WO1998000103A1 - Vitamin c delivery system - Google Patents
Vitamin c delivery system Download PDFInfo
- Publication number
- WO1998000103A1 WO1998000103A1 PCT/EP1997/002691 EP9702691W WO9800103A1 WO 1998000103 A1 WO1998000103 A1 WO 1998000103A1 EP 9702691 W EP9702691 W EP 9702691W WO 9800103 A1 WO9800103 A1 WO 9800103A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- siloxane
- ascorbic acid
- glycol
- vitamin
- esters
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/58—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing atoms other than carbon, hydrogen, halogen, oxygen, nitrogen, sulfur or phosphorus
- A61K8/585—Organosilicon compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/676—Ascorbic acid, i.e. vitamin C
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/89—Polysiloxanes
- A61K8/891—Polysiloxanes saturated, e.g. dimethicone, phenyl trimethicone, C24-C28 methicone or stearyl dimethicone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/89—Polysiloxanes
- A61K8/895—Polysiloxanes containing silicon bound to unsaturated aliphatic groups, e.g. vinyl dimethicone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/52—Stabilizers
Definitions
- the invention relates to a cosmetic product that can stably store ascorbic acid and then deliver same to the skin.
- Vitamin C also known by its common name of Vitamin C, has long been recognized as an active substance benefiting skin appearance. Vitamin C reportedly increases the production of collagen in human skin tissue. Wrinkles and fine lines are thereby reduced. An overall healthier and younger-looking appearance results. Vitamin C has also found utility as an ultraviolet ray blocking or absorbing agent. Whitening or bleaching skin compositions have also employed Vitamin C utilizing its property of interference with the melanin formation process. There also is a belief that ascorbic acid interacts with the human immune system to reduce sensitivity to skin aggravating chemicals. Reduced levels of Vitamin C concentration on the skin have also been implicated with an increase in stress. From all of the foregoing perspectives, Vitamin C or ascorbic acid may provide significant benefit when topically applied.
- Vitamin C is a very unstable substance. Although it is readily soluble in water, rapid oxidation occurs in aqueous media. Solubility of ascorbic acid has been reported to be relatively poor m nonaqueous media, thereby preventing an anhydrous system from achieving any significant level of active concentration.
- U.S. Patent 4,818,521 (Ta abuchi) describes under the background technology a so-called two-pack type cosmetic wherein Vitamin C powder and other ingredients are separately packaged in different containers with mixing just prior to use of the cosmetic.
- the mixing procedure and expensive packaging were said to be drawbacks of this system
- the patent suggests stable oil-m-water type emulsions that are weakly acidic and wherein ascorbic acid has been premixed with a stabilizing oil.
- Water compatible alcohols such as propylene glycol, polypropylene glycol and glycerol have been suggested as co-earners alongside water to improve stability.
- An illustration of this approach can be found in U.S. Patent 4,983,382 (Mlmott and Znaiden) .
- a blend of water and water-miscible organic solvent are combined as a stabilizing system.
- At least about 40% of the organic solvent must be ethanol while the remainder may be selected from such alcohols as propylene glycol, glycerin, dipropylene glycol and polypropylene glycol.
- Japanese Patent 44-22312 (Shionogi) describes the stabilization of Vitamin C in a mainly aqueous medium by a variety of glycols. These include polyethylene glycol, ethylene glycol, diethylene glycol and even ethanol. These formulations are intended for ingestion.
- U.S. Patent 4,372,874 (Modrovich) has reported incorporation of relatively large amounts of ascorbic acid in a polar water-miscible organic solvent such as dimethyl sulfoxide. Levels of water are kept below 0.5% through addition of a particulate desiccant to the carrier. Although highly polar systems such as dimethyl sulfoxide may be effective, this and related carriers are toxicologically questionable.
- Another object of the present invention is to provide a delivery system which assists the penetration of ascorbic acid into the human skin while avoiding irritation thereof .
