WO1996008290A1 - Cuff-elektrode - Google Patents
Cuff-elektrode Download PDFInfo
- Publication number
- WO1996008290A1 WO1996008290A1 PCT/EP1995/003545 EP9503545W WO9608290A1 WO 1996008290 A1 WO1996008290 A1 WO 1996008290A1 EP 9503545 W EP9503545 W EP 9503545W WO 9608290 A1 WO9608290 A1 WO 9608290A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- electrodes
- cuff
- nerve
- electrode
- fingers
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
- A61N1/0551—Spinal or peripheral nerve electrodes
- A61N1/0556—Cuff electrodes
Definitions
- the invention relates to a cuff electrode according to the preamble of claim 1, as e.g. is known from WO 91/17791.
- FLIC FLexible Interdigital Cuff Electrode
- a pre-stretched silicone film is connected to an unstretched film with medical silicone adhesive.
- the electrodes consist of platinum wires that are placed between the foils.
- the active electrode surface is created by opening windows (scalpel, punching iron) in the pre-stretched film.
- the electrode rolls up in a spiral. If the nerve swells, the spiral-shaped cuff electrode can expand somewhat and thereby partially compensate for an increase in pressure.
- helix electrode refers to electrodes wound helically around the nerve. They are used in mono- and bipolar form with a maximum of two electrodes. Due to the open structure of the electrode, the risk of pressure damage to the nerve due to swelling is low, but it is not possible to limit the field to the inside of the electrode during stimulation (lower energy requirement). It has no possibility of selectively stimulating certain parts of the nerve cross section.
- the object of the invention is to improve the cuff electrode according to the preamble of claim 1. In particular, the task is to reduce the contact pressure of the electrode on the nerves.
- a bidirectional coupling to the nerves with a high spatial and temporal resolution is intended to enable the derivation of nerve signals and / or electrical stimulation of nerve fibers.
- the new cuff structure allows the field to be limited to the inside of the electrode, as a result of which the amount of energy required for stimulation can be kept low.
- the large number of electrodes allows a high spatial and temporal resolution and the use of tripolar arrangements to concentrate the electric field as well as the use of transverse control currents to excite deep nerve structures. See the journal IEEE Transactions 1993 cited above.
- FIG. 1 shows the flexible interdigital cuff electrode in a planar state
- FIG. 2 shows the cuff electrode in a rolled-up form, the nerve coming to rest inside the rolled-up fingers.
- the nerve is of course not shown in the figure.
- Fig. 3 shows the side view of the FLIC electrode in the planar state (top view of the cut surface of the connecting cable)
- Fig. 4 shows the sectional view of the FLIC electrode in the planar state (section through the first electrode finger).
- the FLIC consists of a flexible, multilayer substrate in finger structure 1 made of non-conductive silicone, on which raised electrodes 3 made of conductive Silicone.
- the conductor tracks 5 leading to the electrodes 3 run between the non-conductive layers of the fingers and likewise consist of conductive silicone. These conductor tracks are only shown for 48 electrodes in FIGS. 3 and 4, since with the 45 electrodes shown per finger according to FIG. 1 this is difficult to represent in the drawing. 3 and 4 has 6 electrodes per finger with 4 fingers on the left and 4 fingers on the right.
- the conductor tracks and electrodes are created by microstructure molding with negative molds which are produced in conventional silicon technology, for example molds are provided in which silicone rubber is crocheted (laid), which is then thermally crosslinked.
- Both wet-chemically etched structures in silicon can serve as shapes, see, for example, Anton Heuberger Micromechanics "Microfabrication using methods of semiconductor technology", Springer-Verlag Berlin, Heidelberg, New York, London, Paris, Tokyo 1989, and also using precision metrology shapes made by hand.
- the rolled-up shape of the FLIC is created by setting different pre-stresses in the multi-layer structure or by using shape memory alloys or by electrochemical actuators.
- the shape memory metals are inserted in the form of individual strips within the insulating material layers. Since the preload needs to be relatively low, a layer of shape memory material can suffice.
- the shape memory metal is surrounded on all sides with insulating silicone rubber 1 and has no contact with the conductive structures of the electrodes 3 and leads 5, 6.
- the electrodes with the leads in the fingers and the lead cable 4 are insulated from one another and are not isolated on one shown processing unit connected to the electrodes with stimulus currents.
- the lines 5, 6 can be connected in such a way that derivatives of nerve signals can also be received in the processing unit.
- the conductor tracks and electrodes are preferably made of conductive silicone rubber using microstructure technology, as are the insulating silicone layers in between.
- the use of silicone foils is not intended.
- (3) is the active electrode structure made of conductive silicone rubber.
- galvanic aftertreatment can be carried out, for example galvanic deposition of carbon, gold, platinum or iridium on the "dome" shown in FIG. 3. When platinum or iridium is deposited, the amount of charge that can be introduced per stimulation pulse per electrode by means of reversible electrochemical processes also increases.
