WO1996029361A1 - Procede pour preparer des matrices antimicrobiennes - Google Patents

Procede pour preparer des matrices antimicrobiennes Download PDF

Info

Publication number
WO1996029361A1
WO1996029361A1 PCT/GB1996/000605 GB9600605W WO9629361A1 WO 1996029361 A1 WO1996029361 A1 WO 1996029361A1 GB 9600605 W GB9600605 W GB 9600605W WO 9629361 A1 WO9629361 A1 WO 9629361A1
Authority
WO
WIPO (PCT)
Prior art keywords
agent
antimicrobial
matrix
matrix according
antimicrobial agent
Prior art date
Application number
PCT/GB1996/000605
Other languages
English (en)
Inventor
Laurence George Evans
Ian Rorke Burr
Stephen John Cunningham
Original Assignee
Bioshield (Uk) Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bioshield (Uk) Limited filed Critical Bioshield (Uk) Limited
Priority to AU48401/96A priority Critical patent/AU4840196A/en
Publication of WO1996029361A1 publication Critical patent/WO1996029361A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A01N25/34—Shaped forms, e.g. sheets, not provided for in any other sub-group of this main group

Definitions

  • the present invention relates to a process for preparing antimicrobial matrices.
  • it relates to a process for preparing anti-bacterial and anti-fungal matrices.
  • the present invention also relates to anti-bacterial and anti-fungal matrices and articles formed from the matrices.
  • an effective and practical way of removing unwanted infectious agents, such as bacteria, from an article is to wipe the article with a disinfectant solution.
  • a disinfectant solution applied in this way acts both as a bacteriostatic agent (to hinder the growth of bacteria) and as a bacteriocidal agent (to kill
  • antimicrobial agent can pass into the cell to affect either protein synthesis, cell reproduction or internal respiration/energy production or to damage the cell wall sufficiently to cause lysis.
  • the effectiveness of an antimicrobial agent is dependent to some extent upon the "wetting" of a cell wall.
  • the disinfectant solution applied to an article dries, the disinfectant looses its bacteriostatic and bacteriocidal properties. As a result, it is necessary to regularly apply
  • EP-A-0 262 921 discloses bactericidal shields for telephones, wherein the shields comprise a rigid polyvinylchloride or rigid polystyrene formulation
  • PCT/GB 90/00404 discloses a process for preparing bactericidal matrices comprising a plastics-type support matrix, an alkylated diaminoalkane-type antibacterial agent and an organoarsenic-type anti-bacterial agent.
  • the anti-bacterial agents allegedly act
  • the resulting mixture may be extruded, and/or formed or moulded, to produce articles having
  • a surfactant is also mixed with the support matrix.
  • an antimicrobial matrix comprising a support matrix, an antimicrobial agent and a carrying agent, wherein the carrying agent and the antimicrobial agent are adapted to form at least one hydrogen bond or salt bridge therebetween.
  • the antimicrobial matrix may also comprise a surfactant.
  • the carrying agent and the antimicrobial agent are linked by hydrogen bonding or salt bridge and migrate over a period of time through the support matrix to the surface thereof.
  • antimicrobial agent then acts to kill bacteria both on the surface of the matrix, and at a distance therefrom by virtue of further diffusion, thus forming a 'halo' area (inhibition zone).
  • the rate of migration and of diffusion of the carrying agent and the antimicrobial agent through the support matrix is dependent on a number of factors
  • the length of the polymer chain (molecular weight) of the carrying agent including; the length of the polymer chain (molecular weight) of the carrying agent; the hydrophobicity or hydrophilicity of the carrying agent; and the molecular composition and/or density of the support matrix.
  • the rate of migration, the rate of diffusion and/or the surface concentration of the antimicrobial agent can be controlled. These factors will determine the degree and duration of activity of the antimicrobial agent.
  • the carrying agent by virtue of its wetting properties and viscosity, acts as a 'flypaper', adhering bacteria to it.
  • the addition of a surfactant improves the effectiveness of the antimicrobial agent by 'wetting' the cell wall of an organism to enable the antimicrobial agent to pass more easily therein.
  • the surfactant is
  • the antimicrobial agent may be an anti-fungal agent such as undecenoic acid or griseofulvin.
  • the antimicrobial agent may be an antiviral agent or an algaecidal agent.
  • the antimicrobial agent is preferable incorporated into the matrix at a concentration of from 0.5 to 5% weight by volume.
  • the carrying agent is a polymer and may be polyvinyl pyrolidone, coconut oil or polyethylene glycol (PEG).
  • PEG polyethylene glycol
