WO1998024405A1 - Cosmetiques de blanchissement de la peau - Google Patents

Cosmetiques de blanchissement de la peau Download PDF

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Publication number
WO1998024405A1
WO1998024405A1 PCT/CN1997/000141 CN9700141W WO9824405A1 WO 1998024405 A1 WO1998024405 A1 WO 1998024405A1 CN 9700141 W CN9700141 W CN 9700141W WO 9824405 A1 WO9824405 A1 WO 9824405A1
Authority
WO
WIPO (PCT)
Prior art keywords
black rice
whitening
rice extract
cosmetics
substance
Prior art date
Application number
PCT/CN1997/000141
Other languages
English (en)
Chinese (zh)
Inventor
Ming Zhu
Original Assignee
Ming Zhu
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ming Zhu filed Critical Ming Zhu
Priority to AU51870/98A priority Critical patent/AU5187098A/en
Publication of WO1998024405A1 publication Critical patent/WO1998024405A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9794—Liliopsida [monocotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/16—Emollients or protectives, e.g. against radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations

Definitions

  • the present invention relates to a whitening and anti-ultraviolet cosmetics, especially a whitening agent and anti-ultraviolet agent for cosmetics.
  • An object of the present invention is to use black rice extract in cosmetics as a whitening substance.
  • Another object of the present invention is to use black rice extract in cosmetics as an anti-ultraviolet substance.
  • a whitening cosmetic contains an effective amount of black rice extract as a whitening substance.
  • a cosmetic for preventing rough skin containing an effective amount of black rice extract as an anti-ultraviolet substance.
  • FIG. 1 shows the results of the whitening test of B16 cells using the black rice extract of Production Example 1.
  • Fig. 2 shows the results of the whitening test of B16 cells obtained using the black rice extract of Production Example 2.
  • Fig. 3 is an ultraviolet absorption chart (2% hydrochloric acid in methanol) of black rice extract of Production Example 1.
  • Fig. 4 is an ultraviolet absorption chart of a black rice extract of Production Example 2 (2% hydrochloric acid in methanol).
  • the inventors In order to find an ideal natural substance to be used as a whitening substance in cosmetics to increase the whiteness of human skin, the inventors have conducted long-term and extensive research. In the research, the inventors unexpectedly found that the black rice extract has ideal whitening effect, and at the same time has other beneficial characteristics Sex, such as preventing rough skin and so on.
  • Black rice is rice of the genus Oryzae and is edible. Because black rice has high nutritional value, people make black rice into black rice food or black rice beverage. The seed coat of black rice is black (purple), and the pigment of black rice is soluble in water. Therefore, people have extracted the pigment of black rice from black rice and used it as food coloring for food coloring.
  • Black rice extract is used in cosmetics, and there is no report that black rice extract is used in cosmetics as a whitening substance.
  • a whitening cosmetic contains an effective amount of black rice extract as a whitening substance. When the cosmetic is applied to a human body, the whiteness of the human skin can be increased.
  • Black rice extract is extracted from black rice. Black rice can be a variety of black rice from a variety of sources.
  • a cosmetic for preventing rough skin contains an effective amount of black rice extract.
  • a UV-resistant cosmetic contains an effective amount of black rice extract as a UV-resistant substance.
  • a cosmetic product contains an effective amount of black rice extract as a whitening and anti-violet light substance.
  • the black rice extract can be applied to cosmetics as a whitening substance and / or an anti-violet light substance.
  • Black rice extract can be formulated with common items used in cosmetics, such as snow flower cream, lotion, body cream, etc., and the formula of cosmetics can be adjusted according to different needs.
  • Various components commonly used in cosmetics can be used in the present invention, such as liquid oils such as squalene, solid oils such as beesyl alcohol, various active agents, moisturizing agents such as glycerin, and 1,3-butanediol.
  • a whitening substance for cosmetics includes black rice extract, which can increase the whiteness of human skin when it is applied to human skin.
  • an anti-ultraviolet substance for cosmetics includes black rice extract.
  • the black rice extract of the present invention can be prepared by a common method, and can also be prepared by a method invented by the inventor.
  • a method for preparing a black rice extract includes the following steps. First, to obtain the skin of black rice, a rice mill machine can be used to separate the skin of black rice from polished rice. The processed polished rice can be used for food processing or eating. The obtained epidermis is treated with water, alcohol or a mixture of water and alcohol. The treatment temperature is from normal temperature to 100 ° C, and the treatment time is from 30 minutes to 12 hours, preferably from 1 hour to 5 hours. During treatment, the epidermis accounts for % To 50%. Preferably under stirring, the speed of stirring 100 ⁇ 150 rpm, ultrasonic treatment can also be added.
  • the treated material was filtered to obtain a filtrate, and the filtrate was concentrated under vacuum in a N 2 atmosphere, and then freeze-dried to obtain a black rice extract.
  • the powder obtained in the filtration stage can also be treated under reduced pressure and dried to recover. .
  • the black rice extract obtained by the method of the present invention is a dark purple powder with a slight special odor and is soluble in water and water / ethanol mixed solution. Determination test:
  • the citrate buffer (pH 3.0) (1 + 100) of the black rice extract is red to dark purple, and it is alkaline and discolored when NaOH solution (1 + 25) is added.
  • Heavy metals for Pb, 2 (less than ⁇ g / g (l. Og, Japanese Pharmacopoeia test method, third method, comparison solution, lead standard solution is 2.0ml)
  • the effect of the black rice extract is as described above, and the first has whitening effect on the skin.
  • the second is to inhibit active oxygen.
  • Active oxygen oxidizes fatty acids to form acid compounds.
  • the biochemical film's lipid value can also oxidize and cause obstacles.
  • the generated oxides and reactive oxygen species can damage DNA and promote aging. This reactive oxygen species also affects the mechanism that produces melanin from amino acids, which is related to skin darkening. Inhibition of such reactive oxygen species is vital to the skin.
  • the black rice extract of the present invention has the effect of inhibiting such active oxygen, and when used in cosmetics, can prevent rough skin.
  • the cells were detached with 6ml of EDTA (ethylenediaminetetraacetic acid) reagent, and the number of cells was determined from a blood cell counting plate. Cytotoxicity and cell proliferation were determined by the t assay.
  • EDTA ethylenediaminetetraacetic acid
  • Extracts 1 and 2 show whitening effect at 125ppm and 62.5ppra concentrations, respectively. In addition, Above 250 ppm, it has a strong whitening effect, and it is also found that the number of cells is decreasing. See Figure 1 and Figure 2. Active oxygen inhibition test
  • the black rice extract has absorption at 240 ⁇ 340nm. This wavelength range includes UV-B, so the black rice extract has an anti-ultraviolet effect.
  • Black rice (long grain) is treated with a rice mill at 600 grams to obtain the skin of the black rice, which is added to the reaction container, and then 2000 ml of a 60:40 (water and alcohol) solution is added. Stir for 1 hour, then slowly stir for 10 minutes and treat with ultrasound. It was then centrifuged and filtered. The filtrate was concentrated under reduced pressure and then freeze-dried.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Dermatology (AREA)
  • Engineering & Computer Science (AREA)
  • Botany (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Toxicology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Cosmetics (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