- Still another object of the present invention is to provide a system for delivering ascorbic acid that is aesthetically pleasing and imparts a soft and smooth skinfeel .
- a cosmetic composition includes:
- ascorbic acid can be stabilized against decomposition and also stably suspended in a system containing a crosslinked non-emulsifying siloxane elastomer and a volatile siloxane.
- Ascorbic acid is available from several sources including Roche Chemicals. Amounts of this material may range from 0.001 to 50%, preferably from 0.1 to 10%, optimally from 1 to 10% by weight.
- Crosslinked non-emulsifying siloxane elastomers of this invention will have an average number molecular weight in excess of 10,000, preferably in excess of 1,000,000 and optimally will range from 10,000 to 20 million.
- non-emulsifying defines a siloxane from which polyoxyalkylene units are absent.
- the cross- linked non-emulsifying siloxane elastomer is formed from a divinyl monomer reacting with Si-H linkages of a siloxane backbone.
- Illustrative of the elastomer is a material with the CTFA name of Crosslinked Stearyl Methyl-Dimethyl Siloxane Copoly er, available as Gransil SR-CYC (25-35% active elastomer) from Grant Industries, Inc., Elmwood Park, New Jersey. Supply of related elastomer may also be available from the General Electric Company.
- Amounts of the elastomer may range from 0.1 to 30%, preferably from 1 to 15%, optimally from 3 to 10% by weight .
- a third essential element of the present invention is that of a volatile siloxane.
- Illustrative of this category are the cyclo polydimethyl siloxane fluids of the formula
- cyclic siloxanes will have a boiling point of less than 250 C and a viscosity at 25 C of less than 10 centipoise. Cyclo alleone is the common name of such materials.
- the tetramer and pentamer cyclomethicones are commercially available as DC 244 and DC 344 from the Dow Corning Corporation.
- Amounts of the volatile siloxane will range from 10 to 80%, preferably from 20 to 70%, optimally from 30 to 65% by weight .
- compositions of this invention may further include a pharmaceutically acceptable carrier.
- the carrier will be an ingredient which can solubilize Vitamin C and all other elements of the composition. Amounts of the carrier may range from 1 to 70%, preferably from 10 to 60%, optimally from 20 to 50% by weight.
- Pharmaceutically acceptable carriers may be selected from water, polyols, silicone fluids, esters and mixtures thereof. When present, water may range from 0.5 to 20%, preferably from 1 to 10%, usually from 2 to 6%, optimally less than 5% by weight of the composition.
- one or more polyols are present as carriers in the compositions of this invention.
- Illustrative are propylene glycol, dipropylene glycol, polypropylene glycol, polyethylene glycol, sorbitol, hydroxypropyl sorbitol, hexylene glycol, 1,3-butylene glycol, 1,2,6- hexanetriol, glycerin, ethoxylated glycerin, propoxylated glycerin and mixtures thereof.
- the polyol is a mixture of polyethylene glycol, molecular weight ranging from 200 to 2,000, and propylene glycol.
- Preferred weight ratios of polyethylene glycol to propylene glycol range from 5:1 to 1:10, preferably from 2:1 to 1:5, optimally 1:1 to 1:2.
- Amounts of the polyol may range from 1 to 50%, preferably from 10 to 40%, optimally from 25 to 35% by weight of the composition.
- Silicone oils may also be included as carriers in the compositions of this invention. These oils will be nonvolatile.
- the nonvolatile silicone oils useful in the compositions of this invention are exemplified by the polyalkyl siloxanes, polyalklyaryl siloxanes and polyether siloxane copolymers.
- the essentially nonvolatile polyalkyl siloxanes useful herein include, for example, polydimethyl siloxanes with viscosities of from about 5 to about 100,000 centistokes at 25°C.
