WO1997000082A1 - Neue verwendung von collagenase - Google Patents

Neue verwendung von collagenase Download PDF

Info

Publication number
WO1997000082A1
WO1997000082A1 PCT/EP1996/002480 EP9602480W WO9700082A1 WO 1997000082 A1 WO1997000082 A1 WO 1997000082A1 EP 9602480 W EP9602480 W EP 9602480W WO 9700082 A1 WO9700082 A1 WO 9700082A1
Authority
WO
WIPO (PCT)
Prior art keywords
collagenase
treatment
novel use
preparation
wounds
Prior art date
Application number
PCT/EP1996/002480
Other languages
German (de)
English (en)
French (fr)
Inventor
Josef Johna
Lothar Rasthofer
Original Assignee
Knoll Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Knoll Aktiengesellschaft filed Critical Knoll Aktiengesellschaft
Publication of WO1997000082A1 publication Critical patent/WO1997000082A1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/4886—Metalloendopeptidases (3.4.24), e.g. collagenase

Definitions

  • the present invention relates to a new application of collagenase in veterinary medicine.
  • wounds caused by abrasions or infections are treated with main care products or with germicidal substances (antibiotics).
  • antibiotics germicidal substances
  • Such wounds are partly treated with oils, covering the damaged area of the skin with the oil or an oil-containing product and protecting it from external influences. This does not accelerate the actual healing process. Treatment with antibiotic-containing products is also quite lengthy and in many cases unsuccessful.
  • the invention relates to the use of collagenase for the production of externally applicable medicaments for the treatment of wounds on large animals carrying files.
  • a suitable collagenase is, for example, that which is obtained from Clostridia histolyticum and is also used in human medicine. However, it can also be isolated from other Clostridia bacteria or tissues (Merck Index, No. 2477).
  • the mixtures usually used for skin care can be used as the basis for the preparations. So you can incorporate the collagenase in petroleum jelly or paraffin.
  • the collagenase is added to the preparations in an amount of about 0.4 to 2.0 units, preferably 0.6 to 1.2 units, per g.
  • Suitable preparations are, for example, ointments, liposomes, powders, lotions and microencapsulations.
  • the wound in the fur can be healed quickly.
  • the preparation is usually applied to the skin one to four times a day.
  • the wound has usually healed already after a treatment of 2 to 5 days with the preparation. However, it is advisable to continue the treatment for a few more days.
  • the following examples illustrate the invention.
  • a preparation of 1 g collagenase (1000 U / g) in 1000 g of a mixture of viscous paraffin and white petroleum jelly (1: 1) was used as the collagenase preparation.
  • a sport horse showed bulging changes under the fur in the area of the restraints. Treatment with antibiotics had had no visible success after 2 weeks. After a week's treatment (3 times a day) with collagenase, the bulge-like changes could be removed. After another week, the treatment was successfully completed.
  • a cow showed signs of inflammation on the udder that could not be removed with antibiotics. After treatment (3 times a day) with collagenase for 3 days, the inflammation had subsided and did not recur.
PCT/EP1996/002480 1995-06-16 1996-06-07 Neue verwendung von collagenase WO1997000082A1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19521829.9 1995-06-16
DE1995121829 DE19521829A1 (de) 1995-06-16 1995-06-16 Neue Verwendung von Collagenase

Publications (1)

Publication Number Publication Date
WO1997000082A1 true WO1997000082A1 (de) 1997-01-03

Family

ID=7764468

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1996/002480 WO1997000082A1 (de) 1995-06-16 1996-06-07 Neue verwendung von collagenase

Country Status (2)

Country Link
DE (1) DE19521829A1 (it)
WO (1) WO1997000082A1 (it)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4524065A (en) * 1983-08-04 1985-06-18 Bio-Specifics N.V. Method for the prevention and treatment of scars with enzymes
EP0468411A2 (en) * 1990-07-23 1992-01-29 Pliva Farmaceutska, Kemijska, Prehrambena I Kozmeticka Industrija S P.O. A mutant of bacterium Clostridium histolyticum, a process for the obtaining thereof, and its use in the production of clostripain-free collagenase
EP0543521A2 (en) * 1991-11-20 1993-05-26 Advance Biofactures Of Curacao N.V. High dosage topical forms of collagenase

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4524065A (en) * 1983-08-04 1985-06-18 Bio-Specifics N.V. Method for the prevention and treatment of scars with enzymes
EP0468411A2 (en) * 1990-07-23 1992-01-29 Pliva Farmaceutska, Kemijska, Prehrambena I Kozmeticka Industrija S P.O. A mutant of bacterium Clostridium histolyticum, a process for the obtaining thereof, and its use in the production of clostripain-free collagenase
EP0543521A2 (en) * 1991-11-20 1993-05-26 Advance Biofactures Of Curacao N.V. High dosage topical forms of collagenase

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
CHVAPIL M ET AL: "DYNAMICS OF THE HEALING OF SKIN WOUNDS IN THE HORSE AS COMPARED WITH THE RAT.", EXP MOL PATHOL 30 (3). 1979. 349-359, XP000605216 *

Also Published As

Publication number Publication date
DE19521829A1 (de) 1996-12-19

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