  • PEG 300, PEG 400 or PEG 600 may be used, the numerals indicating the average molecular weight of each polymer.
  • the molecular weight of the polymer used affects the rate of replenishment of the antimicrobial agent on the surface of the support matrix.
  • the support matrix may be of natural or synthetic plastics, natural or synthetic rubber, silicone rubber, nitriles, fabric, polymeric species, biopolymers or resin.
  • the support matrix is poly vinyl chloride.
  • it is a synthetic rubber such as Caraflex (trade mark).
  • Other examples are low density polyethylene (LDPE), low density polypropylene (LDPD), polyurethane, ethylene vinyl acetate and
  • ABS acrylonitrile-butadiene-styrene
  • Table 1 shows the results of tests, read on 20 November 1993, conducted by Royal Hampshire County Hospital (District Pathology Laboratory) on samples of an antimicrobial matrix received there and inoculated on 18 November 1993.
  • Table 2 shows the results of tests, read on 28 November 1993, conducted by Royal Hampshire County
  • Table 3 shows the results of tests, read on 21 April 1994, conducted by Royal Hampshire County Hospital (Department of Microbiology) on the samples of the antimicrobial matrix received these on 26 November 1993 and inoculated on 19 April 1994.
  • Table 5 shows the results of tests, read on 27 April 1994, conducted by Royal Hampshire County Hospital (Department of Microbiology) on samples of the
  • the antimicrobial matrices and articles according to the present invention exhibit excellent antimicrobial properties, even after a period of time.
  • Table 8 shows the results of tests, read on 18 February 1996, conducted by Royal Hampshire County Hospital (department of Microbiology) on samples of an antimicrobial matrix received there on 16 February 1996 and innoculated on 17 February 1996.
  • the expanded foam block formed was sliced into thin sheets 2 mm thick and from the sheets were cut a shape about 25 mm across suitable for covering the speech area of telephone mouthpiece, thus forming a telephone shield.
  • an adhesive was applied so that it could be attached to the telephone mouthpiece.
  • the adhesive was then covered with a peel-off covering.
  • a circular pad 40 mm diameter was cut from a strip of 2 nm thick foam plastic material prepared as described above.
  • the pad was fitted centrally over the mouthpiece of the telephone handset, so that all the holes in the mouthpiece were covered.
  • the pad was fixed in place using a 'PrittStick' adhesive stick.
  • the handset was an Eagle type TH7SP obtained from the NESCOT Media Services Department. It was held vertically using a retort stand 15 cm front of a Tannoy Loudspeaker (of cabinet dimensions 30 cm by 50 cm by 30 cm) with the mouthpiece facing towards the loudspeaker and opposite to its centre point.
  • the output signal from the microphone in the handset was measured using a Bruel and Kjaer sound level meter type 2203 fitted with octave band filters type 1613.
  • the sound level meter was first checked to ensure that it was operating satisfactorily using a Bruel and Kjaer calibrator type 4232.
  • the Bruel and Kjaer microphone was then removed and the signal from the microphone in the handset fed into the sound level meter using an adaptor.
  • the signal from the microphone in the handset measured in octave bands from 125 Hz to 8000 Hz.
  • the foam plastic pad was removed from the mouthpiece of the handset and the measurements were repeated. The measurements were also repeated again, with the signal to the loudspeaker reduced to zero, to measure the background noise levels in the laboratory, to ensure that they were not affecting the results of the test.

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Toxicology (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Agronomy & Crop Science (AREA)
  • Engineering & Computer Science (AREA)
  • Dentistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Materials For Medical Uses (AREA)

Abstract

L'invention concerne une matrice antimicrobienne et un procédé pour préparer une telle matrice. La matrice est constituée d'un support, d'un agent antimicrobien et d'un agent vecteur. L'agent vecteur et l'agent antibactérien sont choisis de manière à former entre eux un pont hydrogène et/ou un pont de type sel. L'agent antimicrobien migre à travers la matrice de support vers la surface de celle-ci. Cette matrice peut être extrudée et/ou moulée pour former des articles à usage pharmaceutique, médical, ou personnel, ainsi que des articles utilisés dans les restaurants.
PCT/GB1996/000605 1995-03-17 1996-03-15 Procede pour preparer des matrices antimicrobiennes WO1996029361A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU48401/96A AU4840196A (en) 1995-03-17 1996-03-15 A process for preparing antimicrobial matrices