- Fig. 3 and 4 show the raised electrode structure with a base material made of non-conductive silicone rubber 2.
- the non-conductive silicone rubber 2 is almost like a sleeve around the conductive core and enables electrical insulation of the individual electrodes 3 from each other (see Fig. 4).
- the non-conductive silicone rubber provides the support structure for the supply lines 6 and supports them mechanically and insulates the individual supply lines 5, 6 also in the connecting cable 4.
- the raised electrodes are rod-shaped with a hemispherical electrode tip. Of course, they can also be rods with a square or polygonal cross section and also a rounded tip. This design considerably reduces the effective contact area of the cuff electrode with the nerves. This then results in a punctiform grid on the nerve tissue, the dots having a flat shape due to the impression in the tissue. Graphically speaking, the cavities between the raised structures form the shape of a grid or network. Due to the finger structure, the individual fingers can wrap around the nerves with a mean diameter that may be adapted to the nerves.
- the number of electrodes can vary depending on the type of application. In any case, several electrodes per finger are preferred, for example 4-50 electrodes per finger. The number of fingers also depends on the type of application and the thickness of the nerve. For example, at least two fingers per side are provided, ie a total of four fingers, preferably 4-5 or more fingers per side.
- the fingers are arranged on the left and right of a central part 7, each with 4 fingers.
- the fingers are arranged on one side as with a hand and then lay around the nerve like a hand.
- all fingers are arranged on one side as with a hand and then lay around the nerve like a hand.
- 2 fingers next to each other and on the other side a corresponding empty space.
- the flexible interdigital cuff electrode there are 4 to 6 "fingers" on each side of a central web, each with 6 - 45 raised electrodes, which can be configured as desired in order to use the same FLIC in principle for the derivation of electron neurograms (ENG) as well as being able to use it for stimulation.
- the possible dimensions of the FLIC are approx. 10 mm long with approx. 1.4 mm - 40 mm diameter.
Landscapes
- Health & Medical Sciences (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Electrotherapy Devices (AREA)
Abstract
Description
Claims
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/809,190 US5919220A (en) | 1994-09-16 | 1995-09-08 | Cuff electrode |
EP95932017A EP0843574B1 (de) | 1994-09-16 | 1995-09-08 | Cuff-elektrode |
JP8509886A JPH10505762A (ja) | 1994-09-16 | 1995-09-08 | カフス型電極 |
DE59507542T DE59507542D1 (de) | 1994-09-16 | 1995-09-08 | Cuff-elektrode |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE4433111A DE4433111A1 (de) | 1994-09-16 | 1994-09-16 | Cuff-Elektrode |
DEP4433111.8 | 1994-09-16 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1996008290A1 true WO1996008290A1 (de) | 1996-03-21 |
Family
ID=6528444
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP1995/003545 WO1996008290A1 (de) | 1994-09-16 | 1995-09-08 | Cuff-elektrode |
Country Status (5)
Country | Link |
---|---|
US (1) | US5919220A (de) |
EP (1) | EP0843574B1 (de) |
JP (1) | JPH10505762A (de) |
DE (2) | DE4433111A1 (de) |
WO (1) | WO1996008290A1 (de) |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1999024109A2 (de) | 1997-11-12 | 1999-05-20 | Bartha Johann W | Cuff-elektrode und verfahren zu deren herstellung |
DE19847446A1 (de) * | 1998-10-08 | 2000-04-13 | Biotronik Mess & Therapieg | Nervenelektrodenanordnung |
WO2002055151A1 (de) * | 2001-01-11 | 2002-07-18 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Siebelektrode zur anbindung an einen nervenstumpf |
US8951556B2 (en) | 2002-12-13 | 2015-02-10 | Durect Corporation | Oral drug delivery system |
CN104055598B (zh) * | 2014-06-25 | 2016-09-07 | 上海交通大学 | 鱼类生物机器人的可植入式柔性神经微电极及其制备方法 |
