WO1997000082A1 - Nouvelle utilisation de la collagenase - Google Patents
Nouvelle utilisation de la collagenase Download PDFInfo
- Publication number
- WO1997000082A1 WO1997000082A1 PCT/EP1996/002480 EP9602480W WO9700082A1 WO 1997000082 A1 WO1997000082 A1 WO 1997000082A1 EP 9602480 W EP9602480 W EP 9602480W WO 9700082 A1 WO9700082 A1 WO 9700082A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- collagenase
- treatment
- novel use
- preparation
- wounds
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/4886—Metalloendopeptidases (3.4.24), e.g. collagenase
Definitions
- the present invention relates to a new application of collagenase in veterinary medicine.
- wounds caused by abrasions or infections are treated with main care products or with germicidal substances (antibiotics).
- antibiotics germicidal substances
- Such wounds are partly treated with oils, covering the damaged area of the skin with the oil or an oil-containing product and protecting it from external influences. This does not accelerate the actual healing process. Treatment with antibiotic-containing products is also quite lengthy and in many cases unsuccessful.
- the invention relates to the use of collagenase for the production of externally applicable medicaments for the treatment of wounds on large animals carrying files.
- a suitable collagenase is, for example, that which is obtained from Clostridia histolyticum and is also used in human medicine. However, it can also be isolated from other Clostridia bacteria or tissues (Merck Index, No. 2477).
- the mixtures usually used for skin care can be used as the basis for the preparations. So you can incorporate the collagenase in petroleum jelly or paraffin.
- the collagenase is added to the preparations in an amount of about 0.4 to 2.0 units, preferably 0.6 to 1.2 units, per g.
- Suitable preparations are, for example, ointments, liposomes, powders, lotions and microencapsulations.
- the wound in the fur can be healed quickly.
- the preparation is usually applied to the skin one to four times a day.
- the wound has usually healed already after a treatment of 2 to 5 days with the preparation. However, it is advisable to continue the treatment for a few more days.
- the following examples illustrate the invention.
- a preparation of 1 g collagenase (1000 U / g) in 1000 g of a mixture of viscous paraffin and white petroleum jelly (1: 1) was used as the collagenase preparation.
- a sport horse showed bulging changes under the fur in the area of the restraints. Treatment with antibiotics had had no visible success after 2 weeks. After a week's treatment (3 times a day) with collagenase, the bulge-like changes could be removed. After another week, the treatment was successfully completed.
- a cow showed signs of inflammation on the udder that could not be removed with antibiotics. After treatment (3 times a day) with collagenase for 3 days, the inflammation had subsided and did not recur.
Abstract
L'invention concerne l'utilisation de collagénase pour produire des médicaments à usage externe, pour traiter des blessures chez des animaux de grande taille, couverts de poils.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19521829.9 | 1995-06-16 | ||
DE1995121829 DE19521829A1 (de) | 1995-06-16 | 1995-06-16 | Neue Verwendung von Collagenase |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1997000082A1 true WO1997000082A1 (fr) | 1997-01-03 |
Family
ID=7764468
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP1996/002480 WO1997000082A1 (fr) | 1995-06-16 | 1996-06-07 | Nouvelle utilisation de la collagenase |
Country Status (2)
Country | Link |
---|---|
DE (1) | DE19521829A1 (fr) |
WO (1) | WO1997000082A1 (fr) |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4524065A (en) * | 1983-08-04 | 1985-06-18 | Bio-Specifics N.V. | Method for the prevention and treatment of scars with enzymes |
EP0468411A2 (fr) * | 1990-07-23 | 1992-01-29 | Pliva Farmaceutska, Kemijska, Prehrambena I Kozmeticka Industrija S P.O. | Souche mutante de Clostridium histolyticum, son procédé de préparation et utilisation pour la préparation de collagénase exempt de clostripaine |
EP0543521A2 (fr) * | 1991-11-20 | 1993-05-26 | Advance Biofactures Of Curacao N.V. | Formes topiques de collagenase hautement dosées |
-
1995
- 1995-06-16 DE DE1995121829 patent/DE19521829A1/de not_active Withdrawn
-
1996
