect Effects 0.000 title claims abstract description 14
- 229940127470 Lipase Inhibitors Drugs 0.000 title description 2
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims abstract description 14
- 229940086609 Lipase inhibitor Drugs 0.000 claims abstract description 12
- 239000003814 drug Substances 0.000 claims abstract description 8
- 238000004519 manufacturing process Methods 0.000 claims abstract description 3
- AHLBNYSZXLDEJQ-FWEHEUNISA-N orlistat Chemical group CCCCCCCCCCC[C@H](OC(=O)[C@H](CC(C)C)NC=O)C[C@@H]1OC(=O)[C@H]1CCCCCC AHLBNYSZXLDEJQ-FWEHEUNISA-N 0.000 claims description 20
- 229960001243 orlistat Drugs 0.000 claims description 19
- AHLBNYSZXLDEJQ-UHFFFAOYSA-N N-formyl-L-leucylester Natural products CCCCCCCCCCCC(OC(=O)C(CC(C)C)NC=O)CC1OC(=O)C1CCCCCC AHLBNYSZXLDEJQ-UHFFFAOYSA-N 0.000 claims description 18
- 239000000203 mixture Substances 0.000 description 9
- 239000000902 placebo Substances 0.000 description 9
- 229940068196 placebo Drugs 0.000 description 9
- 206010012601 diabetes mellitus Diseases 0.000 description 7
- 239000007903 gelatin capsule Substances 0.000 description 6
- 238000007410 oral glucose tolerance test Methods 0.000 description 6
- 239000008188 pellet Substances 0.000 description 6
- 238000000034 method Methods 0.000 description 5
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 4
- 239000008103 glucose Substances 0.000 description 4
- 230000001771 impaired effect Effects 0.000 description 4
- 239000000454 talc Substances 0.000 description 4
- 229910052623 talc Inorganic materials 0.000 description 4
- 229920000168 Microcrystalline cellulose Polymers 0.000 description 3
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 3
- 239000008187 granular material Substances 0.000 description 3
- 238000005469 granulation Methods 0.000 description 3
- 230000003179 granulation Effects 0.000 description 3
- 229940016286 microcrystalline cellulose Drugs 0.000 description 3
- 235000019813 microcrystalline cellulose Nutrition 0.000 description 3
- 239000008108 microcrystalline cellulose Substances 0.000 description 3
- 239000008213 purified water Substances 0.000 description 3
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 3
- 229940079832 sodium starch glycolate Drugs 0.000 description 3
- 229920003109 sodium starch glycolate Polymers 0.000 description 3
- 239000008109 sodium starch glycolate Substances 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- 208000002705 Glucose Intolerance Diseases 0.000 description 2
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 2
- 229940100389 Sulfonylurea Drugs 0.000 description 2
- 239000000969 carrier Substances 0.000 description 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
- 239000003925 fat Substances 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 230000002218 hypoglycaemic effect Effects 0.000 description 2
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 2
- 239000008101 lactose Substances 0.000 description 2
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 2
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 2
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 2
- 201000009104 prediabetes syndrome Diseases 0.000 description 2
- 230000002265 prevention Effects 0.000 description 2
- 230000009467 reduction Effects 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
- 229920002261 Corn starch Polymers 0.000 description 1
- 238000000729 Fisher's exact test Methods 0.000 description 1
- 108010023302 HDL Cholesterol Proteins 0.000 description 1
- 102000001554 Hemoglobins Human genes 0.000 description 1
- 108010054147 Hemoglobins Proteins 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- 208000031226 Hyperlipidaemia Diseases 0.000 description 1
- 102000004877 Insulin Human genes 0.000 description 1
- 108090001061 Insulin Proteins 0.000 description 1
- 108010028554 LDL Cholesterol Proteins 0.000 description 1
- 238000008214 LDL Cholesterol Methods 0.000 description 1
- 108010007622 LDL Lipoproteins Proteins 0.000 description 1
- 235000019759 Maize starch Nutrition 0.000 description 1
- 208000008589 Obesity Diseases 0.000 description 1
- 206010033307 Overweight Diseases 0.000 description 1
- 235000021355 Stearic acid Nutrition 0.000 description 1
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 description 1
- 230000005856 abnormality Effects 0.000 description 1
- 239000003472 antidiabetic agent Substances 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- 235000012000 cholesterol Nutrition 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 230000002542 deteriorative effect Effects 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 239000008298 dragée Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 230000002124 endocrine Effects 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000013355 food flavoring agent Nutrition 0.000 description 1
- 230000037406 food intake Effects 0.000 description 1
- 235000003599 food sweetener Nutrition 0.000 description 1
- 230000002641 glycemic effect Effects 0.000 description 1
- 229940126904 hypoglycaemic agent Drugs 0.000 description 1
- 229940125396 insulin Drugs 0.000 description 1
- 229960001375 lactose Drugs 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 235000012054 meals Nutrition 0.000 description 1
- 238000002483 medication Methods 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 235000020824 obesity Nutrition 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- 230000003204 osmotic effect Effects 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 229920005862 polyol Polymers 0.000 description 1
- 150000003077 polyols Chemical class 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- -1 such as Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 150000003626 triacylglycerols Chemical class 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 239000001993 wax Substances 0.000 description 1
- 239000013585 weight reducing agent Substances 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
Definitions
- Diabetes mellitus is a condition characterized by an abnormality of glucose utilization and associated with elevation of blood glucose concentration.