Families Citing this family (125)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6266549B1 (en) * | 1993-12-06 | 2001-07-24 | Heska Corporation | Apparatus and method for evaluating cardiac functions |
US6438400B1 (en) * | 1993-12-06 | 2002-08-20 | Heska Corporation | Electrode for evaluating cardiac functions via esophagus |
US7599736B2 (en) * | 2001-07-23 | 2009-10-06 | Dilorenzo Biomedical, Llc | Method and apparatus for neuromodulation and physiologic modulation for the treatment of metabolic and neuropsychiatric disease |
US6308105B1 (en) * | 1999-07-15 | 2001-10-23 | Medtronic Inc. | Medical electrical stimulation system using an electrode assembly having opposing semi-circular arms |
DE10020846A1 (de) * | 2000-04-28 | 2001-12-06 | Intelligent Implants Gmbh | Mikrokontaktstruktur für Neuroprothesen zur Implantation an Nervengewebe und Verfahren hierzu |
US6895283B2 (en) * | 2000-08-10 | 2005-05-17 | Advanced Neuromodulation Systems, Inc. | Stimulation/sensing lead adapted for percutaneous insertion |
US6985774B2 (en) * | 2000-09-27 | 2006-01-10 | Cvrx, Inc. | Stimulus regimens for cardiovascular reflex control |
US7616997B2 (en) * | 2000-09-27 | 2009-11-10 | Kieval Robert S | Devices and methods for cardiovascular reflex control via coupled electrodes |
US20080177365A1 (en) * | 2000-09-27 | 2008-07-24 | Cvrx, Inc. | Method and apparatus for electronically switching electrode configuration |
US7623926B2 (en) * | 2000-09-27 | 2009-11-24 | Cvrx, Inc. | Stimulus regimens for cardiovascular reflex control |
US7840271B2 (en) | 2000-09-27 | 2010-11-23 | Cvrx, Inc. | Stimulus regimens for cardiovascular reflex control |
US20080167699A1 (en) * | 2000-09-27 | 2008-07-10 | Cvrx, Inc. | Method and Apparatus for Providing Complex Tissue Stimulation Parameters |
US7158832B2 (en) * | 2000-09-27 | 2007-01-02 | Cvrx, Inc. | Electrode designs and methods of use for cardiovascular reflex control devices |
US7499742B2 (en) * | 2001-09-26 | 2009-03-03 | Cvrx, Inc. | Electrode structures and methods for their use in cardiovascular reflex control |
US8086314B1 (en) | 2000-09-27 | 2011-12-27 | Cvrx, Inc. | Devices and methods for cardiovascular reflex control |
US6368349B1 (en) * | 2000-11-21 | 2002-04-09 | Massachusetts Institute Of Technology | Inflatable neural prosthesis |
FR2821275B1 (fr) * | 2001-02-28 | 2004-01-30 | Univ Joseph Fourier | Structure d'electrodes implantable |
US6792314B2 (en) * | 2001-06-18 | 2004-09-14 | Alfred E. Mann Foundation For Scientific Research | Miniature implantable array and stimulation system suitable for eyelid stimulation |
US7499753B2 (en) * | 2001-06-28 | 2009-03-03 | Urologica Ag | Urinary Dysfunction Treatment Apparatus |
US20070162085A1 (en) * | 2001-07-23 | 2007-07-12 | Dilorenzo Biomedical, Llc | Method, apparatus, surgical technique, and stimulation parameters for autonomic neuromodulation for the treatment of obesity |
US20060116736A1 (en) * | 2001-07-23 | 2006-06-01 | Dilorenzo Daniel J | Method, apparatus, and surgical technique for autonomic neuromodulation for the treatment of obesity |
US20140046407A1 (en) * | 2001-08-31 | 2014-02-13 | Bio Control Medical (B.C.M.) Ltd. | Nerve stimulation techniques |
US7778711B2 (en) * | 2001-08-31 | 2010-08-17 | Bio Control Medical (B.C.M.) Ltd. | Reduction of heart rate variability by parasympathetic stimulation |
US8565896B2 (en) | 2010-11-22 | 2013-10-22 | Bio Control Medical (B.C.M.) Ltd. | Electrode cuff with recesses |
AU2003220574A1 (en) * | 2002-03-27 | 2003-10-13 | Cvrx, Inc. | Electrode structures and methods for their use in cardiovascular reflex control |
US8145316B2 (en) | 2002-04-08 | 2012-03-27 | Ardian, Inc. | Methods and apparatus for renal neuromodulation |
US8150519B2 (en) | 2002-04-08 | 2012-04-03 | Ardian, Inc. | Methods and apparatus for bilateral renal neuromodulation |
US7189204B2 (en) | 2002-12-04 | 2007-03-13 | Cardiac Pacemakers, Inc. | Sleep detection using an adjustable threshold |
US7627384B2 (en) | 2004-11-15 | 2009-12-01 | Bio Control Medical (B.C.M.) Ltd. | Techniques for nerve stimulation |
US8880192B2 (en) | 2012-04-02 | 2014-11-04 | Bio Control Medical (B.C.M.) Ltd. | Electrode cuffs |