- Such polyalkyl siloxanes include the Viscasil series (sold by General
- Polyalkylaryl siloxanes include poly (methylphenyl) siloxanes having viscosities of from about 15 to about 65 centistokes at 25°C. These are available, for example, as SF 1075 methylphenyl fluid
- Useful polyether siloxane copolymers include, for example, a polyoxyalkylene ether copolymer having a viscosity of about 1200 to 1500 centistokes at 25°C. Such a fluid is available as SF-1066 organosilicone surfactant (sold by General Electric Company) . Cetyl dimethicone copolyol and cetyl dimethicone are especially preferred because these materials also function as emulsifiers and emollients. The former material is available from Goldschmidt AG under the trademark Abil EM-90. Amounts of the nonvolatile siloxane may range from 0.1 to 40%, preferably from 0.5 to 25% by weight of the composition.
- Esters may also be incorporated into the cosmetic compositions as pharmaceutically acceptable carriers. Amounts may range from 0.1 to 50% by weight of the composition. Among the esters are:
- Alkyl esters of fatty acids having 10 to 20 carbon atoms are useful herein. Examples include hexyl laurate, isohexyl laurate, isohexyl palmitate, isopropyl palmitate, decyl oleate, isodecyl oleate, hexadecyl stearate, decyl stearate, isopropyl isostearate, diisopropyl adipate, diisohexyl adipate, dihexyldecyl adipate, diisopropyl sebacate, lauryl lactate, myristyl lactate, and cetyl lactate. Particularly preferred are C j .-C,. alcohol benzoate esters .
- Alkenyl esters of fatty acids having 10 to 20 carbon atoms examples thereof include oleyl myristate, oleyl stearate, and oleyl oleate.
- Ether-esters such as fatty acid esters of ethoxylated fatty alcohols.
- Ethylene glycol mono and di-fatty acid esters diethylene glycol mono- and di-fatty acid esters, polyethylene glycol (200-6000) mono- and di-fatty acid esters, propylene glycol mono- and di-fatty acid esters, polypropylene glycol 2000 monooleate, polypropylene glycol 2000 monostearate, ethoxylated propylene glycol monostearate, glyceryl mono- and di-fatty acid esters, polyglycerol poly-fatty esters, ethoxylated glyceryl monostearate, 1,3-butylene glycol monostearate, 1,3-butylene glycol distearate, polyoxyethylene polyol fatty acid ester, sorbitan fatty acid esters, and polyoxyethylene sorbitan fatty acid esters are satisfactory polyhyd ⁇ c alcohol esters .
- Wax esters such as beeswax, spermaceti, myristyl myristate, stearyl stearate.
- Sterols esters of which cholesterol fatty acid esters are examples thereof.
- Minor adjunct ingredients may also be included in cosmetic compositions of this invention. These ingredients may be selected from preservatives, fragrances, anti-foam agents, opacifiers, colorants and mixtures thereof, each m their effective amounts to accomplish their respective functions .
- Formulation 1 was a homogeneous stable aesthetically pleasing emulsion of cream-like consistency. By contrast, formulation 1A did not form an emulsion.