- 1996-06-07 WO PCT/EP1996/002480 patent/WO1997000082A1/fr active Application Filing
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4524065A (en) * | 1983-08-04 | 1985-06-18 | Bio-Specifics N.V. | Method for the prevention and treatment of scars with enzymes |
EP0468411A2 (fr) * | 1990-07-23 | 1992-01-29 | Pliva Farmaceutska, Kemijska, Prehrambena I Kozmeticka Industrija S P.O. | Souche mutante de Clostridium histolyticum, son procédé de préparation et utilisation pour la préparation de collagénase exempt de clostripaine |
EP0543521A2 (fr) * | 1991-11-20 | 1993-05-26 | Advance Biofactures Of Curacao N.V. | Formes topiques de collagenase hautement dosées |
Non-Patent Citations (1)
Title |
---|
CHVAPIL M ET AL: "DYNAMICS OF THE HEALING OF SKIN WOUNDS IN THE HORSE AS COMPARED WITH THE RAT.", EXP MOL PATHOL 30 (3). 1979. 349-359, XP000605216 * |
Also Published As
Publication number | Publication date |
---|---|
DE19521829A1 (de) | 1996-12-19 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE69935522T2 (de) | Kosmetische oder dermopharmazeutische verwendung von peptiden zur wundheilung, hydratisierung, verbesserung des hautaussehens bei der natürlichen oder beschleunigten alterung (heliodermie, umweltverschmutzung) | |
DE4393944B4 (de) | Verwendung von Ecdysteroiden in der Dermatologie | |
EP0060553A1 (fr) | Médicament pour le traitement des blessures de la surface dermique et procédé de préparation dudit médicament | |
DE3726797A1 (de) | Arzneimittel fuer den bereich der mundhoehle | |
ATE140918T1 (de) | Derivate in der vitamin d-reihe mit modifikationen in der 20 position, verfahren zu ihrer herstellung, zwischenprodukte für dieses verfahren, diese derivate enthaltende pharmazeutische präparate sowie deren verwendung zur herstellung von arzneimitteln | |
DE4100975A1 (de) | Kosmetische oder pharmazeutische zubereitungen zur verbesserung der haarqualitaet und foerderung des haarwachstums | |
DE1617780B2 (de) | Vernarbungsmittel | |
DE1906155A1 (de) | Zusammensetzung zur Foerderung der Heilung von Wunden | |
EP0912612B1 (fr) | Production simplifiee de fragments d'anticorps bispecifiques | |
EP0366888B1 (fr) | Préparation pharmaceutique pour le traitement des inflammations des membranes muqueuses nasales | |
DE202006020459U1 (de) | Zubereitung mit marinem Kollagen zur Proteinasehemmung | |
WO1997000082A1 (fr) | Nouvelle utilisation de la collagenase | |
DE1768575C3 (de) | 0-(5-Indanyl)-m,N-dimethylthionocarbanilat, Verfahren zu dessen Herstellung und dieses enthaltende Arzneimittel | |
DE2327687A1 (de) | Antiseptisches mittel | |
DE2653595C2 (de) | Verfahren zum Extrahieren von embryonaler Kälberhaut, der dabei erhaltene Extrakt sowie dessen Verwendung als Wirkstoff in Mitteln zur Behandlung der Haut | |
DE4300969A1 (fr) | ||
DE69935889T2 (de) | Polyphosphorsäure enthaltendes Zellwachstumsbeschleunigungsmittel und dessen Verwendung | |
DE3543221A1 (de) | Neue, kosmetische zusammensetzungen fuer die kopfhaut | |
EP1352566B1 (fr) | Procédé de fabrication d'une préparation de principes actifs à partir de cannabis | |
DE3143624A1 (de) | Kosmetisches mittel zur staerkung und foerderung des haarwuchses sowie verfahren zu dessen herstellung | |
DE2659462A1 (de) | Verfahren zur herstellung eines pharmazeutisch verwendbaren feuchten kieselsaeurehydrogels | |
EP0463138B1 (fr) | Medicament servant a ameliorer les reactions ovariennes et la production d'ovules et d'embryons chez les mammiferes domestiques en association avec une transplantation embryonnaire par biotechnologie | |
DE1922193C3 (de) | N-Propionyl- e - aminocapronsäure, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel und kosmetische Zusammensetzungen | |
DE1467791A1 (de) | Verfahren zur Ausscheidung insbesondere von Foetalorganen | |
EP0311963B1 (fr) | Agent thérapeutique comprenant un extrait d'Impatiens Capensis |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AK | Designated states |
Kind code of ref document: A1 Designated state(s): US |
|
AL | Designated countries for regional patents |
Kind code of ref document: A1 Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LU MC NL PT SE |
|
DFPE | Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101) | ||
121 | Ep: the epo has been informed by wipo that ep was designated in this application | ||
WA | Withdrawal of international application | ||
122 | Ep: pct application non-entry in european phase |