WO1997020746A1 - Injecteur - Google Patents

Injecteur Download PDF

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Publication number
WO1997020746A1
WO1997020746A1 PCT/JP1996/003516 JP9603516W WO9720746A1 WO 1997020746 A1 WO1997020746 A1 WO 1997020746A1 JP 9603516 W JP9603516 W JP 9603516W WO 9720746 A1 WO9720746 A1 WO 9720746A1
Authority
WO
WIPO (PCT)
Prior art keywords
nozzle
neck
peripheral surface
mouth
container
Prior art date
Application number
PCT/JP1996/003516
Other languages
English (en)
Japanese (ja)
Inventor
Toshiki Kurumada
Original Assignee
Rohto Pharmaceutical Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rohto Pharmaceutical Co., Ltd. filed Critical Rohto Pharmaceutical Co., Ltd.
Priority to AU76399/96A priority Critical patent/AU7639996A/en
Publication of WO1997020746A1 publication Critical patent/WO1997020746A1/fr

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D47/00—Closures with filling and discharging, or with discharging, devices
    • B65D47/04—Closures with discharging devices other than pumps
    • B65D47/06—Closures with discharging devices other than pumps with pouring spouts or tubes; with discharge nozzles or passages
    • B65D47/18—Closures with discharging devices other than pumps with pouring spouts or tubes; with discharge nozzles or passages for discharging drops; Droppers