- the most common form of diabetes mellitus is non-insulin dependent diabetes mellitus
- NIDDM Type II diabetes mellitus
- Type II diabetes mellitus Over 10 million people in the United States alone are affected with type II diabetes mellitus. The initial approach in treating obese patients affected with type II diabetes mellitus is weight reduction. Other types of treatment include oral hypoglycemics and insulin. See, Gregerman, MD, Section 10, Metabolic and Endocrinological Problems, Chapter 72, Diabetes Mellitus, pages 977-989.
- the invention relates to the use of a gastrointestinal lipase inhibitor for the manufacture of oral medicaments for treating or preventing type II diabetes mellitus.
- the invention relates to an oral medicament for treating or preventing type II diabetes mellitus characterized in that it contains a gastrointestinal lipase inhibitor.
- the gastrointestinal lipase inhibitor is preferably tetrahydrolipstatin.
- Tetrahydrolipstatin also known as orlistat, is a known compound useful for the control or prevention of obesity and hyperlipidemia. See, U.S. Patent No. 4,598,089, issued July 1, 1986, which also discloses processes for making tetrahydrolipstatin.
- a gastrointestinal lipase inhibitor when administered orally is useful in the treatment and prevention of type II diabetes mellitus.
- a gastrointestinal lipase inhibitor preferably tetrahydrolipstatin
- a gastrointestinal lipase inhibitor when administered orally is useful in the treatment and prevention of type II diabetes mellitus.
- a gastrointestinal lipase inhibitor preferably tetrahydrolipstatin
- from 60 to 720 mg per day of the gastrointestinal lipase inhibitor are orally administered in divided doses two to three times per day.
- a gastrointestinal lipase inhibitor is administered to a subject, preferably in divided doses two or, particularly, three times per day.
- the subject is preferably an obese or overweight human, i.e. a human with a body mass index of 25 or greater.
- the gastrointestinal lipase inhibitor be administered within about one or two hours of ingestion of a meal containing fat.
- treatment be administered to 1 ) a human who has a strong family history of type II diabetes mellitus and has obtained a body mass index of 25 or greater; or 2) a human with impaired glucose tolerance who has obtained a body mass index of 25 or greater.
- the term crizstrong family history means a human with at least one first degree relative who has type II diabetes mellitus.
- impaired glucose tolerance would be diagnosed by an oral glucose tolerance test.
- Tetrahydrolipstatin can be administered to humans in conventional oral compositions, such as, tablets, coated tablets, hard and soft gelatin capsules, emulsions or suspensions.
- carriers which can be used for tablets, coated tablets, dragees and hard gelatin capsules are lactose, maize starch or derivatives thereof, talc, stearic acid or its salts and the like.
- Suitable carriers for soft gelatin capsules are, for example, vegetable oils, waxes, fats, semi-solid and liquid polyols and the like.
- the pharmaceutical preparations can contain preserving agents, solubilizers, stabilizing agents, wetting agents, emulsifying agents, sweetening agents, coloring agents, flavoring agents, salts for varying the osmotic pressure, buffers, coating agents or antioxidants. They can also contain still other therapeutically valuable substances.
- the formulations may conveniently be presented in unit dosage form and may be prepared by any methods known in the pharmaceutical art.
- tetrahydrolipstatin is administered according to the formulation of Example 1.