US8014878B2 (en) * | 2005-04-28 | 2011-09-06 | Second Sight Medical Products, Inc. | Flexible circuit electrode array |
US8718791B2 (en) * | 2003-05-23 | 2014-05-06 | Bio Control Medical (B.C.M.) Ltd. | Electrode cuffs |
US8606356B2 (en) | 2003-09-18 | 2013-12-10 | Cardiac Pacemakers, Inc. | Autonomic arousal detection system and method |
US7480532B2 (en) * | 2003-10-22 | 2009-01-20 | Cvrx, Inc. | Baroreflex activation for pain control, sedation and sleep |
US8467875B2 (en) | 2004-02-12 | 2013-06-18 | Medtronic, Inc. | Stimulation of dorsal genital nerves to treat urologic dysfunctions |
US7747323B2 (en) | 2004-06-08 | 2010-06-29 | Cardiac Pacemakers, Inc. | Adaptive baroreflex stimulation therapy for disordered breathing |
US7596413B2 (en) * | 2004-06-08 | 2009-09-29 | Cardiac Pacemakers, Inc. | Coordinated therapy for disordered breathing including baroreflex modulation |
WO2006022993A2 (en) | 2004-06-10 | 2006-03-02 | Ndi Medical, Llc | Implantable generator for muscle and nerve stimulation |
US8195304B2 (en) | 2004-06-10 | 2012-06-05 | Medtronic Urinary Solutions, Inc. | Implantable systems and methods for acquisition and processing of electrical signals |
US9205255B2 (en) | 2004-06-10 | 2015-12-08 | Medtronic Urinary Solutions, Inc. | Implantable pulse generator systems and methods for providing functional and/or therapeutic stimulation of muscles and/or nerves and/or central nervous system tissue |
US8165692B2 (en) | 2004-06-10 | 2012-04-24 | Medtronic Urinary Solutions, Inc. | Implantable pulse generator power management |
US9308382B2 (en) | 2004-06-10 | 2016-04-12 | Medtronic Urinary Solutions, Inc. | Implantable pulse generator systems and methods for providing functional and/or therapeutic stimulation of muscles and/or nerves and/or central nervous system tissue |
US7761167B2 (en) | 2004-06-10 | 2010-07-20 | Medtronic Urinary Solutions, Inc. | Systems and methods for clinician control of stimulation systems |
US20060004417A1 (en) * | 2004-06-30 | 2006-01-05 | Cvrx, Inc. | Baroreflex activation for arrhythmia treatment |
WO2006017634A2 (en) | 2004-08-04 | 2006-02-16 | Ndi Medical, Llc | Devices, systems, and methods employing a molded nerve cuff electrode |
JP2008518694A (ja) * | 2004-11-08 | 2008-06-05 | コンティネンス コントロール システムズ インターナショナル プロプライエタリー リミテッド | 埋め込み可能な電極装置 |
US7536227B1 (en) * | 2005-01-26 | 2009-05-19 | Pacesetter, Inc. | Shielded electrode for nerve sensing |
US7680538B2 (en) * | 2005-03-31 | 2010-03-16 | Case Western Reserve University | Method of treating obstructive sleep apnea using electrical nerve stimulation |
US7395119B2 (en) * | 2005-05-19 | 2008-07-01 | Cvrx, Inc. | Implantable electrode assembly having reverse electrode configuration |
US20060271137A1 (en) * | 2005-05-25 | 2006-11-30 | The Cleveland Clinic Foundation | Apparatus and system to stimulate a nerve |
US7584004B2 (en) * | 2005-06-13 | 2009-09-01 | Cardiac Pacemakers, Inc. | Vascularly stabilized peripheral nerve cuff assembly |
US7596414B2 (en) * | 2005-12-05 | 2009-09-29 | Boston Scientific Neuromodulation Corporation | Cuff electrode arrangement for nerve stimulation and methods of treating disorders |
US8109879B2 (en) | 2006-01-10 | 2012-02-07 | Cardiac Pacemakers, Inc. | Assessing autonomic activity using baroreflex analysis |
US20070173914A1 (en) * | 2006-01-24 | 2007-07-26 | Cyberonics, Inc. | Self-locking electrode assembly usable with an implantable medical device |
US7914842B1 (en) * | 2006-02-10 | 2011-03-29 | Second Sight Medical Products, Inc | Method of manufacturing a flexible circuit electrode array |
US20080004673A1 (en) * | 2006-04-03 | 2008-01-03 | Cvrx, Inc. | Implantable extravascular electrostimulation system having a resilient cuff |
US8180462B2 (en) | 2006-04-18 | 2012-05-15 | Cyberonics, Inc. | Heat dissipation for a lead assembly |
US9480846B2 (en) | 2006-05-17 | 2016-11-01 | Medtronic Urinary Solutions, Inc. | Systems and methods for patient control of stimulation systems |
CA2653864A1 (en) | 2006-06-02 | 2007-12-13 | Victhom Human Bionics Inc. | Nerve cuff, method and apparatus for manufacturing same |