Definitions

  • the present invention relates to a nozzle, and more particularly, to a drip nozzle mounted on the mouth and neck of a drip container suitably used for containing a drug solution such as eye drops and nasal drops.
  • an infusion container with an infusion nozzle attached to the inside of the mouth and neck to discharge drug solutions such as eye drops and nasal drops to the outside of the container for example, Japanese Utility Model Appln. (See 3-3, 365, etc.).
  • the insertion portion is formed of a soft synthetic resin, and the insertion portion is substantially the same as the diameter of the inner peripheral surface of the mouth and neck portion of the container or has a slightly smaller diameter.
  • the mouth and neck of the drip container generally have an inner diameter of 5.5 to 6.5 mm.
  • the above-mentioned container is generally formed from a hard synthetic resin material such as polyethylene terephthalate, and not only is there a possibility that the mouth and neck may expand and contract due to changes in room temperature. When the flow of the liquid resin material becomes uneven, fine grooves and scratches are rarely formed on the inner peripheral surface of the mouth and neck after molding.
  • the seal portion is formed of a soft synthetic resin material as described above, but since the seal portion is formed in a substantially semicircular cross section, the seal portion has a waist relative to the nozzle base. Is strong, and the seal does not easily deform against external force.
  • the seal portion when the insertion portion of the nozzle is pressed and inserted into the inside of the mouth and neck of the container, the seal portion is compressed and deformed radially inward by the inner surface of the mouth and neck, but the deformation rate at this time is very small. .
  • the inner peripheral surface of the mouth and neck of the container is caused by the difference between the forming material on the container side and the forming material on the nozzle side. Due to the dimensional error caused by the difference in the thermal expansion / shrinkage rate due to the room temperature change of the diameter of the nozzle and the outer diameter of the nozzle insertion part, the diameter of the nozzle base is smaller than the standard size with respect to the diameter of the inner peripheral surface of the container neck and neck. When the diameter of the nozzle becomes significantly smaller, the hermeticity of the insertion portion of the nozzle with respect to the inner peripheral surface of the mouth and neck of the container is reduced, and the insertion portion is detached from the mouth and neck of the container, while the diameter of the nozzle base is reduced.
  • the inner peripheral surface of the mouth and neck When the diameter of the inner peripheral surface of the mouth and neck becomes significantly larger than the reference dimension, the inner peripheral surface of the container is pressed outward by the seal portion of the nozzle, and a crack is formed in the neck of the container. There is a risk of occurrence. If the mouth and neck of this container has an inner diameter smaller than the reference size due to manufacturing errors, it becomes difficult to insert the insertion portion of the nozzle into the mouth and neck of the container. If the insertion part is forcibly inserted into the neck part, the inner peripheral surface of the mouth and neck part of the container may be pressed outward by the seal part of the nozzle, and a crack may occur in the neck part. is there.
  • the problem described in (2) occurs due to a small degree of freedom in which the seal portion of the nozzle can enter the inside of a fine groove or a scratch on the inner peripheral surface of the mouth and neck. .
  • a nozzle having the following configuration.
  • this nozzle is a soft synthetic resin nozzle used by being inserted into the cylindrical mouth and neck of a drip container for accommodating drug solutions such as eye drops and nasal drops.
  • the insertion portion of the nozzle which is inserted into the cylindrical mouth and neck and brought into close contact with the inner peripheral surface of the neck, has a nozzle base having a diameter smaller than the diameter of the inner peripheral surface of the cylindrical mouth and neck.
  • a quadrilateral cross-section having an outer diameter slightly larger than the diameter of the inner peripheral surface of the cylindrical mouth-and-neck portion formed integrally with the nozzle base in a circumferential direction of the nozzle base, for example, a rectangular cross-section And cross section square shape Equipped with at least three or more fin-shaped seals with square edges, such as square quadrangular shapes and trapezoidal cross-sections where the long side and short side of a pair of parallel sides are located on the nozzle base side and outer peripheral side, respectively.
  • the soft synthetic resin for example, low-density polyethylene (LDPE), linear low-density polyethylene (LLDP) and the like are suitably used.
  • LDPE low-density polyethylene
  • LLDP linear low-density polyethylene
  • the fin-shaped seal portion of the insertion portion is inserted into the mouth and neck of the nozzle with respect to the nozzle base.
  • the inner peripheral surface of the mouth and neck is hermetically sealed in a state where the inner peripheral surface of the mouth and neck of the container is pressed outward from the inside by being elastically deformed flexibly in the opposite direction.
  • the insertion part of the nozzle can be easily inserted into the mouth and neck of the container with an appropriate insertion pressure. Moreover, at this time, since the inner peripheral surface of the mouth and neck portion of the container is prevented from being pressed outward by a strong force, the occurrence of cracks in the mouth and neck portion is reliably prevented.
  • the depth of a groove or a scratch formed on the inner surface of the mouth and neck portion of the container corresponding to the edge of one fin-shaped seal portion is deep, and the container is not provided with only one edge. Even when it is difficult to seal the groove or the like, it is difficult to seal the inner surface of the mouth and neck of the container other than the above-mentioned seals because the plurality of fin-shaped seals are provided as described above. The function is exhibited, and the hermeticity of the nozzle insertion portion with respect to the inner surface of the neck is ensured.