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Cosmetics (AREA)
- Medicinal Preparation (AREA)
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU29611/97A AU2961197A (en) | 1996-06-28 | 1997-05-16 | Vitamin c delivery system |
JP10503778A JP2000513364A (ja) | 1996-06-28 | 1997-05-16 | ビタミンc送達システム |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US2074496P | 1996-06-28 | 1996-06-28 | |
US60/020,744 | 1996-06-28 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1998000103A1 true WO1998000103A1 (en) | 1998-01-08 |
Family
ID=21800297
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP1997/002691 WO1998000103A1 (en) | 1996-06-28 | 1997-05-16 | Vitamin c delivery system |
Country Status (9)
Country | Link |
---|---|
JP (1) | JP2000513364A (es) |
CN (1) | CN1191054C (es) |
AR (1) | AR007612A1 (es) |
AU (1) | AU2961197A (es) |
ID (1) | ID19426A (es) |
IN (1) | IN188727B (es) |
TW (1) | TW471973B (es) |
WO (1) | WO1998000103A1 (es) |
ZA (1) | ZA971943B (es) |
Cited By (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1999013859A1 (en) * | 1997-09-16 | 1999-03-25 | E-L Management Corp. | Stable anhydrous formulation |
US6039935A (en) * | 1998-12-30 | 2000-03-21 | Elizabeth Arden Company, Division Of Conopco, Inc. | Sunscreen compositions |
WO2000061076A1 (en) * | 1999-04-14 | 2000-10-19 | Unilever Plc | Foaming cosmetic products |
US6299889B1 (en) | 1998-09-10 | 2001-10-09 | Avon Products, Inc. | Stable ascorbic acid preparation for topical use |
WO2002003952A2 (en) * | 2000-07-10 | 2002-01-17 | The Procter & Gamble Company | Skin care compositions containing silicone elastomers |
US6365670B1 (en) | 2000-03-10 | 2002-04-02 | Wacker Silicones Corporation | Organopolysiloxane gels for use in cosmetics |
US6423322B1 (en) | 1999-05-22 | 2002-07-23 | Wacker Silicones Corporation | Organopolysiloxane gels for use in cosmetics |
US6444745B1 (en) | 2000-06-12 | 2002-09-03 | General Electric Company | Silicone polymer network compositions |
US6524598B2 (en) * | 2000-07-10 | 2003-02-25 | The Procter & Gamble Company | Cosmetic compositions |
US6531540B1 (en) | 2001-05-16 | 2003-03-11 | General Electric Company | Polyether siloxane copolymer network compositions |
US6538061B2 (en) | 2001-05-16 | 2003-03-25 | General Electric Company | Cosmetic compositions using polyether siloxane copolymer network compositions |
FR2834449A1 (fr) * | 2002-01-04 | 2003-07-11 | Oreal | Composition contenant un actif hydrophile sensible a l'oxydation, et ses utilisations notamment cosmetiques |
US6685965B1 (en) | 1997-10-22 | 2004-02-03 | Industria E Comercio De Cosmeticos Natura Ltda. | Process for stabilizing levogyre ascorbic acid (laa), a stable aqueous laa composition, a process for preparing a stable topical solution, an emulsion, a vitamin product, and a method for cosmetic, pharmaceutical or nutritional treatment |
US6881416B2 (en) | 2002-04-08 | 2005-04-19 | Wacker Chemical Corporation | Alkyl group-substituted organopolysiloxane gels |
US6936686B2 (en) | 2002-12-11 | 2005-08-30 | Nutech Corporation | Cross-linked silicone gels; products containing the same; and methods of manufacture thereof |
US7094842B2 (en) | 2002-01-04 | 2006-08-22 | L'oreal | Composition containing a silicone copolymer and an AMPS-like polymer and/or organic powder |
US7241835B2 (en) | 2001-05-16 | 2007-07-10 | General Electric Company | Cosmetic compositions comprising silicone gels |
GB2420076B (en) * | 2004-10-15 | 2010-05-19 | Boots Co Plc | Skincare composition |