US20080046054A1 (en) * | 2006-06-23 | 2008-02-21 | Cvrx, Inc. | Implantable electrode assembly utilizing a belt mechanism for sutureless attachment |
US8478420B2 (en) | 2006-07-12 | 2013-07-02 | Cyberonics, Inc. | Implantable medical device charge balance assessment |
US20080027524A1 (en) * | 2006-07-26 | 2008-01-31 | Maschino Steven E | Multi-electrode assembly for an implantable medical device |
US20080091255A1 (en) * | 2006-10-11 | 2008-04-17 | Cardiac Pacemakers | Implantable neurostimulator for modulating cardiovascular function |
US9913982B2 (en) | 2011-01-28 | 2018-03-13 | Cyberonics, Inc. | Obstructive sleep apnea treatment devices, systems and methods |
US9186511B2 (en) | 2006-10-13 | 2015-11-17 | Cyberonics, Inc. | Obstructive sleep apnea treatment devices, systems and methods |
US9744354B2 (en) | 2008-12-31 | 2017-08-29 | Cyberonics, Inc. | Obstructive sleep apnea treatment devices, systems and methods |
US8855771B2 (en) | 2011-01-28 | 2014-10-07 | Cyberonics, Inc. | Screening devices and methods for obstructive sleep apnea therapy |
ES2722849T3 (es) | 2006-10-13 | 2019-08-19 | Cyberonics Inc | Dispositivos y sistemas para el tratamiento de apnea obstructiva del sueño |
US9205262B2 (en) | 2011-05-12 | 2015-12-08 | Cyberonics, Inc. | Devices and methods for sleep apnea treatment |
US7996092B2 (en) | 2007-01-16 | 2011-08-09 | Ndi Medical, Inc. | Devices, systems, and methods employing a molded nerve cuff electrode |
US7974707B2 (en) | 2007-01-26 | 2011-07-05 | Cyberonics, Inc. | Electrode assembly with fibers for a medical device |
US7751880B1 (en) | 2007-02-12 | 2010-07-06 | Pacesetter, Inc. | Shielded electrode assembly for effective nerve sensing and stimulation |
WO2008101225A2 (en) * | 2007-02-16 | 2008-08-21 | Second Sight Medical Products, Inc. | Flexible circuit electrode array with wire or film support |
US8594794B2 (en) | 2007-07-24 | 2013-11-26 | Cvrx, Inc. | Baroreflex activation therapy with incrementally changing intensity |
US8942798B2 (en) | 2007-10-26 | 2015-01-27 | Cyberonics, Inc. | Alternative operation mode for an implantable medical device based upon lead condition |
US8868203B2 (en) * | 2007-10-26 | 2014-10-21 | Cyberonics, Inc. | Dynamic lead condition detection for an implantable medical device |
US8340785B2 (en) * | 2008-05-02 | 2012-12-25 | Medtronic, Inc. | Self expanding electrode cuff |
US9227053B2 (en) * | 2008-05-02 | 2016-01-05 | Medtronic, Inc. | Self expanding electrode cuff |
US8792973B2 (en) * | 2008-11-21 | 2014-07-29 | Washington University | Bipolar sieve electrode and method of assembly |
US8515520B2 (en) | 2008-12-08 | 2013-08-20 | Medtronic Xomed, Inc. | Nerve electrode |
EP2408521B1 (de) | 2009-03-17 | 2014-06-25 | Cardio Thrive, Inc | Externer defibrillator |
US20100298916A1 (en) * | 2009-05-22 | 2010-11-25 | Pierre Rabischong | Pelvic implanted neural electrode and method for implanting same |
US20100324625A1 (en) * | 2009-06-19 | 2010-12-23 | Medtronic, Inc. | Bracketing scar for treating pain with electrical stimulation |
US9386927B2 (en) * | 2009-07-28 | 2016-07-12 | Medtronic, Inc. | Implantable blood pressure monitor |
US8774891B1 (en) * | 2009-11-16 | 2014-07-08 | Pmt Corporation | Cortical electrode assemblies |
US8478428B2 (en) | 2010-04-23 | 2013-07-02 | Cyberonics, Inc. | Helical electrode for nerve stimulation |
EP2605823B1 (de) * | 2010-08-18 | 2015-04-08 | Cardiac Pacemakers, Inc. | Schichtelektrode für eine elektrode eines implantierbaren medizinprodukts |
EP2833961A4 (de) * | 2012-04-02 | 2015-11-25 | Bio Control Medical B C M Ltd | Elektrodenmuffen |
AT512534B1 (de) | 2012-04-26 | 2013-09-15 | Univ Wien Med | Nerven-Cuff-Elektrodenanordnung |
JP5900167B2 (ja) * | 2012-06-01 | 2016-04-06 | ソニー株式会社 | 生体信号測定装置、生体信号測定用装具及び生体信号測定装置セット |
US8880167B2 (en) | 2013-02-13 | 2014-11-04 | Flint Hills Scientific, Llc | Selective recruitment and activation of fiber types in nerves for the control of undesirable brain state changes |