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9505162.9A GB9505162D0 (en) 1995-03-17 1995-03-17 A process for preparing antimicrobial matrices
GB9505162.9 1995-03-17

Publications (1)

Publication Number Publication Date
WO1996029361A1 true WO1996029361A1 (fr) 1996-09-26

Family

ID=10771198

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB1996/000605 WO1996029361A1 (fr) 1995-03-17 1996-03-15 Procede pour preparer des matrices antimicrobiennes

Country Status (3)

Country Link
AU (1) AU4840196A (fr)
GB (1) GB9505162D0 (fr)
WO (1) WO1996029361A1 (fr)

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997024925A2 (fr) * 1996-01-12 1997-07-17 Fenchurch Environmental Group Limited Compositions bactericides et articles les contenant
AU693997B2 (en) * 1995-03-08 1998-07-09 Eastman Kodak Company A material, method and apparatus for inhibiting bacterial growth in an aqueous medium
AU693996B2 (en) * 1995-03-08 1998-07-09 Eastman Kodak Company A material, method and apparatus for inhibiting bacterial growth in an aqueous medium
WO1998052335A1 (fr) * 1997-05-16 1998-11-19 Friedman Neil A Garniture pour berceau de combine telephonique
WO1999062392A1 (fr) * 1998-06-02 1999-12-09 Hogue Aaron G Ensemble de siege et abattant de toilette
WO2011129982A3 (fr) * 2010-04-14 2012-11-29 Avery Dennison Corporation Procédés d'augmentation de l'efficacité d'agents antimicrobiens dans des films polymères
WO2014008264A1 (fr) * 2012-07-05 2014-01-09 3M Innovative Properties Company Composition antimicrobienne durcissable
WO2014209095A1 (fr) 2013-06-25 2014-12-31 Servicios Administrates Penoles, S.A. De C.V. Additif bactériostatique et fongistatique en mélange maître pour une application sur des plastiques et procédé d'obtention de celui-ci
US10335308B2 (en) 2011-12-22 2019-07-02 Avery Dennison Corporation Flexible barrier films containing cyclic olefins
US11220616B2 (en) 2011-08-19 2022-01-11 Avery Dennison Corporation Barrier films

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0141628A1 (fr) * 1983-10-29 1985-05-15 Unitika Ltd. Composition de latex antimicrobien, objet façonné fabriqué à partir de celle-ci et procédé de fabrication d'un objet façonné
WO1993023468A1 (fr) * 1992-05-08 1993-11-25 Olin Corporation Procede destine a obtenir une dispersion de biocides stable
EP0606762A2 (fr) * 1992-12-25 1994-07-20 Japan Synthetic Rubber Co., Ltd. Composition résineuse antibacterielle

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0141628A1 (fr) * 1983-10-29 1985-05-15 Unitika Ltd. Composition de latex antimicrobien, objet façonné fabriqué à partir de celle-ci et procédé de fabrication d'un objet façonné
WO1993023468A1 (fr) * 1992-05-08 1993-11-25 Olin Corporation Procede destine a obtenir une dispersion de biocides stable
EP0606762A2 (fr) * 1992-12-25 1994-07-20 Japan Synthetic Rubber Co., Ltd. Composition résineuse antibacterielle