US7772214B2 (en) | 2000-07-10 | 2010-08-10 | The Procter & Gamble Company | Emulsion cosmetic compositions comprising an emulsifying crosslinked siloxane elastomer |
WO2014149140A2 (en) * | 2013-03-21 | 2014-09-25 | Julius Zecchino | Delivery system having stabilized ascorbic acid and other actives |
WO2020127747A1 (en) | 2018-12-20 | 2020-06-25 | L'oreal | Aqueous composition comprising capsules based on gelled oil containing an oxygen-sensitive active agent |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR100544159B1 (ko) * | 2004-07-14 | 2006-01-24 | 센양 뉴라이프 인더스트리알 코 엘티디 | 아스코르빌 테트라이소팔미테이트와 디팔미토일하이드록시프롤린을 함유한 나노 에멀젼 및 이를함유하는 화장료 조성물 |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1161289A (en) * | 1967-06-30 | 1969-08-13 | Hoffmann La Roche | The Stabilization of Ascorbic Acid and of Derivatives thereof |
JPH04261111A (ja) * | 1991-02-13 | 1992-09-17 | Kanebo Ltd | 油中水滴型乳化化粧料 |
FR2715844A1 (fr) * | 1994-02-04 | 1995-08-11 | Oreal | Emulsion contenant de l'acide ascorbique stabilisé, procédé de traitement cosmétique la mettant en Óoeuvre, ses utilisations. |
EP0669126A1 (fr) * | 1994-01-31 | 1995-08-30 | L'oreal | Emulsion stabilisée, destinée à hydrater la peau et son utilisation |
-
1997
- 1997-03-06 ZA ZA971943A patent/ZA971943B/xx unknown
- 1997-03-19 TW TW086103456A patent/TW471973B/zh not_active IP Right Cessation
- 1997-04-03 IN IN197BO1997 patent/IN188727B/en unknown
- 1997-05-16 AU AU29611/97A patent/AU2961197A/en not_active Abandoned
- 1997-05-16 WO PCT/EP1997/002691 patent/WO1998000103A1/en active Application Filing
- 1997-05-16 CN CNB971957622A patent/CN1191054C/zh not_active Expired - Fee Related
- 1997-05-16 JP JP10503778A patent/JP2000513364A/ja active Pending
- 1997-06-23 AR ARP970102745A patent/AR007612A1/es active IP Right Grant
- 1997-06-23 ID IDP972144A patent/ID19426A/id unknown
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1161289A (en) * | 1967-06-30 | 1969-08-13 | Hoffmann La Roche | The Stabilization of Ascorbic Acid and of Derivatives thereof |
JPH04261111A (ja) * | 1991-02-13 | 1992-09-17 | Kanebo Ltd | 油中水滴型乳化化粧料 |
EP0669126A1 (fr) * | 1994-01-31 | 1995-08-30 | L'oreal | Emulsion stabilisée, destinée à hydrater la peau et son utilisation |
FR2715844A1 (fr) * | 1994-02-04 | 1995-08-11 | Oreal | Emulsion contenant de l'acide ascorbique stabilisé, procédé de traitement cosmétique la mettant en Óoeuvre, ses utilisations. |
Non-Patent Citations (1)
Title |
---|
DATABASE WPI Section Ch Week 9244, Derwent World Patents Index; Class A26, AN 92-360690, XP002041754 * |
Cited By (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1999013859A1 (en) * | 1997-09-16 | 1999-03-25 | E-L Management Corp. | Stable anhydrous formulation |
US6685965B1 (en) | 1997-10-22 | 2004-02-03 | Industria E Comercio De Cosmeticos Natura Ltda. | Process for stabilizing levogyre ascorbic acid (laa), a stable aqueous laa composition, a process for preparing a stable topical solution, an emulsion, a vitamin product, and a method for cosmetic, pharmaceutical or nutritional treatment |
US6299889B1 (en) | 1998-09-10 | 2001-10-09 | Avon Products, Inc. | Stable ascorbic acid preparation for topical use |
US6039935A (en) * | 1998-12-30 | 2000-03-21 | Elizabeth Arden Company, Division Of Conopco, Inc. | Sunscreen compositions |
WO2000061076A1 (en) * | 1999-04-14 | 2000-10-19 | Unilever Plc | Foaming cosmetic products |
US6264964B1 (en) | 1999-04-14 | 2001-07-24 | Conopco, Inc. | Foaming cosmetic products |