  • the axial width of the seal portion on the nozzle base side is 0.4 to 0.8 mm, and the axial width of the seal portion on the outer peripheral surface side is 0.2 to 0.7 mm.
  • the axial width of the former is preferably larger than the axial width of the latter, and more preferably, the axial width of the former is 0.5 mm, and the axial width of the latter is 0.5. 4 mm.
  • a difference between a radius of the inner peripheral surface of the cylindrical mouth and neck portion and a radius of an outer peripheral surface of the seal portion is 0.1 to 0.4 mm, and It is preferable that the difference between the radius of the nozzle base and the radius of the outer peripheral surface of the seal portion is ⁇ .4 to 0.9 mm.
  • FIG. 1 is a longitudinal sectional view of a nozzle according to one embodiment of the present invention.
  • FIG. 2 is a longitudinal sectional view showing a state in which the nozzle of FIG. 1 is attached to the cylindrical mouth and neck of the eyedropper.
  • FIG. 1 is a longitudinal sectional view of a nozzle according to this embodiment
  • FIG. 2 is a longitudinal sectional view showing a state where the nozzle of FIG. 1 is attached to a cylindrical mouth and neck of an eye drop container for eye drops.
  • reference numeral 10 denotes a cylindrical nozzle of the present embodiment
  • 10 A, 10 B, and 10 C respectively constitute the respective portions of the nozzle 10 and are integrally formed with each other.
  • the projected portion, the flange portion, and the inserted portion, 12 are nozzle openings that the nozzle 10 has in the axial direction
  • 20 is an eye drop container to which the nozzle is attached
  • Reference numeral 22 denotes a cylindrical mouth-and-neck portion 22 of the ophthalmic container 20 into which the insertion portion 10C of the nozzle 10 is inserted.
  • the nozzle 10 is configured such that the outer diameter L1 of the flange portion 10B is larger than the inner diameter L2 of the cylindrical mouth-and-neck portion 22 of the ophthalmic container.
  • the insertion part 10 c of 10 is inserted into the cylindrical mouth-and-neck part 22 of the eye drop container 20, the flange part 10 B insertion part 10 0
  • the end face on the C side 11 1 is the eye drop container
  • the mouth and neck portion 20 is in contact with the end face 23 of the neck 22.
  • reference numeral 25 denotes a male screw portion formed integrally with the cylindrical mouth and neck portion 22 of the eye drop container 20 so as to protrude outward, and the protrusion portion of the nozzle 10. 1 It is configured to be screwed into a female screw part of a cap (not shown) inserted from the OA side and put on the outer surface of the cylindrical mouth / neck part 22.
  • the insertion portion 10 C of the nozzle 10 further has an outer diameter L 3 smaller than the inner diameter L 2 of the cylindrical mouth and neck portion 22 of the eyedropper 20. It has a nozzle base 14 and an outer diameter L 4 which is formed in an annular shape integrally with the nozzle base 1 around the nozzle base 14 and is slightly larger than the inner diameter L 2 of the cylindrical mouth and neck 22. Fin 16 As shown in the figure, four such fins 16 are provided at predetermined intervals along the axial direction of the insertion portion 10C, and constitute a seal portion 18 of the insertion portion 10C. I have.
  • each of the fins 16 has an axial width L5 located on the nozzle base 14 side of the insertion portion 10C and an axial width L6 located on the outer peripheral surface side.
  • Each of the edges 16 c of the outer edge 16 a of the fin 16 on the side opposite to the flange portion is formed as a square edge.
  • the end 13 of the insertion portion 10C of the nozzle 1Q on the side opposite to the flange portion has an outer diameter L7 substantially equal to the inner diameter L2 of the cylindrical mouth-and-neck portion 22 of the eyedropper 20.
  • a protruding sealing part 19 is provided.
  • each fin 16 of the nozzle 10 is dropped as described above. Since the outer diameter 16a of each fin 16 is larger than the inner diameter L2 of the cylindrical mouth and neck 22 of the container 20, the outer edge 16a of each fin 16 is inside the cylindrical mouth and neck 22 of the eyedropper 20.
  • the outer surface 16 a is pressed radially inward by the peripheral surface 27, As shown in FIG.
  • the inner peripheral surface 27 of the cylindrical mouth-and-neck portion 22 of the eye drop container 20 has the outer edge 16 a of each fin 16 of the nozzle 10 as shown in FIG. It is always pressed radially outward by the edge 16c with an appropriate pressure, and if a groove or a groove is formed on the inner peripheral surface 27 of the cylindrical mouth and neck portion 22 corresponding to the specific edge 16c. If a flaw or the like is formed, the edge 16c enters the inside of the groove or the like, and the groove or flaw is sealed by the edge 16c.
  • the insertion portion 10 C of the nozzle 10 is provided with the four fins 16 as described above, and is opposed to the inner peripheral surface 27 of the cylindrical mouth-and-neck portion 22 of the eyedropper 20.
  • the end portion 13 on the side opposite to the flange portion of the insertion portion 10 C has an eyedropper 20.
  • the eye drop container 20 used in this test was a container made of a hard synthetic resin having an inner diameter L2 of the cylindrical mouth and neck portion 22 of 5.6 mm.
  • the test was carried out as follows with the commercially available eye drops being filled.
  • the nozzles 10 having various dimensions as shown in Table 1 below are provided on the inner peripheral surface 27 of the cylindrical mouth / neck portion 22 of the eye drop container 20 filled with the eye drops as described above.
  • the insertion section 10 C of the flange section 10 B While being inserted until it comes into contact with the end face 23 of the cylindrical mouth and neck portion 22 of the container 20, a cap (not shown) is placed on the outer peripheral surface of the cylindrical mouth and neck portion 22 to cover the neck 22.
  • the male screw part 25 was securely screwed.
  • the cap is configured so as to securely seal the nozzle opening 12 located on the protruding portion 1OA side of the nozzle 10 in the sealed state.
  • the nozzle 10 When the nozzle 10 is lowered, there is leakage of ophthalmic solution between the inner peripheral surface 27 of the cylindrical mouth-and-neck portion 22 of the eye drop container 20 and the insertion portion 10 C of the nozzle 10.
  • the leaked drug solution is stored in the inner peripheral surface of the cap, so the tester can easily remove this leak by removing the cap from the cylindrical mouth and neck portion 22 of the eye drop container 20. You can check.