Cette invention se réfère à l'utilisation, en termes de cosmétique, d'un extrait de son de riz noir comme agent de blanchissement de la peau agrémenté d'un écran total contre les U.V. Elle traite aussi des cosmétiques contenant cet extrait.
PCT/CN1997/000141 1996-12-05 1997-12-05 Cosmetiques de blanchissement de la peau WO1998024405A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU51870/98A AU5187098A (en) 1996-12-05 1997-12-05 Whitening cosmetics

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN96120760.4 1996-12-05
CN96120760A CN1132571C (zh) 1996-12-05 1996-12-05 增白化妆品

Publications (1)

Publication Number Publication Date
WO1998024405A1 true WO1998024405A1 (fr) 1998-06-11

Family

ID=5126560

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CN1997/000141 WO1998024405A1 (fr) 1996-12-05 1997-12-05 Cosmetiques de blanchissement de la peau

Country Status (3)

Country Link
CN (1) CN1132571C (fr)
AU (1) AU5187098A (fr)
WO (1) WO1998024405A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013249265A (ja) * 2012-05-30 2013-12-12 Bloom Classic Co Ltd 美白剤及び皮膚化粧料

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105113219B (zh) * 2015-09-29 2017-02-01 辽东学院 基于黑米花色素苷的棉织物抗紫外整理剂
CN106137828B (zh) * 2016-07-05 2020-08-28 上海相宜本草化妆品股份有限公司 黑米提取物及其制备方法和在化妆品中的应用
CN107998055A (zh) * 2017-11-30 2018-05-08 浙江海洋大学 微纳米鱼骨基海洋面膜的制备方法

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH05139984A (ja) * 1991-11-13 1993-06-08 Soken:Kk 米からの活性酸素消去剤
JPH05221844A (ja) * 1992-02-17 1993-08-31 Kyoei Kagaku Kogyo Kk 老化防止化粧料
JPH06192061A (ja) * 1991-12-10 1994-07-12 Soken Kk 化粧料
JPH06199679A (ja) * 1992-10-08 1994-07-19 Kyodo Nyugyo Kk チロシナ−ゼ活性阻害剤
JPH0710733A (ja) * 1993-06-18 1995-01-13 Soken Kk 米からの化粧料
JPH07267847A (ja) * 1994-03-30 1995-10-17 Soken Kk 米からの汚れ落し剤

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH05139984A (ja) * 1991-11-13 1993-06-08 Soken:Kk 米からの活性酸素消去剤
JPH06192061A (ja) * 1991-12-10 1994-07-12 Soken Kk 化粧料
JPH05221844A (ja) * 1992-02-17 1993-08-31 Kyoei Kagaku Kogyo Kk 老化防止化粧料
JPH06199679A (ja) * 1992-10-08 1994-07-19 Kyodo Nyugyo Kk チロシナ−ゼ活性阻害剤
JPH0710733A (ja) * 1993-06-18 1995-01-13 Soken Kk 米からの化粧料
JPH07267847A (ja) * 1994-03-30 1995-10-17 Soken Kk 米からの汚れ落し剤

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013249265A (ja) * 2012-05-30 2013-12-12 Bloom Classic Co Ltd 美白剤及び皮膚化粧料

Also Published As

Publication number Publication date
AU5187098A (en) 1998-06-29
CN1132571C (zh) 2003-12-31
CN1191109A (zh) 1998-08-26

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