US6423322B1 (en) | 1999-05-22 | 2002-07-23 | Wacker Silicones Corporation | Organopolysiloxane gels for use in cosmetics |
US6365670B1 (en) | 2000-03-10 | 2002-04-02 | Wacker Silicones Corporation | Organopolysiloxane gels for use in cosmetics |
US6444745B1 (en) | 2000-06-12 | 2002-09-03 | General Electric Company | Silicone polymer network compositions |
WO2002003952A3 (en) * | 2000-07-10 | 2002-04-11 | Procter & Gamble | Skin care compositions containing silicone elastomers |
AU2001273286B2 (en) * | 2000-07-10 | 2005-11-10 | The Procter & Gamble Company | Skin care compositions containing silicone elastomers |
US7772214B2 (en) | 2000-07-10 | 2010-08-10 | The Procter & Gamble Company | Emulsion cosmetic compositions comprising an emulsifying crosslinked siloxane elastomer |
US6524598B2 (en) * | 2000-07-10 | 2003-02-25 | The Procter & Gamble Company | Cosmetic compositions |
WO2002003952A2 (en) * | 2000-07-10 | 2002-01-17 | The Procter & Gamble Company | Skin care compositions containing silicone elastomers |
US6531540B1 (en) | 2001-05-16 | 2003-03-11 | General Electric Company | Polyether siloxane copolymer network compositions |
US7241835B2 (en) | 2001-05-16 | 2007-07-10 | General Electric Company | Cosmetic compositions comprising silicone gels |
US7381769B2 (en) | 2001-05-16 | 2008-06-03 | Momentive Performance Materials Inc. | Cosmetic compositions using polyether siloxane copolymer network compositions |
US6759479B2 (en) | 2001-05-16 | 2004-07-06 | General Electric Company | Process for making cosmetic compositions using polyether siloxane copolymer network compositions |
US6538061B2 (en) | 2001-05-16 | 2003-03-25 | General Electric Company | Cosmetic compositions using polyether siloxane copolymer network compositions |
US7094842B2 (en) | 2002-01-04 | 2006-08-22 | L'oreal | Composition containing a silicone copolymer and an AMPS-like polymer and/or organic powder |
FR2834449A1 (fr) * | 2002-01-04 | 2003-07-11 | Oreal | Composition contenant un actif hydrophile sensible a l'oxydation, et ses utilisations notamment cosmetiques |
US6881416B2 (en) | 2002-04-08 | 2005-04-19 | Wacker Chemical Corporation | Alkyl group-substituted organopolysiloxane gels |
US6936686B2 (en) | 2002-12-11 | 2005-08-30 | Nutech Corporation | Cross-linked silicone gels; products containing the same; and methods of manufacture thereof |
GB2420076B (en) * | 2004-10-15 | 2010-05-19 | Boots Co Plc | Skincare composition |
WO2014149140A2 (en) * | 2013-03-21 | 2014-09-25 | Julius Zecchino | Delivery system having stabilized ascorbic acid and other actives |
WO2014149140A3 (en) * | 2013-03-21 | 2014-11-27 | Julius Zecchino | Delivery system having stabilized ascorbic acid |
WO2020127747A1 (en) | 2018-12-20 | 2020-06-25 | L'oreal | Aqueous composition comprising capsules based on gelled oil containing an oxygen-sensitive active agent |
FR3090330A1 (fr) | 2018-12-20 | 2020-06-26 | L'oreal | Composition aqueuse comprenant des capsules à base d’huile gélifiée contenant un actif sensible à l’oxygène |
Also Published As
Publication number | Publication date |
---|---|
IN188727B (es) | 2002-11-02 |
AR007612A1 (es) | 1999-11-10 |
JP2000513364A (ja) | 2000-10-10 |
TW471973B (en) | 2002-01-11 |
CN1191054C (zh) | 2005-03-02 |
ID19426A (id) | 1998-07-09 |
AU2961197A (en) | 1998-01-21 |
ZA971943B (en) | 1998-09-07 |
CN1222848A (zh) | 1999-07-14 |
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Legal Events
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