  • Table 1 shows the data such as the specific dimensions of the 18 types of nozzles used in this test.
  • L3 is the outer diameter of the nozzle base 14 of the insertion portion 10C of the nozzle 10
  • L4 is the outer diameter of the seal portion 18 of the insertion portion 10C (that is, each filter).
  • L5 is the lateral width of each fin 16 on the nozzle base side
  • L6 is the axial width on the outer peripheral surface side of each fin
  • L7 is the protrusion of the nozzle base 14
  • the outer diameter of the part 19, L 8 is the height of each fin 16, (L 2-L 3)
  • Z 2 is the radius of the inner peripheral surface 27 of the cylindrical mouth and neck part 22 of the eye drop container 20 and the nozzle base 14 of the nozzle 10 (L4—L2) Z2 indicates the difference between the radius of the seal portion 18 of the nozzle 10 and the radius of the inner peripheral surface 27 of the cylindrical mouth / neck portion 22 of the eyedrop container 20. .
  • each of the nozzles 10 has an end face 11 on the side of the insertion portion 10C of the flange portion 10B and a protruding sealing portion of the fin 16 closest to the protruding sealing portion 19 of the nozzle base 14.
  • the distance (length) L 9 between the corner edge 16 c on the side of the portion 19 and the distance between the end surface 11 of the flange portion 10 B and the end surface on the side opposite to the protruding portion of the end portion 13 (length L 9) are approximately 4 mm.
  • Length) L10 is configured to be about 9mm.
  • the samples described in Nos. 1 and 2 are the nozzles according to the conventional example and the like having no fin, respectively.
  • L4, and L7 indicate the outer diameter of the insertion portion.
  • (L2-L3) no2 and (L4-L2) Z2 are the radius of the insertion portion of the nozzle and the cylindrical mouth and neck of the eyedropper. The difference from the radius of 22 is shown.
  • L7 and L3 both indicate the outer diameter of the insertion portion main body of the nozzle, and L4 is integrated with the insertion portion main body in the circumferential direction of the insertion portion main body. 2 shows the outer diameter of the seal portion having a substantially semi-circular cross section provided in FIG.
  • L8 and L5 respectively indicate the height of the seal portion from the outer peripheral surface of the insertion portion main body and the axial width of the seal portion on the insertion portion main body side.
  • — L3) Z2 and (L4— L2) / 2 are the nozzles corresponding to the radius of the inner peripheral surface 27 of the cylindrical mouth and neck 22 of the eyedropper. And the difference from the radius of the insertion portion main body, and the difference from the radius of the seal portion, respectively.
  • the nozzle of No. 18 has a round shape on the outer peripheral surface of the outer edge 16 a of the fin 16, that is, does not have a corner edge, and is a different type from the nozzle of the present embodiment. Nozzle, so the L6 data column is blank.
  • tests 1 to 5 were performed using the nozzles shown in Table 1.
  • Test 1 each of the above 18 types of samples and 10 defective containers prepared for each of the samples and having some kind of scratch on the inner peripheral surface 27 of the cylindrical mouth-and-neck portion 22 were compared with each other.
  • crack test Specifically, the eye drop container 20 filled with the eye drops as described above is left at 50 ° C for one month with the nozzle 10 down, and then the nozzle 10 is placed in the eye drop container 20. After being removed from the cylindrical mouth and neck portion 22, the presence or absence of cracks (cracks) formed on the wall of the neck portion 22 was visually checked. Crack size is divided into three stages: crack size is 2 mm or more, ⁇ L '', l ⁇ 2 mm is ⁇ M '', and lmm or less is ⁇ SJ '' The number of cracks was checked.
  • Test 4 is an insertion force test performed by combining each of the above 18 types of samples with 5 ⁇ 2 eye drop containers prepared for each sample. Specifically, in each sample, the number of the cylindrical mouth and neck portion 22 of the container 20 was 5.65 mm (large) and the number of the samples was 5.4 mm (small). Five of each were prepared, and five of each sample were inserted into the cylindrical mouth and neck 22 of each of these two types of containers 20, and the nozzle insertion force at this time was measured.
  • Test 5 is a pull-out force test conducted by combining each of the above 18 types of samples and 10 eye drop containers prepared for each sample. Specifically, with the eye drop container 20 filled with the eye drops as described above with the nozzle 10 down, 5 (Leave it at TC for 2 weeks, then place the nozzle 10 into the eye drop container 20) Remove the nozzle 10 from the cylindrical neck 22 and then easily remove the nozzle 10 at that time by selecting “5” for those that cannot be pulled out by hand, “4” for those that can be pulled out by hand, but not easily. Those that were difficult to pull out were rated “3”, those that were easy to pull out by hand were rated “2”, and those that easily pulled out were rated “1”.
  • the test results of the above tests 1 to 5 are shown in Tables 2 to 4, respectively.
  • the nozzle 10 having the fin 16 of the present embodiment is the nozzle (No. 1 and No. 1) of the conventional type having no fin. No liquid leakage, no cracks, and the cylindrical port of the container 20 compared to the nozzle (No. 2) and the nozzle with fins but no corner edges (N 0.18). It became clear that it was easy to insert into the neck 22. It was also found that this nozzle 10 was harder to pull out than a nozzle without a corner edge.
  • L5 which is the axial width of each fin 16 on the insertion portion main body side, and the axial width of each fin 16 on the outer peripheral surface side are shown.
  • each dimensional ratio of the above nozzle should be By configuring each part of the nozzle with a substantially equal ratio, it is possible to provide a nozzle that achieves the above effects of the present invention.
  • the nozzles according to the above-described embodiment and the above-described examples each have a fin with a square edge having a trapezoidal cross section.
  • the cross-sectional shape of each fin is formed into, for example, a rectangular shape such as a rectangle.
  • each fin is more preferably formed in a trapezoidal shape as described in the above-described embodiment and the above-mentioned example, than in such a square shape. Have been.