Cited By (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU693997B2 (en) * 1995-03-08 1998-07-09 Eastman Kodak Company A material, method and apparatus for inhibiting bacterial growth in an aqueous medium
AU693996B2 (en) * 1995-03-08 1998-07-09 Eastman Kodak Company A material, method and apparatus for inhibiting bacterial growth in an aqueous medium
GB2310140B (en) * 1996-01-12 2000-08-09 Trevor Woolard Bactericidal compositions and articles containing them
WO1997024925A3 (fr) * 1996-01-12 1997-12-04 Trevor Woolard Compositions bactericides et articles les contenant
WO1997024925A2 (fr) * 1996-01-12 1997-07-17 Fenchurch Environmental Group Limited Compositions bactericides et articles les contenant
WO1998052335A1 (fr) * 1997-05-16 1998-11-19 Friedman Neil A Garniture pour berceau de combine telephonique
US6347415B1 (en) * 1998-06-02 2002-02-19 Aaron G. Hogue Toilet seat and lid assembly
US6154892A (en) * 1998-06-02 2000-12-05 Hogue; Aaron G. Toilet seat and lid assembly
WO1999062392A1 (fr) * 1998-06-02 1999-12-09 Hogue Aaron G Ensemble de siege et abattant de toilette
WO2011129982A3 (fr) * 2010-04-14 2012-11-29 Avery Dennison Corporation Procédés d'augmentation de l'efficacité d'agents antimicrobiens dans des films polymères
CN102946725A (zh) * 2010-04-14 2013-02-27 艾利丹尼森公司 增加聚合膜中抗菌剂的有效性的方法
CN102946725B (zh) * 2010-04-14 2016-01-27 艾利丹尼森公司 增加聚合膜中抗菌剂的有效性的方法
US11220616B2 (en) 2011-08-19 2022-01-11 Avery Dennison Corporation Barrier films
US10335308B2 (en) 2011-12-22 2019-07-02 Avery Dennison Corporation Flexible barrier films containing cyclic olefins
WO2014008264A1 (fr) * 2012-07-05 2014-01-09 3M Innovative Properties Company Composition antimicrobienne durcissable
US9320834B2 (en) 2012-07-05 2016-04-26 3M Innovative Properties Company Hardenable antimicrobial composition
WO2014209095A1 (fr) 2013-06-25 2014-12-31 Servicios Administrates Penoles, S.A. De C.V. Additif bactériostatique et fongistatique en mélange maître pour une application sur des plastiques et procédé d'obtention de celui-ci
EP3575263A1 (fr) 2013-06-25 2019-12-04 Servicios Administrativos Peñoles S.A. de C.V Additif bactériostatique et fongistatique dans un mélange maître pour application dans des matières plastiques et son procédé de production

Also Published As

Publication number Publication date
GB9505162D0 (en) 1995-05-03
AU4840196A (en) 1996-10-08

Similar Documents

Publication Publication Date Title
WO1996029361A1 (fr) Procede pour preparer des matrices antimicrobiennes
CN100381489C (zh) 具有抗微生物或抗凝血性的聚合物树脂制剂及其制备方法
CN1503660A (zh) 抗菌聚氨酯薄膜
CA2323907A1 (fr) Matiere plastique a proprietes de biocide
CN110563911A (zh) 一种抗菌海绵及其制备方法
CN109749250B (zh) 抗菌母粒及其制备方法和应用、抗菌材料
Wallström et al. Development and comparison of test methods for evaluating formation of biofilms on silicones
KR100302831B1 (ko) 항균플라스틱수지필름및그제조방법
CN106221331B (zh) 一种内墙防霉涂料及其制备方法
JPH0892019A (ja) 抗菌性樹脂組成物
US20080248076A1 (en) Antimicrobial rubber bands
JPH04505755A (ja) 殺菌性マトリックスの製造方法
JPS5819691B2 (ja) 熱可塑性樹脂組成物
JPH11293118A (ja) 食品用抗菌・防カビフィルム
JPH0768656A (ja) 抗菌性アクリルフイルム
JP3571554B2 (ja) 脱臭・抗菌剤組成物、脱臭・抗菌性樹脂組成物及び脱臭・抗菌性樹脂成形物
RU2625468C1 (ru) Антимикробная полимерная композиция
CN116277843B (zh) 一种防光防腐蚀的黑膜制备工艺
JP2003192916A (ja) 抗菌性樹脂組成物及びその組成物からなるフィルム
JP3140628B2 (ja) ポリアセタール樹脂組成物
KR20010083379A (ko) 식품 포장용 항균필름
JP3355283B2 (ja) 抗菌・防カビ性合成樹脂材料及びその製造方法
JP2003253059A (ja) 殺菌性樹脂組成物およびその成形物ならびに殺菌性樹脂組成物からなるフィルムの製造方法
EP0262921A2 (fr) Ensemble d'écrans bactériens pour utilisation sur combiné téléphonique
JP3266174B2 (ja) 抗菌性樹脂組成物

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A1

Designated state(s): AL AM AT AU AZ BB BG BR BY CA CH CN CZ DE DK EE ES FI GB GE HU IS JP KE KG KP KR KZ LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK TJ TM TR TT UA UG US UZ VN AM AZ BY KG KZ MD RU TJ TM

AL Designated countries for regional patents

Kind code of ref document: A1

Designated state(s): KE LS MW SD SZ UG AT BE CH DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
121 Ep: the epo has been informed by wipo that ep was designated in this application
REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

122 Ep: pct application non-entry in european phase
NENP Non-entry into the national phase

Ref country code: CA