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Plant Substances (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Priority Applications (16)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK98908008T DK1017408T3 (da) | 1997-02-05 | 1998-01-29 | Anvendelse af tetrahydrolipstatin i behandling af diabetes type II |
| PL334975A PL191222B1 (pl) | 1997-02-05 | 1998-01-29 | Zastosowanie tetrahydrolipstatyny do wytwarzania doustnego farmaceutycznego preparatu do leczenia cukrzycy typu II |
| AT98908008T ATE292975T1 (de) | 1997-02-05 | 1998-01-29 | Verwendung von tetrahydolipstatin in der behandlung von diabetes typ ii |
| DE69829763T DE69829763T2 (de) | 1997-02-05 | 1998-01-29 | Verwendung von tetrahydolipstatin in der behandlung von diabetes typ ii |
| AU66169/98A AU740375B2 (en) | 1997-02-05 | 1998-01-29 | Use of gastrointestinal lipase inhibitors |
| IL13100798A IL131007A0 (en) | 1997-02-05 | 1998-01-29 | Use of gastrointestinal lipase inhibitors |
| NZ336755A NZ336755A (en) | 1997-02-05 | 1998-01-29 | Use of gastrointestinal lipase inhibitors in particular tetrahydrolipstatin (orlistat) |
| CA2278854A CA2278854C (en) | 1997-02-05 | 1998-01-29 | Use of the gastrointestinal lipase inhibitor tetrahydrolipstatin for treating type ii diabetes |
| EP98908008A EP1017408B1 (en) | 1997-02-05 | 1998-01-29 | Use of tethrahydrolipstatin in the treatment of diabetes type ii |
| HU0001014A HU230834B1 (hu) | 1997-02-05 | 1998-01-29 | Tetrahidrolipsztatin felhasználása |
| HK00104500.5A HK1025251B (en) | 1997-02-05 | 1998-01-29 | Use of gastrointestinal lipase inhibitors |
| BR9807655-8A BR9807655A (pt) | 1997-02-05 | 1998-01-29 | Uso de inibidores de lipase gastrintestinal. |
| MEP-903/08A ME00578A (en) | 1997-02-05 | 1998-01-29 | Use of gastrointestinal lipase inhibitors |
| KR10-1999-7006983A KR100479968B1 (ko) | 1997-02-05 | 1998-01-29 | 위장 리파아제 억제제의 용도 |
| JP53371598A JP2001509173A (ja) | 1997-02-05 | 1998-01-29 | 胃腸リパーゼ阻害剤の使用 |
| NO19993717A NO324452B1 (no) | 1997-02-05 | 1999-07-30 | Anvendelse av tetrahydrolipstatin til fremstilling av medikamenter mot diabetes |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3738397P | 1997-02-05 | 1997-02-05 | |
| US60/037,383 | 1997-02-05 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| WO1998034630A1 true WO1998034630A1 (en) | 1998-08-13 |
Family
ID=21894047
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/EP1998/000468 WO1998034630A1 (en) | 1997-02-05 | 1998-01-29 | Use of gastrointestinal lipase inhibitors |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US6147108A (cs) |
| EP (1) | EP1017408B1 (cs) |
| JP (1) | JP2001509173A (cs) |
| KR (1) | KR100479968B1 (cs) |
| CN (1) | CN1154505C (cs) |
| AR (1) | AR011106A1 (cs) |
| AT (1) | ATE292975T1 (cs) |
| AU (1) | AU740375B2 (cs) |
| BR (1) | BR9807655A (cs) |
| CA (1) | CA2278854C (cs) |
| CZ (1) | CZ295567B6 (cs) |
| DE (1) | DE69829763T2 (cs) |
| DK (1) | DK1017408T3 (cs) |
| ES (1) | ES2239799T3 (cs) |
| HU (1) | HU230834B1 (cs) |
| ID (1) | ID22650A (cs) |
| IL (1) | IL131007A0 (cs) |
| ME (1) | ME00578A (cs) |
| NO (1) | NO324452B1 (cs) |
| NZ (1) | NZ336755A (cs) |
| PL (1) | PL191222B1 (cs) |
| PT (1) | PT1017408E (cs) |
| RU (1) | RU2201272C2 (cs) |
| TR (1) | TR199901853T2 (cs) |
| WO (1) | WO1998034630A1 (cs) |
| YU (1) | YU34199A (cs) |
| ZA (1) | ZA98753B (cs) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6147108A (en) * | 1997-02-05 | 2000-11-14 | Hoffman-La Roche Inc. | Method for treating type II diabetes mellitus |
| WO2001019340A1 (en) * | 1999-09-13 | 2001-03-22 | F. Hoffmann-La Roche Ag | Dispersion formulations containing lipase inhibitors |