DE202013002803U1 (de) | 2013-03-22 | 2013-04-09 | Inomed Medizintechnik Gmbh | Elektrodenanordnung zur elektrischen Stimulierung von Nerven |
US10279189B2 (en) | 2013-06-14 | 2019-05-07 | Cardiothrive, Inc. | Wearable multiphasic cardioverter defibrillator system and method |
US10149973B2 (en) | 2013-06-14 | 2018-12-11 | Cardiothrive, Inc. | Multipart non-uniform patient contact interface and method of use |
US9833630B2 (en) | 2013-06-14 | 2017-12-05 | Cardiothrive, Inc. | Biphasic or multiphasic pulse waveform and method |
EP3104768B1 (de) | 2014-02-11 | 2023-07-26 | Cyberonics, Inc. | Systeme zur erkennung und behandlung obstruktiver schlafapnoe |
DE102014014927A1 (de) * | 2014-10-07 | 2016-04-07 | Neuroloop GmbH | Implantierbare Elektrodenanordnung |
DE102014014943A1 (de) | 2014-10-07 | 2016-04-07 | Neuroloop GmbH | Implantierbare Elektrodenanordnung |
DE102014014942A1 (de) | 2014-10-07 | 2016-04-07 | Neuroloop GmbH | Implantierbare Anordnung |
EP3261712B1 (de) | 2015-02-24 | 2024-04-03 | Elira, Inc. | System zur appetitmodulation und/oder verbesserung der ernährungseinhaltung mithilfe eines elektrohautpflasters |
US10765863B2 (en) | 2015-02-24 | 2020-09-08 | Elira, Inc. | Systems and methods for using a transcutaneous electrical stimulation device to deliver titrated therapy |
US10376145B2 (en) | 2015-02-24 | 2019-08-13 | Elira, Inc. | Systems and methods for enabling a patient to achieve a weight loss objective using an electrical dermal patch |
US10864367B2 (en) | 2015-02-24 | 2020-12-15 | Elira, Inc. | Methods for using an electrical dermal patch in a manner that reduces adverse patient reactions |
US9956393B2 (en) | 2015-02-24 | 2018-05-01 | Elira, Inc. | Systems for increasing a delay in the gastric emptying time for a patient using a transcutaneous electro-dermal patch |
US20220062621A1 (en) | 2015-02-24 | 2022-03-03 | Elira, Inc. | Electrical Stimulation-Based Weight Management System |
US10335302B2 (en) | 2015-02-24 | 2019-07-02 | Elira, Inc. | Systems and methods for using transcutaneous electrical stimulation to enable dietary interventions |
US10231736B2 (en) | 2015-06-11 | 2019-03-19 | The Regents Of The University Of California | System and method for soft tissue gripping |
US10814127B2 (en) | 2016-02-05 | 2020-10-27 | Boston Scientific Neuromodulation Corporation | Slotted sleeve neurostimulation device |
WO2017143192A2 (en) * | 2016-02-17 | 2017-08-24 | Verily Life Sciences Llc | Extraneural cuff with spike-shaped electrodes for stimulation and recording |
US10485969B2 (en) | 2016-02-19 | 2019-11-26 | Boston Scientific Neuromodulation Corporation | Electrical stimulation cuff devices and systems |
FR3051676A1 (fr) | 2016-05-25 | 2017-12-01 | Sirmed | Electrode quadripolaire implantable de neurostimulation multi-sequentielle du nerf phrenique |
US10493269B2 (en) | 2016-06-02 | 2019-12-03 | Boston Scientific Neuromodulation Corporation | Leads for electrostimulation of peripheral nerves and other targets |
WO2018022460A1 (en) | 2016-07-29 | 2018-02-01 | Boston Scientific Neuromodulation Corporation | Systems and methods for making and using an electrical stimulation system for peripheral nerve stimulation |
EP3548140B1 (de) | 2016-12-02 | 2022-04-20 | Boston Scientific Neuromodulation Corporation | Systeme zur auswahl von stimulationsparametern für elektrische stimulatoren |
WO2018175482A1 (en) * | 2017-03-22 | 2018-09-27 | Verily Life Sciences Llc | Neural electrode array attachment |
KR102081796B1 (ko) * | 2017-11-15 | 2020-02-26 | 재단법인 대구경북과학기술원 | 자가 고정이 가능한 커프 전극 장치 및 이의 제조방법 |
WO2019122905A1 (en) * | 2017-12-20 | 2019-06-27 | Galvani Bioelectronics Limited | Neural interface device for stimulation of a nerve and measuring impedance |
KR20200103036A (ko) * | 2017-12-21 | 2020-09-01 | 갈바니 바이오일렉트로닉스 리미티드 | 전류 스티어링을 위한 신경 자극 디바이스 |
WO2019122819A1 (en) * | 2017-12-21 | 2019-06-27 | Galvani Bioelectronics Limited | Nerve stimulation device for unidirectional stimulation and current steering |
DE102018000966A1 (de) * | 2018-02-07 | 2019-08-22 | Universität Zu Köln | Neuralhülle |
DE102018204036A1 (de) * | 2018-03-16 | 2019-09-19 | Neuroloop GmbH | Implantat in Art einer Wickelmanschetten-Elektrodenanordnung |
