WO1996005174A1 - Nouveau derive amine, procede pour le preparer et son utilisation comme antiarythmique - Google Patents

Nouveau derive amine, procede pour le preparer et son utilisation comme antiarythmique Download PDF

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Publication number
WO1996005174A1
WO1996005174A1 PCT/JP1995/001134 JP9501134W WO9605174A1 WO 1996005174 A1 WO1996005174 A1 WO 1996005174A1 JP 9501134 W JP9501134 W JP 9501134W WO 9605174 A1 WO9605174 A1 WO 9605174A1
Authority
WO
WIPO (PCT)
Prior art keywords
group
general formula
salt
compound
hydrogen atom
Prior art date
Application number
PCT/JP1995/001134
Other languages
English (en)
Japanese (ja)
Inventor
You Sup Chung
Sung Dae Park
Lae Sung Kwon
Hong Sub Shin
Shigeru Tanabe
Original Assignee
C & C Research Labs.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by C & C Research Labs. filed Critical C & C Research Labs.
Priority to AU26296/95A priority Critical patent/AU2629695A/en
Publication of WO1996005174A1 publication Critical patent/WO1996005174A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
    • C07D211/14—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

L'invention concerne un nouveau dérivé amine représenté par la formule générale (I) ou un sel de cette amine. Ces composés sont utiles comme antiarythmiques. Dans la formule (I), le groupe de la formule (a) a la formule développée (b) ou (c); A représente -NR8-(CH2)a-(hétérocycle azoté à 5 ou 6 éléments)- ou un hétérocycle azoté à 6 éléments, où R8 représente un alkyle inférieur ou un alkyle inférieur hydroxylé et a représente 0 ou 1; D représente -(CH2)m-, -(CH2)m-O-, -CO- ou -SO2-; R1 et R2 représentent chacun indépendamment un hydrogène, un halogène, un alcoxy inférieur ou un alkylsulfonylamino; R3 représente un alkyle inférieur; R4, R5, R6 et R7 représentent chacun d'une manière indépendante un hydrogène ou un alkyl(inférieur)sulfonylamino; R représente un nitro ou un alkyl(inférieur)sulfonylamino; X représente un hydrogène ou un halogène; et m et n représentent chacun 0, 1, 2 ou 3.
PCT/JP1995/001134 1994-08-16 1995-06-07 Nouveau derive amine, procede pour le preparer et son utilisation comme antiarythmique WO1996005174A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU26296/95A AU2629695A (en) 1994-08-16 1995-06-07 Novel amine derivative, process for producing the same, and use thereof as antiarrhythmic

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP6/192499 1994-08-16
JP19249994 1994-08-16

Publications (1)

Publication Number Publication Date
WO1996005174A1 true WO1996005174A1 (fr) 1996-02-22

Family

ID=16292330

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP1995/001134 WO1996005174A1 (fr) 1994-08-16 1995-06-07 Nouveau derive amine, procede pour le preparer et son utilisation comme antiarythmique

Country Status (3)

Country Link
KR (1) KR960007560A (fr)
AU (1) AU2629695A (fr)
WO (1) WO1996005174A1 (fr)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003055321A (ja) * 2001-08-09 2003-02-26 Taiho Yakuhin Kogyo Kk ベンジルアミン誘導体の製造法
WO2003068236A1 (fr) * 2002-02-18 2003-08-21 Glaxo Group Limited Derives de piperidine et de piperazine possedant une affinite pour les recepteurs de type 5ht-1
WO2004009549A3 (fr) * 2002-07-18 2004-06-03 Actelion Pharmaceuticals Ltd Piperidines utiles pour traiter des maladies du systeme nerveux central
JP2010532382A (ja) * 2007-06-29 2010-10-07 エモリー・ユニバーシテイ 神経保護のためのｎｍｄａ受容体拮抗薬
JP2013014607A (ja) * 2009-05-06 2013-01-24 Merck Sharp & Dohme Corp 腎髄質外部カリウムチャネルの阻害剤

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS62281858A (ja) * 1986-02-26 1987-12-07 Eisai Co Ltd ピペリジン誘導体及びその類縁誘導体
JPS6452756A (en) * 1987-08-24 1989-02-28 Eisai Co Ltd Piperdine derivative and remedy and preventive for arrhythmia containing said derivative
JPH04290878A (ja) * 1990-12-05 1992-10-15 Ciba Geigy Ag 置換ｎ−ベンゾイル−ｎ′−（２−フェニルエチル）ピペラジン
JPH04356462A (ja) * 1990-03-28 1992-12-10 Du Pont Merck Pharmaceut Co 向精神薬または植物の真菌殺菌剤としてのピペリジンエーテル誘導体
JPH05500660A (ja) * 1989-09-15 1993-02-12 シエーリング　アクチエンゲゼルシヤフト ２―置換―１（４）―アリールピペラジンおよびその製造方法

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS62281858A (ja) * 1986-02-26 1987-12-07 Eisai Co Ltd ピペリジン誘導体及びその類縁誘導体
JPS6452756A (en) * 1987-08-24 1989-02-28 Eisai Co Ltd Piperdine derivative and remedy and preventive for arrhythmia containing said derivative
JPH05500660A (ja) * 1989-09-15 1993-02-12 シエーリング　アクチエンゲゼルシヤフト ２―置換―１（４）―アリールピペラジンおよびその製造方法
JPH04356462A (ja) * 1990-03-28 1992-12-10 Du Pont Merck Pharmaceut Co 向精神薬または植物の真菌殺菌剤としてのピペリジンエーテル誘導体
JPH04290878A (ja) * 1990-12-05 1992-10-15 Ciba Geigy Ag 置換ｎ−ベンゾイル−ｎ′−（２−フェニルエチル）ピペラジン

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
INDIAN J. CHEM., Sect. B, 19B(11), 1003-5 (1980). *
INDIAN J. CHEM., Sect. B, 20B(8), 680-2 (1981). *

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003055321A (ja) * 2001-08-09 2003-02-26 Taiho Yakuhin Kogyo Kk ベンジルアミン誘導体の製造法
JP4612974B2 (ja) * 2001-08-09 2011-01-12 大鵬薬品工業株式会社 ベンジルアミン誘導体の製造法
WO2003068236A1 (fr) * 2002-02-18 2003-08-21 Glaxo Group Limited Derives de piperidine et de piperazine possedant une affinite pour les recepteurs de type 5ht-1
WO2004009549A3 (fr) * 2002-07-18 2004-06-03 Actelion Pharmaceuticals Ltd Piperidines utiles pour traiter des maladies du systeme nerveux central
JP2010532382A (ja) * 2007-06-29 2010-10-07 エモリー・ユニバーシテイ 神経保護のためのｎｍｄａ受容体拮抗薬
US9079852B2 (en) 2007-06-29 2015-07-14 Emory University NMDA receptor antagonists for neuroprotection
JP2013014607A (ja) * 2009-05-06 2013-01-24 Merck Sharp & Dohme Corp 腎髄質外部カリウムチャネルの阻害剤

Also Published As

Publication number Publication date
AU2629695A (en) 1996-03-07
KR960007560A (ko) 1996-03-22

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