| EP1134231A1 (en) | 2000-03-14 | 2001-09-19 | Unilever N.V. | Antibody heavy chain variable domains against human dietary enzymes, and their uses |
| US6703369B1 (en) | 1999-09-13 | 2004-03-09 | Hoffman-La Roche Inc. | Lipase inhibiting compositions |
| WO2009050720A1 (en) * | 2007-10-15 | 2009-04-23 | Inventis Dds Pvt Limited | Pharmaceutical composition of orlistat |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6867183B2 (en) | 2001-02-15 | 2005-03-15 | Nobex Corporation | Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith |
| US7060675B2 (en) | 2001-02-15 | 2006-06-13 | Nobex Corporation | Methods of treating diabetes mellitus |
| US6828297B2 (en) | 2001-06-04 | 2004-12-07 | Nobex Corporation | Mixtures of insulin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same |
| US7196059B2 (en) | 2001-09-07 | 2007-03-27 | Biocon Limited | Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith |
| US7053080B2 (en) * | 2001-09-21 | 2006-05-30 | Schering Corporation | Methods and therapeutic combinations for the treatment of obesity using sterol absorption inhibitors |
| AU2003236521A1 (en) | 2002-06-13 | 2003-12-31 | Nobex Corporation | Methods of reducing hypoglycemic episodes in the treatment of diabetes mellitus |
| US9174176B2 (en) | 2003-01-09 | 2015-11-03 | Disperse Systems, Inc. | Ultrasonic dispersion apparatus, system, and method |
| RU2248793C1 (ru) * | 2003-11-13 | 2005-03-27 | Лазебник Леонид Борисович | Способ лечения стеатогепатитов |
| US7510849B2 (en) * | 2004-01-29 | 2009-03-31 | Glucolight Corporation | OCT based method for diagnosis and therapy |
| ES2535823T3 (es) | 2004-07-19 | 2015-05-18 | Biocon Limited | Conjugados insulina-oligómero, formulaciones y usos de estos |
| US7254429B2 (en) | 2004-08-11 | 2007-08-07 | Glucolight Corporation | Method and apparatus for monitoring glucose levels in a biological tissue |
| US8036727B2 (en) | 2004-08-11 | 2011-10-11 | Glt Acquisition Corp. | Methods for noninvasively measuring analyte levels in a subject |
| EP1874178A4 (en) | 2005-04-13 | 2009-12-09 | Glucolight Corp | METHOD OF DECREASING AND CALIBRATION OF DATA OF A CROSS-REFERENCE OF A BLOOD GLUCOMETER BASED ON OPTICAL COHERENCE TOMOGRAPHY AND RELATED APPLICATIONS |
| US8217025B2 (en) * | 2006-11-17 | 2012-07-10 | Harbor Therapeutics, Inc. | Drug screening and treatment methods |
| ES2350798T3 (es) * | 2007-09-12 | 2011-01-27 | Mader S.R.L. | Composiciones farmacéuticas para uso oral para tratar a pacientes afectados por la obesidad. |
| KR101234540B1 (ko) | 2007-10-16 | 2013-02-19 | 바이오콘 리미티드 | 경구 투여가능한 고형 약제학적 조성물 및 그 제조방법 |
| US8571617B2 (en) | 2008-03-04 | 2013-10-29 | Glt Acquisition Corp. | Flowometry in optical coherence tomography for analyte level estimation |
| WO2010042499A1 (en) * | 2008-10-06 | 2010-04-15 | Banner Pharmacaps, Inc. | Stable solutions of orlistat for pharmaceutical dosage forms |
| FR3017536B1 (fr) * | 2014-02-18 | 2017-05-26 | Univ La Rochelle | Compositions pour la prevention et/ou le traitement de pathologies liees a l'alpha-glucosidase |
| WO2017161043A1 (en) | 2016-03-16 | 2017-09-21 | The J. David Gladstone Institutes | Methods and compositions for treating obesity and/or diabetes and for identifying candidate treatment agents |
| US20190022061A1 (en) * | 2017-07-21 | 2019-01-24 | Kieu Hoang | Statins (Atorvastatin) can lower blood sugar level in diabetic |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0638317A1 (de) * | 1993-08-05 | 1995-02-15 | F. Hoffmann-La Roche Ag | Pharmazeutisches Präparat |
| US5540917A (en) * | 1992-06-24 | 1996-07-30 | Hoffmann-La Roche Inc. | Biomass lipase inhibitor useful for treating adiposity |