DE102018207709A1 (de) | 2018-05-17 | 2019-11-21 | Neuroloop GmbH | Vorrichtung zur extravasalen oder extraneuronalen Befestigung eines medizinischen Implantats in Art einer Wickelmanschette |
CN108939287B (zh) * | 2018-06-04 | 2020-09-04 | 清华大学 | 柔性螺旋电极的制造方法及神经束检测治疗装置 |
DE102019206388A1 (de) | 2019-05-03 | 2020-11-05 | Neuroloop GmbH | Implantierbare elektrische Kontaktanordnung |
US11833348B2 (en) | 2021-07-09 | 2023-12-05 | The Alfred E. Mann Foundation For Scientific Research | Electrode leads having multi-application helical nerve cuffs and associated systems and methods |
Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3654933A (en) * | 1968-11-18 | 1972-04-11 | Medtronic Inc | Implatable electrode |
US3738368A (en) * | 1970-12-14 | 1973-06-12 | R Avery | Implantable electrodes for the stimulation of the sciatic nerve |
US3774618A (en) * | 1972-07-03 | 1973-11-27 | Avery Labor Inc | Implantable nerve stimulation electrode |
US3955560A (en) * | 1974-06-10 | 1976-05-11 | Stein Richard B | Implantable neural electrode |
WO1987007825A1 (en) * | 1986-06-17 | 1987-12-30 | Alfred E. Mann Foundation For Scientific Research | Electrode array and method of manufacture |
EP0408358A2 (de) * | 1989-07-14 | 1991-01-16 | Case Western Reserve University | Intramuskuläre Elektrode für ein neuromuskuläres Reizungssystem |
WO1991017791A1 (fr) * | 1990-05-21 | 1991-11-28 | Souriau & Cie | Electrode neurale annulaire |
WO1993020887A1 (en) * | 1992-04-20 | 1993-10-28 | Case Western Reserve University | Thin film implantable electrode and method of manufacture |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4750499A (en) * | 1986-08-20 | 1988-06-14 | Hoffer Joaquin A | Closed-loop, implanted-sensor, functional electrical stimulation system for partial restoration of motor functions |
US5038781A (en) * | 1988-01-21 | 1991-08-13 | Hassan Hamedi | Multi-electrode neurological stimulation apparatus |
US4940065A (en) * | 1989-01-23 | 1990-07-10 | Regents Of The University Of California | Surgically implantable peripheral nerve electrode |
US5095905A (en) * | 1990-06-07 | 1992-03-17 | Medtronic, Inc. | Implantable neural electrode |
US5476494A (en) * | 1992-09-11 | 1995-12-19 | Massachusetts Institute Of Technology | Low pressure neural contact structure |
US5344438A (en) * | 1993-04-16 | 1994-09-06 | Medtronic, Inc. | Cuff electrode |
-
1994
- 1994-09-16 DE DE4433111A patent/DE4433111A1/de not_active Withdrawn
-
1995
- 1995-09-08 WO PCT/EP1995/003545 patent/WO1996008290A1/de active IP Right Grant
- 1995-09-08 JP JP8509886A patent/JPH10505762A/ja active Pending
- 1995-09-08 DE DE59507542T patent/DE59507542D1/de not_active Expired - Fee Related
- 1995-09-08 EP EP95932017A patent/EP0843574B1/de not_active Expired - Lifetime
- 1995-09-08 US US08/809,190 patent/US5919220A/en not_active Expired - Fee Related
Patent Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3654933A (en) * | 1968-11-18 | 1972-04-11 | Medtronic Inc | Implatable electrode |
US3738368A (en) * | 1970-12-14 | 1973-06-12 | R Avery | Implantable electrodes for the stimulation of the sciatic nerve |
US3774618A (en) * | 1972-07-03 | 1973-11-27 | Avery Labor Inc | Implantable nerve stimulation electrode |
US3955560A (en) * | 1974-06-10 | 1976-05-11 | Stein Richard B | Implantable neural electrode |
WO1987007825A1 (en) * | 1986-06-17 | 1987-12-30 | Alfred E. Mann Foundation For Scientific Research | Electrode array and method of manufacture |
EP0408358A2 (de) * | 1989-07-14 | 1991-01-16 | Case Western Reserve University | Intramuskuläre Elektrode für ein neuromuskuläres Reizungssystem |
WO1991017791A1 (fr) * | 1990-05-21 | 1991-11-28 | Souriau & Cie | Electrode neurale annulaire |
WO1993020887A1 (en) * | 1992-04-20 | 1993-10-28 | Case Western Reserve University | Thin film implantable electrode and method of manufacture |
Cited By (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1999024109A2 (de) | 1997-11-12 | 1999-05-20 | Bartha Johann W | Cuff-elektrode und verfahren zu deren herstellung |