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  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Closures For Containers (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)

Abstract

Cette invention concerne un injecteur assurant une alimentation de type goutte-à-goutte et destiné à être inséré dans une partie goulot à bec verseur cylindrique d'un récipient de lotion oculaire. Cet injecteur permet de prévenir les fissures au niveau de la partie goulot à bec verseur qui sont imputables à une différence se produisant entre les dimensions de ladite partie goulot à bec verseur et dudit injecteur lors d'une fluctuation de la température ambiante ou analogue. Ce système permet également d'assurer une grande étanchéité en présence de rayures ou de gorges sur la surface circonférentielle interne de la partie goulot à bec verseur. Cet injecteur comprend un corps principal d'insertion possédant une partie d'insertion, laquelle correspond à la surface circonférentielle interne (27) de la partie goulot à bec verseur tubulaire (22) d'un récipient de lotion oculaire, et possède un diamètre inférieur à celui de ladite surface. L'injecteur comprend également une partie d'étanchéité en forme d'ailettes (16a) faisant partie intégrante du corps principal et se trouvant à la circonférence de ce dernier, laquelle partie (16a) possède un diamètre externe légèrement supérieur à celui de la surface circonférentielle interne. La partie bord externe (16c) de chaque partie ailette possède une forme carrée ainsi qu'une section carrée. Lorsque le corps principal d'insertion est inséré dans la partie goulot à bec verseur (22), chaque ailette (16) se replie de manière à compenser les différences entre les dimensions. En cas de présence d'une rayure sur la surface circonférentielle interne (27), le bord carré pénètre dans ladite rayure afin d'assurer l'étanchéité de ladite surface circonférentielle interne (27).
PCT/JP1996/003516 1995-12-04 1996-12-02 Injecteur WO1997020746A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU76399/96A AU7639996A (en) 1995-12-04 1996-12-02 Nozzle

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP7315229A JPH09156662A (ja) 1995-12-04 1995-12-04 ノズル
JP7/315229 1995-12-04

Publications (1)

Publication Number Publication Date
WO1997020746A1 true WO1997020746A1 (fr) 1997-06-12

Family

ID=18062951

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP1996/003516 WO1997020746A1 (fr) 1995-12-04 1996-12-02 Injecteur

Country Status (3)

Country Link
JP (1) JPH09156662A (fr)
AU (1) AU7639996A (fr)
WO (1) WO1997020746A1 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3971329B2 (ja) 2002-10-23 2007-09-05 ロート製薬株式会社 液体用容器のノズル構造
JP4604060B2 (ja) * 2007-05-15 2010-12-22 株式会社オーティス 携帯用局部洗浄器
JP6276932B2 (ja) * 2013-06-17 2018-02-07 伸晃化学株式会社 薬液容器の中栓
JP6577476B2 (ja) * 2014-09-02 2019-09-18 阪神化成工業株式会社 滴下用ノズル及び滴下具
JP6860303B2 (ja) * 2016-07-15 2021-04-14 ロート製薬株式会社 薬液容器
JP7049760B2 (ja) * 2016-07-15 2022-04-07 ロート製薬株式会社 点眼容器

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6342321A (ja) * 1986-08-05 1988-02-23 Kobe Steel Ltd 転炉吹錬用ランス挿入口のシ−ル装置
JPH01176289U (fr) * 1988-05-31 1989-12-15
JPH02105856U (fr) * 1989-02-08 1990-08-22
JPH06265074A (ja) * 1993-03-12 1994-09-20 Toyoda Gosei Co Ltd ホース結合構造

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6342321A (ja) * 1986-08-05 1988-02-23 Kobe Steel Ltd 転炉吹錬用ランス挿入口のシ−ル装置
JPH01176289U (fr) * 1988-05-31 1989-12-15
JPH02105856U (fr) * 1989-02-08 1990-08-22
JPH06265074A (ja) * 1993-03-12 1994-09-20 Toyoda Gosei Co Ltd ホース結合構造

Also Published As

Publication number Publication date
AU7639996A (en) 1997-06-27
JPH09156662A (ja) 1997-06-17

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