| JPH09227398A (ja) * | 1996-02-20 | 1997-09-02 | Zeria Pharmaceut Co Ltd | 抗肥満剤 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
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- 1998-01-29 WO PCT/EP1998/000468 patent/WO1998034630A1/en active IP Right Grant
- 1998-01-29 CZ CZ19992651A patent/CZ295567B6/cs not_active IP Right Cessation
- 1998-01-29 EP EP98908008A patent/EP1017408B1/en not_active Revoked
- 1998-01-29 ID IDW990792A patent/ID22650A/id unknown
- 1998-01-29 PT PT98908008T patent/PT1017408E/pt unknown
- 1998-01-29 YU YU34199A patent/YU34199A/sh unknown
- 1998-01-29 CN CNB988023245A patent/CN1154505C/zh not_active Expired - Lifetime
- 1998-01-29 AU AU66169/98A patent/AU740375B2/en not_active Expired
- 1998-01-29 NZ NZ336755A patent/NZ336755A/en not_active IP Right Cessation
- 1998-01-29 TR TR1999/01853T patent/TR199901853T2/xx unknown
- 1998-01-29 BR BR9807655-8A patent/BR9807655A/pt not_active Application Discontinuation
- 1998-01-29 ES ES98908008T patent/ES2239799T3/es not_active Expired - Lifetime
- 1998-01-29 HU HU0001014A patent/HU230834B1/hu unknown
- 1998-01-29 CA CA2278854A patent/CA2278854C/en not_active Expired - Lifetime
- 1998-01-29 ZA ZA98753A patent/ZA98753B/xx unknown
- 1998-01-29 PL PL334975A patent/PL191222B1/pl unknown
- 1998-01-29 AT AT98908008T patent/ATE292975T1/de active
- 1998-01-29 KR KR10-1999-7006983A patent/KR100479968B1/ko not_active Expired - Lifetime
- 1998-01-29 DK DK98908008T patent/DK1017408T3/da active
- 1998-01-29 IL IL13100798A patent/IL131007A0/xx not_active IP Right Cessation
- 1998-01-29 DE DE69829763T patent/DE69829763T2/de not_active Expired - Lifetime
- 1998-01-29 JP JP53371598A patent/JP2001509173A/ja active Pending
- 1998-01-29 ME MEP-903/08A patent/ME00578A/xx unknown
- 1998-01-29 RU RU99118887/14A patent/RU2201272C2/ru active
- 1998-02-03 AR ARP980100471A patent/AR011106A1/es not_active Application Discontinuation
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1999
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Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6147108A (en) * | 1997-02-05 | 2000-11-14 | Hoffman-La Roche Inc. | Method for treating type II diabetes mellitus |
| WO2001019340A1 (en) * | 1999-09-13 | 2001-03-22 | F. Hoffmann-La Roche Ag | Dispersion formulations containing lipase inhibitors |
| AU769415B2 (en) * | 1999-09-13 | 2004-01-29 | Cheplapharm Arzneimittel Gmbh | Dispersion formulations containing lipase inhibitors |
| US6703369B1 (en) | 1999-09-13 | 2004-03-09 | Hoffman-La Roche Inc. | Lipase inhibiting compositions |
| RU2239428C2 (ru) * | 1999-09-13 | 2004-11-10 | Ф.Хоффманн-Ля Рош Аг | Дисперсионные композиции, содержащие ингибиторы липаз |
| CZ301901B6 (cs) * | 1999-09-13 | 2010-07-28 | F. Hoffmann-La Roche Ag | Farmaceutická kompozice obsahující inhibitor lipázy, zpusob její prípravy a použití |
| HRP20020205B1 (hr) * | 1999-09-13 | 2011-06-30 | F. Hoffmann - La Roche Ag | Disperzijske formulacije koje sadrže inhibitore lipaze |
| US8012494B2 (en) | 1999-09-13 | 2011-09-06 | Hoffmann-La Roche Inc. | Pharmaceutical compositions containing lipase inhibitors |
| EP1134231A1 (en) | 2000-03-14 | 2001-09-19 | Unilever N.V. | Antibody heavy chain variable domains against human dietary enzymes, and their uses |
| US7361741B2 (en) | 2000-03-14 | 2008-04-22 | Lipton, Division Of Conopco, Inc. | Antibody, or fragment thereof, capable of binding specifically to human pancreatic lipase |
| WO2009050720A1 (en) * | 2007-10-15 | 2009-04-23 | Inventis Dds Pvt Limited | Pharmaceutical composition of orlistat |
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