WO1999024109A3 (de) * | 1997-11-12 | 1999-08-19 | Johann W Bartha | Cuff-elektrode und verfahren zu deren herstellung |
DE19847446A1 (de) * | 1998-10-08 | 2000-04-13 | Biotronik Mess & Therapieg | Nervenelektrodenanordnung |
US6292703B1 (en) | 1998-10-08 | 2001-09-18 | Biotronik Mess-Und Therapiegerate Gmbh & Co. | Neural electrode arrangement |
DE19847446B4 (de) * | 1998-10-08 | 2010-04-22 | Biotronik Gmbh & Co. Kg | Nervenelektrodenanordnung |
WO2002055151A1 (de) * | 2001-01-11 | 2002-07-18 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Siebelektrode zur anbindung an einen nervenstumpf |
US6908470B2 (en) | 2001-01-11 | 2005-06-21 | Fraunhofer-Gesellschaft Zur Foderung Der Angewandten Forschung E.V. | Sieve electrode which can be connected to a nerve stump |
US8951556B2 (en) | 2002-12-13 | 2015-02-10 | Durect Corporation | Oral drug delivery system |
CN104055598B (zh) * | 2014-06-25 | 2016-09-07 | 上海交通大学 | 鱼类生物机器人的可植入式柔性神经微电极及其制备方法 |
Also Published As
Publication number | Publication date |
---|---|
JPH10505762A (ja) | 1998-06-09 |
US5919220A (en) | 1999-07-06 |
EP0843574B1 (de) | 1999-12-29 |
DE59507542D1 (de) | 2000-02-03 |
EP0843574A1 (de) | 1998-05-27 |
DE4433111A1 (de) | 1996-03-21 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EP0843574B1 (de) | Cuff-elektrode | |
EP0928212B1 (de) | Flexible künstliche nervenplatte | |
EP0620024B1 (de) | Elektrodenvorrichtung | |
EP1038547B1 (de) | Dilatierbare Herzelektrodenanordnung zur Implantation insbesondere im Koronarsinus des Herzens | |
DE60207216T2 (de) | Leitung mit zwischen elektroden einstellbaren winkel- und raumpositionen | |
DE69733813T2 (de) | Implantierbare hörprothese | |
DE69833426T2 (de) | Gerät und verfahren für perimodiolares cochlea-implantat mit retro-positionierung | |
DE69321690T3 (de) | Elektrodensystem für ein Defibrillationsgerät | |
DE19925854A1 (de) | Elektrodenanordnung | |
EP2120696B1 (de) | Stapediusmuskelelektrode | |
DE3213331A1 (de) | Poroese elektrodenspitze fuer herzschrittmacher und verfahren zum herstellen derselben | |
WO1999024109A2 (de) | Cuff-elektrode und verfahren zu deren herstellung | |
DE602005006364T2 (de) | Stimulations-Lead-Elektrode mit automatischem Capturing | |
EP1349608A1 (de) | Siebelektrode zur anbindung an einen nervenstumpf | |
EP2944281A1 (de) | Elektrodenelement zur elektromedizinischen therapie in einem menschlichen oder tierischen körper | |
DE19507929A1 (de) | Elektrodensystem zur Messung des monophasischen Aktionspotentials | |
EP3423148B1 (de) | Implantierbare manschettenelektrode | |
WO2005087309A1 (de) | Stimulationselektrode | |
DE10028522A1 (de) | Biodegradable Neuroelektrode | |
DE69925949T2 (de) | Impedanzelektrode für eine implantierbare medizinische Vorrichtung, insbesondere für einen Herzschrittmacher | |
EP3884546B1 (de) | Implantierbare elektrische verbindungseinrichtung | |
DE102007020377B4 (de) | Gewebeschonendes Instrument zur Stimulation und/oder Ableitung von bioelektrischen Signalen | |
DE102021100688A1 (de) | Elektromedizinische Elektrode | |
DE102021100685A1 (de) | Elektromedizinische Elektrode | |
DE102021127732A1 (de) | Dehnbare Elektrodenanordnung |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AK | Designated states |
Kind code of ref document: A1 Designated state(s): JP US |
|
AL | Designated countries for regional patents |
Kind code of ref document: A1 Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LU MC NL PT SE |
|
DFPE | Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101) | ||
121 | Ep: the epo has been informed by wipo that ep was designated in this application | ||
WWE | Wipo information: entry into national phase |
Ref document number: 1995932017 Country of ref document: EP |
|
WWE | Wipo information: entry into national phase |
Ref document number: 08809190 Country of ref document: US |
|
WWP | Wipo information: published in national office |
Ref document number: 1995932017 Country of ref document: EP |
|
WWG | Wipo information: grant in national office |
Ref document number: 1995932017 Country of ref document: EP |